Christine Pham, MD

Publication & Research

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.
Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN
Sci Rep. 2019 Jan 24; 9(1)442. doi: 10.1038/s41598-018-37018-3.

PMID:
    30679644
    [PubMed - in process]
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Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
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Intra-articular drug delivery systems for joint diseases.
Rai MF, Pham CT
Curr Opin Pharmacol. 2018 Jun; 4067-73. doi: 10.1016/j.coph.2018.03.013.

PMID:
    29625332
    [PubMed - indexed for MEDLINE]
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Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.
Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA
J Immunol. 2018 Apr 15; 200(8)2786-2797. doi: 10.4049/jimmunol.1701668.

PMID:
    29531168
    [PubMed - indexed for MEDLINE]
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Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA
PLoS One. 2017; 12(2)e0172105. doi: 10.1371/journal.pone.0172105.

PMID:
    28192517
    [PubMed - indexed for MEDLINE]
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Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O
Circulation. 2016 Oct 18; 134(16)1176-1188.

PMID:
    27660294
    [PubMed - indexed for MEDLINE]
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Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed - in process]
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Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Akk A, Springer LE, Pham CT
Front Immunol. 2016; 7325. doi: 10.3389/fimmu.2016.00325.

PMID:
    27617014
    [PubMed]
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Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Yan H, Zhou HF, Akk A, Hu Y, Springer LE, Ennis TL, Pham CTN
Arterioscler Thromb Vasc Biol. 2016 Aug; 36(8)1660-1669. doi: 10.1161/ATVBAHA.116.307786.

PMID:
    27283739
    [PubMed - indexed for MEDLINE]
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Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA
Mol Med. 2016 May 24; 22doi: 10.2119/molmed.2016.00033.

PMID:
    27261776
    [PubMed - indexed for MEDLINE]
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Anti-complement activity of the Ixodes scapularis salivary protein Salp20.
Hourcade DE, Akk AM, Mitchell LM, Zhou HF, Hauhart R, Pham CT
Mol Immunol. 2016 Jan; 6962-9. doi: 10.1016/j.molimm.2015.11.008.

PMID:
    26675068
    [PubMed - indexed for MEDLINE]
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Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.
Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1)85-106. doi: 10.1002/wnan.1355.

PMID:
    26296541
    [PubMed - indexed for MEDLINE]
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Peptide-siRNA nanotherapeutics in arthritis.
Pham CT, Pan H, Wickline SA
Oncotarget. 2015 Jun 20; 6(17)14731-2.

PMID:
    26142704
    [PubMed - indexed for MEDLINE]
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Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
Yan H, Zhou HF, Hu Y, Pham CT
J Rheum Dis Treat. 2015 Feb 28; 1(1)5.

PMID:
    26120598
    [PubMed]
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Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles.
Jallouk AP, Palekar RU, Marsh JN, Pan H, Pham CT, Schlesinger PH, Wickline SA
Bioconjug Chem. 2015 Aug 19; 26(8)1640-50. doi: 10.1021/acs.bioconjchem.5b00246.

PMID:
    26083278
    [PubMed - indexed for MEDLINE]
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Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.
Palekar RU, Jallouk AP, Goette MJ, Chen J, Myerson JW, Allen JS, Akk A, Yang L, Tu Y, Miller MJ, Pham CT, Wickline SA, Pan H
FASEB J. 2015 Jul; 29(7)3100-9. doi: 10.1096/fj.14-269084.

PMID:
    25857553
    [PubMed - indexed for MEDLINE]
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Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesis.
Bertram P, Akk AM, Zhou HF, Mitchell LM, Pham CT, Hourcade DE
Monoclon Antib Immunodiagn Immunother. 2015 Feb; 34(1)1-6. doi: 10.1089/mab.2014.0066.

PMID:
    25723276
    [PubMed - indexed for MEDLINE]
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Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers.
Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM
Nanomedicine. 2015 Apr; 11(3)601-9. doi: 10.1016/j.nano.2014.12.009.

PMID:
    25652900
    [PubMed - indexed for MEDLINE]
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Physicochemical signatures of nanoparticle-dependent complement activation.
Thomas DG, Chikkagoudar S, Heredia-Langer A, Tardiff MF, Xu Z, Hourcade DE, Pham CT, Lanza GM, Weinberger KQ, Baker NA
Comput Sci Discov. 2014 Mar 21; 7(1)015003.

PMID:
    25254068
    [PubMed]
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Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.
Zhou HF, Yan H, Hu Y, Springer LE, Yang X, Wickline SA, Pan D, Lanza GM, Pham CT
ACS Nano. 2014 Jul 22; 8(7)7305-17. doi: 10.1021/nn502372n.

PMID:
    24941020
    [PubMed - indexed for MEDLINE]
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