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David A. Rudnick, MD, PhD

Asociate Professor, Pediatrics
Division of Pediatric Gastroenterology and Nutrition

Specialty Areas

Pediatric Gastroenterology

Board Certifications

Pediatrics
Pediatric Gastroenterology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Gastroenterology in children, nutrition in children, liver regeneration, liver diseases in children

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: 2nd Floor, Suite C
Office Phone: 314-454-6173
Fax: 314-454-2412

Education

Education

Fellowship: Pediatric Gastroenterology and Nutrition, Washington University School of Medicine, St Louis MO 2000
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1997
Ph.D.: Washington University School of Medicine, St. Louis, Missouri 1994
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1994
B.S.: University of Illinois, Champaign-Urbana, Illinois 1987

Publication & Research

Publication & Research

Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure.
Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH, Pediatric Acute Liver Failure Study Group
J Pediatr Gastroenterol Nutr. 2016 Aug 4;

PMID:
    27496798
    [PubMed - as supplied by publisher]
Related citations


Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group.
Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group (PALFSG)
J Pediatr Gastroenterol Nutr. 2016 Sep; 63(3)357-64. doi: 10.1097/MPG.0000000000001178.

PMID:
    27367788
    [PubMed - in process]
Related citations


Clinical Course among Cases of Acute Liver Failure of Indeterminate Diagnosis.
Li R, Belle SH, Horslen S, Chen LW, Zhang S, Squires RH, Pediatric Acute Liver Failure Study Group
J Pediatr. 2016 Apr; 171163-70.e1-3. doi: 10.1016/j.jpeds.2015.12.065.

PMID:
    26831743
    [PubMed - indexed for MEDLINE]
Related citations


Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration.
Huang J, Schriefer AE, Cliften PF, Dietzen D, Kulkarni S, Sing S, Monga SP, Rudnick DA
Am J Pathol. 2016 Mar; 186(3)587-99. doi: 10.1016/j.ajpath.2015.10.027.

PMID:
    26772417
    [PubMed - indexed for MEDLINE]
Related citations


Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance.
Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA
Pediatr Res. 2015 Aug; 78(2)120-7. doi: 10.1038/pr.2015.84.

PMID:
    25938735
    [PubMed - indexed for MEDLINE]
Related citations


Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension.
Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN)
J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1)94-101. doi: 10.1097/MPG.0000000000000753.

PMID:
    25651489
    [PubMed - indexed for MEDLINE]
Related citations


Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition.
Huang J, Schriefer AE, Yang W, Cliften PF, Rudnick DA
Epigenetics. 2014 Nov; 9(11)1521-31. doi: 10.4161/15592294.2014.983371.

PMID:
    25482284
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of viral testing in nonacetaminophen pediatric acute liver failure.
Schwarz KB, Dell Olio D, Lobritto SJ, Lopez MJ, Rodriguez-Baez N, Yazigi NA, Belle SH, Zhang S, Squires RH, Pediatric Acute Liver Failure Study Group
J Pediatr Gastroenterol Nutr. 2014 Nov; 59(5)616-23. doi: 10.1097/MPG.0000000000000512.

PMID:
    25340974
    [PubMed - indexed for MEDLINE]
Related citations


Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.
Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL
Am J Physiol Gastrointest Liver Physiol. 2014 May 15; 306(10)G893-902. doi: 10.1152/ajpgi.00337.2013.

PMID:
    24699334
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure.
Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y, Pediatric Acute Liver Failure Study Group
PLoS One. 2013; 8(11)e78202. doi: 10.1371/journal.pone.0078202.

PMID:
    24244295
    [PubMed - indexed for MEDLINE]
Related citations


Elucidating the metabolic regulation of liver regeneration.
Huang J, Rudnick DA
Am J Pathol. 2014 Feb; 184(2)309-21. doi: 10.1016/j.ajpath.2013.04.034.

PMID:
    24139945
    [PubMed - indexed for MEDLINE]
Related citations


Pregnancy in an NTBC-treated patient with hereditary tyrosinemia type I.
Kassel R, Sprietsma L, Rudnick DA
J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1)e5-7. doi: 10.1097/MPG.0b013e3182a27463.

PMID:
    23838819
    [PubMed - indexed for MEDLINE]
Related citations


Chronic acetaminophen exposure in pediatric acute liver failure.
Leonis MA, Alonso EM, Im K, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group
Pediatrics. 2013 Mar; 131(3)e740-6. doi: 10.1542/peds.2011-3035.

PMID:
    23439908
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration.
Huang J, Barr E, Rudnick DA
Hepatology. 2013 May; 57(5)1742-51. doi: 10.1002/hep.26206.

PMID:
    23258575
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of the role of hepatic PPARγ expression during mouse liver regeneration.
Gazit V, Huang J, Weymann A, Rudnick DA
Hepatology. 2012 Oct; 56(4)1489-98. doi: 10.1002/hep.25880.

PMID:
    22707117
    [PubMed - indexed for MEDLINE]
Related citations


Functional Relationships between Lipid Metabolism and Liver Regeneration.
Rudnick DA, Davidson NO
Int J Hepatol. 2012; 2012549241. doi: 10.1155/2012/549241.

PMID:
    22319652
    [PubMed]
Related citations


The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration.
Huang J, Glauber M, Qiu Z, Gazit V, Dietzen DJ, Rudnick DA
Am J Pathol. 2012 Feb; 180(2)575-82. doi: 10.1016/j.ajpath.2011.10.032.

PMID:
    22155110
    [PubMed - indexed for MEDLINE]
Related citations


Cystic fibrosis-associated liver disease: when will the future be now?
Rudnick DA
J Pediatr Gastroenterol Nutr. 2012 Mar; 54(3)312. doi: 10.1097/MPG.0b013e3182309fd0.

PMID:
    21832947
    [PubMed - indexed for MEDLINE]
Related citations


Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.
Mattie FJ, Stackpole MM, Stone MC, Clippard JR, Rudnick DA, Qiu Y, Tao J, Allender DL, Parmar M, Rolls MM
Curr Biol. 2010 Dec 21; 20(24)2169-77. doi: 10.1016/j.cub.2010.11.050.

PMID:
    21145742
    [PubMed - indexed for MEDLINE]
Related citations


Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.
Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA
Hepatology. 2010 Dec; 52(6)2109-17. doi: 10.1002/hep.23920.

PMID:
    20967828
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Special interest in the mechanisms that regulate liver regeneration