Patient Portal

Conrad C. Weihl, MD, PhD

Professor, Neurology
Division of Adult Neurology

Specialty Areas

Neurology - Adult
Muscle Disorders
ALS - Lou Gehrig's Disease
Neuromuscular Disease
Muscular Dystrophy

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Mechanisms of weakness and atrophy related to neuromuscular disorders including muscular dystrophy, inflammatory myopathy (including inclusion body myositis), myopathy, motor neuron disease, ALS - Lou Gehrig's disease, statin induced myopathy, and elevated CPK.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-747-3752

Education

Education

Residency: Neurology, Barnes-Jewish Hospital at Washington University School of Medicine 2005
Medical Degree: University of Chicago Pritzker School of Medicine, Chicago, Illinois 2001
Ph.D.: University of Chicago Biological Sciences Division, University of Chicago, Chicago, Illinois 1999
B.S.: Cell and Structural Biology, University of Illinois at Urbana 1994

Publication & Research

Publication & Research

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers.
Kedia N, Arhzaouy K, Pittman SK, Sun Y, Batchelor M, Weihl CC, Bieschke J
Proc Natl Acad Sci U S A. 2019 Aug 20; 116(34)16835-16840. doi: 10.1073/pnas.1908263116.

PMID:
    31371504
    [PubMed - in process]
Related citations


Limb-girdle muscular dystrophy: A perspective from adult patients on what matters most.
Hunter M, Heatwole C, Wicklund M, Weihl CC, Mozaffar T, Statland JM, Johnson NE
Muscle Nerve. 2019 Oct; 60(4)419-424. doi: 10.1002/mus.26636.

PMID:
    31298728
    [PubMed - in process]
Related citations


Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D.
Findlay AR, Bengoechea R, Pittman SK, Chou TF, True HL, Weihl CC
Neurol Genet. 2019 Apr; 5(2)e318. doi: 10.1212/NXG.0000000000000318.

PMID:
    31123706
    [PubMed]
Related citations


Estimating prevalence for limb-girdle muscular dystrophy based on public sequencing databases.
Liu W, Pajusalu S, Lake NJ, Zhou G, Ioannidis N, Mittal P, Johnson NE, Weihl CC, Williams BA, Albrecht DE, Rufibach LE, Lek M
Genet Med. 2019 May 20; doi: 10.1038/s41436-019-0544-8.

PMID:
    31105274
    [PubMed - as supplied by publisher]
Related citations


VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC
Autophagy. 2019 Jun; 15(6)1082-1099. doi: 10.1080/15548627.2019.1569933.

PMID:
    30654731
    [PubMed - in process]
Related citations


Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.
Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S, Gestwicki JE, Kampinga HH
Nat Commun. 2018 Dec 17; 9(1)5342. doi: 10.1038/s41467-018-07718-5.

PMID:
    30559338
    [PubMed - indexed for MEDLINE]
Related citations


234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017.
Weihl CC, Udd B, Hanna M, ENMC workshop study group.
Neuromuscul Disord. 2018 Dec; 28(12)1022-1030. doi: 10.1016/j.nmd.2018.09.004.

PMID:
    30424919
    [PubMed - in process]
Related citations


Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN
FASEB J. 2019 Jan; 33(1)652-667. doi: 10.1096/fj.201800361R.

PMID:
    30028636
    [PubMed - indexed for MEDLINE]
Related citations


Homozygous recessive MYH2 mutation mimicking dominant MYH2 associated myopathy.
Findlay AR, Harms MB, Pestronk A, Weihl CC
Neuromuscul Disord. 2018 Aug; 28(8)675-679. doi: 10.1016/j.nmd.2018.05.006.

PMID:
    29934118
    [PubMed - in process]
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CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA).
Garcia-Santibanez R, Zaidman CM, Sommerville RB, Lopate G, Weihl CC, Pestronk A, Bucelli RC
J Neurol. 2018 Jun; 265(6)1402-1409. doi: 10.1007/s00415-018-8853-4.

PMID:
    29633012
    [PubMed - indexed for MEDLINE]
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TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
Lee Y, Jonson PH, Sarparanta J, Palmio J, Sarkar M, Vihola A, Evilä A, Suominen T, Penttilä S, Savarese M, Johari M, Minot MC, Hilton-Jones D, Maddison P, Chinnery P, Reimann J, Kornblum C, Kraya T, Zierz S, Sue C, Goebel H, Azfer A, Ralston SH, Hackman P, Bucelli RC, Taylor JP, Weihl CC, Udd B
J Clin Invest. 2018 Mar 1; 128(3)1164-1177. doi: 10.1172/JCI97103.

PMID:
    29457785
    [PubMed - indexed for MEDLINE]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Aug 22; 20(8)1994. doi: 10.1016/j.celrep.2017.08.019.

PMID:
    28834760
    [PubMed]
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Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease.
Lee Y, Weihl CC
Autophagy. 2017 Sep 2; 13(9)1615-1616. doi: 10.1080/15548627.2017.1339845.

PMID:
    28812433
    [PubMed - indexed for MEDLINE]
Related citations


Comparisons of ELISA and Western blot assays for detection of autophagy flux.
Oh SH, Choi YB, Kim JH, Weihl CC, Ju JS
Data Brief. 2017 Aug; 13696-699. doi: 10.1016/j.dib.2017.06.045.

PMID:
    28725675
    [PubMed]
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Cystinosis distal myopathy, novel clinical, pathological and genetic features.
Cabrera-Serrano M, Junckerstorff RC, Alisheri A, Pestronk A, Laing NG, Weihl CC, Lamont PJ
Neuromuscul Disord. 2017 Sep; 27(9)873-878. doi: 10.1016/j.nmd.2017.05.010.

PMID:
    28629674
    [PubMed - indexed for MEDLINE]
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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B
Nat Commun. 2017 Jun 7; 815750. doi: 10.1038/ncomms15750.

PMID:
    28589926
    [PubMed - indexed for MEDLINE]
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Quantification of autophagy flux using LC3 ELISA.
Oh SH, Choi YB, Kim JH, Weihl CC, Ju JS
Anal Biochem. 2017 Aug 1; 53057-67. doi: 10.1016/j.ab.2017.05.003.

PMID:
    28477964
    [PubMed - indexed for MEDLINE]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Apr 4; 19(1)188-202. doi: 10.1016/j.celrep.2017.03.030.

PMID:
    28380357
    [PubMed - indexed for MEDLINE]
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Establishing prevalence in rare neuromuscular diseases: A lesson from congenital myopathies.
Bamaga AK, Weihl CC
Neurol Genet. 2017 Apr; 3(2)e146. doi: 10.1212/NXG.0000000000000146.

PMID:
    28357412
    [PubMed]
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Sporadic inclusion body myositis - a myodegenerative disease or an inflammatory myopathy.
Weihl CC, Mammen AL
Neuropathol Appl Neurobiol. 2017 Feb; 43(1)82-91. doi: 10.1111/nan.12384.

PMID:
    28111778
    [PubMed - indexed for MEDLINE]
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