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Deborah C. Rubin, MD

Professor, Medicine
Division of Gastroenterology
Professor, Developmental Biology

Specialty Areas

Gastroenterology
Inflammatory Bowel Disease

Board Certifications

Gastroenterology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Gastroenterology consultation, short bowel syndrome, small bowel diseases, endoscopy, inflammatory bowel disease, women's health in gastroenterology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: 314-747-3969
Fax: 314-362-8959

Education

Education

Fellowship: Gastroenterology, Washington University School of Medicine, St. Louis, Missouri 1988
Chief Residency: John Cochran Veterans Administration Hospital, St. Louis, Missouri 1984
Residency: Internal Medicine, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri 1984
Medical Degree: Albert Einstein College Of Medicine, Bronx, New York 1981
B.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1977

Publication & Research

Publication & Research

Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm.
Christophi GP, Sharma Y, Farhan Q, Jain U, Walker T, Sayuc GS, Rubin DC
J Gastrointestin Liver Dis. 2017 Jun; 26(2)183-187. doi: 10.15403/jgld.2014.1121.262.erd.

PMID:
    28617889
    [PubMed - in process]
Related citations


Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.
Zhu D, Xie L, Kang Y, Dolai S, Bondo Hansen J, Qin T, Xie H, Liang T, Rubin DC, Osborne L, Gaisano HY
Diabetes. 2017 Apr; 66(4)948-959. doi: 10.2337/db16-0636.

PMID:
    28115395
    [PubMed - indexed for MEDLINE]
Related citations


Mechanisms of intestinal adaptation.
Rubin DC, Levin MS
Best Pract Res Clin Gastroenterol. 2016 Apr; 30(2)237-48. doi: 10.1016/j.bpg.2016.03.007.

PMID:
    27086888
    [PubMed - indexed for MEDLINE]
Related citations


Proline Absorption and SGK1 Expression are Inhibited in Intestinal Tis7 Transgenic Mice.
Lu J, Garcia AM, Geisman T, Wakeman D, Warner BW, Swietlicki EA, Levin MS, Rubin DC
Cell Physiol Biochem. 2016; 38(4)1532-43. doi: 10.1159/000443094.

PMID:
    27050729
    [PubMed - indexed for MEDLINE]
Related citations


Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands.
Gargus M, Niu C, Vallone JG, Binkley J, Rubin DC, Shaker A
Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1; 308(11)G904-23.

PMID:
    25882613
    [PubMed - indexed for MEDLINE]
Related citations


Tis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome.
Garcia AM, Wakeman D, Lu J, Rowley C, Geisman T, Butler C, Bala S, Swietlicki EA, Warner BW, Levin MS, Rubin DC
Am J Physiol Gastrointest Liver Physiol. 2014 Sep 15; 307(6)G642-54. doi: 10.1152/ajpgi.00374.2013.

PMID:
    25059825
    [PubMed - indexed for MEDLINE]
Related citations


Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities.
Li E, Ji P, Ouyang N, Zhang Y, Wang XY, Rubin DC, Davidson NO, Bergamaschi R, Shroyer KR, Burke S, Zhu W, Williams JL
Int J Oncol. 2014 Aug; 45(2)587-94. doi: 10.3892/ijo.2014.2469.

PMID:
    24865442
    [PubMed - indexed for MEDLINE]
Related citations


Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling.
Shaker A, Gargus M, Fink J, Binkley J, Darwech I, Swietlicki E, Levin MS, Rubin DC
Transl Res. 2014 Jul; 164(1)70-83. doi: 10.1016/j.trsl.2014.03.007.

PMID:
    24731292
    [PubMed - indexed for MEDLINE]
Related citations


Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.
Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC
Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8)G564-72. doi: 10.1152/ajpgi.00486.2012.

