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Christopher D. Smyser, MD

Associate Professor, Neurology
Division of Pediatric Neurology

Specialty Areas

Pediatric Neurology
Neonatal Neurology
Pediatric Stroke

Board Certifications

Pediatric Neurology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Neonatal neurology, pediatric stroke, cerebral palsy, CNS malformations, developmental disorders, general pediatric neurology.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

B.S.: Biomedical Engineering, University of Iowa College of Medicine, Iowa City, IA 1998
Medical Degree: University of Iowa College of Medicine, Iowa City, Iowa 2004
Residency: Child Neurology, Washington University School of Medicine/ St. Louis Children's Hospital, St. Louis, Missouri 2009
Residency: Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 2006
Chief Resident: Neurology, Washington University School of Medicine, St. Louis, Missouri 2009

Publication & Research

Publication & Research

Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years.
Lean RE, Lessov-Shlaggar CN, Gerstein ED, Smyser TA, Paul RA, Smyser CD, Rogers CE
J Child Psychol Psychiatry. 2019 Aug 26; doi: 10.1111/jcpp.13116.

PMID:
    31449335
    [PubMed - as supplied by publisher]
Related citations


Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study.
Matthews LG, Smyser CD, Cherkerzian S, Alexopoulos D, Kenley J, Tuuli MG, Nelson DM, Inder TE
PLoS One. 2019; 14(8)e0219596. doi: 10.1371/journal.pone.0219596.

PMID:
    31433809
    [PubMed - in process]
Related citations


Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury.
Lean RE, Han RH, Smyser TA, Kenley JK, Shimony JS, Rogers CE, Limbrick DD Jr, Smyser CD
Pediatr Res. 2019 Sep; 86(3)365-374. doi: 10.1038/s41390-019-0461-1.

PMID:
    31212303
    [PubMed - in process]
Related citations


Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.
Strahle JM, Triplett RL, Alexopoulos D, Smyser TA, Rogers CE, Limbrick DD Jr, Smyser CD
Neuroimage Clin. 2019; 22101787. doi: 10.1016/j.nicl.2019.101787.

PMID:
    30991622
    [PubMed - in process]
Related citations


Maternal Depression and Stress in the Neonatal Intensive Care Unit: Associations With Mother-Child Interactions at Age 5 Years.
Gerstein ED, Njoroge WFM, Paul RA, Smyser CD, Rogers CE
J Am Acad Child Adolesc Psychiatry. 2019 Mar; 58(3)350-358.e2. doi: 10.1016/j.jaac.2018.08.016.

PMID:
    30768416
    [PubMed - in process]
Related citations


Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children.
Rogers CE, Lean RE, Wheelock MD, Smyser CD
J Neurodev Disord. 2018 Dec 13; 10(1)38. doi: 10.1186/s11689-018-9253-x.

PMID:
    30541449
    [PubMed - indexed for MEDLINE]
Related citations


Prenatal to postnatal trajectory of brain growth in complex congenital heart disease.
Ortinau CM, Mangin-Heimos K, Moen J, Alexopoulos D, Inder TE, Gholipour A, Shimony JS, Eghtesady P, Schlaggar BL, Smyser CD
Neuroimage Clin. 2018; 20913-922. doi: 10.1016/j.nicl.2018.09.029.

PMID:
    30308377
    [PubMed - indexed for MEDLINE]
Related citations


Social Adversity and Cognitive, Language, and Motor Development of Very Preterm Children from 2 to 5 Years of Age.
Lean RE, Paul RA, Smyser TA, Smyser CD, Rogers CE
J Pediatr. 2018 Dec; 203177-184.e1. doi: 10.1016/j.jpeds.2018.07.110.

PMID:
    30244986
    [PubMed - indexed for MEDLINE]
Related citations


Altered functional network connectivity relates to motor development in children born very preterm.
Wheelock MD, Austin NC, Bora S, Eggebrecht AT, Melzer TR, Woodward LJ, Smyser CD
Neuroimage. 2018 Dec; 183574-583. doi: 10.1016/j.neuroimage.2018.08.051.

