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Faculty Physicians

David B. Wilson, MD, PhD

Professor, Pediatrics
Division of Pediatric Hematology and Oncology
Professor, Molecular Biology and Pharmacology

Specialty Areas

Pediatric Hematology
Pediatric Kidney Transplant
Anticoagulation
Pediatric Oncology

Board Certifications

Pediatrics
Pediatric Hematology
Pediatric Oncology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Coagulation disorders; Bone marrow failure

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: 9th Floor
Office Phone: 314-454-6018
Fax: 314-454-2780

Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: E
Floor: 2
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

Fellowship: Pediatrics, Harvard Medical School, Boston, Massachusetts 1990
Fellowship: Medicine Hematology / Oncology, The Children's Hospital, Boston, Massachusetts 1990
Fellowship: Pediatrics, Hematology / Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 1989
Ph.D: Washington University School of Medicine, St. Louis, Missouri 1986
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1986
B.A.: Kalamazoo College, Kalamazoo, Michigan 1980

Publication & Research

Publication & Research

Simulation studies of substrate recognition by the exocellulase CelF from Clostridium cellulolyticum.
Chen M, Himmel ME, Wilson DB, Brady JW
Biotechnol Bioeng. 2015 Dec 22; doi: 10.1002/bit.25909.

PMID:
    26693961
    [PubMed - as supplied by publisher]
Related citations


Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.
Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE, Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium
J Pediatr Surg. 2016 Jan; 51(1)122-7. doi: 10.1016/j.jpedsurg.2015.10.028.

PMID:
    26613837
    [PubMed - in process]
Related citations


Animal models of adrenocortical tumorigenesis.
Galac S, Wilson DB
Endocrinol Metab Clin North Am. 2015 Jun; 44(2)297-310. doi: 10.1016/j.ecl.2015.02.003.

PMID:
    26038202
    [PubMed - in process]
Related citations


GATA factors in endocrine neoplasia.
Pihlajoki M, Färkkilä A, Soini T, Heikinheimo M, Wilson DB
Mol Cell Endocrinol. 2016 Feb 5; 4212-17. doi: 10.1016/j.mce.2015.05.027.

PMID:
    26027919
    [PubMed - in process]
Related citations


Testicular steroidogenic cells to the rescue.
Heikinheimo M, Pihlajoki M, Schrade A, Kyrönlahti A, Wilson DB
Endocrinology. 2015 May; 156(5)1616-9. doi: 10.1210/en.2015-1222.

PMID:
    25886071
    [PubMed - indexed for MEDLINE]
Related citations


The maternal-age-associated risk of congenital heart disease is modifiable.
Schulkey CE, Regmi SD, Magnan RA, Danzo MT, Luther H, Hutchinson AK, Panzer AA, Grady MM, Wilson DB, Jay PY
Nature. 2015 Apr 9; 520(7546)230-3. doi: 10.1038/nature14361.

PMID:
    25830876
    [PubMed - indexed for MEDLINE]
Related citations


Adrenocortical zonation, renewal, and remodeling.
Pihlajoki M, Dörner J, Cochran RS, Heikinheimo M, Wilson DB
Front Endocrinol (Lausanne). 2015; 627. doi: 10.3389/fendo.2015.00027.

PMID:
    25798129
    [PubMed]
Related citations


The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.
Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Diabetes Care. 2015 May; 38(5)940-2. doi: 10.2337/dc14-2787.

PMID:
    25758770
    [PubMed - indexed for MEDLINE]
Related citations


GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.
Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M
Endocrinology. 2015 May; 156(5)1860-72. doi: 10.1210/en.2014-1931.

PMID:
    25668067
    [PubMed - indexed for MEDLINE]
Related citations


Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue.
Röhrig T, Pihlajoki M, Ziegler R, Cochran RS, Schrade A, Schillebeeckx M, Mitra RD, Heikinheimo M, Wilson DB
Mol Cell Endocrinol. 2015 Jun 15; 408165-77. doi: 10.1016/j.mce.2014.12.003.

PMID:
    25498963
    [PubMed - indexed for MEDLINE]
Related citations


Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.
Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium
Am J Hematol. 2015 Mar; 90(3)187-92. doi: 10.1002/ajh.23888.

PMID:
    25382665
    [PubMed - indexed for MEDLINE]
Related citations


Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB
Mol Cell Endocrinol. 2015 Jan 5; 399122-30. doi: 10.1016/j.mce.2014.09.029.

PMID:
    25289806
    [PubMed - indexed for MEDLINE]
Related citations


Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival.
Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ
J Exp Med. 2014 Jul 28; 211(8)1525-31. doi: 10.1084/jem.20140570.

PMID:
    25024137
    [PubMed - indexed for MEDLINE]
Related citations


Validation is a dish oft served cold.
Wilson DB
Blood. 2014 Jun 12; 123(24)3688-9. doi: 10.1182/blood-2014-05-572925.

PMID:
    24926068
    [PubMed - indexed for MEDLINE]
Related citations


Inherited bone marrow failure syndromes in adolescents and young adults.
Wilson DB, Link DC, Mason PJ, Bessler M
Ann Med. 2014 Sep; 46(6)353-63. doi: 10.3109/07853890.2014.915579.

PMID:
    24888387
    [PubMed - indexed for MEDLINE]
Related citations


Differences in response to a dietary intervention between the general population and first-degree relatives of colorectal cancer patients.
McClish D, Carcaise-Edinboro P, Esinhart H, Wilson DB, Bean MK
J Nutr Educ Behav. 2014 Sep-Oct; 46(5)376-83. doi: 10.1016/j.jneb.2014.02.015.

PMID:
    24746549
    [PubMed - indexed for MEDLINE]
Related citations


Experimental and modeling studies of an unusual water-filled pore structure with possible mechanistic implications in family 48 cellulases.
Chen M, Kostylev M, Bomble YJ, Crowley MF, Himmel ME, Wilson DB, Brady JW
J Phys Chem B. 2014 Mar 6; 118(9)2306-15. doi: 10.1021/jp408767j.

PMID:
    24471470
    [PubMed - indexed for MEDLINE]
Related citations


Never underestimate the complexity of remodeling.
Pihlajoki M, Heikinheimo M, Wilson DB
Endocrinology. 2013 Dec; 154(12)4446-9. doi: 10.1210/en.2013-1982.

PMID:
    24273232
    [PubMed - indexed for MEDLINE]
Related citations


Cel48A from Thermobifida fusca: structure and site directed mutagenesis of key residues.
Kostylev M, Alahuhta M, Chen M, Brunecky R, Himmel ME, Lunin VV, Brady J, Wilson DB
Biotechnol Bioeng. 2014 Apr; 111(4)664-73. doi: 10.1002/bit.25139.

PMID:
    24264519
    [PubMed - indexed for MEDLINE]
Related citations


Loop motions important to product expulsion in the Thermobifida fusca glycoside hydrolase family 6 cellobiohydrolase from structural and computational studies.
Wu M, Bu L, Vuong TV, Wilson DB, Crowley MF, Sandgren M, Ståhlberg J, Beckham GT, Hansson H
J Biol Chem. 2013 Nov 15; 288(46)33107-17. doi: 10.1074/jbc.M113.502765.

PMID:
    24085303
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Role of transcription factors in the regulation of differentiation, development and oncogenesis