Patient Portal

David Y. Chen, MD, PhD

Instructor, Medicine
Division of Dermatology

Specialty Areas

Skin Cancer

Board Certifications


Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Melanoma, skin cancer, mole mapping, atypical moles

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Center for Outpatient Health

4901 Forest Park Avenue
St. Louis, MO 63108

Suite: 502
Floor: 5
Office Phone: 314-362-2643
Fax: 314-747-8693



Fellowship, Oliver Langenberg Physician Scientist Training Program: Washington University School of Medicine, St. Louis, MO 2016
Residency, Dermatology: Barnes-Jewish Hospital, St. Louis, MO 2016
PhD, Molecular Cell Biology: Washington University School of Medicine, St. Louis, MO 2012
Medical Degree: Washington University School of Medicine, St. Louis, MO 2012
BS, Cellular and Molecular Biology: University of Michigan, Ann Arbor, MI 2003

Publication & Research

Publication & Research

The SLUG zinc-finger protein represses E-cadherin in breast cancer. KM Hajra, DYS Chen, ER Fearon. Cancer research 62 (6), 1613-1618.

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1–associated human and mouse brain tumors. B Dasgupta, Y Yi, DY Chen, JD Weber, DH Gutmann. Cancer research 65 (7), 2755-2760.

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. S Takeda, DY Chen, TD Westergard, JK Fisher, JA Rubens, S Sasagawa, ...Genes & development 20 (17), 2397-2409.

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. HC Tu, D Ren, GX Wang, DY Chen, TD Westergard, H Kim, S Sasagawa, ... Proceedings of the National Academy of Sciences 106 (4), 1093-1098.

Design, syntheses, and evaluation of Taspase1 inhibitors. JT Lee, DY Chen, Z Yang, AD Ramos, JJD Hsieh, M Bogyo. Bioorganic & medicinal chemistry letters 19 (17), 5086-5090.

Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. DY Chen, H Liu, S Takeda, HC Tu, S Sasagawa, BA Van Tine, D Lu, ... Cancer research 70 (13), 5358-5367.

A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. DY Chen, Y Lee, BA Van Tine, AC Searleman, TD Westergard, H Liu, ...Cancer research 72 (3), 736-746.

Extensive tumoral melanosis associated with ipilimumab-treated melanoma. K Staser, D Chen, J Solus, A Schaffer, L Cornelius, G Linette, R Fields. British Journal of Dermatology

Physicians judging medical negligence: A conflict of values. DY Chen, K Vuylsteke, IJ Kodner, D Brown, S Ray. Surgery 157 (4), 818-823

Areas of Research Interest

Cancer biology