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David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
EMBO J. 2017 Nov 10; pii: e201796700. doi: 10.15252/embj.201796700.

PMID:
    29127155
    [PubMed - as supplied by publisher]
Related citations


Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR
J Natl Cancer Inst. 2017 Aug 1; 109(8)doi: 10.1093/jnci/djx124.

PMID:
    29117388
    [PubMed - in process]
Related citations


Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca., Cancer Genome Atlas Research Network.
Cell. 2017 Nov 2; 171(4)950-965.e28. doi: 10.1016/j.cell.2017.10.014.

PMID:
    29100075
    [PubMed - in process]
Related citations


Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.
Khatua S, Gutmann DH, Packer RJ
Pediatr Blood Cancer. 2017 Oct 19; doi: 10.1002/pbc.26838.

PMID:
    29049847
    [PubMed - as supplied by publisher]
Related citations


Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Zou J, Zhang B, Gutmann DH, Wong M
Epilepsia. 2017 Oct 12; doi: 10.1111/epi.13923.

PMID:
    29023667
    [PubMed - as supplied by publisher]
Related citations


Children with 5'-end <i>NF1</i> gene mutations are more likely to have glioma.
Anastasaki C, Morris SM, Gao F, Gutmann DH
Neurol Genet. 2017 Oct; 3(5)e192. doi: 10.1212/NXG.0000000000000192.

PMID:
    28955729
    [PubMed]
Related citations


Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH
Oncotarget. 2017 Aug 8; 8(32)52474-52487. doi: 10.18632/oncotarget.17193.

PMID:
    28881745
    [PubMed]
Related citations


Neurodevelopmental disorders in children with neurofibromatosis type 1.
Vogel AC, Gutmann DH, Morris SM
Dev Med Child Neurol. 2017 Nov; 59(11)1112-1116. doi: 10.1111/dmcn.13526.

PMID:
    28845518
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.
Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD
Autism Res. 2017 Aug 26; doi: 10.1002/aur.1853.

PMID:
    28842941
    [PubMed - as supplied by publisher]
Related citations


The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.
Gutmann DH
Cell. 2017 Aug 24; 170(5)821-822. doi: 10.1016/j.cell.2017.08.011.

PMID:
    28841413
    [PubMed - indexed for MEDLINE]
Related citations


Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.
de Blank PMK, Fisher MJ, Liu GT, Gutmann DH, Listernick R, Ferner RE, Avery RA
J Neuroophthalmol. 2017 Sep; 37 Suppl 1S23-S32. doi: 10.1097/WNO.0000000000000550.

PMID:
    28806346
    [PubMed - indexed for MEDLINE]
Related citations


Updated nomenclature for human and mouse neurofibromatosis type 1 genes.
Anastasaki C, Le LQ, Kesterson RA, Gutmann DH
Neurol Genet. 2017 Aug; 3(4)e169. doi: 10.1212/NXG.0000000000000169.

PMID:
    28804759
    [PubMed]
Related citations


The power of the few.
Chen R, Pan Y, Gutmann DH
Genes Dev. 2017 Jun 15; 31(12)1177-1179. doi: 10.1101/gad.303453.117.

PMID:
    28765159
    [PubMed - indexed for MEDLINE]
Related citations


CNS Tumors in Neurofibromatosis.
Campian J, Gutmann DH
J Clin Oncol. 2017 Jul 20; 35(21)2378-2385. doi: 10.1200/JCO.2016.71.7199.

PMID:
    28640700
    [PubMed - indexed for MEDLINE]
Related citations


Caddyshack therapeutics: overcoming glioblastoma adaptation.
Gutmann DH
Neuro Oncol. 2017 Oct 19; 19(11)1429-1431. doi: 10.1093/neuonc/nox096.

PMID:
    28637259
    [PubMed - in process]
Related citations


Oligodendroglial myelination requires astrocyte-derived lipids.
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG
PLoS Biol. 2017 May; 15(5)e1002605. doi: 10.1371/journal.pbio.1002605.

PMID:
    28549068
    [PubMed - indexed for MEDLINE]
Related citations


KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
Anastasaki C, Dahiya S, Gutmann DH
Oncotarget. 2017 Jul 18; 8(29)47574-47585. doi: 10.18632/oncotarget.17736.

PMID:
    28548933
    [PubMed - in process]
Related citations


The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.
Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH
Oncotarget. 2017 Jul 18; 8(29)47206-47215. doi: 10.18632/oncotarget.17589.

PMID:
    28525381
    [PubMed - in process]
Related citations


Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.
Chheda MG, Gutmann DH
Cancer Cell. 2017 May 8; 31(5)609-611. doi: 10.1016/j.ccell.2017.04.008.

PMID:
    28486100
    [PubMed - indexed for MEDLINE]
Related citations


Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A
Biophys J. 2017 Apr 25; 112(8)1535-1538. doi: 10.1016/j.bpj.2017.03.017.

PMID:
    28445745
    [PubMed - indexed for MEDLINE]
Related citations

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