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Faculty Physicians

Christopher D. Smyser, MD

Assistant Professor, Neurology
Division of Pediatric Neurology

Specialty Areas

Pediatric Neurology
Neonatal Neurology
Pediatric Stroke

Board Certifications

Pediatric Neurology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Neonatal neurology, pediatric stroke, cerebral palsy, CNS malformations, developmental disorders, general pediatric neurology.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

B.S.: Biomedical Engineering, University of Iowa College of Medicine, Iowa City, IA 1998
Medical Degree: University of Iowa College of Medicine, Iowa City, Iowa 2004
Residency: Child Neurology, Washington University School of Medicine/ St. Louis Children's Hospital, St. Louis, Missouri 2009
Residency: Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 2006
Chief Resident: Neurology, Washington University School of Medicine, St. Louis, Missouri 2009

Publication & Research

Publication & Research

Neonatal Brain Tissue Classification with Morphological Adaptation and Unified Segmentation.
Beare RJ, Chen J, Kelly CE, Alexopoulos D, Smyser CD, Rogers CE, Loh WY, Matthews LG, Cheong JL, Spittle AJ, Anderson PJ, Doyle LW, Inder TE, Seal ML, Thompson DK
Front Neuroinform. 2016; 1012. doi: 10.3389/fninf.2016.00012.

PMID:
    27065840
    [PubMed]
Related citations


Comparison of cortical folding measures for evaluation of developing human brain.
Shimony JS, Smyser CD, Wideman G, Alexopoulos D, Hill J, Harwell J, Dierker D, Van Essen DC, Inder TE, Neil JJ
Neuroimage. 2016 Jan 15; 125780-90. doi: 10.1016/j.neuroimage.2015.11.001.

PMID:
    26550941
    [PubMed - in process]
Related citations


Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study.
Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, Barnett S, Hufnagel RB, Goldstein A, Narumi-Kishimoto Y, Olds C, Collins S, Johnston K, Deleuze JF, Nitschké P, Friend K, Harris C, Goetsch A, Martin B, Boyle EA, Parrini E, Mei D, Tattini L, Slavotinek A, Blair E, Barnett C, Shendure J, Chelly J, Dobyns WB, Guerrini R
Lancet Neurol. 2015 Dec; 14(12)1182-95. doi: 10.1016/S1474-4422(15)00278-1.

PMID:
    26520804
    [PubMed - indexed for MEDLINE]
Related citations


Regional white matter development in very preterm infants: perinatal predictors and early developmental outcomes.
Rogers CE, Smyser T, Smyser CD, Shimony J, Inder TE, Neil JJ
Pediatr Res. 2016 Jan; 79(1-1)87-95. doi: 10.1038/pr.2015.172.

PMID:
    26372513
    [PubMed - in process]
Related citations


Ensuring Quality in the NICU: Translating Research Into Appropriate Clinical Care.
Smith JR, Donze A, Wolf M, Smyser CD, Mathur A, Proctor EK
J Perinat Neonatal Nurs. 2015 Jul-Sep; 29(3)255-61. doi: 10.1097/JPN.0000000000000122.

PMID:
    26218819
    [PubMed - in process]
Related citations


Cortical Gray and Adjacent White Matter Demonstrate Synchronous Maturation in Very Preterm Infants.
Smyser TA, Smyser CD, Rogers CE, Gillespie SK, Inder TE, Neil JJ
Cereb Cortex. 2015 Jul 24; pii: bhv164.

PMID:
    26209848
    [PubMed - as supplied by publisher]
Related citations


De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


Use of resting-state functional MRI to study brain development and injury in neonates.
Smyser CD, Neil JJ
Semin Perinatol. 2015 Mar; 39(2)130-40. doi: 10.1053/j.semperi.2015.01.006.

PMID:
    25813667
    [PubMed - indexed for MEDLINE]
Related citations


Functional Imaging of the Developing Brain at the Bedside Using Diffuse Optical Tomography.
Ferradal SL, Liao SM, Eggebrecht AT, Shimony JS, Inder TE, Culver JP, Smyser CD
Cereb Cortex. 2016 Apr; 26(4)1558-68. doi: 10.1093/cercor/bhu320.

