Patient Portal

Christine Pham, MD

Professor, Medicine
Division of Rheumatology

Specialty Areas

Rheumatology

Board Certifications

Rheumatology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis - John Cochran Division

Areas of Clinical Interest

Rheumatology, arthritis, inflammation and proteases

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

VA Medical Center: John Cochran Division

915 North Grand Boulevard
St. Louis, MO 63106

Office Phone: 314-289-6335
Fax: 314-289-7007

Education

Education

B.S.: University of Florida, Gainesville, Florida 1981
Residency: Washington University School of Medicine, St. Louis, Missouri 1989
Medical Degree: University of Florida College of Medicine, Gainesville, Florida 1985
Fellowship: Rheumatology, Washington University School of Medicine, St. Louis, Missouri 1997

Publication & Research

Publication & Research

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.
Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN
Sci Rep. 2019 Jan 24; 9(1)442. doi: 10.1038/s41598-018-37018-3.

PMID:
    30679644
    [PubMed - in process]
Related citations


Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
Related citations


Intra-articular drug delivery systems for joint diseases.
Rai MF, Pham CT
Curr Opin Pharmacol. 2018 Jun; 4067-73. doi: 10.1016/j.coph.2018.03.013.

PMID:
    29625332
    [PubMed - indexed for MEDLINE]
Related citations


Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.
Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA
J Immunol. 2018 Apr 15; 200(8)2786-2797. doi: 10.4049/jimmunol.1701668.

PMID:
    29531168
    [PubMed - indexed for MEDLINE]
Related citations


Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA
PLoS One. 2017; 12(2)e0172105. doi: 10.1371/journal.pone.0172105.

PMID:
    28192517
    [PubMed - indexed for MEDLINE]
Related citations


Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O
Circulation. 2016 Oct 18; 134(16)1176-1188.

PMID:
    27660294
    [PubMed - indexed for MEDLINE]
Related citations


Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed - in process]
Related citations


Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Akk A, Springer LE, Pham CT
Front Immunol. 2016; 7325. doi: 10.3389/fimmu.2016.00325.

PMID:
    27617014
    [PubMed]
Related citations


Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Yan H, Zhou HF, Akk A, Hu Y, Springer LE, Ennis TL, Pham CTN
Arterioscler Thromb Vasc Biol. 2016 Aug; 36(8)1660-1669. doi: 10.1161/ATVBAHA.116.307786.

PMID:
    27283739
    [PubMed - indexed for MEDLINE]
Related citations


Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA
Mol Med. 2016 May 24; 22doi: 10.2119/molmed.2016.00033.

PMID:
    27261776
    [PubMed - indexed for MEDLINE]
Related citations


Anti-complement activity of the Ixodes scapularis salivary protein Salp20.
Hourcade DE, Akk AM, Mitchell LM, Zhou HF, Hauhart R, Pham CT
Mol Immunol. 2016 Jan; 6962-9. doi: 10.1016/j.molimm.2015.11.008.

PMID:
    26675068
    [PubMed - indexed for MEDLINE]
Related citations


Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.
Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1)85-106. doi: 10.1002/wnan.1355.

PMID:
    26296541
    [PubMed - indexed for MEDLINE]
Related citations


Peptide-siRNA nanotherapeutics in arthritis.
Pham CT, Pan H, Wickline SA
Oncotarget. 2015 Jun 20; 6(17)14731-2.

PMID:
    26142704
    [PubMed - indexed for MEDLINE]
Related citations


Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
Yan H, Zhou HF, Hu Y, Pham CT
J Rheum Dis Treat. 2015 Feb 28; 1(1)5.

PMID:
    26120598
    [PubMed]
Related citations


Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles.
Jallouk AP, Palekar RU, Marsh JN, Pan H, Pham CT, Schlesinger PH, Wickline SA
Bioconjug Chem. 2015 Aug 19; 26(8)1640-50. doi: 10.1021/acs.bioconjchem.5b00246.

PMID:
    26083278
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.
Palekar RU, Jallouk AP, Goette MJ, Chen J, Myerson JW, Allen JS, Akk A, Yang L, Tu Y, Miller MJ, Pham CT, Wickline SA, Pan H
FASEB J. 2015 Jul; 29(7)3100-9. doi: 10.1096/fj.14-269084.

PMID:
    25857553
    [PubMed - indexed for MEDLINE]
Related citations


Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesis.
Bertram P, Akk AM, Zhou HF, Mitchell LM, Pham CT, Hourcade DE
Monoclon Antib Immunodiagn Immunother. 2015 Feb; 34(1)1-6. doi: 10.1089/mab.2014.0066.

PMID:
    25723276
    [PubMed - indexed for MEDLINE]
Related citations


Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers.
Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM
Nanomedicine. 2015 Apr; 11(3)601-9. doi: 10.1016/j.nano.2014.12.009.

PMID:
    25652900
    [PubMed - indexed for MEDLINE]
Related citations


Physicochemical signatures of nanoparticle-dependent complement activation.
Thomas DG, Chikkagoudar S, Heredia-Langer A, Tardiff MF, Xu Z, Hourcade DE, Pham CT, Lanza GM, Weinberger KQ, Baker NA
Comput Sci Discov. 2014 Mar 21; 7(1)015003.

PMID:
    25254068
    [PubMed]
Related citations


Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.
Zhou HF, Yan H, Hu Y, Springer LE, Yang X, Wickline SA, Pan D, Lanza GM, Pham CT
ACS Nano. 2014 Jul 22; 8(7)7305-17. doi: 10.1021/nn502372n.

PMID:
    24941020
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Arthritis, inflammation, proteases