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Daniel E. Goldberg, MD, PhD

Professor, Medicine
Division of Infectious Diseases
Professor, Molecular Microbiology
Co-Director, Division of Infectious Diseases

Specialty Areas

Infectious Diseases

Board Certifications

Infectous Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Infectious diseases, malaria, parasitic diseases, biomedicine, biotechnology

  • Education
  • Publication & Research

Education

Education

Fellowship: Infectious Diseases, Washington University, St. Louis, Missouri 1988
Residency: Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts 1987
Medical Degree & PhD: Molecular Biology, Washington University, St. Louis,Missouri 1985
B.A.: Harvard College, Cambridge, Massachusetts 1978

Publication & Research

Publication & Research

<i>Plasmodium</i> Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.
Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE
Elife. 2019 Mar 19; 8pii: e40529. doi: 10.7554/eLife.40529.

PMID:
    30888318
    [PubMed - in process]
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In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II.
Poti KE, Balaban AE, Pal P, Kobayashi T, Goldberg DE, Sinnis P, Sullivan DJ
Malar J. 2019 Mar 13; 18(1)78. doi: 10.1186/s12936-019-2712-3.

PMID:
    30866956
    [PubMed - indexed for MEDLINE]
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4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
Meyers MJ, Liu J, Xu J, Leng F, Guan J, Liu Z, McNitt SA, Qin L, Dai L, Ma H, Adah D, Zhao S, Li X, Polino AJ, Nasamu AS, Goldberg DE, Liu X, Lu Y, Tu Z, Chen X, Tortorella MD
J Med Chem. 2019 Apr 11; 62(7)3503-3512. doi: 10.1021/acs.jmedchem.8b01972.

PMID:
    30856324
    [PubMed - in process]
Related citations


Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes.
Goldberg DE, Melgar D, Bock Y, Allen RM
J Geophys Res Solid Earth. 2018 Nov; 123(11)9950-9962. doi: 10.1029/2018JB015962.

PMID:
    30775194
    [PubMed]
Related citations


Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.
Bhatnagar S, Nicklas S, Morrisey JM, Goldberg DE, Vaidya AB
ACS Infect Dis. 2019 Apr 12; 5(4)550-558. doi: 10.1021/acsinfecdis.8b00277.

PMID:
    30638365
    [PubMed - in process]
Related citations


Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion.
Paing MM, Salinas ND, Adams Y, Oksman A, Jensen AT, Goldberg DE, Tolia NH
Elife. 2018 Dec 17; 7pii: e43224. doi: 10.7554/eLife.43224.

PMID:
    30556808
    [PubMed - indexed for MEDLINE]
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Fast-Acting Small Molecules Targeting Malarial Aspartyl Proteases, Plasmepsins, Inhibit Malaria Infection at Multiple Life Stages.
Singh S, Rajendran V, He J, Singh AK, Achieng AO, Vandana, Pant A, Nasamu AS, Pandit M, Singh J, Quadiri A, Gupta N, Poonam, Ghosh PC, Singh BK, Narayanan L, Kempaiah P, Chandra R, Dunn BM, Pandey KC, Goldberg DE, Singh AP, Rathi B
ACS Infect Dis. 2019 Feb 8; 5(2)184-198. doi: 10.1021/acsinfecdis.8b00197.

PMID:
    30554511
    [PubMed - in process]
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Toward a chemical vaccine for malaria.
Phillips MA, Goldberg DE
Science. 2018 Dec 7; 362(6419)1112-1113. doi: 10.1126/science.aav7479.

PMID:
    30523095
    [PubMed - indexed for MEDLINE]
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Malaria parasite translocon structure and mechanism of effector export.
Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH
Nature. 2018 Sep; 561(7721)70-75. doi: 10.1038/s41586-018-0469-4.

PMID:
    30150771
    [PubMed - indexed for MEDLINE]
Related citations


EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX.
Garten M, Nasamu AS, Niles JC, Zimmerberg J, Goldberg DE, Beck JR
Nat Microbiol. 2018 Oct; 3(10)1090-1098. doi: 10.1038/s41564-018-0222-7.

PMID:
    30150733
    [PubMed - in process]
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Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro.
Radke JB, Burrows JN, Goldberg DE, Sibley LD
ACS Infect Dis. 2018 Aug 10; 4(8)1264-1274. doi: 10.1021/acsinfecdis.8b00113.

PMID:
    29998728
    [PubMed - in process]
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Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.
Glushakova S, Beck JR, Garten M, Busse BL, Nasamu AS, Tenkova-Heuser T, Heuser J, Goldberg DE, Zimmerberg J
Cell Microbiol. 2018 Oct; 20(10)e12868. doi: 10.1111/cmi.12868.

PMID:
    29900649
    [PubMed - in process]
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Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.
Lehmann C, Tan MSY, de Vries LE, Russo I, Sanchez MI, Goldberg DE, Deu E
PLoS Pathog. 2018 May; 14(5)e1007031. doi: 10.1371/journal.ppat.1007031.

PMID:
    29768491
    [PubMed - indexed for MEDLINE]
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Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.
Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP
Bioorg Med Chem Lett. 2018 Jun 1; 28(10)1846-1848. doi: 10.1016/j.bmcl.2018.04.010.

PMID:
    29691139
    [PubMed - indexed for MEDLINE]
Related citations


Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA
Science. 2018 Jan 12; 359(6372)191-199. doi: 10.1126/science.aan4472.

PMID:
    29326268
    [PubMed - indexed for MEDLINE]
Related citations


Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.
Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE
Science. 2017 Oct 27; 358(6362)518-522. doi: 10.1126/science.aan1478.

PMID:
    29074774
    [PubMed - indexed for MEDLINE]
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Plasmodium heme biosynthesis: To be or not to be essential?
Goldberg DE, Sigala PA
PLoS Pathog. 2017 Sep; 13(9)e1006511. doi: 10.1371/journal.ppat.1006511.

PMID:
    28957449
    [PubMed - indexed for MEDLINE]
Related citations


Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress.
Glushakova S, Busse BL, Garten M, Beck JR, Fairhurst RM, Goldberg DE, Zimmerberg J
Sci Rep. 2017 Sep 25; 7(1)12250. doi: 10.1038/s41598-017-12258-x.

PMID:
    28947749
    [PubMed - in process]
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Plant Size and Competitive Dynamics along Nutrient Gradients.
Goldberg DE, Martina JP, Elgersma KJ, Currie WS
Am Nat. 2017 Aug; 190(2)229-243. doi: 10.1086/692438.

PMID:
    28731795
    [PubMed - indexed for MEDLINE]
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Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.
Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE
PLoS One. 2017; 12(5)e0177142. doi: 10.1371/journal.pone.0177142.

PMID:
    28475625
    [PubMed - indexed for MEDLINE]
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Areas of Research Interest

Intraerythrocytic malaria parasites