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David D. Limbrick, MD, PhD

Chief, Pediatric Neurosurgery
Professor, Neurological Surgery
Professor, Pediatrics
Neurosurgeon-in-Chief, St. Louis Children's Hospital

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Brain Tumors - Pediatric
Spine Surgery - Neurosurgery

Board Certifications

Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

  • Maps & Directions
  • Education
  • Publication & Research
  • In the News

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: (314) 454-4630
Fax: (314) 454-2818

Education

Education

Residency: Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 2007
Medical Degree: Medical College of Virginia, Virginia Commonwealth University 2001
Ph.D.: Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University 2000
Fellowship: Pediatric Neurosurgery, St. Louis Children's Hospital, St. Louis, Missouri 2007
B.S.: Biology, College of William and Mary, Williamsburg, Virginia 1992
M.S.: Physiology, Medical College of Virginia, Virginia Commonwealth University 1995

Publication & Research

Publication & Research

Abstracts from Hydrocephalus 2016.
Adam A, Robison J, Lu J, Jose R, Badran N, Vivas-Buitrago T, Rigamonti D, Sattar A, Omoush O, Hammad M, Dawood M, Maghaslah M, Belcher T, Carson K, Hoffberger J, Jusué Torres I, Foley S, Yasar S, Thai QA, Wemmer J, Klinge P, Al-Mutawa L, Al-Ghamdi H, Carson KA, Asgari M, de Zélicourt D, Kurtcuoglu V, Garnotel S, Salmon S, Balédent O, Lokossou A, Page G, Balardy L, Czosnyka Z, Payoux P, Schmidt EA, Zitoun M, Sevestre MA, Alperin N, Baudracco I, Craven C, Matloob S, Thompson S, Haylock Vize P, Thorne L, Watkins LD, Toma AK, Bechter K, Pong AC, Jugé L, Bilston LE, Cheng S, Bradley W, Hakim F, Ramón JF, Cárdenas MF, Davidson JS, García C, González D, Bermúdez S, Useche N, Mejía JA, Mayorga P, Cruz F, Martinez C, Matiz MC, Vallejo M, Ghotme K, Soto HA, Riveros D, Buitrago A, Mora M, Murcia L, Bermudez S, Cohen D, Dasgupta D, Curtis C, Domínguez L, Remolina AJ, Grijalba MA, Whitehouse KJ, Edwards RJ, Eleftheriou A, Lundin F, Fountas KN, Kapsalaki EZ, Smisson HF, Robinson JS, Fritsch MJ, Arouk W, Garzon M, Kang M, Sandhu K, Baghawatti D, Aquilina K, James G, Thompson D, Gehlen M, Schmid Daners M, Eklund A, Malm J, Gomez D, Guerra M, Jara M, Flores M, Vío K, Moreno I, Rodríguez S, Ortega E, Rodríguez EM, McAllister JP, Guerra MM, Morales DM, Sival D, Jimenez A, Limbrick DD, Ishikawa M, Yamada S, Yamamoto K, Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V, Kehler U, Lilja-Lund O, Kockum K, Larsson EM, Riklund K, Söderström L, Hellström P, Laurell K, Kojoukhova M, Sutela A, Vanninen R, Vanha KI, Timonen M, Rummukainen J, Korhonen V, Helisalmi S, Solje E, Remes AM, Huovinen J, Paananen J, Hiltunen M, Kurki M, Martin B, Loth F, Luciano M, Luikku AJ, Hall A, Herukka SK, Mattila J, Lötjönen J, Alafuzoff I, Jurjević I, Miyajima M, Nakajima M, Murai H, Shin T, Kawaguchi D, Akiba C, Ogino I, Karagiozov K, Arai H, Reis RC, Teixeira MJ, Valêncio CG, da Vigua D, Almeida-Lopes L, Mancini MW, Pinto FCG, Maykot RH, Calia G, Tornai J, Silvestre SSS, Mendes G, Sousa V, Bezerra B, Dutra P, Modesto P, Oliveira MF, Petitto CE, Pulhorn H, Chandran A, McMahon C, Rao AS, Jumaly M, Solomon D, Moghekar A, Relkin N, Hamilton M, Katzen H, Williams M, Bach T, Zuspan S, Holubkov R, Rigamonti A, Clemens G, Sharkey P, Sanyal A, Sankey E, Rigamonti K, Naqvi S, Hung A, Schmidt E, Ory-Magne F, Gantet P, Guenego A, Januel AC, Tall P, Fabre N, Mahieu L, Cognard C, Gray L, Buttner-Ennever JA, Takagi K, Onouchi K, Thompson SD, Thorne LD, Tully HM, Wenger TL, Kukull WA, Doherty D, Dobyns WB, Moran D, Vakili S, Patel MA, Elder B, Goodwin CR, Crawford JA, Pletnikov MV, Xu J, Blitz A, Herzka DA, Guerrero-Cazares H, Quiñones-Hinojosa A, Mori S, Saavedra P, Treviño H, Maitani K, Ziai WC, Eslami V, Nekoovaght-Tak S, Dlugash R, Yenokyan G, McBee N, Hanley DF
Fluids Barriers CNS. 2017 Jun 7; 14(Suppl 1)15. doi: 10.1186/s12987-017-0054-5.

