Patient Portal

David D. Limbrick, MD, PhD

Chief, Pediatric Neurosurgery
Professor, Neurological Surgery
Professor, Pediatrics
Neurosurgeon-in-Chief, St. Louis Children's Hospital

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Brain Tumors - Pediatric
Spine Surgery - Neurosurgery

Board Certifications

Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

  • Location(s)
  • Education
  • Publication & Research
  • In the News

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: (314) 454-4630
Fax: (314) 454-2818

Education

Education

Residency: Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 2007
Medical Degree: Medical College of Virginia, Virginia Commonwealth University 2001
Ph.D.: Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University 2000
Fellowship: Pediatric Neurosurgery, St. Louis Children's Hospital, St. Louis, Missouri 2007
B.S.: Biology, College of William and Mary, Williamsburg, Virginia 1992
M.S.: Physiology, Medical College of Virginia, Virginia Commonwealth University 1995

Publication & Research

Publication & Research

Surgical resource utilization after initial treatment of infant hydrocephalus: comparing ETV, early experience of ETV with choroid plexus cauterization, and shunt insertion in the Hydrocephalus Clinical Research Network.
Pindrik J, Riva-Cambrin J, Kulkarni AV, Alvey JS, Reeder RW, Pollack IF, Wellons JC, Jackson EM, Rozzelle CJ, Whitehead WE, Limbrick DD, Naftel RP, Shannon C, McDonald PJ, Tamber MS, Hankinson TC, Hauptman JS, Simon TD, Krieger MD, Holubkov R, Kestle JRW, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2020 Jun 19; 1-9. doi: 10.3171/2020.4.PEDS19632.

PMID:
    32559741
    [PubMed - as supplied by publisher]
Related citations


Association between supratentorial pediatric high-grade gliomas involved with the subventricular zone and decreased survival: a multi-institutional retrospective study.
Mistry AM, Mummareddy N, CreveCoeur TS, Lillard JC, Vaughn BN, Gallant JN, Hale AT, Griffin N, Wellons JC, Limbrick DD, Klimo P, Naftel RP
J Neurosurg Pediatr. 2020 May 22; 1-7. doi: 10.3171/2020.3.PEDS19593.

PMID:
    32442975
    [PubMed - as supplied by publisher]
Related citations


Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.
Prince E, Whelan R, Donson A, Staulcup S, Hengartner A, Vijmasi T, Agwu C, Lillehei KO, Foreman NK, Johnston JM, Massimi L, Anderson RCE, Souweidane MM, Naftel RP, Limbrick DD, Grant G, Niazi TN, Dudley R, Kilburn L, Jackson EM, Jallo GI, Ginn K, Smith A, Chern JJ, Lee A, Drapeau A, Krieger MD, Handler MH, Hankinson TC, Advancing Treatment for Pediatric Craniopharyngioma Consortium.
Acta Neuropathol Commun. 2020 May 13; 8(1)68. doi: 10.1186/s40478-020-00939-0.

PMID:
    32404202
    [PubMed - in process]
Related citations


Intraventricular Hemorrhage Clearance in Human Neonatal Cerebrospinal Fluid: Associations With Hydrocephalus.
Mahaney KB, Buddhala C, Paturu M, Morales D, Limbrick DD Jr, Strahle JM
Stroke. 2020 Jun; 51(6)1712-1719. doi: 10.1161/STROKEAHA.119.028744.

PMID:
    32397930
    [PubMed - in process]
Related citations


Obex position is associated with syringomyelia and use of posterior fossa decompression among patients with Chiari I malformation.
Haller G, Sadler B, Kuensting T, Lakshman N, Greenberg JK, Strahle JM, Park TS, Dobbs MB, Gurnett CA, Limbrick DD
J Neurosurg Pediatr. 2020 Apr 10; 1-8. doi: 10.3171/2020.2.PEDS19486.

