Christine Pham, MD

Publication & Research

Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis.
Yan H, Hu Y, Akk A, Rai MF, Pan H, Wickline SA, Pham CTN
Pharmaceutics. 2020 Jan 17; 12(1)pii: E73. doi: 10.3390/pharmaceutics12010073.

PMID:
    31963412
    [PubMed]
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Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.
Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN
Precis Nanomed. 2019; 2(1)245-248. doi: 10.33218/prnano2(1).181129.1.

PMID:
    31681908
    [PubMed]
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Complement activation on neutrophils initiates endothelial adhesion and extravasation.
Akk A, Springer LE, Yang L, Hamilton-Burdess S, Lambris JD, Yan H, Hu Y, Wu X, Hourcade DE, Miller MJ, Pham CTN
Mol Immunol. 2019 Oct; 114629-642. doi: 10.1016/j.molimm.2019.09.011.

PMID:
    31542608
    [PubMed - indexed for MEDLINE]
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Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity.
Guang Y, McGrath TM, Klug N, Nims R, Shih CC, Bayguinov PO, Guilak F, Pham CTN, Fitzpatrick JAJ, Setton LA
J Biomech Eng. 2019 Sep 1; doi: 10.1115/1.4044892.

PMID:
    31536113
    [PubMed - as supplied by publisher]
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Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
Sionov RV, Fainsod-Levi T, Zelter T, Polyansky L, Pham CT, Granot Z
Oncoimmunology. 2019; 8(9)e1624129. doi: 10.1080/2162402X.2019.1624129.

PMID:
    31428521
    [PubMed]
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Applications of RNA interference in the treatment of arthritis.
Rai MF, Pan H, Yan H, Sandell LJ, Pham CTN, Wickline SA
Transl Res. 2019 Dec; 2141-16. doi: 10.1016/j.trsl.2019.07.002.

PMID:
    31351032
    [PubMed - in process]
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Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.
Yan H, Hu Y, Akk A, Ye K, Bacon J, Pham CTN
Sci Rep. 2019 Jul 18; 9(1)10447. doi: 10.1038/s41598-019-46909-y.

PMID:
    31320700
    [PubMed - in process]
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Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.
Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN
J Orthop Res. 2019 Jun; 37(6)1287-1293. doi: 10.1002/jor.24304.

PMID:
    30977548
    [PubMed - indexed for MEDLINE]
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Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.
Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN
Sci Rep. 2019 Jan 24; 9(1)442. doi: 10.1038/s41598-018-37018-3.

PMID:
    30679644
    [PubMed - in process]
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Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
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Intra-articular drug delivery systems for joint diseases.
Rai MF, Pham CT
Curr Opin Pharmacol. 2018 Jun; 4067-73. doi: 10.1016/j.coph.2018.03.013.

PMID:
    29625332
    [PubMed - indexed for MEDLINE]
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Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.
Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA
J Immunol. 2018 Apr 15; 200(8)2786-2797. doi: 10.4049/jimmunol.1701668.

PMID:
    29531168
    [PubMed - indexed for MEDLINE]
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Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.
Dai R, Cowan C, Heid B, Khan D, Liang Z, Pham CT, Ahmed SA
PLoS One. 2017; 12(2)e0172105. doi: 10.1371/journal.pone.0172105.

PMID:
    28192517
    [PubMed - indexed for MEDLINE]
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Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O
Circulation. 2016 Oct 18; 134(16)1176-1188.

PMID:
    27660294
    [PubMed - indexed for MEDLINE]
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Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed - in process]
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Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Akk A, Springer LE, Pham CT
Front Immunol. 2016; 7325. doi: 10.3389/fimmu.2016.00325.

PMID:
    27617014
    [PubMed]
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Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Yan H, Zhou HF, Akk A, Hu Y, Springer LE, Ennis TL, Pham CTN
Arterioscler Thromb Vasc Biol. 2016 Aug; 36(8)1660-1669. doi: 10.1161/ATVBAHA.116.307786.

PMID:
    27283739
    [PubMed - indexed for MEDLINE]
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Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA
Mol Med. 2016 May 24; 22doi: 10.2119/molmed.2016.00033.

PMID:
    27261776
    [PubMed - indexed for MEDLINE]
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Anti-complement activity of the Ixodes scapularis salivary protein Salp20.
Hourcade DE, Akk AM, Mitchell LM, Zhou HF, Hauhart R, Pham CT
Mol Immunol. 2016 Jan; 6962-9. doi: 10.1016/j.molimm.2015.11.008.

PMID:
    26675068
    [PubMed - indexed for MEDLINE]
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Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.
Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1)85-106. doi: 10.1002/wnan.1355.

PMID:
    26296541
    [PubMed - indexed for MEDLINE]
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