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David B. Clifford, MD

Professor, Neurology and Medicine
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology

Specialty Areas

HIV Medicine
Neurology - Adult
Neurologic Infectious Diseases

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

HIV neurological disorders, peripheral neuropathy, HIV related dementia, AIDS neurology, progressive multifocal leukoencephalopathy, PML, neurologic infection, multiple sclerosis.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-747-8423
Fax: 314-747-8427
Email: cliffordd@neuro.wustl.edu

Taylor Ave. Building Extension

620 South Taylor Ave.
Suite 100
St. Louis, MO 63110

Suite: Suite 2204
Office Phone: 314-747-8423
Fax: 314-747-8427
Email: cliffordd@neuro.wustl.edu

Education

Education

Fellowship: Neurology, Washington University School of Medicine, St. Louis, Missouri 1981
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 1980
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 1977
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1975
B.A.: Chemistry and History, Southwestern University, Georgetown, Texas 1971

Publication & Research

Publication & Research

A Programme for Risk Assessment and Minimisation of Progressive Multifocal Leukoencephalopathy Developed for Vedolizumab Clinical Trials.
Parikh A, Stephens K, Major E, Fox I, Milch C, Sankoh S, Lev MH, Provenzale JM, Shick J, Patti M, McAuliffe M, Berger JR, Clifford DB
Drug Saf. 2018 Aug; 41(8)807-816. doi: 10.1007/s40264-018-0669-8.

PMID:
    29737503
    [PubMed - in process]
Related citations


Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned.
Major EO, Yousry TA, Clifford DB
Lancet Neurol. 2018 May; 17(5)467-480. doi: 10.1016/S1474-4422(18)30040-1.

PMID:
    29656742
    [PubMed - in process]
Related citations


Could We Harness Human Immunodeficiency Virus Antibodies to Monitor the Brain?
Clifford DB
J Infect Dis. 2018 Mar 13; 217(7)1017-1019. doi: 10.1093/infdis/jix663.

PMID:
    29401231
    [PubMed - in process]
Related citations


Progressive multifocal leukoencephalopathy: Are you aware of it?
Clifford DB, Berger T
Neurology. 2018 Feb 6; 90(6)255-256. doi: 10.1212/WNL.0000000000004935.

PMID:
    29321230
    [PubMed - in process]
Related citations


Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series.
Gelfand JM, Bradshaw MJ, Stern BJ, Clifford DB, Wang Y, Cho TA, Koth LL, Hauser SL, Dierkhising J, Vu N, Sriram S, Moses H, Bagnato F, Kaufmann JA, Ammah DJ, Yohannes TH, Hamblin MJ, Venna N, Green AJ, Pawate S
Neurology. 2017 Nov 14; 89(20)2092-2100. doi: 10.1212/WNL.0000000000004644.

PMID:
    29030454
    [PubMed - indexed for MEDLINE]
Related citations


Differences in Neurocognitive Impairment Among HIV-Infected Latinos in the United States.
Marquine MJ, Heaton A, Johnson N, Rivera-Mindt M, Cherner M, Bloss C, Hulgan T, Umlauf A, Moore DJ, Fazeli P, Morgello S, Franklin D, Letendre S, Ellis R, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Simpson D, McCutchan JA, Grant I, Heaton RK
J Int Neuropsychol Soc. 2018 Feb; 24(2)163-175. doi: 10.1017/S1355617717000832.

PMID:
    28874213
    [PubMed - in process]
Related citations


Genome-wide association study of HIV-associated neurocognitive disorder (HAND): A CHARTER group study.
Jia P, Zhao Z, Hulgan T, Bush WS, Samuels DC, Bloss CS, Heaton RK, Ellis RJ, Schork N, Marra CM, Collier AC, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, McCutchan JA, Barnholtz-Sloan JS, Franklin DR, Rosario D, Letendre SL, Grant I, Kallianpur AR, CHARTER Study Group.
Am J Med Genet B Neuropsychiatr Genet. 2017 Jun; 174(4)413-426. doi: 10.1002/ajmg.b.32530.

PMID:
    28447399
    [PubMed - indexed for MEDLINE]
Related citations


Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment.
Mehta SR, Pérez-Santiago J, Hulgan T, Day TR, Barnholtz-Sloan J, Gittleman H, Letendre S, Ellis R, Heaton R, Patton S, Suben JD, Franklin D, Rosario D, Clifford DB, Collier AC, Marra CM, Gelman BB, McArthur J, McCutchan A, Morgello S, Simpson D, Connor J, Grant I, Kallianpur A
J Neuroinflammation. 2017 Mar 31; 14(1)72. doi: 10.1186/s12974-017-0848-z.

PMID:
    28359324
    [PubMed - indexed for MEDLINE]
Related citations


HIV-associated neurocognitive disorder.
Clifford DB
Curr Opin Infect Dis. 2017 Feb; 30(1)117-122. doi: 10.1097/QCO.0000000000000328.

