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Faculty Physicians

David G. Mutch, MD

Ira C. and Judith Gall Professor of Obstetrics and Gynecology, Obstetrics and Gynecology
Division of Gynecologic Oncology

Specialty Areas

Gynecologic Oncology
Cervical Cancer
Ovarian Cancer
Endometrial Cancer

Board Certifications

Gynecologic Oncology
Obstetrics and Gynecology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
Missouri Baptist Medical Center
St. Louis Children's Hospital

Areas of Clinical Interest

Gynecologic oncology, endometrial cancer, vulva carcinoma, ovarian cancer, cervical cancer, adnexal masses, tumors, hysterectomy, lymphadenectomy, endometrial adenocarcinomas, cervical intraepithelial neoplasia, gynecologic malignancies, ob/gyn, women's health

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Missouri Baptist Medical Center
Building D

3023 N. Ballas Road
Fourth Floor, Suite 450
St. Louis, MO 63131

Floor:
Building D, Fourth Floor, Suite 450
Office Phone: 314-996-6075
Fax: 314-996-6074

Center for Advanced Medicine
Gynecologic Treatment Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 13
Office Phone: 314-362-3181
Fax: 314-362-8644

Education

Education

Fellowship: Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 1987
Residency: Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 1984
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1980
B.A.: Carleton College, Northfield, Minnesota 1976

Publication & Research

Publication & Research

Mesothelin's minimal MUC16 binding moiety converts TR3 into a potent cancer therapeutic via hierarchical binding events at the plasma membrane.
Su Y, Tatzel K, Wang X, Belt B, Binder P, Kuroki L, Powell MA, Mutch DG, Hawkins WG, Spitzer D
Oncotarget. 2016 Apr 22; doi: 10.18632/oncotarget.8925.

PMID:
    27120790
    [PubMed - as supplied by publisher]
Related citations


Clinicopathologic characteristics and survival of patients with gynecologic malignancies metastatic to the brain.
Divine LM, Kizer NT, Hagemann AR, Pittman ME, Chen L, Powell MA, Mutch DG, Rader JS, Thaker PH
Gynecol Oncol. 2016 Apr 23; pii: S0090-8258(16)30163-9. doi: 10.1016/j.ygyno.2016.04.030.

PMID:
    27117923
    [PubMed - as supplied by publisher]
Related citations


The clinical management of inoperable endometrial carcinoma.
Palisoul M, Mutch DG
Expert Rev Anticancer Ther. 2016 May; 16(5)515-521.

PMID:
    26999568
    [PubMed - as supplied by publisher]
Related citations


Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.
Billingsley CC, Cohn DE, Mutch DG, Hade EM, Goodfellow PJ
Int J Gynecol Cancer. 2016 Mar 3;

PMID:
    26937754
    [PubMed - as supplied by publisher]
Related citations


Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D
Sci Rep. 2016 Mar 3; 622661. doi: 10.1038/srep22661.

PMID:
    26935795
    [PubMed - in process]
Related citations


Improved clinical trial enrollments for uterine leiomyosarcoma patients after gynecologic oncology partnership with a sarcoma center.
Lange SE, Liu J, Adkins DR, Powell MA, Van Tine BA, Mutch DG
Gynecol Oncol. 2016 Feb; 140(2)307-12. doi: 10.1016/j.ygyno.2015.12.016.

PMID:
    26718726
    [PubMed - in process]
Related citations


Brachytherapy Is Associated With Improved Survival in Inoperable Stage I Endometrial Adenocarcinoma: A Population-Based Analysis.
Acharya S, Perkins SM, DeWees T, Fischer-Valuck BW, Mutch DG, Powell MA, Schwarz JK, Grigsby PW
Int J Radiat Oncol Biol Phys. 2015 Nov 1; 93(3)649-57. doi: 10.1016/j.ijrobp.2015.06.013.

PMID:
    26461007
    [PubMed - indexed for MEDLINE]
Related citations


Premature Judgment of Uterine Morcellation: Look at the Data Before You Leap.
Mutch DG
J Natl Cancer Inst. 2015 Nov; 107(11)pii: djv283. doi: 10.1093/jnci/djv283.

PMID:
    26449387
    [PubMed - indexed for MEDLINE]
Related citations


The future role of molecular staging in gynecologic cancer.
Binder PS, Prat J, Mutch DG
Int J Gynaecol Obstet. 2015 Oct; 131 Suppl 2S127-31. doi: 10.1016/j.ijgo.2015.06.009.

