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David Michael Holtzman, MD

Andrew B. and Gretchen P. Jones Professor of Neurology
Charlotte and Paul Hagemann Professor of Neurology
Chairman, Department of Neurology
Professor, Molecular Biology and Pharmacology
Neurologist-in-Chief, Barnes-Jewish Hospital

Specialty Areas

Neurology - Adult
Memory Disorders and Diagnosis
Alzheimer's Disease
Dementia

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Neurology, molecular biology, pharmacology, nervous system, Alzheimer's disease, memory, brain research, cerebral blood flow, metabolism, neuroscience, lipid research, neuron, mental retardation, Down's syndrome, neonatal hypoxic-ischemia, brain disorders, spinal fluid.

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985
Email: holtzman@neuro.wustl.edu

Education

Education

Residency: Neurology, University of California, San Francisco, California 1989
Medical Degree: Northwestern University, Chicago, Illinois 1985
BS: Science in Medical Education, Northwestern University, Chicago, Illinois 1983

Publication & Research

Publication & Research

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report.
Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE
Ann N Y Acad Sci. 2020 May 29; doi: 10.1111/nyas.14371.

PMID:
    32472577
    [PubMed - as supplied by publisher]
Related citations


Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M
Nat Med. 2020 May 14; doi: 10.1038/s41591-020-0922-4.

PMID:
    32409732
    [PubMed - as supplied by publisher]
Related citations


SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, Kummer TT
Neuron. 2020 May 6; pii: S0896-6273(20)30281-6. doi: 10.1016/j.neuron.2020.04.012.

PMID:
    32392471
    [PubMed - as supplied by publisher]
Related citations


TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.
Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H
Mol Psychiatry. 2020 May 4; doi: 10.1038/s41380-020-0738-0.

PMID:
    32366951
    [PubMed - as supplied by publisher]
Related citations


Amyloid-β and Tau at the Crossroads of Alzheimer's Disease.
Gallardo G, Holtzman DM
Adv Exp Med Biol. 2019; 1184187-203. doi: 10.1007/978-981-32-9358-8_16.

PMID:
    32096039
    [PubMed - indexed for MEDLINE]
Related citations


<i>APOE</i> genotype regulates pathology and disease progression in synucleinopathy.
Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM
Sci Transl Med. 2020 Feb 5; 12(529)pii: eaay3069. doi: 10.1126/scitranslmed.aay3069.

PMID:
    32024799
    [PubMed - in process]
Related citations


Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M
Nat Med. 2020 Jan; 26(1)131-142. doi: 10.1038/s41591-019-0695-9.

PMID:
    31932797
    [PubMed - indexed for MEDLINE]
Related citations


Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation.
Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C
Nature. 2020 Feb; 578(7793)E9. doi: 10.1038/s41586-019-1925-5.

PMID:
    31932732
    [PubMed]
Related citations


Dementia is not synonymous with Alzheimer's disease.
Jack CR Jr, Holtzman DM, Sperling R
Sci Transl Med. 2019 Dec 11; 11(522)pii: eaav0511. doi: 10.1126/scitranslmed.aav0511.

PMID:
    31826979
    [PubMed - in process]
Related citations


Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease.
Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E
JAMA Netw Open. 2019 Dec 2; 2(12)e1917126. doi: 10.1001/jamanetworkopen.2019.17126.

PMID:
    31825500
    [PubMed - in process]
Related citations


Gut microbiota: from the forgotten organ to a potential key player in the pathology of Alzheimer disease.
Seo DO, Holtzman DM
J Gerontol A Biol Sci Med Sci. 2019 Nov 18; pii: glz262. doi: 10.1093/gerona/glz262.

PMID:
    31738402
    [PubMed - as supplied by publisher]
Related citations


Dietary salt promotes cognitive impairment through tau phosphorylation.
Faraco G, Hochrainer K, Segarra SG, Schaeffer S, Santisteban MM, Menon A, Jiang H, Holtzman DM, Anrather J, Iadecola C
Nature. 2019 Oct; 574(7780)686-690. doi: 10.1038/s41586-019-1688-z.

PMID:
    31645758
    [PubMed - indexed for MEDLINE]
Related citations


Targeting tauopathy with engineered tau-degrading intrabodies.
Gallardo G, Wong CH, Ricardez SM, Mann CN, Lin KH, Leyns CEG, Jiang H, Holtzman DM
Mol Neurodegener. 2019 Oct 22; 14(1)38. doi: 10.1186/s13024-019-0340-6.

PMID:
    31640765
    [PubMed - in process]
Related citations


Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model.
Huynh TV, Wang C, Tran AC, Tabor GT, Mahan TE, Francis CM, Finn MB, Spellman R, Manis M, Tanzi RE, Ulrich JD, Holtzman DM
Mol Neurodegener. 2019 Oct 17; 14(1)37. doi: 10.1186/s13024-019-0337-1.

PMID:
    31623648
    [PubMed - in process]
Related citations


Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Shi Y, Manis M, Long J, Wang K, Sullivan PM, Remolina Serrano J, Hoyle R, Holtzman DM
J Exp Med. 2019 Nov 4; 216(11)2546-2561. doi: 10.1084/jem.20190980.

PMID:
    31601677
    [PubMed - in process]
Related citations


Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Long JM, Holtzman DM
Cell. 2019 Oct 3; 179(2)312-339. doi: 10.1016/j.cell.2019.09.001.

PMID:
    31564456
    [PubMed - in process]
Related citations


The microbiome: A target for Alzheimer disease?
Seo DO, Boros BD, Holtzman DM
Cell Res. 2019 Oct; 29(10)779-780. doi: 10.1038/s41422-019-0227-7.

PMID:
    31488883
    [PubMed - indexed for MEDLINE]
Related citations


Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors.
Wang C, Holtzman DM
Neuropsychopharmacology. 2020 Jan; 45(1)104-120. doi: 10.1038/s41386-019-0478-5.

PMID:
    31408876
    [PubMed - in process]
Related citations


Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.
Xu J, Sun J, Perrin RJ, Mach RH, Bales KR, Morris JC, Benzinger TLS, Holtzman DM
Ann Clin Transl Neurol. 2019 Aug; 6(8)1423-1434. doi: 10.1002/acn3.50837.

PMID:
    31402620
    [PubMed - indexed for MEDLINE]
Related citations


A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.
Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O
Alzheimers Res Ther. 2019 Aug 9; 11(1)71. doi: 10.1186/s13195-019-0524-x.

PMID:
    31399126
    [PubMed - in process]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2019:

Company Name: C2N Diagnostics

Royalties: $200,000 - $249,999

Equity: Yes

Consulting/Advisory Board: $40,000 - $59,999

Speaker Fees:

Reporting Date: May 01, 2020


Company Name: Denali

Royalties: $1 - $9,999

Equity: No

Consulting/Advisory Board: $10,000 - $19,999

Speaker Fees:

Reporting Date: May 01, 2020

Areas of Research Interest

Underlying mechanisms that lead to Alzheimer's disease.