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Daniel J. Lenihan, MD

Professor, Medicine
Division of Cardiovascular Diseases

Specialty Areas

Cardiology
Heart Disease
Heart Failure / Transplant
Cardio-oncology

Board Certifications

Internal Medicine
Cardiology
Advanced Heart Failure

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Cardiotoxicity of cancer therapy, early phase clinical trials, amyloidosis,  cardiomyopathy and cancer survivorship.

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: 314-362-1291
Fax: 314-747-1417

Education

Education

Fellowship, Cardiology: University of Cincinnati, Cincinnati, OH 1995
Residency, Internal Medicine: Wright-Patterson Air Force Base, Dayton, OH 1991
Medical Degree: University of Tennessee Health Science Center, Memphis, TN 1988
BA, Chemistry & Zoology: University of Tennessee, Knoxville, TN 1984

Publication & Research

Publication & Research

Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma.
Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J
Br J Haematol. 2018 Jan; 180(2)271-275. doi: 10.1111/bjh.14970.

PMID:
    29048105
    [PubMed - in process]
Related citations


What's Next for Acute Heart Failure Research?
Collins SP, Levy PD, Fermann GJ, Givertz MM, Martindale JM, Pang PS, Storrow AB, Diercks DD, Michael Felker G, Fonarow GC, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Frank Peacock W, Sawyer DM, Teerlink JR, Butler J
Acad Emerg Med. 2018 Jan; 25(1)85-93. doi: 10.1111/acem.13331.

PMID:
    28990334
    [PubMed - in process]
Related citations


The Horizon in Cardio-Oncology: "You Are Only as Good as Your Endothelium".
Lenihan DJ
J Am Coll Cardiol. 2017 Jul 11; 70(2)163-164. doi: 10.1016/j.jacc.2017.05.048.

PMID:
    28683963
    [PubMed - in process]
Related citations


Clinical utility of single molecule counting technology for quantification of KIM-1 in patients with heart failure and chronic kidney disease.
Miao J, Friedman E, Wu AHB, Todd JA, Estis J, Xu X, Nolan N, Bishop JJ, Lenihan DJ
Clin Biochem. 2017 Nov; 50(16-17)889-895. doi: 10.1016/j.clinbiochem.2017.06.002.

PMID:
    28614696
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.
Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM
Pharmacogenet Genomics. 2017 Jul; 27(7)247-254. doi: 10.1097/FPC.0000000000000284.

PMID:
    28542097
    [PubMed - indexed for MEDLINE]
Related citations


Centers for Medicare and Medicaid Services' readmission reports inaccurately describe an institution's decompensated heart failure admissions.
Cox ZL, Lai P, Lewis CM, Lenihan DJ
Clin Cardiol. 2017 Sep; 40(9)620-625. doi: 10.1002/clc.22711.

PMID:
    28471510
    [PubMed - in process]
Related citations


Cardiomyopathic Toxicity From Chemotherapy: Is There an Opportunity for Preemptive Intervention?
Swiger KJ, Singh J, Lenihan DJ
Curr Treat Options Cardiovasc Med. 2017 Mar; 19(3)20. doi: 10.1007/s11936-017-0517-7.

PMID:
    28299613
    [PubMed]
Related citations


The six-minute walk test is a valuable measure of functional change following chemotherapy for AL (light-chain) cardiac amyloidosis.
Decker I, Goodman SA, Phillips SE, Lenihan DJ, Cornell RF
Br J Haematol. 2017 May; 177(3)481-483. doi: 10.1111/bjh.14585.

PMID:
    28295184
    [PubMed - in process]
Related citations


Cardio-Oncology-A Rapidly Evolving and Expanding Field of Medicine.
Lenihan DJ, Sawyer DB
Heart Fail Clin. 2017 Apr; 13(2)xiii. doi: 10.1016/j.hfc.2017.01.001.

PMID:
    28279426
    [PubMed - in process]
Related citations


Current Concepts of Cardiac Amyloidosis: Diagnosis, Clinical Management, and the Need for Collaboration.
Ritts AJ, Cornell RF, Swiger K, Singh J, Goodman S, Lenihan DJ
Heart Fail Clin. 2017 Apr; 13(2)409-416. doi: 10.1016/j.hfc.2016.12.003.

