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David G. Mutch, MD

Ira C. and Judith Gall Professor of Obstetrics and Gynecology, Obstetrics and Gynecology
Division of Gynecologic Oncology
Vice Chair, Gynecology

Specialty Areas

Gynecologic Oncology
Cervical Cancer
Ovarian Cancer
Endometrial Cancer

Board Certifications

Gynecologic Oncology
Obstetrics and Gynecology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
Missouri Baptist Medical Center
St. Louis Children's Hospital

Areas of Clinical Interest

Gynecologic oncology, endometrial cancer, vulva carcinoma, ovarian cancer, cervical cancer, adnexal masses, tumors, hysterectomy, lymphadenectomy, endometrial adenocarcinomas, cervical intraepithelial neoplasia, gynecologic malignancies, ob/gyn, women's health

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Missouri Baptist Medical Center
Building D

3023 N. Ballas Road
Fourth Floor, Suite 450
St. Louis, MO 63131

Office Phone: 314-996-6075
Fax: 314-996-6074

Center for Advanced Medicine
Gynecologic Treatment Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 13
Office Phone: 314-362-3181
Fax: 314-362-8644

Education

Education

Fellowship: Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 1987
Residency: Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 1984
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1980
B.A.: Carleton College, Northfield, Minnesota 1976

Publication & Research

Publication & Research

Survival of Cervical Cancer Patients Presenting with Occult Supraclavicular Metastases Detected by FDG-Positron Emission Tomography/CT: Impact of Disease Extent and Treatment.
Ioffe YJ, Massad LS, Powell MA, Hagemann AR, Mutch DG, Thaker PH, Schwarz JK, Grigsby PW
Gynecol Obstet Invest. 2017 Apr 8; doi: 10.1159/000458706.

PMID:
    28399524
    [PubMed - as supplied by publisher]
Related citations


Surgical-pathological findings in type 1 and 2 endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol.
Creasman WT, Ali S, Mutch DG, Zaino RJ, Powell MA, Mannel RS, Backes FJ, DiSilvestro PA, Argenta PA, Pearl ML, Lele SB, Guntupalli SR, Waggoner S, Spirtos N, Boggess JF, Edwards RP, Filiaci VL, Miller DS
Gynecol Oncol. 2017 Apr 6; pii: S0090-8258(17)30233-0. doi: 10.1016/j.ygyno.2017.03.017.

PMID:
    28392124
    [PubMed - as supplied by publisher]
Related citations


Nonsteroidal Anti-inflammatory Drugs and Endometrial Carcinoma Mortality and Recurrence.
Brasky TM, Felix AS, Cohn DE, McMeekin DS, Mutch DG, Creasman WT, Thaker PH, Walker JL, Moore RG, Lele SB, Guntupalli SR, Downs LS, Nagel CI, Boggess JF, Pearl ML, Ioffe OB, Park KJ, Ali S, Brinton LA
J Natl Cancer Inst. 2017 Mar 1; 109(3)1-10. doi: 10.1093/jnci/djw251.

PMID:
    28376204
    [PubMed - in process]
Related citations


Sparse feature selection for classification and prediction of metastasis in endometrial cancer.
Ahsen ME, Boren TP, Singh NK, Misganaw B, Mutch DG, Moore KN, Backes FJ, McCourt CK, Lea JS, Miller DS, White MA, Vidyasagar M
BMC Genomics. 2017 Mar 27; 18(Suppl 3)233. doi: 10.1186/s12864-017-3604-y.

PMID:
    28361685
    [PubMed - in process]
Related citations


Hereditary Ovarian Cancer and Risk Reduction.
Andrews L, Mutch DG
Best Pract Res Clin Obstet Gynaecol. 2017 Jan 17; pii: S1521-6934(17)30001-9. doi: 10.1016/j.bpobgyn.2016.10.017.

PMID:
    28254144
    [PubMed - as supplied by publisher]
Related citations


Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma.
Li J, Xing X, Li D, Zhang B, Mutch DG, Hagemann IS, Wang T
Neoplasia. 2017 Feb; 19(2)100-111. doi: 10.1016/j.neo.2016.12.009.

PMID:
    28088687
    [PubMed - in process]
Related citations


Association of post-treatment positron emission tomography with locoregional control and survival after radiation therapy for squamous cell carcinoma of the vulva.
Rao YJ, Hassanzadeh C, Chundury A, Hui C, Siegel BA, Dehdashti F, DeWees T, Mullen D, Powell MA, Mutch DG, Schwarz JK, Grigsby PW
Radiother Oncol. 2017 Mar; 122(3)445-451. doi: 10.1016/j.radonc.2016.12.019.

PMID:
    28063696
    [PubMed - in process]
Related citations


The promise of molecular staging for the future.
Maxwell GL, Mutch DG
Cancer. 2017 Mar 1; 123(5)728-730. doi: 10.1002/cncr.30504.

