Patient Portal

David D. Limbrick, MD, PhD

Chief, Pediatric Neurosurgery
Professor, Neurological Surgery
Professor, Pediatrics
Neurosurgeon-in-Chief, St. Louis Children's Hospital

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Brain Tumors - Pediatric
Spine Surgery - Neurosurgery

Board Certifications

Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

  • Location(s)
  • Education
  • Publication & Research
  • In the News

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: (314) 454-4630
Fax: (314) 454-2818

Education

Education

Residency: Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 2007
Medical Degree: Medical College of Virginia, Virginia Commonwealth University 2001
Ph.D.: Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University 2000
Fellowship: Pediatric Neurosurgery, St. Louis Children's Hospital, St. Louis, Missouri 2007
B.S.: Biology, College of William and Mary, Williamsburg, Virginia 1992
M.S.: Physiology, Medical College of Virginia, Virginia Commonwealth University 1995

Publication & Research

Publication & Research

Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
Strahle JM, Taiwo R, Averill C, Torner J, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Rutlin J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Tyler-Kabara EC, Daniels DJ, Jackson EM, Grant GA, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Baird LC, Bierbrauer K, Chern JJ, Whitehead WE, Ellenbogen RG, Fuchs HE, Guillaume DJ, Hankinson TC, Iantosca MR, Oakes WJ, Keating RF, Khan NR, Muhlbauer MS, McComb JG, Menezes AH, Ragheb J, Smith JL, Maher CO, Greene S, Kelly M, O'Neill BR, Krieger MD, Tamber M, Durham SR, Olavarria G, Stone SSD, Kaufman BA, Heuer GG, Bauer DF, Albert G, Greenfield JP, Wait SD, Van Poppel MD, Eskandari R, Mapstone T, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD
J Neurosurg Pediatr. 2019 Aug 16; 1-8. doi: 10.3171/2019.5.PEDS18527.

PMID:
    31419800
    [PubMed - as supplied by publisher]
Related citations


Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury.
Lean RE, Han RH, Smyser TA, Kenley JK, Shimony JS, Rogers CE, Limbrick DD Jr, Smyser CD
Pediatr Res. 2019 Sep; 86(3)365-374. doi: 10.1038/s41390-019-0461-1.

PMID:
    31212303
    [PubMed - in process]
Related citations


Predictors of success for combined endoscopic third ventriculostomy and choroid plexus cauterization in a North American setting: a Hydrocephalus Clinical Research Network study.
Riva-Cambrin J, Kestle JRW, Rozzelle CJ, Naftel RP, Alvey JS, Reeder RW, Holubkov R, Browd SR, Cochrane DD, Limbrick DD, Shannon CN, Simon TD, Tamber MS, Wellons JC, Whitehead WE, Kulkarni AV, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2019 May 31; 1-11. doi: 10.3171/2019.3.PEDS18532.

PMID:
    31151098
    [PubMed - as supplied by publisher]
Related citations


The Wishbone: A Cranial Midline Localizing Device.
Zanaty M, Banu M, Flouty O, Grady S, Holland MT, Isaacs A, Kung D, Limbrick DD Jr, McKhann G 2nd, Nagahama Y, Zipfel GJ, Howard MA 3rd
World Neurosurg. 2019 May 14; pii: S1878-8750(19)31320-8. doi: 10.1016/j.wneu.2019.05.046.

PMID:
    31100521
    [PubMed - as supplied by publisher]
Related citations


A comparison of resting state functional magnetic resonance imaging to invasive electrocortical stimulation for sensorimotor mapping in pediatric patients.
Roland JL, Hacker CD, Snyder AZ, Shimony JS, Zempel JM, Limbrick DD, Smyth MD, Leuthardt EC
Neuroimage Clin. 2019 May 4; 23101850. doi: 10.1016/j.nicl.2019.101850.

PMID:
    31077983
    [PubMed - as supplied by publisher]
Related citations


Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.
Strahle JM, Triplett RL, Alexopoulos D, Smyser TA, Rogers CE, Limbrick DD Jr, Smyser CD
Neuroimage Clin. 2019; 22101787. doi: 10.1016/j.nicl.2019.101787.

PMID:
    30991622
    [PubMed - in process]
Related citations


Reinfection rates following adherence to Infectious Diseases Society of America guideline recommendations in first cerebrospinal fluid shunt infection treatment.
Simon TD, Kronman MP, Whitlock KB, Browd SR, Holubkov R, Kestle JRW, Kulkarni AV, Langley M, Limbrick DD, Luerssen TG, Oakes WJ, Riva-Cambrin J, Rozzelle C, Shannon CN, Tamber M, Wellons JC, Whitehead WE, Mayer-Hamblett N
J Neurosurg Pediatr. 2019 Feb 15; 1-9. doi: 10.3171/2018.11.PEDS18373.

PMID:
    30771757
    [PubMed - as supplied by publisher]
Related citations


Pediatric Neurocritical Care: Off to a Good Start.
Pineda JA, Limbrick DD
Pediatr Crit Care Med. 2019 Jan; 20(1)97-98. doi: 10.1097/PCC.0000000000001771.

