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Daniel C. Link, MD

Professor, Medicine
Division of Oncology
Section, Bone Marrow Transplant
Assistant Professor, Pathology

Specialty Areas

Bone Marrow Transplant
Oncology
Hematologic Malignancies

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Bone marrow transplant, G-CSF receptor, congenital neutropenia, molecular mechanisms controlling hematopoietic cell proliferation; differentiation; and migration, granulocyte colony stimulating factor receptor signal transduction and biological activities, hematology, oncology, leukemia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Barnard Cancer Center

4960 Children's Place
St. Louis, MO 63110

Suite: Wohl Hospital, 4th Floor
Office Phone: 314-362-7578
Fax: 314-362-9333

Education

Education

Fellowship: Hematology-Oncology, Washington University Medical Center, St. Louis, Missouri 1992
Residency : Medicine, Barnes Hospital, St. Louis, Missouri 1988
Medical Degree: University of Wisconsin-Madison, Madison, Wisconsin 1985
B.S.: University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 1981

Publication & Research

Publication & Research

<i>miR-125b</i> promotes leukemogenesis via <i>VEGFA</i>.
Wong TN, Link DC
Blood. 2017 Mar 16; 129(11)1409-1410. doi: 10.1182/blood-2017-01-761544.

PMID:
    28302689
    [PubMed - in process]
Related citations


N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.
Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R
J Bone Miner Res. 2017 Feb 27; doi: 10.1002/jbmr.3112.

PMID:
    28240364
    [PubMed - as supplied by publisher]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - in process]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - in process]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - in process]
Related citations


Concise Review: The Malignant Hematopoietic Stem Cell Niche.
Yao JC, Link DC
Stem Cells. 2017 Jan; 35(1)3-8. doi: 10.1002/stem.2487.

PMID:
    27647718
    [PubMed - in process]
Related citations


Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.
Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS
Front Endocrinol (Lausanne). 2016; 787. doi: 10.3389/fendo.2016.00087.

PMID:
    27445989
    [PubMed]
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'CHIP'ping away at clonal hematopoiesis.
Link DC, Walter MJ
Leukemia. 2016 Aug; 30(8)1633-5. doi: 10.1038/leu.2016.130.

PMID:
    27311932
    [PubMed - in process]
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Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells.
Zhang J, Link DC
J Bone Miner Res. 2016 Nov; 31(11)2001-2007. doi: 10.1002/jbmr.2877.

PMID:
    27237054
    [PubMed - in process]
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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 Jul; 44(7)603-13. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - in process]
Related citations


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood. 2016 Feb 18; 127(7)893-7. doi: 10.1182/blood-2015-10-677021.

PMID:
    26631115
    [PubMed - indexed for MEDLINE]
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Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
Related citations


The hematopoietic stem cell niche in homeostasis and disease.
Calvi LM, Link DC
Blood. 2015 Nov 26; 126(22)2443-51. doi: 10.1182/blood-2015-07-533588.

PMID:
    26468230
    [PubMed - indexed for MEDLINE]
Related citations


Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia.
Uy GL, Hsu YM, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC
Leuk Res. 2015 Dec; 39(12)1437-42. doi: 10.1016/j.leukres.2015.09.020.

PMID:
    26467815
    [PubMed - indexed for MEDLINE]
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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
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Acute ether lipid deficiency affects neutrophil biology in mice.
Lodhi IJ, Link DC, Semenkovich CF
Cell Metab. 2015 May 5; 21(5)652-3. doi: 10.1016/j.cmet.2015.04.018.

PMID:
    25955199
    [PubMed - indexed for MEDLINE]
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Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.
Day RB, Bhattacharya D, Nagasawa T, Link DC
Blood. 2015 May 14; 125(20)3114-7. doi: 10.1182/blood-2015-02-629444.

PMID:
    25814527
    [PubMed - indexed for MEDLINE]
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MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice.
Trissal MC, DeMoya RA, Schmidt AP, Link DC
PLoS One. 2015; 10(3)e0119304. doi: 10.1371/journal.pone.0119304.

PMID:
    25793640
    [PubMed - indexed for MEDLINE]
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PTEN regulates natural killer cell trafficking in vivo.
Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA
Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7)E700-9. doi: 10.1073/pnas.1413886112.

PMID:
    25646418
    [PubMed - indexed for MEDLINE]
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