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David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1.
Morris SM, Monroe CL, Gutmann DH
J Child Neurol. 2016 Aug 31; pii: 0883073816664659.

PMID:
    27581847
    [PubMed - as supplied by publisher]
Related citations


Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I.
Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA
Dis Model Mech. 2016 Jul 1; 9(7)759-67. doi: 10.1242/dmm.025783.

PMID:
    27482814
    [PubMed - in process]
Related citations


Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Smithson LJ, Gutmann DH
Genes Dev. 2016 Jun 15; 30(12)1383-8. doi: 10.1101/gad.279661.116.

PMID:
    27340174
    [PubMed - in process]
Related citations


Contextual signaling in cancer.
Smithson LJ, Anastasaki C, Chen R, Toonen JA, Williams SB, Gutmann DH
Semin Cell Dev Biol. 2016 Oct; 58118-26. doi: 10.1016/j.semcdb.2016.06.002.

PMID:
    27269372
    [PubMed - in process]
Related citations


Exploring the genetic basis for clinical variation in neurofibromatosis type 1.
Gutmann DH
Expert Rev Neurother. 2016 Sep; 16(9)999-1001. doi: 10.1080/14737175.2016.1189329.

PMID:
    27171602
    [PubMed - in process]
Related citations


Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1.
Johnson KJ, Zoellner NL, Gutmann DH
Cancer Epidemiol. 2016 Jun; 4253-9. doi: 10.1016/j.canep.2016.03.005.

PMID:
    27018750
    [PubMed - in process]
Related citations


ABCG1 maintains high-grade glioma survival in vitro and in vivo.
Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH
Oncotarget. 2016 Apr 26; 7(17)23416-24. doi: 10.18632/oncotarget.8030.

PMID:
    26981778
    [PubMed - in process]
Related citations


De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging.
Zafar R, Hsiao EY, Botteron KN, McKinstry RC, Gutmann DH
Radiol Case Rep. 2016 Mar; 11(1)33-5. doi: 10.1016/j.radcr.2015.12.008.

PMID:
    26973730
    [PubMed]
Related citations


Gliosarcomas lack BRAF<sup>V600E</sup> mutation, but a subset exhibit β-catenin nuclear localization.
Schwetye KE, Joseph NM, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S
Neuropathology. 2016 Mar 2; doi: 10.1111/neup.12293.

PMID:
    26932501
    [PubMed - as supplied by publisher]
Related citations


NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.
Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH
Hum Mol Genet. 2016 May 1; 25(9)1703-13. doi: 10.1093/hmg/ddw039.

PMID:
    26908603
    [PubMed - in process]
Related citations


3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.
Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM
J Proteomics. 2016 Feb 13; pii: S1874-3919(16)30027-6. doi: 10.1016/j.jprot.2016.02.004.

PMID:
    26883872
    [PubMed - as supplied by publisher]
Related citations


Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH
Oncotarget. 2016 Feb 16; 7(7)7403-14. doi: 10.18632/oncotarget.7232.

PMID:
    26859681
    [PubMed - in process]
Related citations


Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG
Cell. 2016 Jan 28; 164(3)550-63. doi: 10.1016/j.cell.2015.12.028.

PMID:
    26824661
    [PubMed - indexed for MEDLINE]
Related citations


The role of microglia and macrophages in glioma maintenance and progression.
Hambardzumyan D, Gutmann DH, Kettenmann H
Nat Neurosci. 2016 Jan; 19(1)20-7. doi: 10.1038/nn.4185.

PMID:
    26713745
    [PubMed - indexed for MEDLINE]
Related citations


Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1.
Porcelli B, Zoellner NL, Abadin SS, Gutmann DH, Johnson KJ
Fam Cancer. 2016 Apr; 15(2)301-8. doi: 10.1007/s10689-015-9855-3.

PMID:
    26666764
    [PubMed - in process]
Related citations


Pediatric gliomas as neurodevelopmental disorders.
Baker SJ, Ellison DW, Gutmann DH
Glia. 2016 Jun; 64(6)879-95. doi: 10.1002/glia.22945.

PMID:
    26638183
    [PubMed - in process]
Related citations


RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.
Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH
Neoplasia. 2015 Oct; 17(10)776-88. doi: 10.1016/j.neo.2015.10.002.

PMID:
    26585233
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1.
Anderson JL, Gutmann DH
Handb Clin Neurol. 2015; 13275-86. doi: 10.1016/B978-0-444-62702-5.00004-4.

PMID:
    26564071
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.
Chen YH, Gianino SM, Gutmann DH
Genes Dev. 2015 Aug 15; 29(16)1677-82. doi: 10.1101/gad.261677.115.

PMID:
    26272820
    [PubMed - indexed for MEDLINE]
Related citations


Distribution and Within-Family Specificity of Quantitative Autistic Traits in Patients with Neurofibromatosis Type I.
Constantino JN, Zhang Y, Holzhauer K, Sant S, Long K, Vallorani A, Malik L, Gutmann DH
J Pediatr. 2015 Sep; 167(3)621-6.e1. doi: 10.1016/j.jpeds.2015.04.075.

PMID:
    26051969
    [PubMed - indexed for MEDLINE]
Related citations