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Faculty Physicians

Christina A. Gurnett, MD, PhD

Associate Professor, Neurology
Division of Pediatric Neurology

Specialty Areas

Pediatric Neurology
EEG
Pediatric Epilepsy

Board Certifications

Pediatric Neurology
Neurology
Clinical Neurophysiology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric neurological disorders, epilepsy, neurogenetic disorders, musculoskeletal disorders.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C/D
Floor: 2nd floor
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Pediatric Epilepsy, St. Louis Children's Hospital, St. Louis, Missouri 2004
Fellowship: Pediatric Neurology, St Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2003
Residency: Pediatrics, University of Iowa, Iowa City, Iowa 2000
Ph.D.: Physiology and Biophysics, University of Iowa, Iowa City, Iowa 1998
B.S.: Biology, University of Notre Dame, Notre Dame, Indiana 1991
Medical Degree: University of Iowa, Iowa City, Iowa 1998

Publication & Research

Publication & Research

De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.
Buchan JG, Gray RS, Gansner JM, Alvarado DM, Burgert L, Gitlin JD, Gurnett CA, Goldsmith MI
Dev Dyn. 2014 Dec; 243(12)1646-57. doi: 10.1002/dvdy.24208.

PMID:
    25283277
    [PubMed - indexed for MEDLINE]
Related citations


Are copy number variants associated with adolescent idiopathic scoliosis?
Buchan JG, Alvarado DM, Haller G, Aferol H, Miller NH, Dobbs MB, Gurnett CA
Clin Orthop Relat Res. 2014 Oct; 472(10)3216-25. doi: 10.1007/s11999-014-3766-8.

PMID:
    25005481
    [PubMed - indexed for MEDLINE]
Related citations


Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.
Buchan JG, Alvarado DM, Haller GE, Cruchaga C, Harms MB, Zhang T, Willing MC, Grange DK, Braverman AC, Miller NH, Morcuende JA, Tang NL, Lam TP, Ng BK, Cheng JC, Dobbs MB, Gurnett CA
Hum Mol Genet. 2014 Oct 1; 23(19)5271-82. doi: 10.1093/hmg/ddu224.

PMID:
    24833718
    [PubMed - indexed for MEDLINE]
Related citations


Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.
Alvarado DM, Yang P, Druley TE, Lovett M, Gurnett CA
Nucleic Acids Res. 2014 Jun; 42(10)e82. doi: 10.1093/nar/gku218.

PMID:
    24682816
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide association study identifies new disease loci for isolated clubfoot.
Zhang TX, Haller G, Lin P, Alvarado DM, Hecht JT, Blanton SH, Stephens Richards B, Rice JP, Dobbs MB, Gurnett CA
J Med Genet. 2014 May; 51(5)334-9. doi: 10.1136/jmedgenet-2014-102303.

PMID:
    24667120
    [PubMed - indexed for MEDLINE]
Related citations


Novel SCN3A variants associated with focal epilepsy in children.
Vanoye CG, Gurnett CA, Holland KD, George AL Jr, Kearney JA
Neurobiol Dis. 2014 Feb; 62313-22. doi: 10.1016/j.nbd.2013.10.015.

PMID:
    24157691
    [PubMed - indexed for MEDLINE]
Related citations


Palliative epilepsy surgery in Aicardi syndrome: a case series and review of literature.
Kasasbeh AS, Gurnett CA, Smyth MD
Childs Nerv Syst. 2014 Mar; 30(3)497-503. doi: 10.1007/s00381-013-2259-5.

PMID:
    23948796
    [PubMed - indexed for MEDLINE]
Related citations


BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma.
Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR
Acta Neuropathol. 2013 Jun; 125(6)901-10. doi: 10.1007/s00401-013-1120-y.

PMID:
    23609006
    [PubMed - indexed for MEDLINE]
Related citations


Polygenic threshold model with sex dimorphism in adolescent idiopathic scoliosis: the Carter effect.
Kruse LM, Buchan JG, Gurnett CA, Dobbs MB
J Bone Joint Surg Am. 2012 Aug 15; 94(16)1485-91.