PMID:
    28279425
    [PubMed - indexed for MEDLINE]
Related citations


ERBB signaling attenuates proinflammatory activation of nonclassical monocytes.
Ryzhov S, Matafonov A, Galindo CL, Zhang Q, Tran TL, Lenihan DJ, Lenneman CG, Feoktistov I, Sawyer DB
Am J Physiol Heart Circ Physiol. 2017 May 1; 312(5)H907-H918. doi: 10.1152/ajpheart.00486.2016.

PMID:
    28235789
    [PubMed - indexed for MEDLINE]
Related citations


Validation of an automated electronic algorithm and "dashboard" to identify and characterize decompensated heart failure admissions across a medical center.
Cox ZL, Lewis CM, Lai P, Lenihan DJ
Am Heart J. 2017 Jan; 18340-48. doi: 10.1016/j.ahj.2016.10.001.

PMID:
    27979040
    [PubMed - indexed for MEDLINE]
Related citations


[2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines].
Zamorano JL, Lancellotti P, Muñoz DR, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GY, Lyon AR, Fernandez TL, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM
Kardiol Pol. 2016; 74(11)1193-1233. doi: 10.5603/KP.2016.0156.

PMID:
    27910076
    [PubMed - indexed for MEDLINE]
Related citations


Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis.
Swiger KJ, Friedman EA, Brittain EL, Tomasek KA, Huang S, Su YR, Sawyer DB, Lenihan DJ
Amyloid. 2016 Dec; 23(4)242-248.

PMID:
    27809600
    [PubMed - indexed for MEDLINE]
Related citations


Response: Proposing and Meeting the Need for Interdisciplinary Cardio-Oncology Subspecialty Training by Sherry-Ann Brown, MD, PhD and Nicole Sandhu, MD, PhD.
Lenihan DJ, Dent S, Carver J
J Card Fail. 2016 Nov; 22(11)936. doi: 10.1016/j.cardfail.2016.09.018.

PMID:
    27663099
    [PubMed - indexed for MEDLINE]
Related citations


2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines:  The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GY, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM, Authors/Task Force Members., ESC Committee for Practice Guidelines (CPG):.
Eur Heart J. 2016 Sep 21; 37(36)2768-2801.

PMID:
    27567406
    [PubMed - in process]
Related citations


2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GY, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol Ç, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GY, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Authors/Task Force Members., ESC Committee for Practice Guidelines (CPG)., Document Reviewers.
Eur J Heart Fail. 2017 Jan; 19(1)9-42. doi: 10.1002/ejhf.654.

PMID:
    27565769
    [PubMed - in process]
Related citations


Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey).
Maurer MS, Hanna M, Grogan M, Dispenzieri A, Witteles R, Drachman B, Judge DP, Lenihan DJ, Gottlieb SS, Shah SJ, Steidley DE, Ventura H, Murali S, Silver MA, Jacoby D, Fedson S, Hummel SL, Kristen AV, Damy T, Planté-Bordeneuve V, Coelho T, Mundayat R, Suhr OB, Waddington Cruz M, Rapezzi C, THAOS Investigators.
J Am Coll Cardiol. 2016 Jul 12; 68(2)161-72. doi: 10.1016/j.jacc.2016.03.596.

PMID:
    27386769
    [PubMed - indexed for MEDLINE]
Related citations


Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group.
Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DE, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink JR, Butler J
Acad Emerg Med. 2016 Aug; 23(8)922-31. doi: 10.1111/acem.13025.

PMID:
    27286136
    [PubMed - indexed for MEDLINE]
Related citations


Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society of Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group.
Collins SP, Levy PD, Martindale JL, Dunlap ME, Storrow AB, Pang PS, Albert NM, Felker GM, Fermann GJ, Fonarow GC, Givertz MM, Hollander JE, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Peacock WF, Sawyer DB, Teerlink JR, Butler J
J Card Fail. 2016 Aug; 22(8)618-27. doi: 10.1016/j.cardfail.2016.04.015.

PMID:
    27262665
    [PubMed - indexed for MEDLINE]
Related citations

Videos

Videos

Areas of Research Interest

Biomarkers, hemodynamic assessments, development of educational tools/curriculae.