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Christina I. Tsien, MD

Professor, Radiation Oncology
Chief, Central Nervouse System (CNS) Service
Director, Clinical Research

Specialty Areas

Radiation Oncology
Brain Tumors
Gamma Knife
Neuro Oncology
Proton Therapy
Stereotactic Body Radiation Therepy
Intensity Modulated Radiation Therapy ( IMRT)

Board Certifications

Radiation Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Brain tumors, gamma knife, proton therapy, stereotactic body radiation therapy

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: LL
Office Phone: 314-747-7236
Fax: 314-362-8521

Education

Education

Medical Degree: McGill University Faculty of Medicine, Montreal, Canada 1995
Residency, Radiation Oncology: McGill University Health Center, Montreal, Canada 2000
Fellowship, Radiation Oncology: University of Michigan, Ann Arbor, MI 2001

Publication & Research

Publication & Research

Multiparametric MRI and [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography Imaging Is a Potential Prognostic Imaging Biomarker in Recurrent Glioblastoma.
Hassanzadeh C, Rao YJ, Chundury A, Rowe J, Ponisio MR, Sharma A, Miller-Thomas M, Tsien CI, Ippolito JE
Front Oncol. 2017; 7178. doi: 10.3389/fonc.2017.00178.

PMID:
    28868256
    [PubMed]
Related citations


Blood-tumor barrier opening changes in brain metastases from pre to one-month post radiation therapy.
Teng F, Tsien CI, Lawrence TS, Cao Y
Radiother Oncol. 2017 Aug 20; pii: S0167-8140(17)32513-6. doi: 10.1016/j.radonc.2017.08.006.

PMID:
    28835339
    [PubMed - as supplied by publisher]
Related citations


Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.
Duan C, Perez-Torres CJ, Yuan L, Engelbach JA, Beeman SC, Tsien CI, Rich KM, Schmidt RE, Ackerman JJH, Garbow JR
J Neurooncol. 2017 May; 133(1)9-16. doi: 10.1007/s11060-017-2410-3.

PMID:
    28425047
    [PubMed - in process]
Related citations


Impact of concurrent chemotherapy with radiation therapy for elderly patients with newly diagnosed glioblastoma: a review of the National Cancer Data Base.
Huang J, Samson P, Perkins SM, Ansstas G, Chheda MG, DeWees TA, Tsien CI, Robinson CG, Campian JL
J Neurooncol. 2017 Feb; 131(3)593-601. doi: 10.1007/s11060-016-2331-6.

PMID:
    27844308
    [PubMed - in process]
Related citations


Molecular and histologic characteristics of pseudoprogression in diffuse gliomas.
Lin AL, White M, Miller-Thomas MM, Fulton RS, Tsien CI, Rich KM, Schmidt RE, Tran DD, Dahiya S
J Neurooncol. 2016 Dec; 130(3)529-533.

PMID:
    27704386
    [PubMed - in process]
Related citations


Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.
Chapman CH, Zhu T, Nazem-Zadeh M, Tao Y, Buchtel HA, Tsien CI, Lawrence TS, Cao Y
Radiother Oncol. 2016 Aug; 120(2)234-40. doi: 10.1016/j.radonc.2016.06.021.

PMID:
    27418525
    [PubMed - indexed for MEDLINE]
Related citations


A phase I study to repurpose disulfiram in combination with temozolomide to treat newly diagnosed glioblastoma after chemoradiotherapy.
Huang J, Campian JL, Gujar AD, Tran DD, Lockhart AC, DeWees TA, Tsien CI, Kim AH
J Neurooncol. 2016 Jun; 128(2)259-66. doi: 10.1007/s11060-016-2104-2.

PMID:
    26966095
    [PubMed - in process]
Related citations


Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study.
Kim MM, Camelo-Piragua S, Schipper M, Tao Y, Normolle D, Junck L, Mammoser A, Betz BL, Cao Y, Kim CJ, Heth J, Sagher O, Lawrence TS, Tsien CI
Int J Radiat Oncol Biol Phys. 2016 Feb 1; 94(2)305-11. doi: 10.1016/j.ijrobp.2015.10.032.

PMID:
    26853339
    [PubMed - indexed for MEDLINE]
Related citations


A Radiation-Induced Hippocampal Vascular Injury Surrogate Marker Predicts Late Neurocognitive Dysfunction.
Farjam R, Pramanik P, Aryal MP, Srinivasan A, Chapman CH, Tsien CI, Lawrence TS, Cao Y
Int J Radiat Oncol Biol Phys. 2015 Nov 15; 93(4)908-15. doi: 10.1016/j.ijrobp.2015.08.014.

