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Christopher D. Smyser, MD

Associate Professor, Neurology
Division of Pediatric Neurology

Specialty Areas

Pediatric Neurology
Neonatal Neurology
Pediatric Stroke

Board Certifications

Pediatric Neurology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Neonatal neurology, pediatric stroke, cerebral palsy, CNS malformations, developmental disorders, general pediatric neurology.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

B.S.: Biomedical Engineering, University of Iowa College of Medicine, Iowa City, IA 1998
Medical Degree: University of Iowa College of Medicine, Iowa City, Iowa 2004
Residency: Child Neurology, Washington University School of Medicine/ St. Louis Children's Hospital, St. Louis, Missouri 2009
Residency: Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 2006
Chief Resident: Neurology, Washington University School of Medicine, St. Louis, Missouri 2009

Publication & Research

Publication & Research

Surgery requiring general anesthesia in preterm infants is associated with altered brain volumes at term equivalent age and neurodevelopmental impairment.
Walsh BH, Paul RA, Inder TE, Shimony JS, Smyser CD, Rogers CE
Pediatr Res. 2020 Jun 23; doi: 10.1038/s41390-020-1030-3.

PMID:
    32575110
    [PubMed - as supplied by publisher]
Related citations


Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry.
Sylvester CM, Yu Q, Srivastava AB, Marek S, Zheng A, Alexopoulos D, Smyser CD, Shimony JS, Ortega M, Dierker DL, Patel GH, Nelson SM, Gilmore AW, McDermott KB, Berg JJ, Drysdale AT, Perino MT, Snyder AZ, Raut RV, Laumann TO, Gordon EM, Barch DM, Rogers CE, Greene DJ, Raichle ME, Dosenbach NUF
Proc Natl Acad Sci U S A. 2020 Feb 18; 117(7)3808-3818. doi: 10.1073/pnas.1910842117.

PMID:
    32015137
    [PubMed - in process]
Related citations


Portable, field-based neuroimaging using high-density diffuse optical tomography.
Fishell AK, Arbeláez AM, Valdés CP, Burns-Yocum TM, Sherafati A, Richter EJ, Torres M, Eggebrecht AT, Smyser CD, Culver JP
Neuroimage. 2020 Jul 15; 215116541. doi: 10.1016/j.neuroimage.2020.116541.

PMID:
    31987995
    [PubMed - in process]
Related citations


MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity.
Isaacs AM, Smyser CD, Lean RE, Alexopoulos D, Han RH, Neil JJ, Zimbalist SA, Rogers CE, Yan Y, Shimony JS, Limbrick DD Jr
Neuroimage Clin. 2019; 24102031. doi: 10.1016/j.nicl.2019.102031.

PMID:
    31795043
    [PubMed - in process]
Related citations


Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years.
Lean RE, Lessov-Shlaggar CN, Gerstein ED, Smyser TA, Paul RA, Smyser CD, Rogers CE
J Child Psychol Psychiatry. 2020 Feb; 61(2)157-166. doi: 10.1111/jcpp.13116.

PMID:
    31449335
    [PubMed - in process]
Related citations


Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study.
Matthews LG, Smyser CD, Cherkerzian S, Alexopoulos D, Kenley J, Tuuli MG, Nelson DM, Inder TE
PLoS One. 2019; 14(8)e0219596. doi: 10.1371/journal.pone.0219596.

PMID:
    31433809
    [PubMed - indexed for MEDLINE]
Related citations


Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury.
Lean RE, Han RH, Smyser TA, Kenley JK, Shimony JS, Rogers CE, Limbrick DD Jr, Smyser CD
Pediatr Res. 2019 Sep; 86(3)365-374. doi: 10.1038/s41390-019-0461-1.

PMID:
    31212303
    [PubMed - in process]
Related citations


Impaired hippocampal development and outcomes in very preterm infants with perinatal brain injury.
Strahle JM, Triplett RL, Alexopoulos D, Smyser TA, Rogers CE, Limbrick DD Jr, Smyser CD
Neuroimage Clin. 2019; 22101787. doi: 10.1016/j.nicl.2019.101787.