PMID:
    23886856
    [PubMed - indexed for MEDLINE]
Related citations


Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Xie Y, Matsumoto H, Nalbantoglu I, Kerr TA, Luo J, Rubin DC, Kennedy S, Davidson NO
PLoS One. 2013; 8(6)e67819. doi: 10.1371/journal.pone.0067819.

PMID:
    23805328
    [PubMed - in process]
Related citations


Gastric cancer in Zambian adults: a prospective case-control study that assessed dietary intake and antioxidant status by using urinary isoprostane excretion.
Asombang AW, Kayamba V, Mwanza-Lisulo M, Colditz G, Mudenda V, Yarasheski K, Chott R, Rubin DC, Gyawali CP, Sinkala E, Mwanamakondo S, Anderson-Spearie C, Kelly P
Am J Clin Nutr. 2013 May; 97(5)1029-35. doi: 10.3945/ajcn.112.051284.

PMID:
    23535107
    [PubMed - indexed for MEDLINE]
Related citations


Foxf2: a mesenchymal regulator of intestinal adenoma development.
van den Brink GR, Rubin DC
Gastroenterology. 2013 May; 144(5)873-6. doi: 10.1053/j.gastro.2013.03.016.

PMID:
    23523844
    [PubMed - indexed for MEDLINE]
Related citations


Stromal cells participate in the murine esophageal mucosal injury response.
Shaker A, Binkley J, Darwech I, Swietlicki E, McDonald K, Newberry R, Rubin DC
Am J Physiol Gastrointest Liver Physiol. 2013 Apr 1; 304(7)G662-72. doi: 10.1152/ajpgi.00225.2012.

PMID:
    23370675
    [PubMed - indexed for MEDLINE]
Related citations


Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.
Rubin DC, Shaker A, Levin MS
Front Immunol. 2012; 3107. doi: 10.3389/fimmu.2012.00107.

PMID:
    22586430
    [PubMed]
Related citations


Stem cells: One step closer to gut repair.
Shaker A, Rubin DC
Nature. 2012 May 9; 485(7397)181-2. doi: 10.1038/485181a.

PMID:
    22575955
    [PubMed - indexed for MEDLINE]
Related citations


Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection.
Yu C, Jiang S, Lu J, Coughlin CC, Wang Y, Swietlicki EA, Wang L, Vietor I, Huber LA, Cikes D, Coleman T, Xie Y, Semenkovich CF, Davidson NO, Levin MS, Rubin DC
J Nutr. 2010 Nov; 140(11)1907-14. doi: 10.3945/jn.110.127084.

PMID:
    20861213
    [PubMed - indexed for MEDLINE]
Related citations


Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche.
Shaker A, Rubin DC
Transl Res. 2010 Sep; 156(3)180-7. doi: 10.1016/j.trsl.2010.06.003.

PMID:
    20801415
    [PubMed - indexed for MEDLINE]
Related citations


Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion.
Shaker A, Swietlicki EA, Wang L, Jiang S, Onal B, Bala S, DeSchryver K, Newberry R, Levin MS, Rubin DC
J Clin Invest. 2010 Jun; 120(6)2081-93. doi: 10.1172/JCI40676.

PMID:
    20458144
    [PubMed - indexed for MEDLINE]
Related citations


Intestinal redox status of major intracellular thiols in a rat model of chronic alcohol consumption.
Tian J, Brown LA, Jones DP, Levin MS, Wang L, Rubin DC, Ziegler TR
JPEN J Parenter Enteral Nutr. 2009 Nov-Dec; 33(6)662-8. doi: 10.1177/0148607109336600.

PMID:
    19597188
    [PubMed - indexed for MEDLINE]
Related citations


Protein losing enteropathy associated with follicular lymphoma of the small bowel.
Cashen AF, Rubin DC, Bartlett NL
Am J Clin Oncol. 2009 Apr; 32(2)222-3. doi: 10.1097/01.coc.0000235998.99400.8d.

PMID:
    19346818
    [PubMed - indexed for MEDLINE]
Related citations