Patient Portal

Clay F. Semenkovich, MD

Professor, Medicine
Irene E. and Michael M. Karl Professor
Chief, Division of Endocrinology, Metabolism and Lipid Research
Professor, Cell Biology & Physiology

Specialty Areas

Diabetes
Hyperlipidemia
Thyroid Disorders
Endocrinology

Board Certifications

Endocrinology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hyperlipidemia, diabetes, general endocrinology

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Diabetes Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 13
Office Phone: 314-747-7300
Fax: 314-747-7065

Education

Education

Chief Resident: Barnes Hospital, Washington University, St. Louis, Missouri 1987
Fellowship: Endocrinology & Metabolism, Washington University, St. Louis, Missouri 1986
Residency: Barnes Hospital, Washington University, St. Louis, Missouri 1984
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1981
B.A.: University of Virginia, Charlottesville, Virginia 1977

Publication & Research

Publication & Research

Association of Retinopathy and Insulin Resistance: NHANES 2005-2008.
Bao YK, Yan Y, Wilson B, Gordon MO, Semenkovich CF, Rajagopal R
Curr Eye Res. 2019 Aug 28; 1-4. doi: 10.1080/02713683.2019.1659977.

PMID:
    31460803
    [PubMed - as supplied by publisher]
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Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF
Diabetol Metab Syndr. 2019; 1161. doi: 10.1186/s13098-019-0456-4.

PMID:
    31384309
    [PubMed]
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Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, Giannone RJ, Hettich RL, Ilkayeva O, Muehlbauer M, Newgard CB, Sawyer C, Head RD, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Hossain MI, Islam M, Choudhury N, Sarker SA, Huq S, Mahmud I, Mostafa I, Mahfuz M, Barratt MJ, Ahmed T, Gordon JI
Science. 2019 Jul 12; 365(6449)pii: eaau4732. doi: 10.1126/science.aau4732.

PMID:
    31296738
    [PubMed - in process]
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Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated.
De Silva GS, Desai K, Darwech M, Naim U, Jin X, Adak S, Harroun N, Sanchez LA, Semenkovich CF, Zayed MA
Atherosclerosis. 2019 Aug; 28738-45. doi: 10.1016/j.atherosclerosis.2019.05.016.

PMID:
    31202106
    [PubMed - in process]
Related citations


CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes.
Dimas P, Montani L, Pereira JA, Moreno D, Trötzmüller M, Gerber J, Semenkovich CF, Köfeler HC, Suter U
Elife. 2019 May 7; 8pii: e44702. doi: 10.7554/eLife.44702.

PMID:
    31063129
    [PubMed - in process]
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Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis.
Millman JR, Doggett T, Thebeau C, Zhang S, Semenkovich CF, Rajagopal R
J Vis Exp. 2019 Jan 7; (143)doi: 10.3791/58626.

PMID:
    30663677
    [PubMed - in process]
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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.
Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P
Cell Metab. 2018 Dec 4; 28(6)866-880.e15. doi: 10.1016/j.cmet.2018.07.019.

PMID:
    30146486
    [PubMed - in process]
Related citations


Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques.
Zayed MA, Hsu FF, Patterson BW, Yan Y, Naim U, Darwesh M, De Silva G, Yang C, Semenkovich CF
J Lipid Res. 2018 Apr; 59(4)730-738. doi: 10.1194/jlr.M081026.

PMID:
    29478028
    [PubMed - indexed for MEDLINE]
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De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.
Montani L, Pereira JA, Norrmén C, Pohl HBF, Tinelli E, Trötzmüller M, Figlia G, Dimas P, von Niederhäusern B, Schwager R, Jessberger S, Semenkovich CF, Köfeler HC, Suter U
J Cell Biol. 2018 Apr 2; 217(4)1353-1368. doi: 10.1083/jcb.201706010.

PMID:
    29434029
    [PubMed - indexed for MEDLINE]
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Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.
Rajagopal R, Zhang S, Wei X, Doggett T, Adak S, Enright J, Shah V, Ling G, Chen S, Yoshino J, Hsu FF, Semenkovich CF
JCI Insight. 2018 Jan 11; 3(1)pii: 97076. doi: 10.1172/jci.insight.97076.

PMID:
    29321376
    [PubMed - in process]
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PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression.
Lodhi IJ, Dean JM, He A, Park H, Tan M, Feng C, Song H, Hsu FF, Semenkovich CF
Cell Rep. 2017 Sep 19; 20(12)2766-2774. doi: 10.1016/j.celrep.2017.08.077.

PMID:
    28930673
    [PubMed - indexed for MEDLINE]
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Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.
Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP
Mol Metab. 2017 Aug; 6(8)781-796. doi: 10.1016/j.molmet.2017.05.012.

PMID:
    28752043
    [PubMed - indexed for MEDLINE]
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Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.
Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F
Sci Rep. 2017 Jul 17; 7(1)5611. doi: 10.1038/s41598-017-05935-4.

PMID:
    28717166
    [PubMed - indexed for MEDLINE]
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We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin Bierman Award Lecture.
Semenkovich CF
Diabetes. 2017 Jul; 66(7)1735-1741. doi: 10.2337/db17-0093.

PMID:
    28637825
    [PubMed - indexed for MEDLINE]
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<i>N</i>-Acetylcysteine accelerates amputation stump healing in the setting of diabetes.
Zayed MA, Wei X, Park KM, Belaygorod L, Naim U, Harvey J, Yin L, Blumer K, Semenkovich CF
FASEB J. 2017 Jun; 31(6)2686-2695. doi: 10.1096/fj.201601348R.

PMID:
    28280002
    [PubMed - indexed for MEDLINE]
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Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans.
Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF
Int J Obes (Lond). 2017 Apr; 41(4)631-638. doi: 10.1038/ijo.2017.19.

PMID:
    28119529
    [PubMed - indexed for MEDLINE]
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Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Singh SB, Kang L, Nawrocki AR, Zhou D, Wu M, Previs S, Miller C, Liu H, Hines CD, Madeira M, Cao J, Herath K, Spears LD, Semenkovich CF, Wang L, Kelley DE, Li C, Guan HP
PLoS One. 2017; 12(1)e0170721. doi: 10.1371/journal.pone.0170721.

PMID:
    28103304
    [PubMed]
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Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Wei X, Song H, Yin L, Rizzo MG, Sidhu R, Covey DF, Ory DS, Semenkovich CF
Nature. 2016 Nov 10; 539(7628)294-298. doi: 10.1038/nature20117.

PMID:
    27806377
    [PubMed - indexed for MEDLINE]
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The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Singh SB, Kang L, Nawrocki AR, Zhou D, Wu M, Previs S, Miller C, Liu H, Hines CD, Madeira M, Cao J, Herath K, Spears LD, Semenkovich CF, Wang L, Kelley DE, Li C, Guan HP
PLoS One. 2016; 11(10)e0164133. doi: 10.1371/journal.pone.0164133.

PMID:
    27695056
    [PubMed]
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Diabetes Update 2016: What Bartleby the Scrivener Can Teach Us About Diabetes Care.
Semenkovich CF
Mo Med. 2016 Sep-Oct; 113(5)359-360.

PMID:
    30228500
    [PubMed]
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