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David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.
Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH
Oncotarget. 2017 May 3; doi: 10.18632/oncotarget.17589.

PMID:
    28525381
    [PubMed - as supplied by publisher]
Related citations


Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.
Chheda MG, Gutmann DH
Cancer Cell. 2017 May 8; 31(5)609-611. doi: 10.1016/j.ccell.2017.04.008.

PMID:
    28486100
    [PubMed - in process]
Related citations


Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH
Oncotarget. 2017 Apr 18; doi: 10.18632/oncotarget.17193.

PMID:
    28477028
    [PubMed - as supplied by publisher]
Related citations


Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A
Biophys J. 2017 Apr 25; 112(8)1535-1538. doi: 10.1016/j.bpj.2017.03.017.

PMID:
    28445745
    [PubMed - in process]
Related citations


The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.
Blakeley JO, Bakker A, Barker A, Clapp W, Ferner R, Fisher MJ, Giovannini M, Gutmann DH, Karajannis MA, Kissil JL, Legius E, Lloyd AC, Packer RJ, Ramesh V, Riccardi VM, Stevenson DA, Ullrich NJ, Upadhyaya M, Stemmer-Rachamimov A
Am J Med Genet A. 2017 Apr 24; doi: 10.1002/ajmg.a.38239.

PMID:
    28436162
    [PubMed - as supplied by publisher]
Related citations


microRNA profiling reveals marker of motor neuron disease in ALS models.
Hoye ML, Koval ED, Wegener AJ, Hyman TS, Yang C, O'Brien DR, Miller RL, Cole T, Schoch KM, Shen T, Kunikata T, Richard JP, Gutmann DH, Maragakis NJ, Kordasiewicz HB, Dougherty JD, Miller TM
J Neurosci. 2017 Apr 17; pii: 3582-16. doi: 10.1523/JNEUROSCI.3582-16.2017.

PMID:
    28416596
    [PubMed - as supplied by publisher]
Related citations


Human stem cell modeling in neurofibromatosis type 1 (NF1).
Wegscheid ML, Anastasaki C, Gutmann DH
Exp Neurol. 2017 Apr 6; pii: S0014-4886(17)30094-8. doi: 10.1016/j.expneurol.2017.04.001.

PMID:
    28392281
    [PubMed - as supplied by publisher]
Related citations


Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.
Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH
Oncotarget. 2017 May 16; 8(20)32977-32989. doi: 10.18632/oncotarget.16516.

PMID:
    28380429
    [PubMed - in process]
Related citations


A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1.
Mahdi J, Shah AC, Sato A, Morris SM, McKinstry RC, Listernick R, Packer RJ, Fisher MJ, Gutmann DH
Neurology. 2017 Apr 18; 88(16)1584-1589. doi: 10.1212/WNL.0000000000003881.

PMID:
    28330960
    [PubMed - indexed for MEDLINE]
Related citations


Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma.
Chen Z, Feng X, Herting CJ, Garcia VA, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D
Cancer Res. 2017 May 1; 77(9)2266-2278. doi: 10.1158/0008-5472.CAN-16-2310.

PMID:
    28235764
    [PubMed - in process]
Related citations


Neurofibromatosis type 1.
Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ
Nat Rev Dis Primers. 2017 Feb 23; 317004. doi: 10.1038/nrdp.2017.4.

PMID:
    28230061
    [PubMed - in process]
Related citations


Dissecting Clinical Heterogeneity in Neurofibromatosis Type 1.
Monroe CL, Dahiya S, Gutmann DH
Annu Rev Pathol. 2017 Jan 24; 1253-74. doi: 10.1146/annurev-pathol-052016-100228.

PMID:
    28135565
    [PubMed - in process]
Related citations


Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma.
Ricker CA, Pan Y, Gutmann DH, Keller C
Front Oncol. 2016; 6259. doi: 10.3389/fonc.2016.00259.

PMID:
    28066715
    [PubMed - in process]
Related citations


Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.
Toonen JA, Ma Y, Gutmann DH
Neuro Oncol. 2017 Jun 1; 19(6)808-819. doi: 10.1093/neuonc/now267.

PMID:
    28039362
    [PubMed - in process]
Related citations


Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1.
Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium.
Neurology. 2016 Dec 13; 87(24)2575-2584.

PMID:
    27956565
    [PubMed - indexed for MEDLINE]
Related citations


A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.
Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N
J Biol Chem. 2017 Jan 27; 292(4)1240-1250. doi: 10.1074/jbc.M116.748871.

PMID:
    27941025
    [PubMed - in process]
Related citations


Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.
Toonen JA, Solga AC, Ma Y, Gutmann DH
J Exp Med. 2017 Jan; 214(1)17-25. doi: 10.1084/jem.20160447.

PMID:
    27923908
    [PubMed - in process]
Related citations


Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
Cancer. 2017 Apr 1; 123(7)1194-1201. doi: 10.1002/cncr.30455.

PMID:
    27875628
    [PubMed - in process]
Related citations


3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.
Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM
J Proteomics. 2016 Oct 21; 14977-84. doi: 10.1016/j.jprot.2016.02.004.

PMID:
    26883872
    [PubMed - in process]
Related citations


Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT).
Morris SM, Acosta MT, Garg S, Green J, Huson S, Legius E, North KN, Payne JM, Plasschaert E, Frazier TW, Weiss LA, Zhang Y, Gutmann DH, Constantino JN
JAMA Psychiatry. 2016 Dec 1; 73(12)1276-1284. doi: 10.1001/jamapsychiatry.2016.2600.

PMID:
    27760236
    [PubMed - indexed for MEDLINE]
Related citations