Patient Portal

David H. Gutmann, MD, PhD

Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas

Pediatric Neurology
Neuro Oncology
Neurofibromatosis

Board Certifications

Neurology
Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Human Molecular Genetics, University of Michigan Medical Center 1993
Residency: Neurology, Hospital of the University of Pennsylvania 1990
Medical Degree: University of Michigan, Ann Arbor, Michigan 1986
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 1984
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan 1980

Publication & Research

Publication & Research

Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.
Durón C, Pan Y, Gutmann DH, Hardin J, Radunskaya A
Bull Math Biol. 2018 Oct 22; doi: 10.1007/s11538-018-0526-z.

PMID:
    30350013
    [PubMed - as supplied by publisher]
Related citations


Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.
Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, Stemmer-Rachamimov AO, Fahrenkrug SC, Gutmann DH, Giovannini M, Moertel CL, Largaespada DA, Watson AL
Commun Biol. 2018; 1158. doi: 10.1038/s42003-018-0163-y.

PMID:
    30302402
    [PubMed]
Related citations


Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1.
Griffith JL, Morris SM, Mahdi J, Goyal MS, Hershey T, Gutmann DH
Neurol Clin Pract. 2018 Aug; 8(4)283-291. doi: 10.1212/CPJ.0000000000000494.

PMID:
    30140579
    [PubMed]
Related citations


Independent <i>NF1</i> mutations underlie café-au-lait macule development in a woman with segmental NF1.
Freret ME, Anastasaki C, Gutmann DH
Neurol Genet. 2018 Aug; 4(4)e261. doi: 10.1212/NXG.0000000000000261.

PMID:
    30065955
    [PubMed]
Related citations


Height Growth Impairment in Children With Neurofibromatosis Type 1 Is Characterized by Decreased Pubertal Growth Velocity in Both Sexes.
Zessis NR, Gao F, Vadlamudi G, Gutmann DH, Hollander AS
J Child Neurol. 2018 Oct; 33(12)762-766. doi: 10.1177/0883073818786807.

PMID:
    30009646
    [PubMed - in process]
Related citations


Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.
Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J
PLoS One. 2018; 13(5)e0190001. doi: 10.1371/journal.pone.0190001.

PMID:
    29787563
    [PubMed - indexed for MEDLINE]
Related citations


Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1.
Freret ME, Gutmann DH
J Neurosci Res. 2018 Apr 28; doi: 10.1002/jnr.24250.

PMID:
    29704429
    [PubMed - as supplied by publisher]
Related citations


Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of <i>Nf1</i> low-grade glioma growth.
Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH
Genes Dev. 2018 Apr 1; 32(7-8)491-496. doi: 10.1101/gad.310797.117.

PMID:
    29632086
    [PubMed - indexed for MEDLINE]
Related citations


β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH
Neuro Oncol. 2018 May 18; 20(6)858-860. doi: 10.1093/neuonc/noy038.

PMID:
    29596596
    [PubMed - in process]
Related citations


A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A
Cell Rep. 2018 Mar 27; 22(13)3416-3426. doi: 10.1016/j.celrep.2018.03.014.

PMID:
    29590612
    [PubMed - in process]
Related citations


Neurofibromatosis type 1.
Cimino PJ, Gutmann DH
Handb Clin Neurol. 2018; 148799-811. doi: 10.1016/B978-0-444-64076-5.00051-X.

PMID:
    29478615
    [PubMed - indexed for MEDLINE]
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A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1.
Morris SM, Gutmann DH
Neurology. 2018 Feb 20; 90(8)377-379. doi: 10.1212/WNL.0000000000005000.

PMID:
    29367450
    [PubMed - in process]
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Optic Pathway Gliomas in Neurofibromatosis Type 1.
Campen CJ, Gutmann DH
J Child Neurol. 2018 Jan; 33(1)73-81. doi: 10.1177/0883073817739509.

PMID:
    29246098
    [PubMed - indexed for MEDLINE]
Related citations


Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
EMBO J. 2017 Dec 15; 36(24)3650-3665. doi: 10.15252/embj.201796700.

PMID:
    29127155
    [PubMed - indexed for MEDLINE]
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Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR
J Natl Cancer Inst. 2017 Aug 1; 109(8)doi: 10.1093/jnci/djx124.

PMID:
    29117388
    [PubMed - indexed for MEDLINE]
Related citations


Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.
Cancer Genome Atlas Research Network. Electronic address: elizabeth.demicco@sinaihealthsystem.ca., Cancer Genome Atlas Research Network.
Cell. 2017 Nov 2; 171(4)950-965.e28. doi: 10.1016/j.cell.2017.10.014.

PMID:
    29100075
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.
Khatua S, Gutmann DH, Packer RJ
Pediatr Blood Cancer. 2018 Mar; 65(3)doi: 10.1002/pbc.26838.

PMID:
    29049847
    [PubMed - in process]
Related citations


Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.
Zou J, Zhang B, Gutmann DH, Wong M
Epilepsia. 2017 Dec; 58(12)2053-2063. doi: 10.1111/epi.13923.

PMID:
    29023667
    [PubMed - indexed for MEDLINE]
Related citations


Children with 5'-end <i>NF1</i> gene mutations are more likely to have glioma.
Anastasaki C, Morris SM, Gao F, Gutmann DH
Neurol Genet. 2017 Oct; 3(5)e192. doi: 10.1212/NXG.0000000000000192.

PMID:
    28955729
    [PubMed]
Related citations


Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH
Oncotarget. 2017 Aug 8; 8(32)52474-52487. doi: 10.18632/oncotarget.17193.

PMID:
    28881745
    [PubMed]
Related citations

Videos

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