Patient Portal

Daniel J. Lenihan, MD

Professor, Medicine
Division of Cardiovascular Diseases

Specialty Areas

Cardiology
Heart Disease
Heart Failure / Transplant
Cardio-oncology

Board Certifications

Internal Medicine
Cardiology
Advanced Heart Failure

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Cardiotoxicity of cancer therapy, early phase clinical trials, amyloidosis,  cardiomyopathy and cancer survivorship.

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: 314-362-1291
Fax: 314-747-1417

Education

Education

Fellowship, Cardiology: University of Cincinnati, Cincinnati, OH 1995
Residency, Internal Medicine: Wright-Patterson Air Force Base, Dayton, OH 1991
Medical Degree: University of Tennessee Health Science Center, Memphis, TN 1988
BA, Chemistry & Zoology: University of Tennessee, Knoxville, TN 1984

Publication & Research

Publication & Research

Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction.
Miao J, Huang S, Su YR, Lenneman CA, Wright M, Harrell FE, Sawyer DB, Lenihan DJ
Biomarkers. 2018 Aug 17; 1-5. doi: 10.1080/1354750X.2018.1485054.

PMID:
    29871526
    [PubMed - as supplied by publisher]
Related citations


Customizing national models for a medical center's population to rapidly identify patients at high risk of 30-day all-cause hospital readmission following a heart failure hospitalization.
Cox ZL, Lai P, Lewis CM, Lindenfeld J, Collins SP, Lenihan DJ
Heart Lung. 2018 Jul - Aug; 47(4)290-296. doi: 10.1016/j.hrtlng.2018.05.012.

PMID:
    29853327
    [PubMed - in process]
Related citations


That an Ounce of Prevention Is Worth a Pound of Cure Is Certainly True for Patients With Breast Cancer.
Lenihan DJ
J Oncol Pract. 2018 Apr; 14(4)216. doi: 10.1200/JOP.18.00155.

PMID:
    29641948
    [PubMed - in process]
Related citations


Advances in Treatment of Cardiac Amyloid.
Dahm CN, Cornell RF, Lenihan DJ
Curr Treat Options Cardiovasc Med. 2018 Apr 7; 20(5)37. doi: 10.1007/s11936-018-0631-1.

PMID:
    29627865
    [PubMed]
Related citations


Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma.
Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J
Br J Haematol. 2018 Jan; 180(2)271-275. doi: 10.1111/bjh.14970.

PMID:
    29048105
    [PubMed - indexed for MEDLINE]
Related citations


What's Next for Acute Heart Failure Research?
Collins SP, Levy PD, Fermann GJ, Givertz MM, Martindale JM, Pang PS, Storrow AB, Diercks DD, Michael Felker G, Fonarow GC, Lanfear DJ, Lenihan DJ, Lindenfeld JM, Frank Peacock W, Sawyer DM, Teerlink JR, Butler J
Acad Emerg Med. 2018 Jan; 25(1)85-93. doi: 10.1111/acem.13331.

PMID:
    28990334
    [PubMed - in process]
Related citations


The Horizon in Cardio-Oncology: "You Are Only as Good as Your Endothelium".
Lenihan DJ
J Am Coll Cardiol. 2017 Jul 11; 70(2)163-164. doi: 10.1016/j.jacc.2017.05.048.

PMID:
    28683963
    [PubMed - in process]
Related citations


Clinical utility of single molecule counting technology for quantification of KIM-1 in patients with heart failure and chronic kidney disease.
Miao J, Friedman E, Wu AHB, Todd JA, Estis J, Xu X, Nolan N, Bishop JJ, Lenihan DJ
Clin Biochem. 2017 Nov; 50(16-17)889-895. doi: 10.1016/j.clinbiochem.2017.06.002.

PMID:
    28614696
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.
Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM
Pharmacogenet Genomics. 2017 Jul; 27(7)247-254. doi: 10.1097/FPC.0000000000000284.

PMID:
    28542097
    [PubMed - indexed for MEDLINE]
Related citations


Centers for Medicare and Medicaid Services' readmission reports inaccurately describe an institution's decompensated heart failure admissions.
Cox ZL, Lai P, Lewis CM, Lenihan DJ
Clin Cardiol. 2017 Sep; 40(9)620-625. doi: 10.1002/clc.22711.

