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Christina I. Tsien, MD

Professor, Radiation Oncology
Chief, Central Nervouse System (CNS) Service
Director, Clinical Research

Specialty Areas

Radiation Oncology
Brain Tumors
Gamma Knife
Neuro Oncology
Proton Therapy
Stereotactic Body Radiation Therepy
Intensity Modulated Radiation Therapy ( IMRT)

Board Certifications

Radiation Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Brain tumors, gamma knife, proton therapy, stereotactic body radiation therapy

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: LL
Office Phone: 314-747-7236
Fax: 314-362-8521

Education

Education

Medical Degree: McGill University Faculty of Medicine, Montreal, Canada 1995
Residency, Radiation Oncology: McGill University Health Center, Montreal, Canada 2000
Fellowship, Radiation Oncology: University of Michigan, Ann Arbor, MI 2001

Publication & Research

Publication & Research

A rapid, computational approach for assessing interfraction esophageal motion for use in stereotactic body radiation therapy planning.
Cardenas ML, Mazur TR, Tsien CI, Green OL
Adv Radiat Oncol. 2018 Apr-Jun; 3(2)209-215. doi: 10.1016/j.adro.2017.10.003.

PMID:
    29904747
    [PubMed]
Related citations


Progression of Low-Grade Glioma During Pregnancy With Subsequent Regression Postpartum Without Treatment-A Case Report.
Shah AS, Nicoletti LK, Kurtovic E, Tsien CI, Benzinger TLS, Chicoine MR
Neurosurgery. 2018 May 21; doi: 10.1093/neuros/nyy191.

PMID:
    29788426
    [PubMed - as supplied by publisher]
Related citations


Preclinical MRI: Studies of the irradiated brain.
Garbow JR, Tsien CI, Beeman SC
J Magn Reson. 2018 Jul; 29273-81. doi: 10.1016/j.jmr.2018.03.011.

PMID:
    29705034
    [PubMed - in process]
Related citations


Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain.
Yang R, Duan C, Yuan L, Engelbach JA, Tsien CI, Beeman SC, Perez-Torres CJ, Ge X, Rich KM, Ackerman JJH, Garbow JR
Int J Radiat Oncol Biol Phys. 2018 Mar 15; 100(4)1016-1025. doi: 10.1016/j.ijrobp.2017.12.257.

PMID:
    29485043
    [PubMed - in process]
Related citations


Completion of Gamma Knife radiosurgery for AVM treatment after unplanned interruption-technical note.
Raman HS, Santanam L, Vellimana AK, Drzymala RE, Tsien CI, Zipfel GJ
Acta Neurochir (Wien). 2018 Jul; 160(7)1343-1347. doi: 10.1007/s00701-018-3493-0.

PMID:
    29455411
    [PubMed - in process]
Related citations


Standard dose and dose-escalated radiation therapy are associated with favorable survival in select elderly patients with newly diagnosed glioblastoma.
Jackson WC, Tsien CI, Junck L, Leung D, Hervey-Jumper S, Orringer D, Heth J, Wahl DR, Spratt DE, Cao Y, Lawrence TS, Kim MM
J Neurooncol. 2018 May; 138(1)155-162. doi: 10.1007/s11060-018-2782-z.

PMID:
    29388034
    [PubMed - in process]
Related citations


Distant intracranial failure in melanoma brain metastases treated with stereotactic radiosurgery in the era of immunotherapy and targeted agents.
Acharya S, Mahmood M, Mullen D, Yang D, Tsien CI, Huang J, Perkins SM, Rich K, Chicoine M, Leuthardt E, Dowling J, Dunn G, Keller J, Robinson CG, Abraham C
Adv Radiat Oncol. 2017 Oct-Dec; 2(4)572-580. doi: 10.1016/j.adro.2017.07.003.

PMID:
    29204524
    [PubMed]
Related citations


Multiparametric MRI and [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography Imaging Is a Potential Prognostic Imaging Biomarker in Recurrent Glioblastoma.
Hassanzadeh C, Rao YJ, Chundury A, Rowe J, Ponisio MR, Sharma A, Miller-Thomas M, Tsien CI, Ippolito JE
Front Oncol. 2017; 7178. doi: 10.3389/fonc.2017.00178.

PMID:
    28868256
    [PubMed]
Related citations


Blood-tumor barrier opening changes in brain metastases from pre to one-month post radiation therapy.
Teng F, Tsien CI, Lawrence TS, Cao Y
Radiother Oncol. 2017 Oct; 125(1)89-93. doi: 10.1016/j.radonc.2017.08.006.

