Patient Portal

Christine Pham, MD

Professor, Medicine
Division of Rheumatology

Specialty Areas

Rheumatology

Board Certifications

Rheumatology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis - John Cochran Division

Areas of Clinical Interest

Rheumatology, arthritis, inflammation and proteases

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

VA Medical Center: John Cochran Division

915 North Grand Boulevard
St. Louis, MO 63106

Office Phone: 314-289-6335
Fax: 314-289-7007

Education

Education

B.S.: University of Florida, Gainesville, Florida 1981
Residency: Washington University School of Medicine, St. Louis, Missouri 1989
Medical Degree: University of Florida College of Medicine, Gainesville, Florida 1985
Fellowship: Rheumatology, Washington University School of Medicine, St. Louis, Missouri 1997

Publication & Research

Publication & Research

Global Retinoblastoma Presentation and Analysis by National Income Level.
Global Retinoblastoma Study Group., Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Adamou Boubacar S, Ademola-Popoola DS, Adio A, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MNR, Al Harby L, Al Ani MH, Alakbarova A, Portabella SA, Al-Badri SAF, Alcasabas APA, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad C, Al-Hussaini HHY, Ali AM, Alia DB, Al-Jadiry MF, Al-Jumaly U, Alkatan HM, All-Eriksson C, Al-Mafrachi AARM, Almeida AA, Alsawidi KM, Al-Shaheen AASM, Al-Shammary EH, Amiruddin PO, Antonino R, Astbury NJ, Atalay HT, Atchaneeyasakul LO, Atsiaya R, Attaseth T, Aung TH, Ayala S, Baizakova B, Balaguer J, Balayeva R, Balwierz W, Barranco H, Bascaran C, Beck Popovic M, Benavides R, Benmiloud S, Bennani Guebessi N, Berete RC, Berry JL, Bhaduri A, Bhat S, Biddulph SJ, Biewald EM, Bobrova N, Boehme M, Boldt HC, Bonanomi MTBC, Bornfeld N, Bouda GC, Bouguila H, Boumedane A, Brennan RC, Brichard BG, Buaboonnam J, Calderón-Sotelo P, Calle Jara DA, Camuglia JE, Cano MR, Capra M, Cassoux N, Castela G, Castillo L, Català-Mora J, Chantada GL, Chaudhry S, Chaugule SS, Chauhan A, Chawla B, Chernodrinska VS, Chiwanga FS, Chuluunbat T, Cieslik K, Cockcroft RL, Comsa C, Correa ZM, Correa Llano MG, Corson TW, Cowan-Lyn KE, Csóka M, Cui X, Da Gama IV, Dangboon W, Das A, Das S, Davanzo JM, Davidson A, De Potter P, Delgado KQ, Demirci H, Desjardins L, Diaz Coronado RY, Dimaras H, Dodgshun AJ, Donaldson C, Donato Macedo CR, Dragomir MD, Du Y, Du Bruyn M, Edison KS, Eka Sutyawan IW, El Kettani A, Elbahi AM, Elder JE, Elgalaly D, Elhaddad AM, Elhassan MMA, Elzembely MM, Essuman VA, Evina TGA, Fadoo Z, Fandiño AC, Faranoush M, Fasina O, Fernández DDPG, Fernández-Teijeiro A, Foster A, Frenkel S, Fu LD, Fuentes-Alabi SL, Gallie BL, Gandiwa M, Garcia JL, García Aldana D, Gassant PY, Geel JA, Ghassemi F, Girón AV, Gizachew Z, Goenz MA, Gold AS, Goldberg-Lavid M, Gole GA, Gomel N, Gonzalez E, Gonzalez Perez G, González-Rodríguez L, Garcia Pacheco HN, Graells J, Green L, Gregersen PA, Grigorovski NDAK, Guedenon KM, Gunasekera DS, Gündüz AK, Gupta H, Gupta S, Hadjistilianou T, Hamel P, Hamid SA, Hamzah N, Hansen ED, Harbour JW, Hartnett ME, Hasanreisoglu M, Hassan S, Hassan S, Hederova S, Hernandez J, Hernandez LMC, Hessissen L, Hordofa DF, Huang LC, Hubbard GB, Hummlen M, Husakova K, Hussein Al-Janabi AN, Ida R, Ilic VR, Jairaj V, Jeeva