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David B. Clifford, MD

Professor, Neurology and Medicine
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology

Specialty Areas

HIV Medicine
Neurology - Adult
Neurologic Infectious Diseases

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

HIV neurological disorders, peripheral neuropathy, HIV related dementia, AIDS neurology, progressive multifocal leukoencephalopathy, PML, neurologic infection, multiple sclerosis.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-747-8423
Fax: 314-747-8427
Email: cliffordd@neuro.wustl.edu

Taylor Ave. Building Extension

620 South Taylor Ave.
Suite 100
St. Louis, MO 63110

Suite: Suite 2204
Office Phone: 314-747-8423
Fax: 314-747-8427
Email: cliffordd@neuro.wustl.edu

Education

Education

Fellowship: Neurology, Washington University School of Medicine, St. Louis, Missouri 1981
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 1980
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis, Missouri 1977
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1975
B.A.: Chemistry and History, Southwestern University, Georgetown, Texas 1971

Publication & Research

Publication & Research

Checkpoint therapy for progressive multifocal leukoencephalopathy: pointless?
Clifford DB
Eur J Neurol. 2020 Jul 9; doi: 10.1111/ene.14434.

PMID:
    32644212
    [PubMed - as supplied by publisher]
Related citations


Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.
Ellis RJ, Diaz M, Sacktor N, Marra C, Collier AC, Clifford DB, Calcutt N, Fields JA, Heaton RK, Letendre SL, CNS Antiretroviral Therapy Effects Research (CHARTER) Study Group.
Ann Clin Transl Neurol. 2020 Jul; 7(7)1166-1173. doi: 10.1002/acn3.51097.

PMID:
    32619341
    [PubMed - in process]
Related citations


Interleukin-15 superagonist (N-803) treatment of PML and JCV in a post-allogeneic hematopoietic stem cell transplant patient.
Oza A, Rettig MP, Powell P, O'Brien K, Clifford DB, Ritchey J, Gehrs L, Hollaway J, Major E, Fehniger TA, Miller CA, Soon-Shiong P, Rock A, DiPersio JF
Blood Adv. 2020 Jun 9; 4(11)2387-2391. doi: 10.1182/bloodadvances.2019000664.

PMID:
    32484854
    [PubMed - in process]
Related citations


Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials.
Cudkowicz M, Chase MK, Coffey CS, Ecklund DJ, Thornell BJ, Lungu C, Mahoney K, Gutmann L, Shefner JM, Staley KJ, Bosch M, Foster E, Long JD, Bayman EO, Torner J, Yankey J, Peters R, Huff T, Conwit RA, and the NeuroNEXT Clinical Study Sites., Shinnar S, Patch D, Darras BT, Ellis A, Packer RJ, Marder KS, Chiriboga CA, Henchcliffe C, Moran JA, Nikolov B, Factor SA, Seeley C, Greenberg SM, Amato AA, DeGregorio S, Simuni T, Ward T, Kissel JT, Kolb SJ, Bartlett A, Quinn JF, Keith K, Levine SR, Gilles N, Coyle PK, Lamb J, Wolfe GI, Crumlish A, Mejico L, Iqbal MM, Bowen JD, Tongco C, Nabors LB, Bashir K, Benge M, McDonald CM, Henricson EK, Oskarsson B, Dobkin BH, Canamar C, Glauser TA, Woo D, Molloy A, Clark P, Vollmer TL, Stein AJ, Barohn RJ, Dimachkie MM, Le Pichon JB, Benatar MG, Steele J, Wechsler L, Clemens PR, Amity C, Holloway RG, Annis C, Goldberg MP, Andersen M, Iannaccone ST, Smith AG, Singleton JR, Doudova M, Haley EC, Quigg MS, Lowenhaupt S, Malow BA, Adkins K, Clifford DB, Teshome MA, Connolly N
JAMA Neurol. 2020 Mar 23; doi: 10.1001/jamaneurol.2020.0367.

PMID:
    32202612
    [PubMed - as supplied by publisher]
Related citations


Treatment of Progressive Multifocal Leukoencephalopathy Using Immune Restoration.
Dunham SR, Schmidt R, Clifford DB
Neurotherapeutics. 2020 Mar 12; doi: 10.1007/s13311-020-00848-z.

PMID:
    32166631
    [PubMed - as supplied by publisher]
Related citations


Use of Neuroimaging to Inform Optimal Neurocognitive Criteria for Detecting HIV-Associated Brain Abnormalities.
Campbell LM, Fennema-Notestine C, Saloner R, Hussain M, Chen A, Franklin D, Umlauf A, Ellis RJ, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, McCutchan JA, Letendre S, Grant I, Heaton RK, CHARTER Group.
J Int Neuropsychol Soc. 2020 Feb; 26(2)147-162. doi: 10.1017/S1355617719000985.

PMID:
    31576785
    [PubMed - in process]
Related citations


Dosing interval of natalizumab in MS: Do good things come to those who wait?
Clifford DB, Tyler KL
Neurology. 2019 Oct 8; 93(15)655-656. doi: 10.1212/WNL.0000000000008238.

PMID:
    31515289
    [PubMed - indexed for MEDLINE]
Related citations


Thinking About Getting Older With Human Immunodeficiency Virus.
Clifford DB
Clin Infect Dis. 2020 Jun 10; 70(12)2649-2651. doi: 10.1093/cid/ciz675.

PMID:
    31343069
    [PubMed - in process]
Related citations


Is successful HIV therapy a Pyrrhic victory for the brain?
Clifford DB
J Clin Invest. 2019 Jul 15; 129(8)3052-3053. doi: 10.1172/JCI127831.