PMID:
    28835339
    [PubMed - indexed for MEDLINE]
Related citations


Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.
Duan C, Perez-Torres CJ, Yuan L, Engelbach JA, Beeman SC, Tsien CI, Rich KM, Schmidt RE, Ackerman JJH, Garbow JR
J Neurooncol. 2017 May; 133(1)9-16. doi: 10.1007/s11060-017-2410-3.

PMID:
    28425047
    [PubMed - indexed for MEDLINE]
Related citations


Impact of concurrent chemotherapy with radiation therapy for elderly patients with newly diagnosed glioblastoma: a review of the National Cancer Data Base.
Huang J, Samson P, Perkins SM, Ansstas G, Chheda MG, DeWees TA, Tsien CI, Robinson CG, Campian JL
J Neurooncol. 2017 Feb; 131(3)593-601. doi: 10.1007/s11060-016-2331-6.

PMID:
    27844308
    [PubMed - indexed for MEDLINE]
Related citations


Molecular and histologic characteristics of pseudoprogression in diffuse gliomas.
Lin AL, White M, Miller-Thomas MM, Fulton RS, Tsien CI, Rich KM, Schmidt RE, Tran DD, Dahiya S
J Neurooncol. 2016 Dec; 130(3)529-533.

PMID:
    27704386
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.
Chapman CH, Zhu T, Nazem-Zadeh M, Tao Y, Buchtel HA, Tsien CI, Lawrence TS, Cao Y
Radiother Oncol. 2016 Aug; 120(2)234-40. doi: 10.1016/j.radonc.2016.06.021.

PMID:
    27418525
    [PubMed - indexed for MEDLINE]
Related citations


A phase I study to repurpose disulfiram in combination with temozolomide to treat newly diagnosed glioblastoma after chemoradiotherapy.
Huang J, Campian JL, Gujar AD, Tran DD, Lockhart AC, DeWees TA, Tsien CI, Kim AH
J Neurooncol. 2016 Jun; 128(2)259-66. doi: 10.1007/s11060-016-2104-2.

PMID:
    26966095
    [PubMed - indexed for MEDLINE]
Related citations


Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study.
Kim MM, Camelo-Piragua S, Schipper M, Tao Y, Normolle D, Junck L, Mammoser A, Betz BL, Cao Y, Kim CJ, Heth J, Sagher O, Lawrence TS, Tsien CI
Int J Radiat Oncol Biol Phys. 2016 Feb 1; 94(2)305-11. doi: 10.1016/j.ijrobp.2015.10.032.

PMID:
    26853339
    [PubMed - indexed for MEDLINE]
Related citations


A Radiation-Induced Hippocampal Vascular Injury Surrogate Marker Predicts Late Neurocognitive Dysfunction.
Farjam R, Pramanik P, Aryal MP, Srinivasan A, Chapman CH, Tsien CI, Lawrence TS, Cao Y
Int J Radiat Oncol Biol Phys. 2015 Nov 15; 93(4)908-15. doi: 10.1016/j.ijrobp.2015.08.014.

PMID:
    26530761
    [PubMed - indexed for MEDLINE]
Related citations


Hypercellularity Components of Glioblastoma Identified by High b-Value Diffusion-Weighted Imaging.
Pramanik PP, Parmar HA, Mammoser AG, Junck LR, Kim MM, Tsien CI, Lawrence TS, Cao Y
Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4)811-9. doi: 10.1016/j.ijrobp.2015.02.058.

PMID:
    26104935
    [PubMed - indexed for MEDLINE]
Related citations


Aggressive Myeloid Sarcoma Causing Recurrent Spinal Cord Compression.
Joseph JR, Wilkinson DA, Bailey NG, Lieberman AP, Tsien CI, Orringer DA
World Neurosurg. 2015 Sep; 84(3)866.e7-10. doi: 10.1016/j.wneu.2015.04.017.

PMID:
    25888811
    [PubMed - indexed for MEDLINE]
Related citations


Response-driven imaging biomarkers for predicting radiation necrosis of the brain.
Nazem-Zadeh MR, Chapman CH, Chenevert T, Lawrence TS, Ten Haken RK, Tsien CI, Cao Y
Phys Med Biol. 2014 May 21; 59(10)2535-47. doi: 10.1088/0031-9155/59/10/2535.

PMID:
    24778364
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion abnormality index: a new imaging biomarker for early assessment of tumor response to therapy.
Farjam R, Tsien CI, Feng FY, Hayman JA, Lawrence TS, Cao Y
Pract Radiat Oncol. 2013 Apr-Jun; 3(2 Suppl 1)S5. doi: 10.1016/j.prro.2013.01.018.

PMID:
    24674561
    [PubMed]
Related citations

Areas of Research Interest

Glioblastoma radiation therapy treatment. Imaging biomarkers to improve tumor response assessment and to reduce normal tissue toxicity. Translational research for brain metastases and recurrent glioblastoma.