PMID:
    22992817
    [PubMed - indexed for MEDLINE]
Related citations


Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.
Alvarado DM, Buchan JG, Frick SL, Herzenberg JE, Dobbs MB, Gurnett CA
Eur J Hum Genet. 2013 Apr; 21(4)373-80. doi: 10.1038/ejhg.2012.177.

PMID:
    22892537
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.
Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu YH, Ptáček LJ
Cell Rep. 2012 Jan 26; 1(1)2-12. doi: 10.1016/j.celrep.2011.11.001.

PMID:
    22832103
    [PubMed - indexed for MEDLINE]
Related citations


Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle.
Vydyanath A, Gurnett CA, Marston S, Luther PK
J Muscle Res Cell Motil. 2012 May; 33(1)61-74. doi: 10.1007/s10974-012-9286-9.

PMID:
    22415774
    [PubMed - indexed for MEDLINE]
Related citations


Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot.
Weymouth KS, Blanton SH, Bamshad MJ, Beck AE, Alvarez C, Richards S, Gurnett CA, Dobbs MB, Barnes D, Mitchell LE, Hecht JT
Am J Med Genet A. 2011 Sep; 155A(9)2170-9. doi: 10.1002/ajmg.a.34167.

PMID:
    21834041
    [PubMed - indexed for MEDLINE]
Related citations


Genetics of clubfoot.
Dobbs MB, Gurnett CA
J Pediatr Orthop B. 2012 Jan; 21(1)7-9. doi: 10.1097/BPB.0b013e328349927c.

PMID:
    21817922
    [PubMed - indexed for MEDLINE]
Related citations


Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice.
Alvarado DM, McCall K, Aferol H, Silva MJ, Garbow JR, Spees WM, Patel T, Siegel M, Dobbs MB, Gurnett CA
Hum Mol Genet. 2011 Oct 15; 20(20)3943-52. doi: 10.1093/hmg/ddr313.

PMID:
    21775501
    [PubMed - indexed for MEDLINE]
Related citations


Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
McGregor TL, Gurnett CA, Dobbs MB, Wise CA, Morcuende JA, Morgan TM, Menon R, Muglia LJ
BMC Med Genet. 2011 Jul 8; 1292. doi: 10.1186/1471-2350-12-92.

PMID:
    21740577
    [PubMed - indexed for MEDLINE]
Related citations


Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function.
Paciorkowski AR, Thio LL, Rosenfeld JA, Gajecka M, Gurnett CA, Kulkarni S, Chung WK, Marsh ED, Gentile M, Reggin JD, Wheless JW, Balasubramanian S, Kumar R, Christian SL, Marini C, Guerrini R, Maltsev N, Shaffer LG, Dobyns WB
Eur J Hum Genet. 2011 Dec; 19(12)1238-45. doi: 10.1038/ejhg.2011.121.

PMID:
    21694734
    [PubMed - indexed for MEDLINE]
Related citations


Re: Ward K, Ogilvie JW, Singleton MV, et al. Validation of DNA-based prognostic testing to predict spinal curve progression in adolescent idiopathic scoliosis. Spine 2010;35:E1455-64.
Dobbs MB, Gurnett CA
Spine (Phila Pa 1976). 2011 Jul 1; 36(15)1257; author reply 1257. doi: 10.1097/BRS.0b013e31821987ba.

PMID:
    21691188
    [PubMed - indexed for MEDLINE]
Related citations


Exome sequencing identifies an MYH3 mutation in a family with distal arthrogryposis type 1.
Alvarado DM, Buchan JG, Gurnett CA, Dobbs MB
J Bone Joint Surg Am. 2011 Jun 1; 93(11)1045-50. doi: 10.2106/JBJS.J.02004.

PMID:
    21531865
    [PubMed - indexed for MEDLINE]
Related citations