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Daniel E. Goldberg, MD, PhD

Professor, Medicine
Division of Infectious Diseases
Professor, Molecular Microbiology
Co-Director, Division of Infectious Diseases

Specialty Areas

Infectious Diseases

Board Certifications

Infectous Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Infectious diseases, malaria, parasitic diseases, biomedicine, biotechnology

  • Education
  • Publication & Research

Education

Education

Fellowship: Infectious Diseases, Washington University, St. Louis, Missouri 1988
Residency: Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts 1987
Medical Degree & PhD: Molecular Biology, Washington University, St. Louis,Missouri 1985
B.A.: Harvard College, Cambridge, Massachusetts 1978

Publication & Research

Publication & Research

Evaluation of current and emerging anti-malarial medicines for inhibition of Toxoplasma gondii growth in vitro.
Radke J, Burrows JN, Goldberg DE, Sibley LD
ACS Infect Dis. 2018 Jul 12; doi: 10.1021/acsinfecdis.8b00113.

PMID:
    29998728
    [PubMed - as supplied by publisher]
Related citations


Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.
Glushakova S, Beck JR, Garten M, Busse BL, Nasamu AS, Tenkova-Heuser T, Heuser J, Goldberg DE, Zimmerberg J
Cell Microbiol. 2018 Jun 13; e12868. doi: 10.1111/cmi.12868.

PMID:
    29900649
    [PubMed - as supplied by publisher]
Related citations


Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.
Lehmann C, Tan MSY, de Vries LE, Russo I, Sanchez MI, Goldberg DE, Deu E
PLoS Pathog. 2018 May; 14(5)e1007031. doi: 10.1371/journal.ppat.1007031.

PMID:
    29768491
    [PubMed - indexed for MEDLINE]
Related citations


Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.
Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP
Bioorg Med Chem Lett. 2018 Jun 1; 28(10)1846-1848. doi: 10.1016/j.bmcl.2018.04.010.

PMID:
    29691139
    [PubMed - in process]
Related citations


Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA
Science. 2018 Jan 12; 359(6372)191-199. doi: 10.1126/science.aan4472.

PMID:
    29326268
    [PubMed - indexed for MEDLINE]
Related citations


Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.
Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE
Science. 2017 Oct 27; 358(6362)518-522. doi: 10.1126/science.aan1478.

PMID:
    29074774
    [PubMed - indexed for MEDLINE]
Related citations


Plasmodium heme biosynthesis: To be or not to be essential?
Goldberg DE, Sigala PA
PLoS Pathog. 2017 Sep; 13(9)e1006511. doi: 10.1371/journal.ppat.1006511.

PMID:
    28957449
    [PubMed - indexed for MEDLINE]
Related citations


Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress.
Glushakova S, Busse BL, Garten M, Beck JR, Fairhurst RM, Goldberg DE, Zimmerberg J
Sci Rep. 2017 Sep 25; 7(1)12250. doi: 10.1038/s41598-017-12258-x.

PMID:
    28947749
    [PubMed - in process]
Related citations


Plant Size and Competitive Dynamics along Nutrient Gradients.
Goldberg DE, Martina JP, Elgersma KJ, Currie WS
Am Nat. 2017 Aug; 190(2)229-243. doi: 10.1086/692438.

PMID:
    28731795
    [PubMed - indexed for MEDLINE]
Related citations


Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.
Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE
PLoS One. 2017; 12(5)e0177142. doi: 10.1371/journal.pone.0177142.

PMID:
    28475625
    [PubMed - indexed for MEDLINE]
Related citations


Reply to "Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases".
Goldberg DE, Spillman NJ
MBio. 2017 Mar 7; 8(2)pii: e00235-17. doi: 10.1128/mBio.00235-17.

PMID:
    28270581
    [PubMed - indexed for MEDLINE]
Related citations


Esterase mutation is a mechanism of resistance to antimalarial compounds.
Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE
Nat Commun. 2017 Jan 20; 814240. doi: 10.1038/ncomms14240.

PMID:
    28106035
    [PubMed - in process]
Related citations


The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol.
Spillman NJ, Beck JR, Ganesan SM, Niles JC, Goldberg DE
Cell Microbiol. 2017 Jun; 19(6)doi: 10.1111/cmi.12719.

PMID:
    28067475
    [PubMed - indexed for MEDLINE]
Related citations


Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection.
Spillman NJ, Dalmia VK, Goldberg DE
MBio. 2016 Oct 18; 7(5)pii: e01538-16. doi: 10.1128/mBio.01538-16.

PMID:
    27795395
    [PubMed - indexed for MEDLINE]
Related citations


In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis.
Sigala PA, Morante K, Tsumoto K, Caaveiro JM, Goldberg DE
Biochemistry. 2016 Aug 30; 55(34)4836-49. doi: 10.1021/acs.biochem.6b00562.

PMID:
    27490825
    [PubMed - indexed for MEDLINE]
Related citations


A broad analysis of resistance development in the malaria parasite.
Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, Prats S, Meister S, Tanaseichuk O, Wree M, Zhou Y, Willis PA, Gamo FJ, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA
Nat Commun. 2016 Jun 15; 711901. doi: 10.1038/ncomms11901.

PMID:
    27301419
    [PubMed - in process]
Related citations


Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.
Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE
MBio. 2016 Jun 7; 7(3)pii: e00617-16. doi: 10.1128/mBio.00617-16.

PMID:
    27273825
    [PubMed - indexed for MEDLINE]
Related citations


Erratum: Plasmepsin V shows its carnivorous side.
Goldberg DE
Nat Struct Mol Biol. 2015 Nov; 22(11)939. doi: 10.1038/nsmb1115-939a.

PMID:
    26581524
    [PubMed]
Related citations


Plasmepsin V shows its carnivorous side.
Goldberg DE
Nat Struct Mol Biol. 2015 Sep; 22(9)647-8. doi: 10.1038/nsmb.3077.

PMID:
    26333709
    [PubMed - indexed for MEDLINE]
Related citations


Deconvoluting heme biosynthesis to target blood-stage malaria parasites.
Sigala PA, Crowley JR, Henderson JP, Goldberg DE
Elife. 2015 Jul 14; 4doi: 10.7554/eLife.09143.

PMID:
    26173178
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Intraerythrocytic malaria parasites