PMID:
    28061001
    [PubMed - in process]
Related citations


A phase I trial of paclitaxel, cisplatin, and veliparib in the treatment of persistent or recurrent carcinoma of the cervix: an NRG Oncology Study (NCT#01281852).
Thaker PH, Salani R, Brady WE, Lankes HA, Cohn DE, Mutch DG, Mannel RS, Bell-McGuinn KM, Di Silvestro PA, Jelovac D, Carter JS, Duan W, Resnick KE, Dizon DS, Aghajanian C, Fracasso PM
Ann Oncol. 2017 Mar 1; 28(3)505-511. doi: 10.1093/annonc/mdw635.

PMID:
    27998970
    [PubMed - in process]
Related citations


Synuclein-γ in uterine serous carcinoma impacts survival: An NRG Oncology/Gynecologic Oncology Group study.
Winder AD, Maniar KP, Wei JJ, Liu D, Scholtens DM, Lurain JR, Schink JC, Buttin BM, Filiaci VL, Lankes HA, Ramirez NC, Park K, Singh M, Lieberman RW, Mannel RS, Powell MA, Backes FJ, Mathews CA, Pearl ML, Secord AA, Peace DJ, Mutch DG, Creasman WT, Kim JJ
Cancer. 2017 Apr 1; 123(7)1144-1155. doi: 10.1002/cncr.30477.

PMID:
    27926776
    [PubMed - in process]
Related citations


What is the role of retroperitoneal exploration in optimally debulked stage IIIC epithelial ovarian cancer? An NRG Oncology/Gynecologic Oncology Group ancillary data study.
Rungruang BJ, Miller A, Krivak TC, Horowitz NS, Rodriguez N, Hamilton CA, Backes FJ, Carson LF, Friedlander M, Mutch DG, Goodheart MJ, Tewari KS, Wenham RM, Bookman MA, Maxwell GL, Richard SD
Cancer. 2017 May 15; 123(6)985-993. doi: 10.1002/cncr.30414.

PMID:
    27864921
    [PubMed - in process]
Related citations


The mutational spectrum of FOXA2 in endometrioid endometrial cancer points to a tumor suppressor role.
Smith B, Neff R, Cohn DE, Backes FJ, Suarez AA, Mutch DG, Rush CM, Walker CJ, Goodfellow PJ
Gynecol Oncol. 2016 Nov; 143(2)398-405. doi: 10.1016/j.ygyno.2016.08.237.

PMID:
    27538367
    [PubMed - in process]
Related citations


AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer.
Divine LM, Nguyen MR, Meller E, Desai RA, Arif B, Rankin EB, Bligard KH, Meyerson C, Hagemann IS, Massad M, Thaker PH, Hagemann AR, McCourt CK, Powell MA, Mutch DG, Fuh KC
Oncotarget. 2016 Nov 22; 7(47)77291-77305. doi: 10.18632/oncotarget.12637.

PMID:
    27764792
    [PubMed - in process]
Related citations


Reply.
Binder PS, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt CK, Peipert JF, Kallogjeri D, Brooks RA
Am J Obstet Gynecol. 2017 Feb; 216(2)192-193. doi: 10.1016/j.ajog.2016.09.084.

PMID:
    27640937
    [PubMed - in process]
Related citations


Targeted therapy in endometrial cancer: Making progress.
Mutch DG
Cancer. 2016 Sep 7; doi: 10.1002/cncr.30285.

PMID:
    27602801
    [PubMed - as supplied by publisher]
Related citations


Adult Comorbidity Evaluation 27 score as a predictor of survival in endometrial cancer patients.
Binder PS, Peipert JF, Kallogjeri D, Brooks RA, Massad LS, Mutch DG, Powell MA, Thaker PH, McCourt CK
Am J Obstet Gynecol. 2016 Dec; 215(6)766.e1-766.e9. doi: 10.1016/j.ajog.2016.07.035.

PMID:
    27457116
    [PubMed - in process]
Related citations


A novel algorithm for network-based prediction of cancer recurrence.
Ruan J, Jahid MJ, Gu F, Lei C, Huang YW, Hsu YT, Mutch DG, Chen CL, Kirma NB, Huang TH
Genomics. 2016 Jul 21; pii: S0888-7543(16)30074-X. doi: 10.1016/j.ygeno.2016.07.005.

PMID:
    27453286
    [PubMed - as supplied by publisher]
Related citations


MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair.
Walker CJ, Miranda MA, O'Hern MJ, Blachly JS, Moyer CL, Ivanovich J, Kroll KW, Eisfeld AK, Sapp CE, Mutch DG, Cohn DE, Bundschuh R, Goodfellow PJ
Hum Mutat. 2016 Oct; 37(10)1004-12. doi: 10.1002/humu.23036.

PMID:
    27346418
    [PubMed - in process]
Related citations


Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study.
McMeekin DS, Tritchler DL, Cohn DE, Mutch DG, Lankes HA, Geller MA, Powell MA, Backes FJ, Landrum LM, Zaino R, Broaddus RD, Ramirez N, Gao F, Ali S, Darcy KM, Pearl ML, DiSilvestro PA, Lele SB, Goodfellow PJ
J Clin Oncol. 2016 Sep 1; 34(25)3062-8. doi: 10.1200/JCO.2016.67.8722.

PMID:
    27325856
    [PubMed - in process]
Related citations


Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D
Sci Rep. 2016 May 4; 625217. doi: 10.1038/srep25217.

PMID:
    27142169
    [PubMed]
Related citations