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David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of <i>Nf1</i> low-grade glioma growth.
Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH
Genes Dev. 2018 Apr 9; doi: 10.1101/gad.310797.117.

PMID:
    29632086
    [PubMed - as supplied by publisher]
Related citations


β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH
Neuro Oncol. 2018 Mar 27; doi: 10.1093/neuonc/noy038.

PMID:
    29596596
    [PubMed - as supplied by publisher]
Related citations


A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A
Cell Rep. 2018 Mar 27; 22(13)3416-3426. doi: 10.1016/j.celrep.2018.03.014.

PMID:
    29590612
    [PubMed - in process]
Related citations


Neurofibromatosis type 1.
Cimino PJ, Gutmann DH
Handb Clin Neurol. 2018; 148799-811. doi: 10.1016/B978-0-444-64076-5.00051-X.

PMID:
    29478615
    [PubMed - in process]
Related citations


A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1.
Morris SM, Gutmann DH
Neurology. 2018 Feb 20; 90(8)377-379. doi: 10.1212/WNL.0000000000005000.

PMID:
    29367450
    [PubMed - in process]
Related citations


Optic Pathway Gliomas in Neurofibromatosis Type 1.
Campen CJ, Gutmann DH
J Child Neurol. 2018 Jan; 33(1)73-81. doi: 10.1177/0883073817739509.

PMID:
    29246098
    [PubMed - in process]
Related citations


Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
EMBO J. 2017 Dec 15; 36(24)3650-3665. doi: 10.15252/embj.201796700.

PMID:
    29127155
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR
J Natl Cancer Inst. 2017 Aug 1; 109(8)doi: 10.1093/jnci/djx124.

PMID:
    29117388
    [PubMed - indexed for MEDLINE]
Related citations


Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca., Cancer Genome Atlas Research Network.
Cell. 2017 Nov 2; 171(4)950-965.e28. doi: 10.1016/j.cell.2017.10.014.

PMID:
    29100075
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.
Khatua S, Gutmann DH, Packer RJ
Pediatr Blood Cancer. 2018 Mar; 65(3)doi: 10.1002/pbc.26838.

PMID:
    29049847
    [PubMed - in process]
Related citations


Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Zou J, Zhang B, Gutmann DH, Wong M
Epilepsia. 2017 Dec; 58(12)2053-2063. doi: 10.1111/epi.13923.

PMID:
    29023667
    [PubMed - indexed for MEDLINE]
Related citations


Children with 5'-end <i>NF1</i> gene mutations are more likely to have glioma.
Anastasaki C, Morris SM, Gao F, Gutmann DH
Neurol Genet. 2017 Oct; 3(5)e192. doi: 10.1212/NXG.0000000000000192.

PMID:
    28955729
    [PubMed]
Related citations


Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH
Oncotarget. 2017 Aug 8; 8(32)52474-52487. doi: 10.18632/oncotarget.17193.

PMID:
    28881745
    [PubMed]
Related citations


Neurodevelopmental disorders in children with neurofibromatosis type 1.
Vogel AC, Gutmann DH, Morris SM
Dev Med Child Neurol. 2017 Nov; 59(11)1112-1116. doi: 10.1111/dmcn.13526.

PMID:
    28845518
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.
Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD
Autism Res. 2018 Jan; 11(1)44-58. doi: 10.1002/aur.1853.

PMID:
    28842941
    [PubMed - in process]
Related citations


The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.
Gutmann DH
Cell. 2017 Aug 24; 170(5)821-822. doi: 10.1016/j.cell.2017.08.011.

PMID:
    28841413
    [PubMed - indexed for MEDLINE]
Related citations


Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.
de Blank PMK, Fisher MJ, Liu GT, Gutmann DH, Listernick R, Ferner RE, Avery RA
J Neuroophthalmol. 2017 Sep; 37 Suppl 1S23-S32. doi: 10.1097/WNO.0000000000000550.

PMID:
    28806346
    [PubMed - indexed for MEDLINE]
Related citations


Updated nomenclature for human and mouse neurofibromatosis type 1 genes.
Anastasaki C, Le LQ, Kesterson RA, Gutmann DH
Neurol Genet. 2017 Aug; 3(4)e169. doi: 10.1212/NXG.0000000000000169.

PMID:
    28804759
    [PubMed]
Related citations


The power of the few.
Chen R, Pan Y, Gutmann DH
Genes Dev. 2017 Jun 15; 31(12)1177-1179. doi: 10.1101/gad.303453.117.

PMID:
    28765159
    [PubMed - indexed for MEDLINE]
Related citations


CNS Tumors in Neurofibromatosis.
Campian J, Gutmann DH
J Clin Oncol. 2017 Jul 20; 35(21)2378-2385. doi: 10.1200/JCO.2016.71.7199.

PMID:
    28640700
    [PubMed - indexed for MEDLINE]
Related citations

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