PMID:
    26433669
    [PubMed - in process]
Related citations


Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.
Walker CJ, Miranda MA, O'Hern MJ, McElroy JP, Coombes KR, Bundschuh R, Cohn DE, Mutch DG, Goodfellow PJ
J Natl Cancer Inst. 2015 Nov; 107(11)pii: djv249. doi: 10.1093/jnci/djv249.

PMID:
    26330387
    [PubMed - indexed for MEDLINE]
Related citations


Chemotherapy Response Rates Among Patients With Endometrial Cancer Who Have Elevated Serum Platelets.
Kizer NT, Hatem H, Nugent EK, Zhou G, Moore K, Heller P, Mutch DG, Thaker PH
Int J Gynecol Cancer. 2015 Jul; 25(6)1015-22. doi: 10.1097/IGC.0000000000000453.

PMID:
    26098089
    [PubMed - indexed for MEDLINE]
Related citations


Awareness of the association between obesity and peri-operative risk among newly diagnosed patients with complex atypical hyperplasia and endometrial cancer.
Kuroki LM, Benn TE, Dukes JL, Hagemann AR, Thaker PH, Powell MA, Mutch DG, Massad LS, Zighelboim I
Gynecol Oncol Rep. 2015 Apr; 1241-44.

PMID:
    25995994
    [PubMed]
Related citations


Molecular staging of gynecological cancer: What is the future?
Binder PS, Prat J, Mutch DG
Best Pract Res Clin Obstet Gynaecol. 2015 Aug; 29(6)776-89. doi: 10.1016/j.bpobgyn.2015.01.008.

PMID:
    25934522
    [PubMed - in process]
Related citations


Adjuvant radiotherapy in Stage II endometrial carcinoma: Is brachytherapy alone sufficient for local control?
Paydar I, DeWees T, Powell M, Mutch DG, Grigsby PW, Schwarz JK
Brachytherapy. 2015 Jul-Aug; 14(4)427-32. doi: 10.1016/j.brachy.2015.02.196.

PMID:
    25911995
    [PubMed - indexed for MEDLINE]
Related citations


Impact of an immunohistochemistry-based universal screening protocol for Lynch syndrome in endometrial cancer on genetic counseling and testing.
Frolova AI, Babb SA, Zantow E, Hagemann AR, Powell MA, Thaker PH, Gao F, Mutch DG
Gynecol Oncol. 2015 Apr; 137(1)7-13. doi: 10.1016/j.ygyno.2015.01.535.

PMID:
    25617771
    [PubMed - indexed for MEDLINE]
Related citations


Ovarian cancer in the United States: contemporary patterns of care associated with improved survival.
Cliby WA, Powell MA, Al-Hammadi N, Chen L, Philip Miller J, Roland PY, Mutch DG, Bristow RE
Gynecol Oncol. 2015 Jan; 136(1)11-7. doi: 10.1016/j.ygyno.2014.10.023.

PMID:
    25449311
    [PubMed - indexed for MEDLINE]
Related citations


ACOG Practice Bulletin No. 147: Lynch syndrome.
Committee on Practice Bulletins-Gynecology, Society of Gynecologic Oncology
Obstet Gynecol. 2014 Nov; 124(5)1042-54. doi: 10.1097/01.AOG.0000456325.50739.72.

PMID:
    25437740
    [PubMed - indexed for MEDLINE]
Related citations


Can molecular diagnostics usher in a new era for screening, diagnosis, and treatment of ovarian cancer?
Mutch DG
Obstet Gynecol. 2014 Nov; 124(5)870-2. doi: 10.1097/AOG.0000000000000534.

PMID:
    25437712
    [PubMed - indexed for MEDLINE]
Related citations


Neoadjuvant chemotherapy versus primary cytoreductive surgery for stage IV uterine serous carcinoma.
Wilkinson-Ryan I, Frolova AI, Liu J, Stewart Massad L, Thaker PH, Powell MA, Mutch DG, Hagemann AR
Int J Gynecol Cancer. 2015 Jan; 25(1)63-8. doi: 10.1097/IGC.0000000000000321.

PMID:
    25365590
    [PubMed - indexed for MEDLINE]
Related citations


A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study.
Dizon DS, Sill MW, Schilder JM, McGonigle KF, Rahman Z, Miller DS, Mutch DG, Leslie KK
Gynecol Oncol. 2014 Dec; 135(3)441-5. doi: 10.1016/j.ygyno.2014.10.001.

PMID:
    25312396
    [PubMed - indexed for MEDLINE]
Related citations