PMID:
    30991622
    [PubMed - indexed for MEDLINE]
Related citations


Maternal Depression and Stress in the Neonatal Intensive Care Unit: Associations With Mother-Child Interactions at Age 5 Years.
Gerstein ED, Njoroge WFM, Paul RA, Smyser CD, Rogers CE
J Am Acad Child Adolesc Psychiatry. 2019 Mar; 58(3)350-358.e2. doi: 10.1016/j.jaac.2018.08.016.

PMID:
    30768416
    [PubMed - indexed for MEDLINE]
Related citations


Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children.
Rogers CE, Lean RE, Wheelock MD, Smyser CD
J Neurodev Disord. 2018 Dec 13; 10(1)38. doi: 10.1186/s11689-018-9253-x.

PMID:
    30541449
    [PubMed - indexed for MEDLINE]
Related citations


Prenatal to postnatal trajectory of brain growth in complex congenital heart disease.
Ortinau CM, Mangin-Heimos K, Moen J, Alexopoulos D, Inder TE, Gholipour A, Shimony JS, Eghtesady P, Schlaggar BL, Smyser CD
Neuroimage Clin. 2018; 20913-922. doi: 10.1016/j.nicl.2018.09.029.

PMID:
    30308377
    [PubMed - indexed for MEDLINE]
Related citations


Social Adversity and Cognitive, Language, and Motor Development of Very Preterm Children from 2 to 5 Years of Age.
Lean RE, Paul RA, Smyser TA, Smyser CD, Rogers CE
J Pediatr. 2018 Dec; 203177-184.e1. doi: 10.1016/j.jpeds.2018.07.110.

PMID:
    30244986
    [PubMed - indexed for MEDLINE]
Related citations


Altered functional network connectivity relates to motor development in children born very preterm.
Wheelock MD, Austin NC, Bora S, Eggebrecht AT, Melzer TR, Woodward LJ, Smyser CD
Neuroimage. 2018 Dec; 183574-583. doi: 10.1016/j.neuroimage.2018.08.051.

PMID:
    30144569
    [PubMed - indexed for MEDLINE]
Related citations


Neonatal brain injury and aberrant connectivity.
Smyser CD, Wheelock MD, Limbrick DD Jr, Neil JJ
Neuroimage. 2019 Jan 15; 185609-623. doi: 10.1016/j.neuroimage.2018.07.057.

PMID:
    30059733
    [PubMed - indexed for MEDLINE]
Related citations


Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study.
Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, Strahle JM, Olsen MA, Limbrick DD Jr
Childs Nerv Syst. 2018 Nov; 34(11)2203-2213. doi: 10.1007/s00381-018-3897-4.

PMID:
    29987373
    [PubMed - indexed for MEDLINE]
Related citations


Recent advances in the use of MRI to assess early human cortical development.
Neil JJ, Smyser CD
J Magn Reson. 2018 Aug; 29356-69. doi: 10.1016/j.jmr.2018.05.013.

PMID:
    29894905
    [PubMed - indexed for MEDLINE]
Related citations


Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants.
El Ters NM, Vesoulis ZA, Liao SM, Smyser CD, Mathur AM
Early Hum Dev. 2018 Apr; 11968-72. doi: 10.1016/j.earlhumdev.2018.02.010.

PMID:
    29579560
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic patterns of cortical expansion during folding of the preterm human brain.
Garcia KE, Robinson EC, Alexopoulos D, Dierker DL, Glasser MF, Coalson TS, Ortinau CM, Rueckert D, Taber LA, Van Essen DC, Rogers CE, Smyser CD, Bayly PV
Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12)3156-3161. doi: 10.1073/pnas.1715451115.

PMID:
    29507201
    [PubMed - indexed for MEDLINE]
Related citations


Cerebellar Functional Connectivity in Term- and Very Preterm-Born Infants.
Herzmann CS, Snyder AZ, Kenley JK, Rogers CE, Shimony JS, Smyser CD
Cereb Cortex. 2019 Mar 1; 29(3)1174-1184. doi: 10.1093/cercor/bhy023.

PMID:
    29420701
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Project mapping structural connections within and between systems in the neonatal brain through collection and analysis of functional connectivity MRI data (2007-current).