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Faculty Physicians

David G. Mutch, MD

Ira C. and Judith Gall Professor of Obstetrics and Gynecology, Obstetrics and Gynecology
Division Chief, Gynecologic Oncology

Specialty Areas

Gynecologic Oncology
Cervical Cancer
Ovarian Cancer
Endometrial Cancer

Board Certifications

Gynecologic Oncology
Obstetrics and Gynecology

Areas of Clinical Interest

Gynecologic oncology, endometrial cancer, vulva carcinoma, ovarian cancer, cervical cancer, adnexal masses, tumors, hysterectomy, lymphadenectomy, endometrial adenocarcinomas, cervical intraepithelial neoplasia, gynecologic malignancies, ob/gyn, women's health

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Missouri Baptist Medical Center
Building D

3023 N. Ballas Road
Fourth Floor, Suite 450
St. Louis, MO 63131

Floor:
Building D, Fourth Floor, Suite 450
Office Phone: 314-996-6071
Fax: 314-996-6060

Center for Advanced Medicine
Gynecologic Treatment Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 13
Office Phone: 314-362-3181
Fax: 314-362-8644

Education

Education

Fellowship: Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 1987
Residency: Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 1984
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1980
B.A.: Carleton College, Northfield, Minnesota 1976

Publication & Research

Publication & Research

Impact of an immunohistochemistry-based universal screening protocol for Lynch syndrome in endometrial cancer on genetic counseling and testing.
Frolova AI, Babb SA, Zantow E, Hagemann AR, Powell MA, Thaker PH, Gao F, Mutch DG
Gynecol Oncol. 2015 Apr; 137(1)7-13. doi: 10.1016/j.ygyno.2015.01.535.

PMID:
    25617771
    [PubMed - indexed for MEDLINE]
Related citations


Ovarian cancer in the United States: contemporary patterns of care associated with improved survival.
Cliby WA, Powell MA, Al-Hammadi N, Chen L, Philip Miller J, Roland PY, Mutch DG, Bristow RE
Gynecol Oncol. 2015 Jan; 136(1)11-7. doi: 10.1016/j.ygyno.2014.10.023.

PMID:
    25449311
    [PubMed - indexed for MEDLINE]
Related citations


ACOG Practice Bulletin No. 147: Lynch syndrome.
Committee on Practice Bulletins-Gynecology, Society of Gynecologic Oncology
Obstet Gynecol. 2014 Nov; 124(5)1042-54. doi: 10.1097/01.AOG.0000456325.50739.72.

PMID:
    25437740
    [PubMed - indexed for MEDLINE]
Related citations


Can molecular diagnostics usher in a new era for screening, diagnosis, and treatment of ovarian cancer?
Mutch DG
Obstet Gynecol. 2014 Nov; 124(5)870-2. doi: 10.1097/AOG.0000000000000534.

PMID:
    25437712
    [PubMed - indexed for MEDLINE]
Related citations


A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study.
Dizon DS, Sill MW, Schilder JM, McGonigle KF, Rahman Z, Miller DS, Mutch DG, Leslie KK
Gynecol Oncol. 2014 Dec; 135(3)441-5. doi: 10.1016/j.ygyno.2014.10.001.

PMID:
    25312396
    [PubMed - indexed for MEDLINE]
Related citations


Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.
Zhang B, Xing X, Li J, Lowdon RF, Zhou Y, Lin N, Zhang B, Sundaram V, Chiappinelli KB, Hagemann IS, Mutch DG, Goodfellow PJ, Wang T
BMC Genomics. 2014 Oct 6; 15868. doi: 10.1186/1471-2164-15-868.

PMID:
    25286960
    [PubMed - indexed for MEDLINE]
Related citations


Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.
Billingsley CC, Cohn DE, Mutch DG, Stephens JA, Suarez AA, Goodfellow PJ
Cancer. 2015 Feb 1; 121(3)386-94. doi: 10.1002/cncr.29046.

PMID:
    25224212
    [PubMed - indexed for MEDLINE]
Related citations


Update on prognostic markers for endometrial cancer.
Binder PS, Mutch DG
Womens Health (Lond Engl). 2014 May; 10(3)277-88. doi: 10.2217/whe.14.13.

PMID:
    24956294
    [PubMed - indexed for MEDLINE]
Related citations


A phase II trial of a surgical protocol to decrease the incidence of wound complications in obese gynecologic oncology patients.
Novetsky AP, Zighelboim I, Guntupalli SR, Ioffe YJ, Kizer NT, Hagemann AR, Powell MA, Thaker PH, Mutch DG, Massad LS
Gynecol Oncol. 2014 Aug; 134(2)233-7. doi: 10.1016/j.ygyno.2014.06.012.

