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Conrad C. Weihl, MD, PhD

Professor, Neurology
Division of Adult Neurology

Specialty Areas

Neurology - Adult
Muscle Disorders
ALS - Lou Gehrig's Disease
Neuromuscular Disease
Muscular Dystrophy

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Mechanisms of weakness and atrophy related to neuromuscular disorders including muscular dystrophy, inflammatory myopathy (including inclusion body myositis), myopathy, motor neuron disease, ALS - Lou Gehrig's disease, statin induced myopathy, and elevated CPK.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-747-3752

Education

Education

Residency: Neurology, Barnes-Jewish Hospital at Washington University School of Medicine 2005
Medical Degree: University of Chicago Pritzker School of Medicine, Chicago, Illinois 2001
Ph.D.: University of Chicago Biological Sciences Division, University of Chicago, Chicago, Illinois 1999
B.S.: Cell and Structural Biology, University of Illinois at Urbana 1994

Publication & Research

Publication & Research

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC
Autophagy. 2019 Jan 18; 1-18. doi: 10.1080/15548627.2019.1569933.

PMID:
    30654731
    [PubMed - as supplied by publisher]
Related citations


Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks.
Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S, Gestwicki JE, Kampinga HH
Nat Commun. 2018 Dec 17; 9(1)5342. doi: 10.1038/s41467-018-07718-5.

PMID:
    30559338
    [PubMed - indexed for MEDLINE]
Related citations


234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017.
Weihl CC, Udd B, Hanna M, ENMC workshop study group.
Neuromuscul Disord. 2018 Dec; 28(12)1022-1030. doi: 10.1016/j.nmd.2018.09.004.

PMID:
    30424919
    [PubMed - in process]
Related citations


Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN
FASEB J. 2019 Jan; 33(1)652-667. doi: 10.1096/fj.201800361R.

PMID:
    30028636
    [PubMed - in process]
Related citations


Homozygous recessive MYH2 mutation mimicking dominant MYH2 associated myopathy.
Findlay AR, Harms MB, Pestronk A, Weihl CC
Neuromuscul Disord. 2018 Aug; 28(8)675-679. doi: 10.1016/j.nmd.2018.05.006.

PMID:
    29934118
    [PubMed - in process]
Related citations


CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA).
Garcia-Santibanez R, Zaidman CM, Sommerville RB, Lopate G, Weihl CC, Pestronk A, Bucelli RC
J Neurol. 2018 Jun; 265(6)1402-1409. doi: 10.1007/s00415-018-8853-4.

PMID:
    29633012
    [PubMed - indexed for MEDLINE]
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TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.
Lee Y, Jonson PH, Sarparanta J, Palmio J, Sarkar M, Vihola A, Evilä A, Suominen T, Penttilä S, Savarese M, Johari M, Minot MC, Hilton-Jones D, Maddison P, Chinnery P, Reimann J, Kornblum C, Kraya T, Zierz S, Sue C, Goebel H, Azfer A, Ralston SH, Hackman P, Bucelli RC, Taylor JP, Weihl CC, Udd B
J Clin Invest. 2018 Mar 1; 128(3)1164-1177. doi: 10.1172/JCI97103.

PMID:
    29457785
    [PubMed - in process]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Aug 22; 20(8)1994. doi: 10.1016/j.celrep.2017.08.019.

PMID:
    28834760
    [PubMed]
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Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease.
Lee Y, Weihl CC
Autophagy. 2017 Sep 2; 13(9)1615-1616. doi: 10.1080/15548627.2017.1339845.

PMID:
    28812433
    [PubMed - indexed for MEDLINE]
Related citations


Comparisons of ELISA and Western blot assays for detection of autophagy flux.
Oh SH, Choi YB, Kim JH, Weihl CC, Ju JS
Data Brief. 2017 Aug; 13696-699. doi: 10.1016/j.dib.2017.06.045.

PMID:
    28725675
    [PubMed]
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Cystinosis distal myopathy, novel clinical, pathological and genetic features.
Cabrera-Serrano M, Junckerstorff RC, Alisheri A, Pestronk A, Laing NG, Weihl CC, Lamont PJ
Neuromuscul Disord. 2017 Sep; 27(9)873-878. doi: 10.1016/j.nmd.2017.05.010.

PMID:
    28629674
    [PubMed - indexed for MEDLINE]
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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B
Nat Commun. 2017 Jun 7; 815750. doi: 10.1038/ncomms15750.

PMID:
    28589926
    [PubMed - indexed for MEDLINE]
Related citations


Quantification of autophagy flux using LC3 ELISA.
Oh SH, Choi YB, Kim JH, Weihl CC, Ju JS
Anal Biochem. 2017 Aug 1; 53057-67. doi: 10.1016/j.ab.2017.05.003.

PMID:
    28477964
    [PubMed - indexed for MEDLINE]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Apr 4; 19(1)188-202. doi: 10.1016/j.celrep.2017.03.030.

PMID:
    28380357
    [PubMed - indexed for MEDLINE]
Related citations


Establishing prevalence in rare neuromuscular diseases: A lesson from congenital myopathies.
Bamaga AK, Weihl CC
Neurol Genet. 2017 Apr; 3(2)e146. doi: 10.1212/NXG.0000000000000146.

PMID:
    28357412
    [PubMed]
Related citations


Sporadic inclusion body myositis - a myodegenerative disease or an inflammatory myopathy.
Weihl CC, Mammen AL
Neuropathol Appl Neurobiol. 2017 Feb; 43(1)82-91. doi: 10.1111/nan.12384.

PMID:
    28111778
    [PubMed - indexed for MEDLINE]
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Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis.
Güttsches AK, Brady S, Krause K, Maerkens A, Uszkoreit J, Eisenacher M, Schreiner A, Galozzi S, Mertens-Rill J, Tegenthoff M, Holton JL, Harms MB, Lloyd TE, Vorgerd M, Weihl CC, Marcus K, Kley RA
Ann Neurol. 2017 Feb; 81(2)227-239. doi: 10.1002/ana.24847.

PMID:
    28009083
    [PubMed - indexed for MEDLINE]
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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.
Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H
EMBO J. 2017 Jan 17; 36(2)135-150. doi: 10.15252/embj.201695148.

PMID:
    27753622
    [PubMed - indexed for MEDLINE]
Related citations


215th ENMC International Workshop VCP-related multi-system proteinopathy (IBMPFD) 13-15 November 2015, Heemskerk, The Netherlands.
Evangelista T, Weihl CC, Kimonis V, Lochmüller H, VCP related diseases Consortium.
Neuromuscul Disord. 2016 Aug; 26(8)535-47. doi: 10.1016/j.nmd.2016.05.017.

PMID:
    27312024
    [PubMed - indexed for MEDLINE]
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TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.
Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A
J Neurosci. 2016 Apr 27; 36(17)4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016.

PMID:
    27122027
    [PubMed - indexed for MEDLINE]
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