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David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Dissecting Clinical Heterogeneity in Neurofibromatosis Type 1.
Monroe CL, Dahiya S, Gutmann DH
Annu Rev Pathol. 2017 Jan 24; 1253-74. doi: 10.1146/annurev-pathol-052016-100228.

PMID:
    28135565
    [PubMed - in process]
Related citations


Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma.
Ricker CA, Pan Y, Gutmann DH, Keller C
Front Oncol. 2016 Dec 20; 6259. doi: 10.3389/fonc.2016.00259.

PMID:
    28066715
    [PubMed - in process]
Related citations


Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.
Toonen JA, Ma Y, Gutmann DH
Neuro Oncol. 2016 Dec 29; pii: now267. doi: 10.1093/neuonc/now267.

PMID:
    28039362
    [PubMed - as supplied by publisher]
Related citations


Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.
Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium.
Neurology. 2016 Dec 13; 87(24)2575-2584.

PMID:
    27956565
    [PubMed - in process]
Related citations


A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.
Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N
J Biol Chem. 2017 Jan 27; 292(4)1240-1250. doi: 10.1074/jbc.M116.748871.

PMID:
    27941025
    [PubMed - in process]
Related citations


Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.
Toonen JA, Solga AC, Ma Y, Gutmann DH
J Exp Med. 2017 Jan; 214(1)17-25. doi: 10.1084/jem.20160447.

PMID:
    27923908
    [PubMed - in process]
Related citations


Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
Cancer. 2016 Nov 22; doi: 10.1002/cncr.30455.

PMID:
    27875628
    [PubMed - as supplied by publisher]
Related citations


3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.
Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM
J Proteomics. 2016 Oct 21; 14977-84. doi: 10.1016/j.jprot.2016.02.004.

PMID:
    26883872
    [PubMed - in process]
Related citations


Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT).
Morris SM, Acosta MT, Garg S, Green J, Huson S, Legius E, North KN, Payne JM, Plasschaert E, Frazier TW, Weiss LA, Zhang Y, Gutmann DH, Constantino JN
JAMA Psychiatry. 2016 Dec 1; 73(12)1276-1284. doi: 10.1001/jamapsychiatry.2016.2600.

PMID:
    27760236
    [PubMed - in process]
Related citations


Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.
Morris SM, Monroe CL, Gutmann DH
J Child Neurol. 2016 Dec; 31(14)1540-1545.

PMID:
    27581847
    [PubMed - in process]
Related citations


Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I.
Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA
Dis Model Mech. 2016 Jul 1; 9(7)759-67. doi: 10.1242/dmm.025783.

PMID:
    27482814
    [PubMed - in process]
Related citations


Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Smithson LJ, Gutmann DH
Genes Dev. 2016 Jun 15; 30(12)1383-8. doi: 10.1101/gad.279661.116.

PMID:
    27340174
    [PubMed - in process]
Related citations


Contextual signaling in cancer.
Smithson LJ, Anastasaki C, Chen R, Toonen JA, Williams SB, Gutmann DH
Semin Cell Dev Biol. 2016 Oct; 58118-26. doi: 10.1016/j.semcdb.2016.06.002.

PMID:
    27269372
    [PubMed - in process]
Related citations


Exploring the genetic basis for clinical variation in neurofibromatosis type 1.
Gutmann DH
Expert Rev Neurother. 2016 Sep; 16(9)999-1001. doi: 10.1080/14737175.2016.1189329.

PMID:
    27171602
    [PubMed - in process]
Related citations


Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.
Johnson KJ, Zoellner NL, Gutmann DH
Cancer Epidemiol. 2016 Jun; 4253-9. doi: 10.1016/j.canep.2016.03.005.

PMID:
    27018750
    [PubMed - indexed for MEDLINE]
Related citations


ABCG1 maintains high-grade glioma survival in vitro and in vivo.
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH
Oncotarget. 2016 Apr 26; 7(17)23416-24. doi: 10.18632/oncotarget.8030.

PMID:
    26981778
    [PubMed - in process]
Related citations


De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging.
Zafar R, Hsiao EY, Botteron KN, McKinstry RC, Gutmann DH
Radiol Case Rep. 2016 Feb 2; 11(1)33-5. doi: 10.1016/j.radcr.2015.12.008.

PMID:
    26973730
    [PubMed]
Related citations


Gliosarcomas lack BRAF<sup>V600E</sup> mutation, but a subset exhibit β-catenin nuclear localization.
Schwetye KE, Joseph NM, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S
Neuropathology. 2016 Oct; 36(5)448-455. doi: 10.1111/neup.12293.

PMID:
    26932501
    [PubMed - indexed for MEDLINE]
Related citations


NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.
Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH
Hum Mol Genet. 2016 May 1; 25(9)1703-13. doi: 10.1093/hmg/ddw039.

PMID:
    26908603
    [PubMed - in process]
Related citations


Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH
Oncotarget. 2016 Feb 16; 7(7)7403-14. doi: 10.18632/oncotarget.7232.

PMID:
    26859681
    [PubMed - indexed for MEDLINE]
Related citations