Patient Portal

Christina A. Gurnett, MD, PhD

Professor of Neurology, Pediatrics
A. Ernest and Jane G. Stein Professor of Developmental Neurology
Director, Division of Pediatric and Developmental Neurology
Neurologist-in-Chief, St Louis Children’s Hospital

Specialty Areas

Pediatric Neurology
EEG
Pediatric Epilepsy

Board Certifications

Pediatric Neurology
Neurology
Clinical Neurophysiology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric neurological disorders, epilepsy, neurogenetic disorders, musculoskeletal disorders.

  • Location(s)
  • Education
  • Publication & Research
  • Videos

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite C/D
Floor: 2nd floor
Office Phone: 314-454-6120
Fax: 314-454-2523

Education

Education

Fellowship: Pediatric Epilepsy, St. Louis Children's Hospital, St. Louis, Missouri 2004
Fellowship: Pediatric Neurology, St Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2003
Residency: Pediatrics, University of Iowa, Iowa City, Iowa 2000
Ph.D.: Physiology and Biophysics, University of Iowa, Iowa City, Iowa 1998
B.S.: Biology, University of Notre Dame, Notre Dame, Indiana 1991
Medical Degree: University of Iowa, Iowa City, Iowa 1998

Publication & Research

Publication & Research

The genetics of isolated and syndromic clubfoot.
Sadler B, Gurnett CA, Dobbs MB
J Child Orthop. 2019 Jun 1; 13(3)238-244. doi: 10.1302/1863-2548.13.190063.

PMID:
    31312262
    [PubMed]
Related citations


Distal chromosome 16p11.2 duplications containing <i>SH2B1</i> in patients with scoliosis.
Sadler B, Haller G, Antunes L, Bledsoe X, Morcuende J, Giampietro P, Raggio C, Miller N, Kidane Y, Wise CA, Amarillo I, Walton N, Seeley M, Johnson D, Jenkins C, Jenkins T, Oetjens M, Tong RS, Druley TE, Dobbs MB, Gurnett CA
J Med Genet. 2019 Jul; 56(7)427-433. doi: 10.1136/jmedgenet-2018-105877.

PMID:
    30803986
    [PubMed - in process]
Related citations


Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.
Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS
PLoS Genet. 2018 Nov; 14(11)e1007817. doi: 10.1371/journal.pgen.1007817.

PMID:
    30475797
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.
Khanshour AM, Kou I, Fan Y, Einarsdottir E, Makki N, Kidane YH, Kere J, Grauers A, Johnson TA, Paria N, Patel C, Singhania R, Kamiya N, Takeda K, Otomo N, Watanabe K, Luk KDK, Cheung KMC, Herring JA, Rios JJ, Ahituv N, Gerdhem P, Gurnett CA, Song YQ, Ikegawa S, Wise CA
Hum Mol Genet. 2018 Nov 15; 27(22)3986-3998. doi: 10.1093/hmg/ddy306.

PMID:
    30395268
    [PubMed - indexed for MEDLINE]
Related citations


A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.
Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA
Nat Commun. 2018 Oct 9; 9(1)4171. doi: 10.1038/s41467-018-06705-0.

PMID:
    30301978
    [PubMed - indexed for MEDLINE]
Related citations


De novo KCNA1 variants in the PVP motif cause infantile epileptic encephalopathy and cognitive impairment similar to recurrent KCNA2 variants.
Rogers A, Golumbek P, Cellini E, Doccini V, Guerrini R, Wallgren-Pettersson C, Thuresson AC, Gurnett CA
Am J Med Genet A. 2018 Aug; 176(8)1748-1752. doi: 10.1002/ajmg.a.38840.

PMID:
    30055040
    [PubMed - indexed for MEDLINE]
Related citations


Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.
Giampietro PF, Pourquie O, Raggio C, Ikegawa S, Turnpenny PD, Gray R, Dunwoodie SL, Gurnett CA, Alman B, Cheung K, Kusumi K, Hadley-Miller N, Wise CA
Am J Med Genet A. 2018 Jan; 176(1)253-256. doi: 10.1002/ajmg.a.38550.

PMID:
    29159998
    [PubMed - indexed for MEDLINE]
Related citations


Missense variants in the chromatin remodeler <i>CHD1</i> are associated with neurodevelopmental disability.
Pilarowski GO, Vernon HJ, Applegate CD, Boukas L, Cho MT, Gurnett CA, Benke PJ, Beaver E, Heeley JM, Medne L, Krantz ID, Azage M, Niyazov D, Henderson LB, Wentzensen IM, Baskin B, Sacoto MJG, Bowman GD, Bjornsson HT
J Med Genet. 2018 Aug; 55(8)561-566. doi: 10.1136/jmedgenet-2017-104759.

