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Faculty Physicians

David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Pediatric Neurology

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

A multidisciplinary approach in neurofibromatosis 1--authors' reply.
Epstein JA, Ingram DA Jr, Hirbe AC, Gutmann DH
Lancet Neurol. 2015 Jan; 14(1)30-1. doi: 10.1016/S1474-4422(14)70298-4.

PMID:
    25496893
    [PubMed - indexed for MEDLINE]
Related citations


Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues.
Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M
Am J Med Genet A. 2015 Jan; 167A(1)1-10. doi: 10.1002/ajmg.a.36793.

PMID:
    25393061
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Update from the 2013 International Neurofibromatosis Conference.
Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Kalamarides M, McClatchey AI, Messiaen L, Morrison H, Parkinson DB, Stemmer-Rachamimov AO, Van Raamsdonk CD, Riccardi VM, Rosser T, Schindeler A, Smith MJ, Stevenson DA, Ullrich NJ, van der Vaart T, Weiss B, Widemann BC, Zhu Y, Bakker AC, Lloyd AC
Am J Med Genet A. 2014 Dec; 164A(12)2969-78. doi: 10.1002/ajmg.a.36754.

PMID:
    25255738
    [PubMed - indexed for MEDLINE]
Related citations


Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions.
Schwetye KE, Gutmann DH
Expert Rev Neurother. 2014 Oct; 14(10)1139-52. doi: 10.1586/14737175.2014.953931.

PMID:
    25161109
    [PubMed - indexed for MEDLINE]
Related citations


Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation.
Anastasaki C, Gutmann DH
Hum Mol Genet. 2014 Dec 20; 23(25)6712-21. doi: 10.1093/hmg/ddu389.

PMID:
    25070947
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1: a multidisciplinary approach to care.
Hirbe AC, Gutmann DH
Lancet Neurol. 2014 Aug; 13(8)834-43. doi: 10.1016/S1474-4422(14)70063-8.

PMID:
    25030515
    [PubMed - indexed for MEDLINE]
Related citations


Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1.
Gutmann DH
Neurology. 2014 Jul 29; 83(5)463-71. doi: 10.1212/WNL.0000000000000652.

PMID:
    24975854
    [PubMed - indexed for MEDLINE]
Related citations


Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study.
Weiss B, Widemann BC, Wolters P, Dombi E, Vinks AA, Cantor A, Korf B, Perentesis J, Gutmann DH, Schorry E, Packer R, Fisher MJ
Pediatr Blood Cancer. 2014 Jun; 61(6)982-6.

PMID:
    24851266
    [PubMed - indexed for MEDLINE]
Related citations


cDNA hybrid capture improves transcriptome analysis on low-input and archived samples.
Cabanski CR, Magrini V, Griffith M, Griffith OL, McGrath S, Zhang J, Walker J, Ly A, Demeter R, Fulton RS, Pong WW, Gutmann DH, Govindan R, Mardis ER, Maher CA
J Mol Diagn. 2014 Jul; 16(4)440-51. doi: 10.1016/j.jmoldx.2014.03.004.

PMID:
    24814956
    [PubMed - indexed for MEDLINE]
Related citations


Reply: To PMID 24375753.
Diggs-Andrews KA, Brown JA, Gianino SM, D'Agostino McGowan L, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 May; 75(5)800-1. doi: 10.1002/ana.24156.

PMID:
    24752946
    [PubMed - indexed for MEDLINE]
Related citations


Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma.
Fisher MJ, Loguidice M, Gutmann DH, Listernick R, Ferner RE, Ullrich NJ, Packer RJ, Tabori U, Hoffman RO, Ardern-Holmes SL, Hummel TR, Hargrave DR, Bouffet E, Charrow J, Bilaniuk LT, Balcer LJ, D'Agostino McGowan L, Liu GT
Ann Neurol. 2014 May; 75(5)799-800. doi: 10.1002/ana.24157.

PMID:
    24740685
    [PubMed - indexed for MEDLINE]
Related citations


Evaluation of participant recruitment methods to a rare disease online registry.
Johnson KJ, Mueller NL, Williams K, Gutmann DH
Am J Med Genet A. 2014 Jul; 164A(7)1686-94. doi: 10.1002/ajmg.a.36530.

PMID:
    24700441
    [PubMed - indexed for MEDLINE]
Related citations


Glomus tumors in individuals with neurofibromatosis type 1.
Kumar MG, Emnett RJ, Bayliss SJ, Gutmann DH
J Am Acad Dermatol. 2014 Jul; 71(1)44-8. doi: 10.1016/j.jaad.2014.01.913.

PMID:
    24685357
    [PubMed - indexed for MEDLINE]
Related citations


In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila.
Gavilan HS, Kulikauskas RM, Gutmann DH, Fehon RG
PLoS One. 2014; 9(3)e90853. doi: 10.1371/journal.pone.0090853.

PMID:
    24595234
    [PubMed - indexed for MEDLINE]
Related citations


CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.
Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H
Am J Med Genet A. 2014 Mar; 164A(3)563-78. doi: 10.1002/ajmg.a.36312.

PMID:
    24443315
    [PubMed - indexed for MEDLINE]
Related citations


Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.
Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK
Cancer Res. 2014 Mar 1; 74(5)1429-39. doi: 10.1158/0008-5472.CAN-13-2117.

PMID:
    24436148
    [PubMed - indexed for MEDLINE]
Related citations


Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.
Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH
Ann Neurol. 2014 Feb; 75(2)309-16. doi: 10.1002/ana.24093.

PMID:
    24375753
    [PubMed - indexed for MEDLINE]
Related citations


BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
Neuro Oncol. 2014 Mar; 16(3)466-7. doi: 10.1093/neuonc/not248.

PMID:
    24366910
    [PubMed - indexed for MEDLINE]
Related citations


BRAF-V600E mutation in pediatric and adult glioblastoma.
Dahiya S, Emnett RJ, Haydon DH, Leonard JR, Phillips JJ, Perry A, Gutmann DH
Neuro Oncol. 2014 Jan; 16(2)318-9. doi: 10.1093/neuonc/not146.

PMID:
    24311634
    [PubMed - indexed for MEDLINE]
Related citations