PMID:
    28471510
    [PubMed - indexed for MEDLINE]
Related citations


Cardiomyopathic Toxicity From Chemotherapy: Is There an Opportunity for Preemptive Intervention?
Swiger KJ, Singh J, Lenihan DJ
Curr Treat Options Cardiovasc Med. 2017 Mar; 19(3)20. doi: 10.1007/s11936-017-0517-7.

PMID:
    28299613
    [PubMed]
Related citations


The six-minute walk test is a valuable measure of functional change following chemotherapy for AL (light-chain) cardiac amyloidosis.
Decker I, Goodman SA, Phillips SE, Lenihan DJ, Cornell RF
Br J Haematol. 2017 May; 177(3)481-483. doi: 10.1111/bjh.14585.

PMID:
    28295184
    [PubMed - indexed for MEDLINE]
Related citations


Cardio-Oncology-A Rapidly Evolving and Expanding Field of Medicine.
Lenihan DJ, Sawyer DB
Heart Fail Clin. 2017 Apr; 13(2)xiii. doi: 10.1016/j.hfc.2017.01.001.

PMID:
    28279426
    [PubMed - in process]
Related citations


Current Concepts of Cardiac Amyloidosis: Diagnosis, Clinical Management, and the Need for Collaboration.
Ritts AJ, Cornell RF, Swiger K, Singh J, Goodman S, Lenihan DJ
Heart Fail Clin. 2017 Apr; 13(2)409-416. doi: 10.1016/j.hfc.2016.12.003.

PMID:
    28279425
    [PubMed - indexed for MEDLINE]
Related citations


ERBB signaling attenuates proinflammatory activation of nonclassical monocytes.
Ryzhov S, Matafonov A, Galindo CL, Zhang Q, Tran TL, Lenihan DJ, Lenneman CG, Feoktistov I, Sawyer DB
Am J Physiol Heart Circ Physiol. 2017 May 1; 312(5)H907-H918. doi: 10.1152/ajpheart.00486.2016.

PMID:
    28235789
    [PubMed - indexed for MEDLINE]
Related citations


Cardio-Oncology: Time to Get More Mechanistic.
Moslehi J, Lenihan DJ
JACC Basic Transl Sci. 2017 Feb; 2(1)54-55. doi: 10.1016/j.jacbts.2017.01.002.

PMID:
    30167554
    [PubMed]
Related citations


A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure.
Lenihan DJ, Anderson SA, Lenneman CG, Brittain E, Muldowney JAS 3rd, Mendes L, Zhao PZ, Iaci J, Frohwein S, Zolty R, Eisen A, Sawyer DB, Caggiano AO
JACC Basic Transl Sci. 2016 Dec; 1(7)576-586. doi: 10.1016/j.jacbts.2016.09.005.

PMID:
    30167542
    [PubMed]
Related citations


Validation of an automated electronic algorithm and "dashboard" to identify and characterize decompensated heart failure admissions across a medical center.
Cox ZL, Lewis CM, Lai P, Lenihan DJ
Am Heart J. 2017 Jan; 18340-48. doi: 10.1016/j.ahj.2016.10.001.

PMID:
    27979040
    [PubMed - indexed for MEDLINE]
Related citations


[2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines].
Zamorano JL, Lancellotti P, Muñoz DR, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip GY, Lyon AR, Fernandez TL, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM
Kardiol Pol. 2016; 74(11)1193-1233. doi: 10.5603/KP.2016.0156.

PMID:
    27910076
    [PubMed - indexed for MEDLINE]
Related citations


Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis.
Swiger KJ, Friedman EA, Brittain EL, Tomasek KA, Huang S, Su YR, Sawyer DB, Lenihan DJ
Amyloid. 2016 Dec; 23(4)242-248.

PMID:
    27809600
    [PubMed - indexed for MEDLINE]
Related citations

Videos

Videos

Areas of Research Interest

Biomarkers, hemodynamic assessments, development of educational tools/curriculae.