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Faculty Physicians

David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Pediatric Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell. 2016 Jan 28; 164(3)550-63. doi: 10.1016/j.cell.2015.12.028.

PMID:
    26824661
    [PubMed - in process]
Related citations


The role of microglia and macrophages in glioma maintenance and progression.
Hambardzumyan D, Gutmann DH, Kettenmann H
Nat Neurosci. 2015 Dec 29; 19(1)20-7. doi: 10.1038/nn.4185.

PMID:
    26713745
    [PubMed - in process]
Related citations


Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1.
Porcelli B, Zoellner NL, Abadin SS, Gutmann DH, Johnson KJ
Fam Cancer. 2015 Dec 14;

PMID:
    26666764
    [PubMed - as supplied by publisher]
Related citations


Pediatric gliomas as neurodevelopmental disorders.
Baker SJ, Ellison DW, Gutmann DH
Glia. 2015 Dec 6; doi: 10.1002/glia.22945.

PMID:
    26638183
    [PubMed - as supplied by publisher]
Related citations


RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.
Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH
Neoplasia. 2015 Oct; 17(10)776-88. doi: 10.1016/j.neo.2015.10.002.

PMID:
    26585233
    [PubMed - in process]
Related citations


Neurofibromatosis type 1.
Anderson JL, Gutmann DH
Handb Clin Neurol. 2015; 13275-86. doi: 10.1016/B978-0-444-62702-5.00004-4.

PMID:
    26564071
    [PubMed - in process]
Related citations


Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.
Chen YH, Gianino SM, Gutmann DH
Genes Dev. 2015 Aug 15; 29(16)1677-82. doi: 10.1101/gad.261677.115.

PMID:
    26272820
    [PubMed - indexed for MEDLINE]
Related citations


Distribution and Within-Family Specificity of Quantitative Autistic Traits in Patients with Neurofibromatosis Type I.
Constantino JN, Zhang Y, Holzhauer K, Sant S, Long K, Vallorani A, Malik L, Gutmann DH
J Pediatr. 2015 Sep; 167(3)621-6.e1. doi: 10.1016/j.jpeds.2015.04.075.

PMID:
    26051969
    [PubMed - indexed for MEDLINE]
Related citations


Racial/Ethnic Differences in Pediatric Brain Tumor Diagnoses in Patients with Neurofibromatosis Type 1.
Abadin SS, Zoellner NL, Schaeffer M, Porcelli B, Gutmann DH, Johnson KJ
J Pediatr. 2015 Sep; 167(3)613-20.e1-2. doi: 10.1016/j.jpeds.2015.04.076.

PMID:
    26028287
    [PubMed - indexed for MEDLINE]
Related citations


Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
Clin Cancer Res. 2015 Sep 15; 21(18)4201-11. doi: 10.1158/1078-0432.CCR-14-3049.

PMID:
    25925892
    [PubMed - in process]
Related citations


HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.
Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y
Mol Psychiatry. 2015 Nov; 20(11)1311-21. doi: 10.1038/mp.2015.48.

PMID:
    25917366
    [PubMed - in process]
Related citations


Elucidating the impact of neurofibromatosis-1 germline mutations on neurofibromin function and dopamine-based learning.
Anastasaki C, Woo AS, Messiaen LM, Gutmann DH
Hum Mol Genet. 2015 Jun 15; 24(12)3518-28. doi: 10.1093/hmg/ddv103.

PMID:
    25788518
    [PubMed - indexed for MEDLINE]
Related citations


Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.
Bender RH, Haigis KM, Gutmann DH
Stem Cells. 2015 Jun; 33(6)1998-2010. doi: 10.1002/stem.1990.

PMID:
    25788415
    [PubMed - in process]
Related citations


Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.
Chen YH, McGowan LD, Cimino PJ, Dahiya S, Leonard JR, Lee da Y, Gutmann DH
Cell Rep. 2015 Mar 24; 10(11)1899-912. doi: 10.1016/j.celrep.2015.02.041.

PMID:
    25772366
    [PubMed - indexed for MEDLINE]
Related citations


Improving outcomes for neurofibromatosis 1-associated brain tumors.
Brossier NM, Gutmann DH
Expert Rev Anticancer Ther. 2015 Apr; 15(4)415-23. doi: 10.1586/14737140.2015.1009043.

PMID:
    25652347
    [PubMed - indexed for MEDLINE]
Related citations


The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR
Nat Commun. 2015 Jan 21; 66122. doi: 10.1038/ncomms7122.

PMID:
    25607772
    [PubMed - in process]
Related citations


The taxonomy of brain cancer stem cells: what's in a name?
Gutmann DH
Oncoscience. 2014; 1(3)241-7.

PMID:
    25594016
    [PubMed]
Related citations


Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.
Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH
Neuro Oncol. 2015 Jun; 17(6)843-53. doi: 10.1093/neuonc/nou329.

PMID:
    25534823
    [PubMed - in process]
Related citations


Validity of participant-reported diagnoses in an online patient registry: a report from the NF1 Patient Registry Initiative.
Sharkey EK, Zoellner NL, Abadin S, Gutmann DH, Johnson KJ
Contemp Clin Trials. 2015 Jan; 40212-7. doi: 10.1016/j.cct.2014.12.006.

PMID:
    25533730
    [PubMed - indexed for MEDLINE]
Related citations


Microglia in the tumor microenvironment: taking their TOLL on glioma biology.
Gutmann DH
Neuro Oncol. 2015 Feb; 17(2)171-3. doi: 10.1093/neuonc/nou346.

PMID:
    25523594
    [PubMed - indexed for MEDLINE]
Related citations