PMID:
    25595183
    [PubMed - in process]
Related citations


An allometric scaling relationship in the brain of preterm infants.
Paul RA, Smyser CD, Rogers CE, English I, Wallendorf M, Alexopoulos D, Meyer EJ, Van Essen DC, Neil JJ, Inder TE
Ann Clin Transl Neurol. 2014 Nov; 1(11)933-7. doi: 10.1002/acn3.130.

PMID:
    25540808
    [PubMed]
Related citations


Resting-State Network Complexity and Magnitude Are Reduced in Prematurely Born Infants.
Smyser CD, Snyder AZ, Shimony JS, Mitra A, Inder TE, Neil JJ
Cereb Cortex. 2016 Jan; 26(1)322-33. doi: 10.1093/cercor/bhu251.

PMID:
    25331596
    [PubMed - in process]
Related citations


The impact of prenatal and neonatal infection on neurodevelopmental outcomes in very preterm infants.
Lee I, Neil JJ, Huettner PC, Smyser CD, Rogers CE, Shimony JS, Kidokoro H, Mysorekar IU, Inder TE
J Perinatol. 2014 Oct; 34(10)741-7. doi: 10.1038/jp.2014.79.

PMID:
    25033076
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion tractography and neuromotor outcome in very preterm children with white matter abnormalities.
Estep ME, Smyser CD, Anderson PJ, Ortinau CM, Wallendorf M, Katzman CS, Doyle LW, Thompson DK, Neil JJ, Inder TE, Shimony JS
Pediatr Res. 2014 Jul; 76(1)86-92. doi: 10.1038/pr.2014.45.

PMID:
    24713814
    [PubMed - indexed for MEDLINE]
Related citations


Scoliosis and vertebral anomalies: additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement.
Al-Kateb H, Khanna G, Filges I, Hauser N, Grange DK, Shen J, Smyser CD, Kulkarni S, Shinawi M
Am J Med Genet A. 2014 May; 164A(5)1118-26. doi: 10.1002/ajmg.a.36401.

PMID:
    24458548
    [PubMed - indexed for MEDLINE]
Related citations


Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments.
Pineda RG, Neil J, Dierker D, Smyser CD, Wallendorf M, Kidokoro H, Reynolds LC, Walker S, Rogers C, Mathur AM, Van Essen DC, Inder T
J Pediatr. 2014 Jan; 164(1)52-60.e2. doi: 10.1016/j.jpeds.2013.08.047.

PMID:
    24139564
    [PubMed - indexed for MEDLINE]
Related citations


Effects of white matter injury on resting state fMRI measures in prematurely born infants.
Smyser CD, Snyder AZ, Shimony JS, Blazey TM, Inder TE, Neil JJ
PLoS One. 2013; 8(7)e68098. doi: 10.1371/journal.pone.0068098.

PMID:
    23874510
    [PubMed - indexed for MEDLINE]
Related citations


Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis.
Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS
J Child Neurol. 2014 Jun; 29(6)837-42. doi: 10.1177/0883073813486295.

PMID:
    23666045
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome.
McDonell LM, Mirzaa GM, Alcantara D, Schwartzentruber J, Carter MT, Lee LJ, Clericuzio CL, Graham JM Jr, Morris-Rosendahl DJ, Polster T, Acsadi G, Townshend S, Williams S, Halbert A, Isidor B, David A, Smyser CD, Paciorkowski AR, Willing M, Woulfe J, Das S, Beaulieu CL, Marcadier J, FORGE Canada Consortium, Geraghty MT, Frey BJ, Majewski J, Bulman DE, Dobyns WB, O'Driscoll M, Boycott KM
Nat Genet. 2013 May; 45(5)556-62. doi: 10.1038/ng.2602.

PMID:
    23542699
    [PubMed - indexed for MEDLINE]
Related citations


Magnetic resonance imaging of the brain at term equivalent age in extremely premature neonates: to scan or not to scan?
Smyser CD, Kidokoro H, Inder TE
J Paediatr Child Health. 2012 Sep; 48(9)794-800. doi: 10.1111/j.1440-1754.2012.02535.x.

PMID:
    22970674
    [PubMed - indexed for MEDLINE]
Related citations


Resting-state fMRI: a review of methods and clinical applications.
Lee MH, Smyser CD, Shimony JS
AJNR Am J Neuroradiol. 2013 Oct; 34(10)1866-72. doi: 10.3174/ajnr.A3263.

PMID:
    22936095
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Project mapping structural connections within and between systems in the neonatal brain through collection and analysis of functional connectivity MRI data (2007-current).