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David Hershel Alpers, MD

Emeritus William B. Kountz Professor, Internal Medicine
Division of Gastroenterology
Co-Director, Center for Human Nutrition

Specialty Areas

Gastroenterology
Internal Medicine

Board Certifications

Gastroenterology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital
VA Medical Center - St. Louis

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Nutrition/malnutrition, small and large intestinal diseases, general GI

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: 314-747-3969
Fax: 314-362-8230

Education

Education

Fellowship: Clinical and Research in Medicine, Massachusetts General Hospital, Boston, Massachusetts 1965
Research Associate: Molecular Biology, National Institutes of Health, Bethesda, Maryland 1964
Residency: Massachusetts General Hospital, Boston, Massachusetts 1962
Medical Degree: Harvard Medical School, Cambridge, Massachusetts 1960
B.A.: Harvard College, Cambridge, Massachusetts 1956

Publication & Research

Publication & Research

Drug-development concepts as guides for optimizing clinical trials of supplemental zinc for populations at risk of deficiency or diarrhea.
Alpers DH, Young GP, Tran CD, Mortimer EK, Gopalsamy GL, Krebs NF, Manary MJ, Ramakrishna BS, Binder HJ, Brown IL, Miller LV
Nutr Rev. 2017 Mar 1; 75(3)147-162. doi: 10.1093/nutrit/nuw065.

PMID:
    28399577
    [PubMed - indexed for MEDLINE]
Related citations


The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying.
Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ, Dukes GE
Br J Pharmacol. 2016 Jun; 173(11)1768-77. doi: 10.1111/bph.13475.

PMID:
    26924243
    [PubMed - indexed for MEDLINE]
Related citations


Absorption and blood/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations.
Alpers DH
Biochimie. 2016 Jul; 12652-6. doi: 10.1016/j.biochi.2015.11.006.

PMID:
    26586110
    [PubMed - indexed for MEDLINE]
Related citations


Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database.
Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM, Krasa H, Ouyang J, Torres VE, Czerwiec FS, Zimmer CA
Drug Saf. 2015 Nov; 38(11)1103-13. doi: 10.1007/s40264-015-0327-3.

PMID:
    26188764
    [PubMed - indexed for MEDLINE]
Related citations


Introduction to the series "Best (but Oft-Forgotten) Practices".
Bier DM, Allison DB, Alpers DH, Astrup A, Cashman KD, Coates PM, Fukagawa NK, Klurfeld DM, Mattes RD, Uauy R
Am J Clin Nutr. 2015 Aug; 102(2)239-40. doi: 10.3945/ajcn.115.117697.

PMID:
    26178729
    [PubMed - indexed for MEDLINE]
Related citations


The relevance of the colon to zinc nutrition.
Gopalsamy GL, Alpers DH, Binder HJ, Tran CD, Ramakrishna BS, Brown I, Manary M, Mortimer E, Young GP
Nutrients. 2015 Jan 14; 7(1)572-83. doi: 10.3390/nu7010572.

PMID:
    25594440
    [PubMed - indexed for MEDLINE]
Related citations


History and impact of nutritional epidemiology.
Alpers DH, Bier DM, Carpenter KJ, McCormick DB, Miller AB, Jacques PF
Adv Nutr. 2014 Sep; 5(5)534-6.

PMID:
    25469385
    [PubMed - indexed for MEDLINE]
Related citations


Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop.
Young GP, Mortimer EK, Gopalsamy GL, Alpers DH, Binder HJ, Manary MJ, Ramakrishna BS, Brown IL, Brewer TG
Am J Clin Nutr. 2014 Oct; 100(4)1198-207. doi: 10.3945/ajcn.113.075036.

PMID:
    25240082
    [PubMed - indexed for MEDLINE]
Related citations


Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats.
Seo M, Inoue I, Tanaka M, Matsuda N, Nakano T, Awata T, Katayama S, Alpers DH, Komoda T
Dig Dis Sci. 2013 Dec; 58(12)3534-44. doi: 10.1007/s10620-013-2879-3.