I, Jenkinson H, Ji X, Jo DH, Johnson KP, Johnson WJ, Jones MM, Kabesha TBA, Kabore RL, Kaliki S, Kalinaki A, Kantar M, Kao LY, Kardava T, Kebudi R, Kepak T, Keren-Froim N, Khan ZJ, Khaqan HA, Khauv P, Kheir WJ, Khetan V, Khodabande A, Khotenashvili Z, Kim JW, Kim JH, Kiratli H, Kivelä TT, Klett A, Komba Palet JEK, Krivaitiene D, Kruger M, Kulvichit K, Kuntorini MW, Kyara A, Lachmann ES, Lam CPS, Lam GC, Larson SA, Latinovic S, Laurenti KD, Le BHA, Lecuona K, Leverant AA, Li C, Limbu B, Long QB, López JP, Lukamba RM, Lumbroso L, Luna-Fineman S, Lutfi D, Lysytsia L, Magrath GN, Mahajan A, Majeed AR, Maka E, Makan M, Makimbetov EK, Manda C, Martín Begue N, Mason L, Mason JO 3rd, Matende IO, Materin M, Mattosinho CCDS, Matua M, Mayet I, Mbumba FB, McKenzie JD, Medina-Sanson A, Mehrvar A, Mengesha AA, Menon V, Mercado GJVD, Mets MB, Midena E, Mishra DKC, Mndeme FG, Mohamedani AA, Mohammad MT, Moll AC, Montero MM, Morales RA, Moreira C, Mruthyunjaya P, Msina MS, Msukwa G, Mudaliar SS, Muma KI, Munier FL, Murgoi G, Murray TG, Musa KO, Mushtaq A, Mustak H, Muyen OM, Naidu G, Nair AG, Naumenko L, Ndoye Roth PA, Nency YM, Neroev V, Ngo H, Nieves RM, Nikitovic M, Nkanga ED, Nkumbe H, Nuruddin M, Nyaywa M, Obono-Obiang G, Oguego NC, Olechowski A, Oliver SCN, Osei-Bonsu P, Ossandon D, Paez-Escamilla MA, Pagarra H, Painter SL, Paintsil V, Paiva L, Pal BP, Palanivelu MS, Papyan R, Parrozzani R, Parulekar M, Pascual Morales CR, Paton KE, Pawinska-Wasikowska K, Pe'er J, Peña A, Peric S, Pham CTM, Philbert R, Plager DA, Pochop P, Polania RA, Polyakov VG, Pompe MT, Pons JJ, Prat D, Prom V, Purwanto I, Qadir AO, Qayyum S, Qian J, Rahman A, Rahman S, Rahmat J, Rajkarnikar P, Ramanjulu R, Ramasubramanian A, Ramirez-Ortiz MA, Raobela L, Rashid R, Reddy MA, Reich E, Renner LA, Reynders D, Ribadu D, Riheia MM, Ritter-Sovinz P, Rojanaporn D, Romero L, Roy SR, Saab RH, Saakyan S, Sabhan AH, Sagoo MS, Said AMA, Saiju R, Salas B, San Román Pacheco S, Sánchez GL, Sayalith P, Scanlan TA, Schefler AC, Schoeman J, Sedaghat A, Seregard S, Seth R, Shah AS, Shakoor SA, Sharma MK, Sherief ST, Shetye NG, Shields CL, Siddiqui SN, Sidi Cheikh S, Silva S, Singh AD, Singh N, Singh U, Singha P, Sitorus RS, Skalet AH, Soebagjo HD, Sorochynska T, Ssali G, Stacey AW, Staffieri SE, Stahl ED, Stathopoulos C, Stirn Kranjc B, Stones DK, Strahlendorf C, Suarez MEC, Sultana S, Sun X, Sundy M, Superstein R, Supriyadi E, Surukrattanaskul S, Suzuki S, Svojgr K, Sylla F, Tamamyan G, Tan D, Tandili A, Tarrillo Leiva FF, Tashvighi M, Tateshi B, Tehuteru ES, Teixeira LF, Teh KH, Theophile T, Toledano H, Trang DL, Traoré F, Trichaiyaporn S, Tuncer S, Tyau-Tyau H, Umar AB, Unal E, Uner OE, Urbak SF, Ushakova TL, Usmanov RH, Valeina S, van Hoefen Wijsard M, Varadisai A, Vasquez L, Vaughan LO, Veleva-Krasteva NV, Verma N, Victor AA, Viksnins M, Villacís Chafla EG, Vishnevskia-Dai V, Vora T, Wachtel AE, Wackernagel W, Waddell K, Wade PD, Wali AH, Wang YZ, Weiss A, Wilson MW, Wime ADC, Wiwatwongwana A, Wiwatwongwana D, Wolley Dod C, Wongwai P, Xiang D, Xiao Y, Yam JC, Yang H, Yanga JM, Yaqub MA, Yarovaya VA, Yarovoy AA, Ye H, Yousef YA, Yuliawati P, Zapata López AM, Zein E, Zhang C, Zhang Y, Zhao J, Zheng X, Zhilyaeva K, Zia N, Ziko OAO, Zondervan M, Bowman R
JAMA Oncol. 2020 Feb 27; doi: 10.1001/jamaoncol.2019.6716.