PMID:
    32276247
    [PubMed - as supplied by publisher]
Related citations


Radiological and clinical associations with scoliosis outcomes after posterior fossa decompression in patients with Chiari malformation and syrinx from the Park-Reeves Syringomyelia Research Consortium.
Strahle JM, Taiwo R, Averill C, Torner J, Gewirtz JI, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Anderson RCE, Kelly MP, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD, Park-Reeves Syringomyelia Research Consortium.
J Neurosurg Pediatr. 2020 Apr 10; 1-7. doi: 10.3171/2020.1.PEDS18755.

PMID:
    32276246
    [PubMed - as supplied by publisher]
Related citations


Pediatric neurosurgery training during residency in the United States: a program director survey.
Limoges N, D'Agostino E, Gelinne A, Maher CO, Scott RM, Grant G, Krieger MD, Limbrick DD, White M, Durham S
J Neurosurg Pediatr. 2020 Mar 20; 1-7. doi: 10.3171/2020.1.PEDS19662.

PMID:
    32197250
    [PubMed - as supplied by publisher]
Related citations


Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.
Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD Jr, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT
Nat Rev Neurol. 2020 May; 16(5)285-296. doi: 10.1038/s41582-020-0321-y.

PMID:
    32152460
    [PubMed - in process]
Related citations


Factors associated with syrinx size in pediatric patients treated for Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium.
Hale AT, Adelson PD, Albert GW, Aldana PR, Alden TD, Anderson RCE, Bauer DF, Bonfield CM, Brockmeyer DL, Chern JJ, Couture DE, Daniels DJ, Durham SR, Ellenbogen RG, Eskandari R, George TM, Grant GA, Graupman PC, Greene S, Greenfield JP, Gross NL, Guillaume DJ, Heuer GG, Iantosca M, Iskandar BJ, Jackson EM, Johnston JM, Keating RF, Leonard JR, Maher CO, Mangano FT, McComb JG, Meehan T, Menezes AH, O'Neill B, Olavarria G, Park TS, Ragheb J, Selden NR, Shah MN, Smyth MD, Stone SSD, Strahle JM, Wait SD, Wellons JC, Whitehead WE, Shannon CN, Limbrick DD, Park-Reeves Syringomyelia Research Consortium Investigators.
J Neurosurg Pediatr. 2020 Mar 6; 1-11. doi: 10.3171/2020.1.PEDS19493.

PMID:
    32114543
    [PubMed - as supplied by publisher]
Related citations


Prevalence and Impact of Underlying Diagnosis and Comorbidities on Chiari 1 Malformation.
Sadler B, Kuensting T, Strahle J, Park TS, Smyth M, Limbrick DD, Dobbs MB, Haller G, Gurnett CA
Pediatr Neurol. 2020 May; 10632-37. doi: 10.1016/j.pediatrneurol.2019.12.005.

PMID:
    32113729
    [PubMed - in process]
Related citations


A Multi-Institutional Analysis of Factors Influencing Surgical Outcomes for Patients with Newly Diagnosed Grade I Gliomas.
Yahanda AT, Patel B, Sutherland G, Honeycutt J, Jensen RL, Smyth MD, Limbrick DD Jr, Dacey RG Jr, Dowling JL, Dunn GP, Kim AH, Leuthardt EC, Rich KM, Zipfel GJ, Leonard JR, Cahill DP, Shah MV, Abram SR, Evans J, Tao Y, Chicoine MR
World Neurosurg. 2020 Mar; 135e754-e764. doi: 10.1016/j.wneu.2019.12.156.

PMID:
    31901497
    [PubMed - indexed for MEDLINE]
Related citations


MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity.
Isaacs AM, Smyser CD, Lean RE, Alexopoulos D, Han RH, Neil JJ, Zimbalist SA, Rogers CE, Yan Y, Shimony JS, Limbrick DD Jr
Neuroimage Clin. 2019; 24102031. doi: 10.1016/j.nicl.2019.102031.