PMID:
    28866611
    [PubMed - in process]
Related citations


Lack of joint hypermobility increases the risk of surgery in adolescent idiopathic scoliosis.
Haller G, Zabriskie H, Spehar S, Kuensting T, Bledsoe X, Syed A, Gurnett CA, Dobbs MB
J Pediatr Orthop B. 2018 Mar; 27(2)152-158. doi: 10.1097/BPB.0000000000000489.

PMID:
    28777161
    [PubMed - indexed for MEDLINE]
Related citations


Scoliosis severity does not impact the risk of scoliosis in family members.
Rudnick SB, Zabriskie H, Ho J, Gurnett CA, Dobbs MB
J Pediatr Orthop B. 2018 Mar; 27(2)147-151. doi: 10.1097/BPB.0000000000000473.

PMID:
    28628580
    [PubMed - indexed for MEDLINE]
Related citations


The 2017 ABJS Nicolas Andry Award: Advancing Personalized Medicine for Clubfoot Through Translational Research.
Dobbs MB, Gurnett CA
Clin Orthop Relat Res. 2017 Jun; 475(6)1716-1725. doi: 10.1007/s11999-017-5290-0.

PMID:
    28236079
    [PubMed - indexed for MEDLINE]
Related citations


Massively parallel single-nucleotide mutagenesis using reversibly terminated inosine.
Haller G, Alvarado D, McCall K, Mitra RD, Dobbs MB, Gurnett CA
Nat Methods. 2016 Nov; 13(11)923-924. doi: 10.1038/nmeth.4015.

PMID:
    27694911
    [PubMed - indexed for MEDLINE]
Related citations


Design and descriptive data of the randomized Clubfoot Foot Abduction Brace Length of Treatment Study (FAB24).
Dobbs MB, Frick SL, Mosca VS, Raney E, VanBosse HJ, Lerman JA, Talwalkar VR, Steger-May K, Gurnett CA
J Pediatr Orthop B. 2017 Mar; 26(2)101-107. doi: 10.1097/BPB.0000000000000387.

PMID:
    27632641
    [PubMed - indexed for MEDLINE]
Related citations


Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
Alvarado DM, McCall K, Hecht JT, Dobbs MB, Gurnett CA
J Med Genet. 2016 Apr; 53(4)250-5. doi: 10.1136/jmedgenet-2015-103505.

PMID:
    26729820
    [PubMed - indexed for MEDLINE]
Related citations


A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis.
Haller G, Alvarado D, Mccall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA
Hum Mol Genet. 2016 Jan 1; 25(1)202-9. doi: 10.1093/hmg/ddv463.

PMID:
    26566670
    [PubMed - indexed for MEDLINE]
Related citations


Genetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.
Haller G, Alvarado DM, Willing MC, Braverman AC, Bridwell KH, Kelly M, Lenke LG, Luhmann SJ, Gurnett CA, Dobbs MB
J Bone Joint Surg Am. 2015 Sep 2; 97(17)1411-7. doi: 10.2106/JBJS.O.00290.

PMID:
    26333736
    [PubMed - indexed for MEDLINE]
Related citations


Identification of Medically Actionable Secondary Findings in the 1000 Genomes.
Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ
PLoS One. 2015; 10(9)e0135193. doi: 10.1371/journal.pone.0135193.

PMID:
    26332594
    [PubMed - indexed for MEDLINE]
Related citations


De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


Adolescent idiopathic scoliosis.
Cheng JC, Castelein RM, Chu WC, Danielsson AJ, Dobbs MB, Grivas TB, Gurnett CA, Luk KD, Moreau A, Newton PO, Stokes IA, Weinstein SL, Burwell RG
Nat Rev Dis Primers. 2015 Sep 24; 115030. doi: 10.1038/nrdp.2015.30.

PMID:
    27188385
    [PubMed - indexed for MEDLINE]
Related citations


Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis.
Baschal EE, Wethey CI, Swindle K, Baschal RM, Gowan K, Tang NL, Alvarado DM, Haller GE, Dobbs MB, Taylor MR, Gurnett CA, Jones KL, Miller NH
G3 (Bethesda). 2014 Dec 12; 5(2)167-74. doi: 10.1534/g3.114.015669.

PMID:
    25504735
    [PubMed - indexed for MEDLINE]
Related citations

Videos

Videos