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David D. Limbrick, MD, PhD

Chief, Pediatric Neurosurgery
Professor, Neurological Surgery
Professor, Pediatrics
Neurosurgeon-in-Chief, St. Louis Children's Hospital

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Brain Tumors - Pediatric
Spine Surgery - Neurosurgery

Board Certifications

Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

  • Maps & Directions
  • Education
  • Publication & Research
  • In the News

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: (314) 454-4630
Fax: (314) 454-2818

Education

Education

Residency: Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 2007
Medical Degree: Medical College of Virginia, Virginia Commonwealth University 2001
Ph.D.: Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University 2000
Fellowship: Pediatric Neurosurgery, St. Louis Children's Hospital, St. Louis, Missouri 2007
B.S.: Biology, College of William and Mary, Williamsburg, Virginia 1992
M.S.: Physiology, Medical College of Virginia, Virginia Commonwealth University 1995

Publication & Research

Publication & Research

Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus.
Limbrick DD Jr, Baksh B, Morgan CD, Habiyaremye G, McAllister JP 2nd, Inder TE, Mercer D, Holtzman DM, Strahle J, Wallendorf MJ, Morales DM
PLoS One. 2017 Feb 17; 12(2)e0172353. doi: 10.1371/journal.pone.0172353.

PMID:
    28212403
    [PubMed - in process]
Related citations


Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury.
Greenberg JK, Yan Y, Carpenter CR, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD
JAMA Pediatr. 2017 Feb 13; doi: 10.1001/jamapediatrics.2016.4520.

PMID:
    28192567
    [PubMed - as supplied by publisher]
Related citations


Ventricular catheter entry site and not catheter tip location predicts shunt survival: a secondary analysis of 3 large pediatric hydrocephalus studies.
Whitehead WE, Riva-Cambrin J, Kulkarni AV, Wellons JC 3rd, Rozzelle CJ, Tamber MS, Limbrick DD Jr, Browd SR, Naftel RP, Shannon CN, Simon TD, Holubkov R, Illner A, Cochrane DD, Drake JM, Luerssen TG, Oakes WJ, Kestle JR,  for the Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2017 Feb; 19(2)157-167. doi: 10.3171/2016.8.PEDS16229.

PMID:
    27813457
    [PubMed - indexed for MEDLINE]
Related citations


Hemispherotomy in children with electrical status epilepticus of sleep.
Jeong A, Strahle J, Vellimana AK, Limbrick DD Jr, Smyth MD, Bertrand M
J Neurosurg Pediatr. 2017 Jan; 19(1)56-62. doi: 10.3171/2016.8.PEDS16319.

PMID:
    27791702
    [PubMed - indexed for MEDLINE]
Related citations


Left hemisphere structural connectivity abnormality in pediatric hydrocephalus patients following surgery.
Yuan W, Meller A, Shimony JS, Nash T, Jones BV, Holland SK, Altaye M, Barnard H, Phillips J, Powell S, McKinstry RC, Limbrick DD, Rajagopal A, Mangano FT
Neuroimage Clin. 2016 Sep 4; 12631-639.

PMID:
    27722087
    [PubMed - in process]
Related citations


Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study.
Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC 3rd, Whitehead WE, Mayer-Hamblett N, Hydrocephalus Clinical Research Network (HCRN).
J Pediatr. 2016 Dec; 179185-191.e2. doi: 10.1016/j.jpeds.2016.08.094.

PMID:
    27692463
    [PubMed - in process]
Related citations


Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein α, and L1 Cell Adhesion Molecule.
Morales DM, Silver SA, Morgan CD, Mercer D, Inder TE, Holtzman DM, Wallendorf MJ, Rao R, McAllister JP, Limbrick DD Jr
Neurosurgery. 2016 Aug 26;

PMID:
    27571524
    [PubMed - as supplied by publisher]
Related citations


Palliative epilepsy surgery in Dravet syndrome-case series and review of the literature.
Dlouhy BJ, Miller B, Jeong A, Bertrand ME, Limbrick DD Jr, Smyth MD
Childs Nerv Syst. 2016 Sep; 32(9)1703-8. doi: 10.1007/s00381-016-3201-4.

PMID:
    27465677
    [PubMed - in process]
Related citations


Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.
Yuan W, Harpster K, Jones BV, Shimony JS, McKinstry RC, Weckherlin N, Powell SS, Barnard H, Engsberg J, Kadis DS, Dodd J, Altaye M, Limbrick DD, Holland SK, Simpson SM, Bidwell S, Mangano FT
Neuropediatrics. 2016 Oct; 47(5)336-40. doi: 10.1055/s-0036-1584938.

PMID:
    27438376
    [PubMed - indexed for MEDLINE]
Related citations


183 A Clinical Risk Score for Managing Children With Glasgow Coma Scale 13 to 15 Head Injuries and Intracranial Injury.
Greenberg JK, Yan Y, Carpenter C, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD
Neurosurgery. 2016 Aug; 63 Suppl 1172-3. doi: 10.1227/01.neu.0000489752.67038.e7.