PMID:
    28929972
    [PubMed - in process]
Related citations


Time-to-event analysis of surgically treated posthemorrhagic hydrocephalus in preterm infants: a single-institution retrospective study.
Han RH, Berger D, Gabir M, Baksh BS, Morales DM, Mathur AM, Smyser CD, Strahle JM, Limbrick DD Jr
Childs Nerv Syst. 2017 Sep 7; doi: 10.1007/s00381-017-3588-6.

PMID:
    28884229
    [PubMed - as supplied by publisher]
Related citations


Endoscopic Third Ventriculostomy in Patients with Neurofibromatosis Type I: A Multicenter International Experience.
Roth J, Ber R, Wisoff JH, Hidalgo ET, Limbrick DD, Berger DS, Thomale UW, Schulz M, Cinalli G, Santoro C, Constantini S
World Neurosurg. 2017 Aug 22; pii: S1878-8750(17)31354-2. doi: 10.1016/j.wneu.2017.08.053.

PMID:
    28842232
    [PubMed - as supplied by publisher]
Related citations


Cerebrospinal Fluid Biomarkers of Pediatric Hydrocephalus.
Limbrick DD Jr, Castaneyra-Ruiz L, Han RH, Berger D, McAllister JP, Morales DM
Pediatr Neurosurg. 2017 Aug 11; doi: 10.1159/000477175.

PMID:
    28797007
    [PubMed - as supplied by publisher]
Related citations


Applications of a robotic stereotactic arm for pediatric epilepsy and neurooncology surgery.
Miller BA, Salehi A, Limbrick DD Jr, Smyth MD
J Neurosurg Pediatr. 2017 Aug 4; 1-7. doi: 10.3171/2017.5.PEDS1782.

PMID:
    28777037
    [PubMed - as supplied by publisher]
Related citations


Analysis and interrater reliability of pB-C2 using MRI and CT: data from the Park-Reeves Syringomyelia Research Consortium on behalf of the Pediatric Craniocervical Society.
Hankinson TC, Tuite GF, Moscoso DI, Robinson LC, Torner JC, Limbrick DD Jr, Park TS, Anderson RCE
J Neurosurg Pediatr. 2017 Aug; 20(2)170-175. doi: 10.3171/2017.3.PEDS16604.

PMID:
    28524792
    [PubMed - indexed for MEDLINE]
Related citations


Ventricular Zone Disruption in Human Neonates With Intraventricular Hemorrhage.
McAllister JP, Guerra MM, Ruiz LC, Jimenez AJ, Dominguez-Pinos D, Sival D, den Dunnen W, Morales DM, Schmidt RE, Rodriguez EM, Limbrick DD
J Neuropathol Exp Neurol. 2017 May 1; 76(5)358-375. doi: 10.1093/jnen/nlx017.

PMID:
    28521038
    [PubMed - indexed for MEDLINE]
Related citations


Shunting outcomes in posthemorrhagic hydrocephalus: results of a Hydrocephalus Clinical Research Network prospective cohort study.
Wellons JC 3rd, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni AV, Limbrick DD Jr, Whitehead W, Browd S, Rozzelle C, Simon TD, Tamber MS, Oakes WJ, Drake J, Luerssen TG, Kestle J, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2017 Jul; 20(1)19-29. doi: 10.3171/2017.1.PEDS16496.

PMID:
    28452657
    [PubMed - indexed for MEDLINE]
Related citations


Electrophysiological Sequelae of Hemispherotomy in Ipsilateral Human Cortex.
Hawasli AH, Chacko R, Szrama NP, Bundy DT, Pahwa M, Yarbrough CK, Dlouhy BJ, Limbrick DD, Barbour DL, Smyth MD, Leuthardt EC
Front Hum Neurosci. 2017; 11149. doi: 10.3389/fnhum.2017.00149.

PMID:
    28424599
    [PubMed]
Related citations


Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus.
Limbrick DD Jr, Baksh B, Morgan CD, Habiyaremye G, McAllister JP 2nd, Inder TE, Mercer D, Holtzman DM, Strahle J, Wallendorf MJ, Morales DM
PLoS One. 2017; 12(2)e0172353. doi: 10.1371/journal.pone.0172353.