PMID:
    30144569
    [PubMed - indexed for MEDLINE]
Related citations


Neonatal brain injury and aberrant connectivity.
Smyser CD, Wheelock MD, Limbrick DD Jr, Neil JJ
Neuroimage. 2019 Jan 15; 185609-623. doi: 10.1016/j.neuroimage.2018.07.057.

PMID:
    30059733
    [PubMed - indexed for MEDLINE]
Related citations


Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study.
Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, Strahle JM, Olsen MA, Limbrick DD Jr
Childs Nerv Syst. 2018 Nov; 34(11)2203-2213. doi: 10.1007/s00381-018-3897-4.

PMID:
    29987373
    [PubMed - indexed for MEDLINE]
Related citations


Recent advances in the use of MRI to assess early human cortical development.
Neil JJ, Smyser CD
J Magn Reson. 2018 Aug; 29356-69. doi: 10.1016/j.jmr.2018.05.013.

PMID:
    29894905
    [PubMed - in process]
Related citations


Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants.
El Ters NM, Vesoulis ZA, Liao SM, Smyser CD, Mathur AM
Early Hum Dev. 2018 Apr; 11968-72. doi: 10.1016/j.earlhumdev.2018.02.010.

PMID:
    29579560
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic patterns of cortical expansion during folding of the preterm human brain.
Garcia KE, Robinson EC, Alexopoulos D, Dierker DL, Glasser MF, Coalson TS, Ortinau CM, Rueckert D, Taber LA, Van Essen DC, Rogers CE, Smyser CD, Bayly PV
Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12)3156-3161. doi: 10.1073/pnas.1715451115.

PMID:
    29507201
    [PubMed - indexed for MEDLINE]
Related citations


Cerebellar Functional Connectivity in Term- and Very Preterm-Born Infants.
Herzmann CS, Snyder AZ, Kenley JK, Rogers CE, Shimony JS, Smyser CD
Cereb Cortex. 2019 Mar 1; 29(3)1174-1184. doi: 10.1093/cercor/bhy023.

PMID:
    29420701
    [PubMed - in process]
Related citations


Differential Rates of Perinatal Maturation of Human Primary and Nonprimary Auditory Cortex.
Monson BB, Eaton-Rosen Z, Kapur K, Liebenthal E, Brownell A, Smyser CD, Rogers CE, Inder TE, Warfield SK, Neil JJ
eNeuro. 2018 Jan-Feb; 5(1)pii: ENEURO.0380-17.2017. doi: 10.1523/ENEURO.0380-17.2017.

PMID:
    29354680
    [PubMed - indexed for MEDLINE]
Related citations


Brain growth in the NICU: critical periods of tissue-specific expansion.
Matthews LG, Walsh BH, Knutsen C, Neil JJ, Smyser CD, Rogers CE, Inder TE
Pediatr Res. 2018 May; 83(5)976-981. doi: 10.1038/pr.2018.4.

PMID:
    29320484
    [PubMed - indexed for MEDLINE]
Related citations


Intraventricular Hemorrhage in Moderate to Severe Congenital Heart Disease.
Ortinau CM, Anadkat JS, Smyser CD, Eghtesady P
Pediatr Crit Care Med. 2018 Jan; 19(1)56-63. doi: 10.1097/PCC.0000000000001374.

PMID:
    29210924
    [PubMed - indexed for MEDLINE]
Related citations


Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years.
Lean RE, Paul RA, Smyser CD, Rogers CE
J Child Psychol Psychiatry. 2018 Feb; 59(2)150-159. doi: 10.1111/jcpp.12810.

PMID:
    28925538
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Project mapping structural connections within and between systems in the neonatal brain through collection and analysis of functional connectivity MRI data (2007-current).