PMID:
    31305261
    [PubMed - indexed for MEDLINE]
Related citations


Correlates of HIV RNA concentrations in cerebrospinal fluid during antiretroviral therapy: a longitudinal cohort study.
Livelli A, Vaida F, Ellis RJ, Ma Q, Ferrara M, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Sacktor N, Simpson DM, Grant I, Letendre SL, CHARTER Group.
Lancet HIV. 2019 Jul; 6(7)e456-e462. doi: 10.1016/S2352-3018(19)30143-2.

PMID:
    31208949
    [PubMed - indexed for MEDLINE]
Related citations


High alert!
Clifford DB
Mult Scler. 2019 Oct; 25(12)1685. doi: 10.1177/1352458519858603.

PMID:
    31208273
    [PubMed - indexed for MEDLINE]
Related citations


Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis.
Montalban X, Arnold DL, Weber MS, Staikov I, Piasecka-Stryczynska K, Willmer J, Martin EC, Dangond F, Syed S, Wolinsky JS, Evobrutinib Phase 2 Study Group.
N Engl J Med. 2019 Jun 20; 380(25)2406-2417. doi: 10.1056/NEJMoa1901981.

PMID:
    31075187
    [PubMed - indexed for MEDLINE]
Related citations


Neurocognitive SuperAging in Older Adults Living With HIV: Demographic, Neuromedical and Everyday Functioning Correlates.
Saloner R, Campbell LM, Serrano V, Montoya JL, Pasipanodya E, Paolillo EW, Franklin D, Ellis RJ, Letendre SL, Collier AC, Clifford DB, Gelman BB, Marra CM, McCutchan JA, Morgello S, Sacktor N, Jeste DV, Grant I, Heaton RK, Moore DJ, CHARTER and HNRP Groups.
J Int Neuropsychol Soc. 2019 May; 25(5)507-519. doi: 10.1017/S1355617719000018.

PMID:
    30890191
    [PubMed - indexed for MEDLINE]
Related citations


Effects of comorbidity burden and age on brain integrity in HIV.
Saloner R, Heaton RK, Campbell LM, Chen A, Franklin D Jr, Ellis RJ, Collier AC, Marra C, Clifford DB, Gelman B, Sacktor N, Morgello S, McCutchan JA, Letendre S, Grant I, Fennema-Notestine C, CHARTER Study Group.
AIDS. 2019 Jun 1; 33(7)1175-1185. doi: 10.1097/QAD.0000000000002192.

PMID:
    30870195
    [PubMed - indexed for MEDLINE]
Related citations


Progressive multifocal leukoencephalopathy treated with nivolumab.
Hoang E, Bartlett NL, Goyal MS, Schmidt RE, Clifford DB
J Neurovirol. 2019 Apr; 25(2)284-287. doi: 10.1007/s13365-019-00738-x.

PMID:
    30864100
    [PubMed - in process]
Related citations


Cerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy: prevalence, risk factors and neurocognitive effects.
Pérez-Valero I, Ellis R, Heaton R, Deutsch R, Franklin D, Clifford DB, Collier A, Gelman B, Marra C, McCutchan JA, Navis A, Sacktor N, Simpson D, Grant I, Letendre S
AIDS. 2019 Mar 1; 33(3)475-481. doi: 10.1097/QAD.0000000000002074.

PMID:
    30702516
    [PubMed - indexed for MEDLINE]
Related citations


White matter damage, neuroinflammation, and neuronal integrity in HAND.
Alakkas A, Ellis RJ, Watson CW, Umlauf A, Heaton RK, Letendre S, Collier A, Marra C, Clifford DB, Gelman B, Sacktor N, Morgello S, Simpson D, McCutchan JA, Kallianpur A, Gianella S, Marcotte T, Grant I, Fennema-Notestine C, CHARTER Group.
J Neurovirol. 2019 Feb; 25(1)32-41. doi: 10.1007/s13365-018-0682-9.

PMID:
    30291567
    [PubMed - in process]
Related citations


Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection.
Kallianpur AR, Gittleman H, Letendre S, Ellis R, Barnholtz-Sloan JS, Bush WS, Heaton R, Samuels DC, Franklin DR Jr, Rosario-Cookson D, Clifford DB, Collier AC, Gelman B, Marra CM, McArthur JC, McCutchan JA, Morgello S, Grant I, Simpson D, Connor JR, Hulgan T, CHARTER Study Group.
Mol Neurobiol. 2019 May; 56(5)3808-3818. doi: 10.1007/s12035-018-1329-9.

PMID:
    30209774
    [PubMed - indexed for MEDLINE]
Related citations


Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group.
Stern BJ, Royal W 3rd, Gelfand JM, Clifford DB, Tavee J, Pawate S, Berger JR, Aksamit AJ, Krumholz A, Pardo CA, Moller DR, Judson MA, Drent M, Baughman RP
JAMA Neurol. 2018 Dec 1; 75(12)1546-1553. doi: 10.1001/jamaneurol.2018.2295.

PMID:
    30167654
    [PubMed - indexed for MEDLINE]
Related citations


Progressive multifocal leukoencephalopathy with extended natalizumab dosing.
Baldassari LE, Jones SE, Clifford DB, Fox RJ
Neurol Clin Pract. 2018 Jun; 8(3)e12-e14. doi: 10.1212/CPJ.0000000000000457.

PMID:
    30105172
    [PubMed]
Related citations