PMID:
    27399462
    [PubMed - in process]
Related citations


Predicting Blunt Cerebrovascular Injury in Pediatric Trauma: Validation of the "Utah Score".
Ravindra VM, Bollo RJ, Sivakumar W, Akbari H, Naftel RP, Limbrick DD Jr, Jea A, Gannon S, Shannon C, Birkas Y, Yang GL, Prather CT, Kestle JR, Riva-Cambrin J
J Neurotrauma. 2017 Jan 15; 34(2)391-399. doi: 10.1089/neu.2016.4415.

PMID:
    27297774
    [PubMed - in process]
Related citations


Endoscopic third ventriculostomy in children: prospective, multicenter results from the Hydrocephalus Clinical Research Network.
Kulkarni AV, Riva-Cambrin J, Holubkov R, Browd SR, Cochrane DD, Drake JM, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE, Kestle JR, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2016 Oct; 18(4)423-429.

PMID:
    27258593
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes.
Mangano FT, Altaye M, McKinstry RC, Shimony JS, Powell SK, Phillips JM, Barnard H, Limbrick DD Jr, Holland SK, Jones BV, Dodd J, Simpson S, Mercer D, Rajagopal A, Bidwell S, Yuan W
J Neurosurg Pediatr. 2016 Sep; 18(3)306-19. doi: 10.3171/2016.2.PEDS15628.

PMID:
    27203134
    [PubMed - indexed for MEDLINE]
Related citations


Natural history of colloid cysts of the third ventricle.
Beaumont TL, Limbrick DD Jr, Rich KM, Wippold FJ 2nd, Dacey RG Jr
J Neurosurg. 2016 Dec; 125(6)1420-1430.

PMID:
    26967781
    [PubMed - in process]
Related citations


Chiari malformation Type I surgery in pediatric patients. Part 1: validation of an ICD-9-CM code search algorithm.
Ladner TR, Greenberg JK, Guerrero N, Olsen MA, Shannon CN, Yarbrough CK, Piccirillo JF, Anderson RC, Feldstein NA, Wellons JC 3rd, Smyth MD, Park TS, Limbrick DD Jr
J Neurosurg Pediatr. 2016 May; 17(5)519-24. doi: 10.3171/2015.10.PEDS15370.

PMID:
    26799412
    [PubMed - indexed for MEDLINE]
Related citations


Chiari malformation Type I surgery in pediatric patients. Part 2: complications and the influence of comorbid disease in California, Florida, and New York.
Greenberg JK, Olsen MA, Yarbrough CK, Ladner TR, Shannon CN, Piccirillo JF, Anderson RC, Wellons JC 3rd, Smyth MD, Park TS, Limbrick DD Jr
J Neurosurg Pediatr. 2016 May; 17(5)525-32. doi: 10.3171/2015.10.PEDS15369.

PMID:
    26799408
    [PubMed - indexed for MEDLINE]
Related citations


A new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection.
Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, Jerry Oakes W, Riva-Cambrin J, Rozzelle C, Simon TD, Walker ML, Wellons JC 3rd, Browd SR, Drake JM, Shannon CN, Tamber MS, Whitehead WE, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2016 Apr; 17(4)391-6. doi: 10.3171/2015.8.PEDS15253.

PMID:
    26684763
    [PubMed - indexed for MEDLINE]
Related citations


Risk factors for shunt malfunction in pediatric hydrocephalus: a multicenter prospective cohort study.
Riva-Cambrin J, Kestle JR, Holubkov R, Butler J, Kulkarni AV, Drake J, Whitehead WE, Wellons JC 3rd, Shannon CN, Tamber MS, Limbrick DD Jr, Rozzelle C, Browd SR, Simon TD, Hydrocephalus Clinical Research Network.
J Neurosurg Pediatr. 2016 Apr; 17(4)382-90. doi: 10.3171/2015.6.PEDS14670.

PMID:
    26636251
    [PubMed - indexed for MEDLINE]
Related citations


Chiari I Malformation: Adult and Pediatric Considerations.
Leonard JR, Limbrick DD Jr
Neurosurg Clin N Am. 2015 Oct; 26(4)xiii-xiv. doi: 10.1016/j.nec.2015.07.002.

PMID:
    26408069
    [PubMed - indexed for MEDLINE]
Related citations


In Reply: Chiari Severity Index: A Novel Grading System Intended for Preoperative Counseling.
Greenberg JK, Yarbrough CK, Radmanesh A, Godzik J, Yu M, Jeffe DB, Smyth MD, Park TS, Piccirillo JF, Limbrick DD Jr
Neurosurgery. 2015 Nov; 77(5)E842. doi: 10.1227/NEU.0000000000000936.

PMID:
    26258944
    [PubMed - indexed for MEDLINE]
Related citations

In the News

Areas of Research Interest

Cerebrospinal fluid physiology and neonatal hydrocephalus.