PMID:
    30614985
    [PubMed - in process]
Related citations


North American survey on the post-neuroimaging management of children with mild head injuries.
Greenberg JK, Jeffe DB, Carpenter CR, Yan Y, Pineda JA, Lumba-Brown A, Keller MS, Berger D, Bollo RJ, Ravindra VM, Naftel RP, Dewan MC, Shah MN, Burns EC, O'Neill BR, Hankinson TC, Whitehead WE, Adelson PD, Tamber MS, McDonald PJ, Ahn ES, Titsworth W, West AN, Brownson RC, Limbrick DD
J Neurosurg Pediatr. 2018 Oct 26; 23(2)227-235. doi: 10.3171/2018.7.PEDS18263.

PMID:
    30485194
    [PubMed - in process]
Related citations


Development of best practices to minimize wound complications after complex tethered spinal cord surgery: a modified Delphi study.
Alexiades NG, Ahn ES, Blount JP, Brockmeyer DL, Browd SR, Grant GA, Heuer GG, Hankinson TC, Iskandar BJ, Jea A, Krieger MD, Leonard JR, Limbrick DD, Maher CO, Proctor MR, Sandberg DI, Wellons JC, Shao B, Feldstein NA, Anderson RCE
J Neurosurg Pediatr. 2018 Dec 1; 22(6)701-709. doi: 10.3171/2018.6.PEDS18243.

PMID:
    30215584
    [PubMed - indexed for MEDLINE]
Related citations


Treatment of pediatric intracranial aneurysms: case series and meta-analysis.
Yasin JT, Wallace AN, Madaelil TP, Osbun JW, Moran CJ, Cross DT, Limbrick DD, Zipfel GJ, Dacey RG, Kansagra AP
J Neurointerv Surg. 2019 Mar; 11(3)257-264. doi: 10.1136/neurintsurg-2018-014001.

PMID:
    30100557
    [PubMed - indexed for MEDLINE]
Related citations


Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation.
Baksh BS, Sinha N, Salehi A, Han RH, Miller BA, Dahiya S, Gauvain KM, Limbrick DD Jr
World Neurosurg. 2018 Nov; 119233-236. doi: 10.1016/j.wneu.2018.07.284.

PMID:
    30099178
    [PubMed - indexed for MEDLINE]
Related citations


Neonatal brain injury and aberrant connectivity.
Smyser CD, Wheelock MD, Limbrick DD Jr, Neil JJ
Neuroimage. 2019 Jan 15; 185609-623. doi: 10.1016/j.neuroimage.2018.07.057.

PMID:
    30059733
    [PubMed - indexed for MEDLINE]
Related citations


Blood Exposure Causes Ventricular Zone Disruption and Glial Activation In Vitro.
Castaneyra-Ruiz L, Morales DM, McAllister JP, Brody SL, Isaacs AM, Strahle JM, Dahiya SM, Limbrick DD
J Neuropathol Exp Neurol. 2018 Sep 1; 77(9)803-813. doi: 10.1093/jnen/nly058.

PMID:
    30032242
    [PubMed - in process]
Related citations


Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study.
Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, Strahle JM, Olsen MA, Limbrick DD Jr
Childs Nerv Syst. 2018 Nov; 34(11)2203-2213. doi: 10.1007/s00381-018-3897-4.

PMID:
    29987373
    [PubMed - in process]
Related citations


De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.
Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, Antwi P, Loring E, Butler WE, Smith ER, Warf BC, Strahle JM, Limbrick DD, Storm PB, Heuer G, Jackson EM, Iskandar BJ, Johnston JM, Tikhonova I, Castaldi C, López-Giráldez F, Bjornson RD, Knight JR, Bilguvar K, Mane S, Alper SL, Haider S, Guclu B, Bayri Y, Sahin Y, Apuzzo MLJ, Duncan CC, DiLuna ML, Günel M, Lifton RP, Kahle KT
Neuron. 2018 Jul 25; 99(2)302-314.e4. doi: 10.1016/j.neuron.2018.06.019.

PMID:
    29983323
    [PubMed - indexed for MEDLINE]
Related citations


Development of the CIDSS<sub>2</sub> Score for Children with Mild Head Trauma without Intracranial Injury.
Greenberg JK, Yan Y, Carpenter CR, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD
J Neurotrauma. 2018 Nov 15; 35(22)2699-2707. doi: 10.1089/neu.2017.5324.

PMID:
    29882466
    [PubMed - in process]
Related citations


Patient and Treatment Characteristics by Infecting Organism in Cerebrospinal Fluid Shunt Infection.
Simon TD, Kronman MP, Whitlock KB, Browd SR, Holubkov R, Kestle JRW, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon CN, Tamber M, Wellons Iii JC, Whitehead WE, Mayer-Hamblett N, Hydrocephalus Clinical Research Network.
J Pediatric Infect Dis Soc. 2018 May 15; doi: 10.1093/jpids/piy035.

PMID:
    29771360
    [PubMed - as supplied by publisher]
Related citations


Growth and alignment of the pediatric subaxial cervical spine following rigid instrumentation and fusion: a multicenter study of the Pediatric Craniocervical Society.
Goldstein HE, Neira JA, Banu M, Aldana PR, Braga BP, Brockmeyer DL, DiLuna ML, Fulkerson DH, Hankinson TC, Jea AH, Lew SM, Limbrick DD, Martin J, Pahys JM, Rodriguez LF, Rozzelle CJ, Tuite GF, Wetjen NM, Anderson RCE
J Neurosurg Pediatr. 2018 Jul; 22(1)81-88. doi: 10.3171/2018.1.PEDS17551.

PMID:
    29676682
    [PubMed - indexed for MEDLINE]
Related citations

In the News

Areas of Research Interest

Cerebrospinal fluid physiology and neonatal hydrocephalus.