PMID:
    26530761
    [PubMed - indexed for MEDLINE]
Related citations


Hypercellularity Components of Glioblastoma Identified by High b-Value Diffusion-Weighted Imaging.
Pramanik PP, Parmar HA, Mammoser AG, Junck LR, Kim MM, Tsien CI, Lawrence TS, Cao Y
Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4)811-9. doi: 10.1016/j.ijrobp.2015.02.058.

PMID:
    26104935
    [PubMed - indexed for MEDLINE]
Related citations


Aggressive Myeloid Sarcoma Causing Recurrent Spinal Cord Compression.
Joseph JR, Wilkinson DA, Bailey NG, Lieberman AP, Tsien CI, Orringer DA
World Neurosurg. 2015 Sep; 84(3)866.e7-10. doi: 10.1016/j.wneu.2015.04.017.

PMID:
    25888811
    [PubMed - indexed for MEDLINE]
Related citations


Response-driven imaging biomarkers for predicting radiation necrosis of the brain.
Nazem-Zadeh MR, Chapman CH, Chenevert T, Lawrence TS, Ten Haken RK, Tsien CI, Cao Y
Phys Med Biol. 2014 May 21; 59(10)2535-47. doi: 10.1088/0031-9155/59/10/2535.

PMID:
    24778364
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion abnormality index: a new imaging biomarker for early assessment of tumor response to therapy.
Farjam R, Tsien CI, Feng FY, Hayman JA, Lawrence TS, Cao Y
Pract Radiat Oncol. 2013 Apr-Jun; 3(2 Suppl 1)S5. doi: 10.1016/j.prro.2013.01.018.

PMID:
    24674561
    [PubMed]
Related citations


Ipilimumab and radiation therapy for melanoma brain metastases.
Silk AW, Bassetti MF, West BT, Tsien CI, Lao CD
Cancer Med. 2013 Dec; 2(6)899-906. doi: 10.1002/cam4.140.

PMID:
    24403263
    [PubMed - indexed for MEDLINE]
Related citations


DCE-MRI defined subvolumes of a brain metastatic lesion by principle component analysis and fuzzy-c-means clustering for response assessment of radiation therapy.
Farjam R, Tsien CI, Lawrence TS, Cao Y
Med Phys. 2014 Jan; 41(1)011708. doi: 10.1118/1.4842556.

PMID:
    24387500
    [PubMed - indexed for MEDLINE]
Related citations


Investigation of the diffusion abnormality index as a new imaging biomarker for early assessment of brain tumor response to radiation therapy.
Farjam R, Tsien CI, Feng FY, Gomez-Hassan D, Hayman JA, Lawrence TS, Cao Y
Neuro Oncol. 2014 Jan; 16(1)131-9. doi: 10.1093/neuonc/not153.

PMID:
    24327584
    [PubMed - indexed for MEDLINE]
Related citations


Concurrent whole brain radiotherapy and bortezomib for brain metastasis.
Lao CD, Friedman J, Tsien CI, Normolle DP, Chapman C, Cao Y, Lee O, Schipper M, Van Poznak C, Hamstra D, Lawrence T, Hayman J, Redman BG
Radiat Oncol. 2013 Aug 21; 8204. doi: 10.1186/1748-717X-8-204.

PMID:
    23965287
    [PubMed - indexed for MEDLINE]
Related citations


Uncertainty in assessment of radiation-induced diffusion index changes in individual patients.
Nazem-Zadeh MR, Chapman CH, Lawrence TS, Tsien CI, Cao Y
Phys Med Biol. 2013 Jun 21; 58(12)4277-96. doi: 10.1088/0031-9155/58/12/4277.

PMID:
    23732399
    [PubMed - indexed for MEDLINE]
Related citations


Regional variation in brain white matter diffusion index changes following chemoradiotherapy: a prospective study using tract-based spatial statistics.
Chapman CH, Nazem-Zadeh M, Lee OE, Schipper MJ, Tsien CI, Lawrence TS, Cao Y
PLoS One. 2013; 8(3)e57768. doi: 10.1371/journal.pone.0057768.

PMID:
    23469234
    [PubMed - indexed for MEDLINE]
Related citations


Physiological imaging-defined, response-driven subvolumes of a tumor.
Farjam R, Tsien CI, Feng FY, Gomez-Hassan D, Hayman JA, Lawrence TS, Cao Y
Int J Radiat Oncol Biol Phys. 2013 Apr 1; 85(5)1383-90. doi: 10.1016/j.ijrobp.2012.10.036.

PMID:
    23257692
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Glioblastoma radiation therapy treatment. Imaging biomarkers to improve tumor response assessment and to reduce normal tissue toxicity. Translational research for brain metastases and recurrent glioblastoma.