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Daniel C. Link, MD

Professor, Medicine
Division of Oncology
Section, Bone Marrow Transplant
Assistant Professor, Pathology

Specialty Areas

Bone Marrow Transplant
Oncology
Hematologic Malignancies

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Barnard Cancer Center

4960 Children's Place
St. Louis, MO 63110

Suite: Wohl Hospital, 4th Floor
Office Phone: 314-362-7578
Fax: 314-362-9333

Education

Education

Fellowship: Hematology-Oncology, Washington University Medical Center, St. Louis, Missouri 1992
Residency : Medicine, Barnes Hospital, St. Louis, Missouri 1988
Medical Degree: University of Wisconsin-Madison, Madison, Wisconsin 1985
B.S.: University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 1981

Publication & Research

Publication & Research

Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.
Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS
Front Endocrinol (Lausanne). 2016; 787. doi: 10.3389/fendo.2016.00087.

PMID:
    27445989
    [PubMed]
Related citations


'CHIP'ping away at clonal hematopoiesis.
Link DC, Walter MJ
Leukemia. 2016 Jun 17; doi: 10.1038/leu.2016.130.

PMID:
    27311932
    [PubMed - as supplied by publisher]
Related citations


Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells.
Zhang J, Link DC
J Bone Miner Res. 2016 May 30; doi: 10.1002/jbmr.2877.

PMID:
    27237054
    [PubMed - as supplied by publisher]
Related citations


Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 Jul; 44(7)603-13. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - in process]
Related citations


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood. 2016 Feb 18; 127(7)893-7. doi: 10.1182/blood-2015-10-677021.

PMID:
    26631115
    [PubMed - indexed for MEDLINE]
Related citations


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
Related citations


The hematopoietic stem cell niche in homeostasis and disease.
Calvi LM, Link DC
Blood. 2015 Nov 26; 126(22)2443-51. doi: 10.1182/blood-2015-07-533588.

PMID:
    26468230
    [PubMed - indexed for MEDLINE]
Related citations


Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia.
Uy GL, Hsu YM, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC
Leuk Res. 2015 Dec; 39(12)1437-42. doi: 10.1016/j.leukres.2015.09.020.

PMID:
    26467815
    [PubMed - indexed for MEDLINE]
Related citations


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
Related citations


Acute ether lipid deficiency affects neutrophil biology in mice.
Lodhi IJ, Link DC, Semenkovich CF
Cell Metab. 2015 May 5; 21(5)652-3. doi: 10.1016/j.cmet.2015.04.018.

PMID:
    25955199
    [PubMed - indexed for MEDLINE]
Related citations


Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.
Day RB, Bhattacharya D, Nagasawa T, Link DC
Blood. 2015 May 14; 125(20)3114-7. doi: 10.1182/blood-2015-02-629444.

PMID:
    25814527
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.
Trissal MC, DeMoya RA, Schmidt AP, Link DC
PLoS One. 2015; 10(3)e0119304. doi: 10.1371/journal.pone.0119304.

PMID:
    25793640
    [PubMed - indexed for MEDLINE]
Related citations


PTEN regulates natural killer cell trafficking in vivo.
Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA
Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7)E700-9. doi: 10.1073/pnas.1413886112.

PMID:
    25646418
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
Leukemia. 2015 Jul; 29(7)1608-11. doi: 10.1038/leu.2015.17.

PMID:
    25644247
    [PubMed - indexed for MEDLINE]
Related citations


Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF
Cell Metab. 2015 Jan 6; 21(1)51-64. doi: 10.1016/j.cmet.2014.12.002.

PMID:
    25565205
    [PubMed - indexed for MEDLINE]
Related citations


Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature. 2015 Feb 26; 518(7540)552-5. doi: 10.1038/nature13968.

PMID:
    25487151
    [PubMed - indexed for MEDLINE]
Related citations


Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice.
Rao M, Supakorndej T, Schmidt AP, Link DC
Exp Hematol. 2015 Feb; 43(2)110-4.e1-2. doi: 10.1016/j.exphem.2014.10.012.

PMID:
    25461255
    [PubMed - indexed for MEDLINE]
Related citations


The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.
Makaryan V, Zeidler C, Bolyard AA, Skokowa J, Rodger E, Kelley ML, Boxer LA, Bonilla MA, Newburger PE, Shimamura A, Zhu B, Rosenberg PS, Link DC, Welte K, Dale DC
Curr Opin Hematol. 2015 Jan; 22(1)3-11. doi: 10.1097/MOH.0000000000000105.

PMID:
    25427142
    [PubMed - indexed for MEDLINE]
Related citations


Megakaryocytes in the hematopoietic stem cell niche.
Day RB, Link DC
Nat Med. 2014 Nov; 20(11)1233-4. doi: 10.1038/nm.3745.

PMID:
    25375920
    [PubMed]
Related citations


Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
Blood. 2014 Dec 18; 124(26)3887-95. doi: 10.1182/blood-2014-06-582551.

PMID:
    25349173
    [PubMed - indexed for MEDLINE]
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