PMID:
    24166662
    [PubMed - indexed for MEDLINE]
Related citations


Vitamin B12, a fascinating micronutrient, which influences human health in the very early and later stages of life.
Guéant JL, Alpers DH
Biochimie. 2013 May; 95(5)967-9. doi: 10.1016/j.biochi.2013.02.007.

PMID:
    23415651
    [PubMed - indexed for MEDLINE]
Related citations


Intraluminal bioavailability of divalent cations.
Alpers DH
Curr Opin Gastroenterol. 2013 Mar; 29(2)164-9. doi: 10.1097/MOG.0b013e32835d9f8e.

PMID:
    23299755
    [PubMed - indexed for MEDLINE]
Related citations


Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. a personal journey.
Alpers DH, Russell-Jones G
Biochimie. 2013 May; 95(5)989-94. doi: 10.1016/j.biochi.2012.12.006.

PMID:
    23274574
    [PubMed - indexed for MEDLINE]
Related citations


Novel in vitro model for studying hepatic ischemia-reperfusion injury using liver cubes.
DuBray BJ Jr, Conzen KD, Upadhya GA, Balachandran P, Jia J, Knolhoff BL, Alpers DH, Mohanakumar T, Chapman WC, Anderson CD
Surgery. 2012 Aug; 152(2)247-53. doi: 10.1016/j.surg.2012.02.012.

PMID:
    22698934
    [PubMed - indexed for MEDLINE]
Related citations


Translational approaches for pharmacotherapy development for acute diarrhea.
Donowitz M, Alpers DH, Binder HJ, Brewer T, Carrington J, Grey MJ
Gastroenterology. 2012 Mar; 142(3)e1-9. doi: 10.1053/j.gastro.2012.01.014.

PMID:
    22266149
    [PubMed - indexed for MEDLINE]
Related citations


Subclinical micronutrient deficiency: a problem in recognition.
Alpers DH
Curr Opin Gastroenterol. 2012 Mar; 28(2)135-8. doi: 10.1097/MOG.0b013e32834e09f8.

PMID:
    22134221
    [PubMed - indexed for MEDLINE]
Related citations


Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis.
Shao JS, Carmel R, Alpers DH
Dig Dis Sci. 2011 Nov; 56(11)3209-19. doi: 10.1007/s10620-011-1738-3.

PMID:
    21567190
    [PubMed - indexed for MEDLINE]
Related citations


Vitamins as drugs: the importance of pharmacokinetics in oral dosing.
Alpers DH
Curr Opin Gastroenterol. 2011 Mar; 27(2)146-51. doi: 10.1097/MOG.0b013e32834172c0.

PMID:
    21157328
    [PubMed - indexed for MEDLINE]
Related citations


Measurement of intestinal protein synthesis by continuous arterial tracer application: intrinsically difficult problems arising from different protein pools and study techniques.
Hartl WH, Alpers DH, Patterson BW
Clin Nutr. 2011 Feb; 30(1)28-32. doi: 10.1016/j.clnu.2010.04.005.

PMID:
    20493598
    [PubMed - indexed for MEDLINE]
Related citations


The trophic effects of substrate, insulin, and the route of administration on protein synthesis and the preservation of small bowel mucosal mass in large mammals.
Hartl WH, Alpers DH
Clin Nutr. 2011 Feb; 30(1)20-7. doi: 10.1016/j.clnu.2010.03.002.

PMID:
    20488593
    [PubMed - indexed for MEDLINE]
Related citations


Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin c: implication in oxidative stress.
Matsunaga T, Tsuji Y, Kaai K, Kohno S, Hirayama R, Alpers DH, Komoda T, Hara A
Cancer Chemother Pharmacol. 2010 Aug; 66(3)517-26. doi: 10.1007/s00280-009-1192-5.

PMID:
    19967538
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: GSK

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Otsuka

Royalties:

Equity: No

Consulting/Advisory Board: $25,001 - $50,000

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Pfizer

Royalties:

Equity: No

Consulting/Advisory Board: $25,001 - $50,000

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Takeda

Royalties:

Equity: No

Consulting/Advisory Board: $50,001 - $100,000

Speaker Fees:

Reporting Date: May 01, 2017