PMID:
    24952366
    [PubMed - indexed for MEDLINE]
Related citations


2014 FIGO staging for ovarian, fallopian tube and peritoneal cancer.
Mutch DG, Prat J
Gynecol Oncol. 2014 Jun; 133(3)401-4. doi: 10.1016/j.ygyno.2014.04.013.

PMID:
    24878391
    [PubMed - indexed for MEDLINE]
Related citations


Etiology and workup of fevers in gynecologic oncology patients.
McCartney SA, Sabo MC, Massad LS, Hagemann AR, Mutch DG, Powell MA, Thaker PH, Novetsky AP
Int J Gynecol Cancer. 2014 Jun; 24(5)950-5. doi: 10.1097/IGC.0000000000000129.

PMID:
    24819658
    [PubMed - indexed for MEDLINE]
Related citations


Postradiation damage to the pelvic girdle in cervical cancer patients: is intensity-modulated radiation therapy safer than conventional radiation?
Ioffe YJ, Hillen TJ, Zhou G, Schwarz JK, Massad LS, Powell MA, Hagemann AR, Mutch DG, Thaker PH
Int J Gynecol Cancer. 2014 May; 24(4)806-12. doi: 10.1097/IGC.0000000000000117.

PMID:
    24670967
    [PubMed - indexed for MEDLINE]
Related citations


The prognostic significance of lymphovascular space invasion in laparoscopic versus abdominal hysterectomy for endometrioid endometrial cancer.
Dewdney SB, Jiao Z, Roma AA, Gao F, Rimel BJ, Thaker PH, Powell MA, Massad LS, Mutch DG, Zighelboim I
Eur J Gynaecol Oncol. 2014; 35(1)7-10.

PMID:
    24654453
    [PubMed - indexed for MEDLINE]
Related citations


Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade serous ovarian cancer by BRCAPRO: a multi-institution study.
Daniels MS, Babb SA, King RH, Urbauer DL, Batte BA, Brandt AC, Amos CI, Buchanan AH, Mutch DG, Lu KH
J Clin Oncol. 2014 Apr 20; 32(12)1249-55. doi: 10.1200/JCO.2013.50.6055.

PMID:
    24638001
    [PubMed - indexed for MEDLINE]
Related citations


Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.
Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D
Mol Cancer. 2014 Mar 7; 1350. doi: 10.1186/1476-4598-13-50.

PMID:
    24602489
    [PubMed - indexed for MEDLINE]
Related citations


Patterns of care, predictors, and outcomes of chemotherapy in elderly women with early-stage uterine carcinosarcoma: a population-based analysis.
Garg G, Yee C, Schwartz K, Mutch DG, Morris RT, Powell MA
Gynecol Oncol. 2014 May; 133(2)242-9. doi: 10.1016/j.ygyno.2014.02.021.

PMID:
    24561247
    [PubMed - indexed for MEDLINE]
Related citations


Racial disparities in uterine clear cell carcinoma: a multi-institution study.
Al-Wahab ZR, Kumar S, Mutch DG, Dowdy SC, Hensley SA, Wang Y, Mahdi H, Ali-Fehmi R, Morris RT, Elshaikh M, Munkarah AR
Int J Gynecol Cancer. 2014 Mar; 24(3)541-8. doi: 10.1097/IGC.0000000000000068.

PMID:
    24552897
    [PubMed - indexed for MEDLINE]
Related citations


Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.
Garg G, Gibbs J, Belt B, Powell MA, Mutch DG, Goedegebuure P, Collins L, Piwnica-Worms D, Hawkins WG, Spitzer D
BMC Cancer. 2014 Jan 21; 1435. doi: 10.1186/1471-2407-14-35.

PMID:
    24447304
    [PubMed - indexed for MEDLINE]
Related citations


High frequency strand slippage mutations in CTCF in MSI-positive endometrial cancers.
Zighelboim I, Mutch DG, Knapp A, Ding L, Xie M, Cohn DE, Goodfellow PJ
Hum Mutat. 2014 Jan; 35(1)63-5.

PMID:
    24130125
    [PubMed - indexed for MEDLINE]
Related citations


Disclosing a diagnosis of cancer: considerations specific to gynecologic oncology patients.
Kuroki LM, Zhao Q, Jeffe DB, Powell MA, Hagemann AR, Thaker PH, Massad LS, Mutch DG, Zighelboim I
Obstet Gynecol. 2013 Nov; 122(5)1033-9. doi: 10.1097/AOG.0b013e3182a9bf42.

PMID:
    24104784
    [PubMed - indexed for MEDLINE]
Related citations