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Faculty Physicians

Christina A. Gurnett, MD, PhD

Associate Professor, Neurology
Division of Pediatric Neurology

Specialty Areas

Pediatric Neurology
EEG
Pediatric Epilepsy

Board Certifications

Pediatric Neurology
Neurology
Clinical Neurophysiology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric neurological disorders, epilepsy, neurogenetic disorders, musculoskeletal disorders.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C/D
Floor: 2nd floor
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Pediatric Epilepsy, St. Louis Children's Hospital, St. Louis, Missouri 2004
Fellowship: Pediatric Neurology, St Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2003
Residency: Pediatrics, University of Iowa, Iowa City, Iowa 2000
Ph.D.: Physiology and Biophysics, University of Iowa, Iowa City, Iowa 1998
B.S.: Biology, University of Notre Dame, Notre Dame, Indiana 1991
Medical Degree: University of Iowa, Iowa City, Iowa 1998

Publication & Research

Publication & Research

Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
Alvarado DM, McCall K, Hecht JT, Dobbs MB, Gurnett CA
J Med Genet. 2016 Jan 4; pii: jmedgenet-2015-103505. doi: 10.1136/jmedgenet-2015-103505.

PMID:
    26729820
    [PubMed - as supplied by publisher]
Related citations


A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis.
Haller G, Alvarado D, Mccall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA
Hum Mol Genet. 2016 Jan 1; 25(1)202-9. doi: 10.1093/hmg/ddv463.

PMID:
    26566670
    [PubMed - in process]
Related citations


Genetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.
Haller G, Alvarado DM, Willing MC, Braverman AC, Bridwell KH, Kelly M, Lenke LG, Luhmann SJ, Gurnett CA, Dobbs MB
J Bone Joint Surg Am. 2015 Sep 2; 97(17)1411-7. doi: 10.2106/JBJS.O.00290.

PMID:
    26333736
    [PubMed - indexed for MEDLINE]
Related citations


Identification of Medically Actionable Secondary Findings in the 1000 Genomes.
Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ
PLoS One. 2015; 10(9)e0135193. doi: 10.1371/journal.pone.0135193.

PMID:
    26332594
    [PubMed - in process]
Related citations


De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis.
Baschal EE, Wethey CI, Swindle K, Baschal RM, Gowan K, Tang NL, Alvarado DM, Haller GE, Dobbs MB, Taylor MR, Gurnett CA, Jones KL, Miller NH
G3 (Bethesda). 2014 Dec 12; 5(2)167-74. doi: 10.1534/g3.114.015669.

PMID:
    25504735
    [PubMed - indexed for MEDLINE]
Related citations


Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.
Buchan JG, Gray RS, Gansner JM, Alvarado DM, Burgert L, Gitlin JD, Gurnett CA, Goldsmith MI
Dev Dyn. 2014 Dec; 243(12)1646-57. doi: 10.1002/dvdy.24208.

PMID:
    25283277
    [PubMed - indexed for MEDLINE]
Related citations


Soft-Tissue Abnormalities Associated with Treatment-Resistant and Treatment-Responsive Clubfoot: Findings of MRI Analysis.
Moon DK, Gurnett CA, Aferol H, Siegel MJ, Commean PK, Dobbs MB
J Bone Joint Surg Am. 2014 Aug 6; 96(15)1249-1256.

PMID:
    25100771
    [PubMed - as supplied by publisher]
Related citations


Are copy number variants associated with adolescent idiopathic scoliosis?
Buchan JG, Alvarado DM, Haller G, Aferol H, Miller NH, Dobbs MB, Gurnett CA
Clin Orthop Relat Res. 2014 Oct; 472(10)3216-25. doi: 10.1007/s11999-014-3766-8.

PMID:
    25005481
    [PubMed - indexed for MEDLINE]
Related citations


Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.
Buchan JG, Alvarado DM, Haller GE, Cruchaga C, Harms MB, Zhang T, Willing MC, Grange DK, Braverman AC, Miller NH, Morcuende JA, Tang NL, Lam TP, Ng BK, Cheng JC, Dobbs MB, Gurnett CA
Hum Mol Genet. 2014 Oct 1; 23(19)5271-82. doi: 10.1093/hmg/ddu224.

PMID:
    24833718
    [PubMed - indexed for MEDLINE]
Related citations


Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.
Alvarado DM, Yang P, Druley TE, Lovett M, Gurnett CA
Nucleic Acids Res. 2014 Jun; 42(10)e82. doi: 10.1093/nar/gku218.

PMID:
    24682816
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide association study identifies new disease loci for isolated clubfoot.
Zhang TX, Haller G, Lin P, Alvarado DM, Hecht JT, Blanton SH, Stephens Richards B, Rice JP, Dobbs MB, Gurnett CA
J Med Genet. 2014 May; 51(5)334-9. doi: 10.1136/jmedgenet-2014-102303.

PMID:
    24667120
    [PubMed - indexed for MEDLINE]
Related citations


Novel SCN3A variants associated with focal epilepsy in children.
Vanoye CG, Gurnett CA, Holland KD, George AL Jr, Kearney JA
Neurobiol Dis. 2014 Feb; 62313-22. doi: 10.1016/j.nbd.2013.10.015.

PMID:
    24157691
    [PubMed - indexed for MEDLINE]
Related citations


Palliative epilepsy surgery in Aicardi syndrome: a case series and review of literature.
Kasasbeh AS, Gurnett CA, Smyth MD
Childs Nerv Syst. 2014 Mar; 30(3)497-503. doi: 10.1007/s00381-013-2259-5.

PMID:
    23948796
    [PubMed - indexed for MEDLINE]
Related citations


MYBPC1 mutations impair skeletal muscle function in zebrafish models of arthrogryposis.
Ha K, Buchan JG, Alvarado DM, McCall K, Vydyanath A, Luther PK, Goldsmith MI, Dobbs MB, Gurnett CA
Hum Mol Genet. 2013 Dec 15; 22(24)4967-77. doi: 10.1093/hmg/ddt344.

PMID:
    23873045
    [PubMed - indexed for MEDLINE]
Related citations


BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma.
Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR
Acta Neuropathol. 2013 Jun; 125(6)901-10. doi: 10.1007/s00401-013-1120-y.

PMID:
    23609006
    [PubMed - indexed for MEDLINE]
Related citations


Polygenic threshold model with sex dimorphism in adolescent idiopathic scoliosis: the Carter effect.
Kruse LM, Buchan JG, Gurnett CA, Dobbs MB
J Bone Joint Surg Am. 2012 Aug 15; 94(16)1485-91.

PMID:
    22992817
    [PubMed - indexed for MEDLINE]
Related citations


Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.
Alvarado DM, Buchan JG, Frick SL, Herzenberg JE, Dobbs MB, Gurnett CA
Eur J Hum Genet. 2013 Apr; 21(4)373-80. doi: 10.1038/ejhg.2012.177.

PMID:
    22892537
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.
Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu YH, Ptáček LJ
Cell Rep. 2012 Jan 26; 1(1)2-12. doi: 10.1016/j.celrep.2011.11.001.

PMID:
    22832103
    [PubMed - indexed for MEDLINE]
Related citations


Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle.
Vydyanath A, Gurnett CA, Marston S, Luther PK
J Muscle Res Cell Motil. 2012 May; 33(1)61-74. doi: 10.1007/s10974-012-9286-9.

PMID:
    22415774
    [PubMed - indexed for MEDLINE]
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