PMID:
    31795043
    [PubMed - in process]
Related citations


The role of screening spinal MRI in children with solitary posterior fossa low-grade glial tumors.
Roth J, Fischer N, Limbrick DD, CreveCoeur T, Ben-Sira L, Constantini S
J Neurosurg Pediatr. 2019 Nov 15; 1-5. doi: 10.3171/2019.9.PEDS19358.

PMID:
    31731277
    [PubMed - as supplied by publisher]
Related citations


Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
Strahle JM, Taiwo R, Averill C, Torner J, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Rutlin J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Tyler-Kabara EC, Daniels DJ, Jackson EM, Grant GA, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Baird LC, Bierbrauer K, Chern JJ, Whitehead WE, Ellenbogen RG, Fuchs HE, Guillaume DJ, Hankinson TC, Iantosca MR, Oakes WJ, Keating RF, Khan NR, Muhlbauer MS, McComb JG, Menezes AH, Ragheb J, Smith JL, Maher CO, Greene S, Kelly M, O'Neill BR, Krieger MD, Tamber M, Durham SR, Olavarria G, Stone SSD, Kaufman BA, Heuer GG, Bauer DF, Albert G, Greenfield JP, Wait SD, Van Poppel MD, Eskandari R, Mapstone T, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD
J Neurosurg Pediatr. 2019 Aug 16; 1-8. doi: 10.3171/2019.5.PEDS18527.

PMID:
    31419800
    [PubMed - as supplied by publisher]
Related citations


Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury.
Lean RE, Han RH, Smyser TA, Kenley JK, Shimony JS, Rogers CE, Limbrick DD Jr, Smyser CD
Pediatr Res. 2019 Sep; 86(3)365-374. doi: 10.1038/s41390-019-0461-1.

PMID:
    31212303
    [PubMed - in process]
Related citations


Predictors of success for combined endoscopic third ventriculostomy and choroid plexus cauterization in a North American setting: a Hydrocephalus Clinical Research Network study.
Riva-Cambrin J, Kestle JRW, Rozzelle CJ, Naftel RP, Alvey JS, Reeder RW, Holubkov R, Browd SR, Cochrane DD, Limbrick DD, Shannon CN, Simon TD, Tamber MS, Wellons JC, Whitehead WE, Kulkarni AV, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2019 May 31; 1-11. doi: 10.3171/2019.3.PEDS18532.

PMID:
    31151098
    [PubMed - as supplied by publisher]
Related citations


The Wishbone: A Cranial Midline Localizing Device.
Zanaty M, Banu M, Flouty O, Grady S, Holland MT, Isaacs A, Kung D, Limbrick DD Jr, McKhann G 2nd, Nagahama Y, Zipfel GJ, Howard MA 3rd
World Neurosurg. 2019 Aug; 128600-605.e1. doi: 10.1016/j.wneu.2019.05.046.

PMID:
    31100521
    [PubMed - indexed for MEDLINE]
Related citations


A comparison of resting state functional magnetic resonance imaging to invasive electrocortical stimulation for sensorimotor mapping in pediatric patients.
Roland JL, Hacker CD, Snyder AZ, Shimony JS, Zempel JM, Limbrick DD, Smyth MD, Leuthardt EC
Neuroimage Clin. 2019; 23101850. doi: 10.1016/j.nicl.2019.101850.

PMID:
    31077983
    [PubMed - indexed for MEDLINE]
Related citations


Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.
Strahle JM, Triplett RL, Alexopoulos D, Smyser TA, Rogers CE, Limbrick DD Jr, Smyser CD
Neuroimage Clin. 2019; 22101787. doi: 10.1016/j.nicl.2019.101787.

PMID:
    30991622
    [PubMed - indexed for MEDLINE]
Related citations

In the News

Areas of Research Interest

Cerebrospinal fluid physiology and neonatal hydrocephalus.