PMID:
    32105305
    [PubMed - as supplied by publisher]
Related citations


Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis.
Yan H, Hu Y, Akk A, Rai MF, Pan H, Wickline SA, Pham CTN
Pharmaceutics. 2020 Jan 17; 12(1)pii: E73. doi: 10.3390/pharmaceutics12010073.

PMID:
    31963412
    [PubMed]
Related citations


Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.
Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN
Precis Nanomed. 2019; 2(1)245-248. doi: 10.33218/prnano2(1).181129.1.

PMID:
    31681908
    [PubMed]
Related citations


Complement activation on neutrophils initiates endothelial adhesion and extravasation.
Akk A, Springer LE, Yang L, Hamilton-Burdess S, Lambris JD, Yan H, Hu Y, Wu X, Hourcade DE, Miller MJ, Pham CTN
Mol Immunol. 2019 Oct; 114629-642. doi: 10.1016/j.molimm.2019.09.011.

PMID:
    31542608
    [PubMed - indexed for MEDLINE]
Related citations


Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity.
Guang Y, McGrath TM, Klug N, Nims R, Shih CC, Bayguinov PO, Guilak F, Pham CTN, Fitzpatrick JAJ, Setton LA
J Biomech Eng. 2019 Sep 1; doi: 10.1115/1.4044892.

PMID:
    31536113
    [PubMed - as supplied by publisher]
Related citations


Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
Sionov RV, Fainsod-Levi T, Zelter T, Polyansky L, Pham CT, Granot Z
Oncoimmunology. 2019; 8(9)e1624129. doi: 10.1080/2162402X.2019.1624129.

PMID:
    31428521
    [PubMed]
Related citations


Applications of RNA interference in the treatment of arthritis.
Rai MF, Pan H, Yan H, Sandell LJ, Pham CTN, Wickline SA
Transl Res. 2019 Dec; 2141-16. doi: 10.1016/j.trsl.2019.07.002.

PMID:
    31351032
    [PubMed - indexed for MEDLINE]
Related citations


Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.
Yan H, Hu Y, Akk A, Ye K, Bacon J, Pham CTN
Sci Rep. 2019 Jul 18; 9(1)10447. doi: 10.1038/s41598-019-46909-y.

PMID:
    31320700
    [PubMed - in process]
Related citations


Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.
Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN
J Orthop Res. 2019 Jun; 37(6)1287-1293. doi: 10.1002/jor.24304.

PMID:
    30977548
    [PubMed - indexed for MEDLINE]
Related citations


Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.
Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN
Sci Rep. 2019 Jan 24; 9(1)442. doi: 10.1038/s41598-018-37018-3.

PMID:
    30679644
    [PubMed - in process]
Related citations


Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
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Intra-articular drug delivery systems for joint diseases.
Rai MF, Pham CT
Curr Opin Pharmacol. 2018 Jun; 4067-73. doi: 10.1016/j.coph.2018.03.013.

PMID:
    29625332
    [PubMed - indexed for MEDLINE]
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Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.
Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA
J Immunol. 2018 Apr 15; 200(8)2786-2797. doi: 10.4049/jimmunol.1701668.

PMID:
    29531168
    [PubMed - indexed for MEDLINE]
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Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA
PLoS One. 2017; 12(2)e0172105. doi: 10.1371/journal.pone.0172105.

PMID:
    28192517
    [PubMed - indexed for MEDLINE]
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Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O
Circulation. 2016 Oct 18; 134(16)1176-1188.

PMID:
    27660294
    [PubMed - indexed for MEDLINE]
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Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed]
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Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Akk A, Springer LE, Pham CT
Front Immunol. 2016; 7325. doi: 10.3389/fimmu.2016.00325.

PMID:
    27617014
    [PubMed]
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Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Yan H, Zhou HF, Akk A, Hu Y, Springer LE, Ennis TL, Pham CTN
Arterioscler Thromb Vasc Biol. 2016 Aug; 36(8)1660-1669. doi: 10.1161/ATVBAHA.116.307786.

PMID:
    27283739
    [PubMed - indexed for MEDLINE]
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Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA
Mol Med. 2016 May 24; 22doi: 10.2119/molmed.2016.00033.

PMID:
    27261776
    [PubMed - indexed for MEDLINE]
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Anti-complement activity of the Ixodes scapularis salivary protein Salp20.
Hourcade DE, Akk AM, Mitchell LM, Zhou HF, Hauhart R, Pham CT
Mol Immunol. 2016 Jan; 6962-9. doi: 10.1016/j.molimm.2015.11.008.

PMID:
    26675068
    [PubMed - indexed for MEDLINE]
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Areas of Research Interest

Arthritis, inflammation, proteases