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David G. Mutch, MD

Ira C. and Judith Gall Professor of Obstetrics and Gynecology
Division of Gynecologic Oncology
Vice Chair, Gynecology

Fellowship Director, Gynecologic Oncology

Specialty Areas

Gynecologic Oncology
Cervical Cancer
Ovarian Cancer
Endometrial Cancer

Board Certifications

Gynecologic Oncology
Obstetrics and Gynecology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
Missouri Baptist Medical Center
St. Louis Children's Hospital

Areas of Clinical Interest

Gynecologic oncology, endometrial cancer, vulva carcinoma, ovarian cancer, cervical cancer, adnexal masses, tumors, hysterectomy, lymphadenectomy, endometrial adenocarcinomas, cervical intraepithelial neoplasia, gynecologic malignancies, ob/gyn, women's health

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Missouri Baptist Medical Center
Building D

3023 N. Ballas Road
Fourth Floor, Suite 450
St. Louis, MO 63131

Office Phone: 314-996-6075
Fax: 314-996-6074

Center for Advanced Medicine
Gynecologic Treatment Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 13
Office Phone: 314-362-3181
Fax: 314-362-8644

Education

Education

Fellowship: Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 1987
Residency: Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 1984
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1980
B.A.: Carleton College, Northfield, Minnesota 1976

Publication & Research

Publication & Research

Lymphnode staging update in the American Joint Committee on Cancer 8th Edition cancer staging manual.
Olawaiye AB, Mutch DG
Gynecol Oncol. 2018 Mar 12; pii: S0090-8258(18)30140-9. doi: 10.1016/j.ygyno.2018.02.021.

PMID:
    29540290
    [PubMed - as supplied by publisher]
Related citations


Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer.
Kuroki LM, Jin X, Dmitriev IP, Kashentseva EA, Powell MA, Mutch DG, Dietz AB, Curiel DT, Hawkins WG, Spitzer D
PLoS One. 2017; 12(12)e0190125. doi: 10.1371/journal.pone.0190125.

PMID:
    29267342
    [PubMed - indexed for MEDLINE]
Related citations


Clinicopathologic characteristics associated with long-term survival in advanced epithelial ovarian cancer: an NRG Oncology/Gynecologic Oncology Group ancillary data study.
Hamilton CA, Miller A, Casablanca Y, Horowitz NS, Rungruang B, Krivak TC, Richard SD, Rodriguez N, Birrer MJ, Backes FJ, Geller MA, Quinn M, Goodheart MJ, Mutch DG, Kavanagh JJ, Maxwell GL, Bookman MA
Gynecol Oncol. 2018 Feb; 148(2)275-280. doi: 10.1016/j.ygyno.2017.11.018.

PMID:
    29195926
    [PubMed - in process]
Related citations


Predictive modeling for determination of microscopic residual disease at primary cytoreduction: An NRG Oncology/Gynecologic Oncology Group 182 Study.
Horowitz NS, Larry Maxwell G, Miller A, Hamilton CA, Rungruang B, Rodriguez N, Richard SD, Krivak TC, Fowler JM, Mutch DG, Van Le L, Lee RB, Argenta P, Bender D, Tewari KS, Gershenson D, Java JJ, Bookman MA
Gynecol Oncol. 2018 Jan; 148(1)49-55. doi: 10.1016/j.ygyno.2017.10.011.

PMID:
    29174555
    [PubMed - in process]
Related citations


MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.
Walker CJ, Rush CM, Dama P, O'Hern MJ, Cosgrove CM, Gillespie JL, Zingarelli RA, Smith B, Stein ME, Mutch DG, Shakya R, Chang CW, Selvendiran K, Song JW, Cohn DE, Goodfellow PJ
J Natl Cancer Inst. 2017 Nov 15; doi: 10.1093/jnci/djx238.

PMID:
    29155953
    [PubMed - as supplied by publisher]
Related citations


Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials.
MacKay HJ, Levine DA, Bae-Jump VL, Bell DW, McAlpine JN, Santin A, Fleming GF, Mutch DG, Nephew KP, Wentzensen N, Goodfellow PJ, Dorigo O, Nijman HW, Broaddus R, Kohn EC
Oncotarget. 2017 Oct 13; 8(48)84579-84594. doi: 10.18632/oncotarget.19961.

PMID:
    29137450
    [PubMed]
Related citations


An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer.
Cosgrove CM, Tritchler DL, Cohn DE, Mutch DG, Rush CM, Lankes HA, Creasman WT, Miller DS, Ramirez NC, Geller MA, Powell MA, Backes FJ, Landrum LM, Timmers C, Suarez AA, Zaino RJ, Pearl ML, DiSilvestro PA, Lele SB, Goodfellow PJ
Gynecol Oncol. 2018 Jan; 148(1)174-180. doi: 10.1016/j.ygyno.2017.10.037.

PMID:
    29132872
    [PubMed - in process]
Related citations


Endometrial carcinoma recurrence according to race and ethnicity: An NRG Oncology/Gynecologic Oncology Group 210 Study.
Felix AS, Brasky TM, Cohn DE, Mutch DG, Creasman WT, Thaker PH, Walker JL, Moore RG, Lele SB, Guntupalli SR, Downs LS, Nagel C, Boggess JF, Pearl ML, Ioffe OB, Deng W, Miller DS, Brinton LA
Int J Cancer. 2018 Mar 15; 142(6)1102-1115. doi: 10.1002/ijc.31127.