PMID:
    28212403
    [PubMed - indexed for MEDLINE]
Related citations


Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury.
Greenberg JK, Yan Y, Carpenter CR, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD
JAMA Pediatr. 2017 Apr 1; 171(4)342-349. doi: 10.1001/jamapediatrics.2016.4520.

PMID:
    28192567
    [PubMed - indexed for MEDLINE]
Related citations


Ventricular catheter entry site and not catheter tip location predicts shunt survival: a secondary analysis of 3 large pediatric hydrocephalus studies.
Whitehead WE, Riva-Cambrin J, Kulkarni AV, Wellons JC 3rd, Rozzelle CJ, Tamber MS, Limbrick DD Jr, Browd SR, Naftel RP, Shannon CN, Simon TD, Holubkov R, Illner A, Cochrane DD, Drake JM, Luerssen TG, Oakes WJ, Kestle JR,  for the Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2017 Feb; 19(2)157-167. doi: 10.3171/2016.8.PEDS16229.

PMID:
    27813457
    [PubMed - indexed for MEDLINE]
Related citations


Hemispherotomy in children with electrical status epilepticus of sleep.
Jeong A, Strahle J, Vellimana AK, Limbrick DD Jr, Smyth MD, Bertrand M
J Neurosurg Pediatr. 2017 Jan; 19(1)56-62. doi: 10.3171/2016.8.PEDS16319.

PMID:
    27791702
    [PubMed - indexed for MEDLINE]
Related citations


Left hemisphere structural connectivity abnormality in pediatric hydrocephalus patients following surgery.
Yuan W, Meller A, Shimony JS, Nash T, Jones BV, Holland SK, Altaye M, Barnard H, Phillips J, Powell S, McKinstry RC, Limbrick DD, Rajagopal A, Mangano FT
Neuroimage Clin. 2016; 12631-639.

PMID:
    27722087
    [PubMed - in process]
Related citations


Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study.
Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC 3rd, Whitehead WE, Mayer-Hamblett N, Hydrocephalus Clinical Research Network (HCRN).
J Pediatr. 2016 Dec; 179185-191.e2. doi: 10.1016/j.jpeds.2016.08.094.

PMID:
    27692463
    [PubMed - indexed for MEDLINE]
Related citations


Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein α, and L1 Cell Adhesion Molecule.
Morales DM, Silver SA, Morgan CD, Mercer D, Inder TE, Holtzman DM, Wallendorf MJ, Rao R, McAllister JP, Limbrick DD Jr
Neurosurgery. 2017 Jan 1; 80(1)82-90. doi: 10.1227/NEU.0000000000001415.

PMID:
    27571524
    [PubMed - in process]
Related citations


Palliative epilepsy surgery in Dravet syndrome-case series and review of the literature.
Dlouhy BJ, Miller B, Jeong A, Bertrand ME, Limbrick DD Jr, Smyth MD
Childs Nerv Syst. 2016 Sep; 32(9)1703-8. doi: 10.1007/s00381-016-3201-4.

PMID:
    27465677
    [PubMed - indexed for MEDLINE]
Related citations


Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.
Yuan W, Harpster K, Jones BV, Shimony JS, McKinstry RC, Weckherlin N, Powell SS, Barnard H, Engsberg J, Kadis DS, Dodd J, Altaye M, Limbrick DD, Holland SK, Simpson SM, Bidwell S, Mangano FT
Neuropediatrics. 2016 Oct; 47(5)336-40. doi: 10.1055/s-0036-1584938.

PMID:
    27438376
    [PubMed - indexed for MEDLINE]
Related citations


183 A Clinical Risk Score for Managing Children With Glasgow Coma Scale 13 to 15 Head Injuries and Intracranial Injury.
Greenberg JK, Yan Y, Carpenter C, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD
Neurosurgery. 2016 Aug; 63 Suppl 1172-3. doi: 10.1227/01.neu.0000489752.67038.e7.

PMID:
    27399462
    [PubMed - in process]
Related citations


Predicting Blunt Cerebrovascular Injury in Pediatric Trauma: Validation of the "Utah Score".
Ravindra VM, Bollo RJ, Sivakumar W, Akbari H, Naftel RP, Limbrick DD Jr, Jea A, Gannon S, Shannon C, Birkas Y, Yang GL, Prather CT, Kestle JR, Riva-Cambrin J
J Neurotrauma. 2017 Jan 15; 34(2)391-399. doi: 10.1089/neu.2016.4415.

PMID:
    27297774
    [PubMed - in process]
Related citations

In the News

Areas of Research Interest

Cerebrospinal fluid physiology and neonatal hydrocephalus.