Patient Portal

David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Location(s)
  • Education
  • Publication & Research
  • Videos

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations.
Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Cobb O, Dougherty JD, Gutmann DH
Stem Cell Reports. 2020 Mar 20; pii: S2213-6711(20)30097-7. doi: 10.1016/j.stemcr.2020.03.007.

PMID:
    32243842
    [PubMed - as supplied by publisher]
Related citations


A Phase II Study of Continuous Oral mTOR Inhibitor Everolimus for Recurrent, Radiographic-Progressive Neurofibromatosis Type 1-Associated Pediatric Low-Grade Glioma: A Neurofibromatosis Clinical Trials Consortium Study.
Ullrich NJ, Prabhu SP, Reddy AT, Fisher MJ, Packer R, Goldman S, Robison NJ, Gutmann DH, Viskochil DH, Allen JC, Korf B, Cantor A, Cutter G, Thomas C, Perentesis JP, Mizuno T, Vinks AA, Manley PE, Chi SN, Kieran MW, NF Clinical Trials Consortium.
Neuro Oncol. 2020 Apr 1; pii: noaa071. doi: 10.1093/neuonc/noaa071.

PMID:
    32236425
    [PubMed - as supplied by publisher]
Related citations


Erratum to "KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production" [Neoplasia, Volume: 21, Issue:1, (2019) 52-60].
Chen R, Keoni C, Waker CA, Lober RM, Chen YH, Gutmann DH
Neoplasia. 2020 Mar; 22(3)e1. doi: 10.1016/j.neo.2019.04.005.

PMID:
    32098655
    [PubMed]
Related citations


Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference.
Packer RJ, Iavarone A, Jones DTW, Blakeley JO, Bouffet E, Fisher MJ, Hwang E, Hawkins C, Kilburn L, MacDonald T, Pfister SM, Rood B, Rodriguez FJ, Tabori U, Ramaswamy V, Zhu Y, Fangusaro J, Johnston SA, Gutmann DH
Neuro Oncol. 2020 Feb 14; pii: noaa036. doi: 10.1093/neuonc/noaa036.

PMID:
    32055852
    [PubMed - as supplied by publisher]
Related citations


Melanoma in individuals with neurofibromatosis type 1: a retrospective study.
Zhang M, Bhat T, Gutmann DH, Johnson KJ
Dermatol Online J. 2019 Nov 15; 25(11)pii: 13030/qt5ck3f722.

PMID:
    32045143
    [PubMed - indexed for MEDLINE]
Related citations


The Sociobiology of Brain Tumors.
Gutmann DH
Adv Exp Med Biol. 2020; 1225115-125. doi: 10.1007/978-3-030-35727-6_8.

PMID:
    32030651
    [PubMed - indexed for MEDLINE]
Related citations


Correction to: Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.
Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH
Acta Neuropathol Commun. 2020 Jan 8; 8(1)1. doi: 10.1186/s40478-019-0875-3.

PMID:
    31915069
    [PubMed]
Related citations


Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1.
Payne JM, Haebich KM, MacKenzie R, Walsh KS, Hearps SJC, Coghill D, Barton B, Pride NA, Ullrich NJ, Tonsgard JH, Viskochil D, Schorry EK, Klesse L, Fisher MJ, Gutmann DH, Rosser T, Packer RJ, Korf B, Acosta MT, Bellgrove MA, North KN
J Atten Disord. 2019 Dec 14; 1087054719894384. doi: 10.1177/1087054719894384.

PMID:
    31838937
    [PubMed - as supplied by publisher]
Related citations


let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7.
Buonfiglioli A, Efe IE, Guneykaya D, Ivanov A, Huang Y, Orlowski E, Krüger C, Deisz RA, Markovic D, Flüh C, Newman AG, Schneider UC, Beule D, Wolf SA, Dzaye O, Gutmann DH, Semtner M, Kettenmann H, Lehnardt S
Cell Rep. 2019 Dec 10; 29(11)3460-3471.e7. doi: 10.1016/j.celrep.2019.11.029.

PMID:
    31825829
    [PubMed - in process]
Related citations


Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1.
Payne JM, Hearps SJC, Walsh KS, Paltin I, Barton B, Ullrich NJ, Haebich KM, Coghill D, Gioia GA, Cantor A, Cutter G, Tonsgard JH, Viskochil D, Rey-Casserly C, Schorry EK, Ackerson JD, Klesse L, Fisher MJ, Gutmann DH, Rosser T, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium.
Ann Clin Transl Neurol. 2019 Dec; 6(12)2555-2565. doi: 10.1002/acn3.50952.

PMID:
    31797581
    [PubMed - in process]
Related citations


Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology.
Gutmann DH, Kettenmann H
Neuron. 2019 Nov 6; 104(3)442-449. doi: 10.1016/j.neuron.2019.08.028.

PMID:
    31697921
    [PubMed - indexed for MEDLINE]
Related citations


Pain symptomology, functional impact, and treatment of people with Neurofibromatosis type 1.
Buono FD, Grau LE, Sprong ME, Morford KL, Johnson KJ, Gutmann DH
J Pain Res. 2019; 122555-2561. doi: 10.2147/JPR.S209540.

PMID:
    31692483
    [PubMed]
Related citations


NF1 glioblastoma clonal profiling reveals <i>KMT2B</i> mutations as potential somatic oncogenic events.
Wong WH, Junck L, Druley TE, Gutmann DH
Neurology. 2019 Dec 10; 93(24)1067-1069. doi: 10.1212/WNL.0000000000008623.

PMID:
    31690684
    [PubMed - indexed for MEDLINE]
Related citations


Microglia as Dynamic Cellular Mediators of Brain Function.
Wright-Jin EC, Gutmann DH
Trends Mol Med. 2019 Nov; 25(11)967-979. doi: 10.1016/j.molmed.2019.08.013.

PMID:
    31597593
    [PubMed - in process]
Related citations


Understanding a complicated Gal-1.
Hirbe AC, Gutmann DH
Neuro Oncol. 2019 Nov 4; 21(11)1341-1343. doi: 10.1093/neuonc/noz165.

PMID:
    31538650
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis 2 in children presenting during the first decade of life.
Gaudioso C, Listernick R, Fisher MJ, Campen CJ, Paz A, Gutmann DH
Neurology. 2019 Sep 3; 93(10)e964-e967. doi: 10.1212/WNL.0000000000008065.

PMID:
    31363058
    [PubMed - indexed for MEDLINE]
Related citations


Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1.
Haage V, Elmadany N, Roll L, Faissner A, Gutmann DH, Semtner M, Kettenmann H
Brain Behav Immun. 2019 Oct; 81470-483. doi: 10.1016/j.bbi.2019.06.047.

PMID:
    31271872
    [PubMed - in process]
Related citations


Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.
Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ
Nat Rev Clin Oncol. 2019 Aug; 16(8)522-523. doi: 10.1038/s41571-019-0236-y.

PMID:
    31150022
    [PubMed - indexed for MEDLINE]
Related citations


Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia.
Guo X, Pan Y, Gutmann DH
Neuro Oncol. 2019 Oct 9; 21(10)1250-1262. doi: 10.1093/neuonc/noz080.

PMID:
    31111915
    [PubMed - in process]
Related citations


Commentary: Identification of Mutation Regions on <i>NF1</i> Responsible for High- and Low-Risk Development of Optic Pathway Glioma in Neurofibromatosis Type I.
Anastasaki C, Gao F, Gutmann DH
Front Genet. 2019; 10115. doi: 10.3389/fgene.2019.00115.

PMID:
    30881378
    [PubMed]
Related citations

Videos

Videos