PMID:
    29063589
    [PubMed - in process]
Related citations


Novel <i>SOX17</i> frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations.
Walker CJ, O'Hern MJ, Serna VA, Kurita T, Miranda MA, Sapp CE, Mutch DG, Cohn DE, Goodfellow PJ
Oncotarget. 2017 Sep 15; 8(40)68758-68768. doi: 10.18632/oncotarget.20213.

PMID:
    28978154
    [PubMed]
Related citations


Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in a Multi-institutional Cohort of 165 Cases.
Abdulfatah E, Sakr S, Thomas S, Al-Wahab Z, Mutch DG, Dowdy S, Bandyopadhyay S, Munkarah A, Elshaikh M, Morris R, Ali-Fehmi R
Int J Gynecol Cancer. 2017 Oct; 27(8)1714-1721. doi: 10.1097/IGC.0000000000001050.

PMID:
    28945214
    [PubMed - indexed for MEDLINE]
Related citations


The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas.
Le Gallo M, Rudd ML, Urick ME, Hansen NF, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program., Merino MJ, Mutch DG, Goodfellow PJ, Mullikin JC, Bell DW
Cancer. 2018 Jan 1; 124(1)65-73. doi: 10.1002/cncr.30971.

PMID:
    28940304
    [PubMed - indexed for MEDLINE]
Related citations


Two sisters with Mayer-Rokitansky-Küster-Hauser syndrome and serous adenocarcinoma of the ovary.
Huepenbecker SP, Divine L, Chu CS, Mutch DG
Gynecol Oncol Rep. 2017 Nov; 2213-15. doi: 10.1016/j.gore.2017.09.002.

PMID:
    28932808
    [PubMed]
Related citations


Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA, ARIEL3 investigators.
Lancet. 2017 Oct 28; 390(10106)1949-1961. doi: 10.1016/S0140-6736(17)32440-6.

PMID:
    28916367
    [PubMed - in process]
Related citations


Benefit of combination chemotherapy and radiation stratified by grade of stage IIIC endometrial cancer.
Binder PS, Kuroki LM, Zhao P, Cusworth S, Divine LM, Hagemann AR, McCourt CK, Thaker PH, Powell MA, Mutch DG, Massad LS
Gynecol Oncol. 2017 Nov; 147(2)309-314. doi: 10.1016/j.ygyno.2017.08.031.

PMID:
    28916118
    [PubMed - indexed for MEDLINE]
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Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer.
Palisoul ML, Quinn JM, Schepers E, Hagemann IS, Guo L, Reger K, Hagemann AR, McCourt CK, Thaker PH, Powell MA, Mutch DG, Fuh KC
Mol Cancer Ther. 2017 Dec; 16(12)2881-2891. doi: 10.1158/1535-7163.MCT-17-0587.

PMID:
    28904132
    [PubMed - in process]
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An evaluation of progression free survival and overall survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: An NRG Oncology/Gynecologic Oncology Group experience.
Oliver KE, Brady WE, Birrer M, Gershenson DM, Fleming G, Copeland LJ, Tewari K, Argenta PA, Mannel RS, Secord AA, Stephan JM, Mutch DG, Stehman FB, Muggia FM, Rose PG, Armstrong DK, Bookman MA, Burger RA, Farley JH
Gynecol Oncol. 2017 Nov; 147(2)243-249. doi: 10.1016/j.ygyno.2017.08.004.

PMID:
    28807367
    [PubMed - indexed for MEDLINE]
Related citations


Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP
Nat Med. 2017 Sep; 23(9)1046-1054. doi: 10.1038/nm.4372.

PMID:
    28805821
    [PubMed - indexed for MEDLINE]
Related citations


A Transperineal Approach to Hysterectomy of a Retained Didelphic Uterine Horn.
Mullen MM, Kuroki LM, Hunt SR, Ratkowski KL, Mutch DG
Obstet Gynecol. 2017 Sep; 130(3)561-564. doi: 10.1097/AOG.0000000000002196.

PMID:
    28796686
    [PubMed - indexed for MEDLINE]
Related citations


The effect of a multidisciplinary palliative care initiative on end of life care in gynecologic oncology patients.
Mullen MM, Divine LM, Porcelli BP, Wilkinson-Ryan I, Dans MC, Powell MA, Mutch DG, Hagemann AR, Thaker PH
Gynecol Oncol. 2017 Nov; 147(2)460-464. doi: 10.1016/j.ygyno.2017.08.002.

PMID:
    28784245
    [PubMed - indexed for MEDLINE]
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Intensity modulated radiation therapy for squamous cell carcinoma of the vulva: Treatment technique and outcomes.
Rao YJ, Chundury A, Schwarz JK, Hassanzadeh C, DeWees T, Mullen D, Powell MA, Mutch DG, Grigsby PW
Adv Radiat Oncol. 2017 Apr-Jun; 2(2)148-158. doi: 10.1016/j.adro.2017.02.006.

PMID:
    28740926
    [PubMed]
Related citations