PMID:
    27798498
    [PubMed - indexed for MEDLINE]
Related citations


Prevalence and Correlates of Persistent HIV-1 RNA in Cerebrospinal Fluid During Antiretroviral Therapy.
Anderson AM, Muñoz-Moreno JA, McClernon DR, Ellis RJ, Cookson D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Sacktor N, Simpson DM, Franklin DR, Heaton RK, Grant I, Letendre SL, CHARTER Group.
J Infect Dis. 2017 Jan 1; 215(1)105-113. doi: 10.1093/infdis/jiw505.

PMID:
    27789723
    [PubMed - indexed for MEDLINE]
Related citations


A decade of natalizumab and PML: Has there been a tacit transfer of risk acceptance?
Clifford DB, Yousry TA, Major EO
Mult Scler. 2017 Jun; 23(7)934-936. doi: 10.1177/1352458516670735.

PMID:
    27679459
    [PubMed - indexed for MEDLINE]
Related citations


The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.
Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C, DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2017 Jan; 13(1)8-19. doi: 10.1016/j.jalz.2016.07.005.

PMID:
    27583651
    [PubMed - indexed for MEDLINE]
Related citations


JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
Soleimani-Meigooni DN, Schwetye KE, Angeles MR, Ryschkewitsch CF, Major EO, Dang X, Koralnik IJ, Schmidt RE, Clifford DB, Kuhlmann FM, Bucelli RC
J Neurovirol. 2017 Feb; 23(1)141-146. doi: 10.1007/s13365-016-0465-0.

PMID:
    27421731
    [PubMed - indexed for MEDLINE]
Related citations


Clinical Trials in Neurovirology: Successes, Challenges, and Pitfalls.
Haubenberger D, Clifford DB
Neurotherapeutics. 2016 Jul; 13(3)571-81. doi: 10.1007/s13311-016-0440-8.

PMID:
    27194073
    [PubMed - indexed for MEDLINE]
Related citations


Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals.
Cooley SA, Paul RH, Fennema-Notestine C, Morgan EE, Vaida F, Deng Q, Chen JA, Letendre S, Ellis R, Clifford DB, Marra CM, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Ances BM, CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group.
J Neurovirol. 2016 Oct; 22(5)607-614.

PMID:
    27021072
    [PubMed - indexed for MEDLINE]
Related citations


The Safety and Immunogenicity of an Interleukin-12-Enhanced Multiantigen DNA Vaccine Delivered by Electroporation for the Treatment of HIV-1 Infection.
Jacobson JM, Zheng L, Wilson CC, Tebas P, Matining RM, Egan MA, Eldridge J, Landay AL, Clifford DB, Luetkemeyer AF, Tiu J, Martinez AL, Janik J, Spitz TA, Hural J, McElrath J, Frahm N, ACTG A5281 Protocol Team.
J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2)163-71. doi: 10.1097/QAI.0000000000000830.

PMID:
    26761518
    [PubMed - indexed for MEDLINE]
Related citations


Persistent CSF but not plasma HIV RNA is associated with increased risk of new-onset moderate-to-severe depressive symptoms; a prospective cohort study.
Hammond ER, Crum RM, Treisman GJ, Mehta SH, Clifford DB, Ellis RJ, Gelman BB, Grant I, Letendre SL, Marra CM, Morgello S, Simpson DM, Mcarthur JC, CHARTER Group.
J Neurovirol. 2016 Aug; 22(4)479-87. doi: 10.1007/s13365-015-0416-1.

PMID:
    26727907
    [PubMed - indexed for MEDLINE]
Related citations


Anemia and Red Blood Cell Indices Predict HIV-Associated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era.
Kallianpur AR, Wang Q, Jia P, Hulgan T, Zhao Z, Letendre SL, Ellis RJ, Heaton RK, Franklin DR, Barnholtz-Sloan J, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I, CHARTER Study Group.
J Infect Dis. 2016 Apr 1; 213(7)1065-73. doi: 10.1093/infdis/jiv754.

PMID:
    26690344
    [PubMed - indexed for MEDLINE]
Related citations


Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.
Fazeli PL, Moore DJ, Franklin DR, Umlauf A, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor NC, Morgello S, Simpson DM, McCutchan JA, Grant I, Letendre SL
Curr HIV Res. 2016; 14(4)324-30.

PMID:
    26673902
    [PubMed - indexed for MEDLINE]
Related citations


2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment.
Patera AC, Butler SL, Cinque P, Clifford DB, Elston R, Garcea RL, Major EO, Pavlovic D, Peterson IS, Ryan AM, Tyler KL, Weber T, PML Consortium.
J Neurovirol. 2015 Dec; 21(6)702-5. doi: 10.1007/s13365-015-0392-5.

PMID:
    26501778
    [PubMed - indexed for MEDLINE]
Related citations