Patient Portal

Charles S. Eby, MD

Professor, Pathology & Immunology
Professor, Medicine
Associate Chief, Division of Laboratory and Genomic Medicine

Specialty Areas

Pathology
Blood Bank and Transfusion Medicine

Board Certifications

Medical Oncology
Pathology - Transfusion Medicine
Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Benign clinical and laboratory hematology; coagulation hemostasis, anticoagulation anemia thrombocytopenia

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

Chief Resident, Medicine: Strong Memorial Hospital, Rochester, NY 1985
Fellowship, Medical Oncology: University of Rochester School of Medicine and Dentistry, Rochester, NY 1986
Fellowship, Hematology: University of Rochester School of Medicine and Dentistry, Rochester, NY 1987
Fellowship, Transfusion Medicine: Washington University School of Medicine, St. Louis, MO 1991
Bachelor of Science, Zoology: Duke University, Durham, NC 1977
Medical Degree: Vanderbilt University, Nashville, TN 1981
Residency, Internal Medicine: Strong Memorial Hospital, Rochester, NY 1984

Publication & Research

Publication & Research

Heartland Virus and Hemophagocytic Lymphohistiocytosis in Immunocompromised Patient, Missouri, USA.
Carlson AL, Pastula DM, Lambert AJ, Staples JE, Muehlenbachs A, Turabelidze G, Eby CS, Keller J, Hess B, Buller RS, Storch GA, Byrnes K, Dehner L, Kirmani N, Kuhlmann FM
Emerg Infect Dis. 2018 May; 24(5)893-897. doi: 10.3201/eid2405.171802.

PMID:
    29664369
    [PubMed - in process]
Related citations


Genotype vs Clinically Guided Dosing of Warfarin to Prevent Adverse Events-Reply.
Gage BF, Bass AR, Eby CS
JAMA. 2018 Mar 27; 319(12)1279-1280. doi: 10.1001/jama.2018.0195.

PMID:
    29584836
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial.
Gage BF, Bass AR, Lin H, Woller SC, Stevens SM, Al-Hammadi N, Li J, Rodríguez T Jr, Miller JP, McMillin GA, Pendleton RC, Jaffer AK, King CR, Whipple BD, Porche-Sorbet R, Napoli L, Merritt K, Thompson AM, Hyun G, Anderson JL, Hollomon W, Barrack RL, Nunley RM, Moskowitz G, Dávila-Román V, Eby CS
JAMA. 2017 Sep 26; 318(12)1115-1124. doi: 10.1001/jama.2017.11469.

PMID:
    28973620
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Eby CS
Clin Chem. 2017 Sep; 63(9)1444-1445. doi: 10.1373/clinchem.2016.269498.

PMID:
    28848027
    [PubMed - in process]
Related citations


Elevated serum ferritin is not specific for hemophagocytic lymphohistiocytosis.
Otrock ZK, Hock KG, Riley SB, de Witte T, Eby CS, Scott MG
Ann Hematol. 2017 Oct; 96(10)1667-1672. doi: 10.1007/s00277-017-3072-0.

PMID:
    28762079
    [PubMed - indexed for MEDLINE]
Related citations


Diagnostic Challenges of Hemophagocytic Lymphohistiocytosis.
Otrock ZK, Daver N, Kantarjian HM, Eby CS
Clin Lymphoma Myeloma Leuk. 2017 Jul; 17SS105-S110. doi: 10.1016/j.clml.2017.02.017.

PMID:
    28760295
    [PubMed - indexed for MEDLINE]
Related citations


Safety and collection efficiency with a lower transfusion threshold for extracorporeal photopheresis in adult patients with graft-versus-host disease.
Liu C, Schindler E, LeRoy M, Martin-Bredahl K, Dino M, Shah K, Dynis M, Eby CS, Grossman BJ
Vox Sang. 2017 May; 112(4)379-387. doi: 10.1111/vox.12504.

PMID:
    28271523
    [PubMed - indexed for MEDLINE]
Related citations


Triangulating Dynamic of Clinical Laboratory Testing.
Weinert K, Gyorda P, Rifai N, Evans S, Kaufman HW, Eby CS, Ashwood ER, Moore N
Clin Chem. 2015 Nov; 61(11)1320-7. doi: 10.1373/clinchem.2015.248112.

PMID:
    26378064
    [PubMed - indexed for MEDLINE]
Related citations


Ehrlichia-Induced Hemophagocytic Lymphohistiocytosis: A Case Series and Review of Literature.
Otrock ZK, Gonzalez MD, Eby CS
Blood Cells Mol Dis. 2015 Oct; 55(3)191-3. doi: 10.1016/j.bcmd.2015.06.009.

PMID:
    26227842
    [PubMed - indexed for MEDLINE]
Related citations


Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis.
Otrock ZK, Eby CS
Am J Hematol. 2015 Mar; 90(3)220-4. doi: 10.1002/ajh.23911.

PMID:
    25469675
    [PubMed - indexed for MEDLINE]
Related citations


A randomized phase II trial investigating the effect of platelet function inhibition on circulating tumor cells in patients with metastatic breast cancer.
Roop RP, Naughton MJ, Van Poznak C, Schneider JG, Lammers PE, Pluard TJ, Johnson F, Eby CS, Weilbaecher KN
Clin Breast Cancer. 2013 Dec; 13(6)409-15. doi: 10.1016/j.clbc.2013.08.006.

PMID:
    24267729
    [PubMed - indexed for MEDLINE]
Related citations


A pharmacogenetic versus a clinical algorithm for warfarin dosing.
Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF, Rosenberg YD, Eby CS, Madigan RA, McBane RB, Abdel-Rahman SZ, Stevens SM, Yale S, Mohler ER 3rd, Fang MC, Shah V, Horenstein RB, Limdi NA, Muldowney JA 3rd, Gujral J, Delafontaine P, Desnick RJ, Ortel TL, Billett HH, Pendleton RC, Geller NL, Halperin JL, Goldhaber SZ, Caldwell MD, Califf RM, Ellenberg JH, COAG Investigators.
N Engl J Med. 2013 Dec 12; 369(24)2283-93. doi: 10.1056/NEJMoa1310669.

PMID:
    24251361
    [PubMed - indexed for MEDLINE]
Related citations


Rationale and design of the Clarification of Optimal Anticoagulation through Genetics trial.
Kimmel SE, French B, Anderson JL, Gage BF, Johnson JA, Rosenberg YD, Geller NL, Kasner SE, Eby CS, Joo J, Caldwell MD, Goldhaber SZ, Hart RG, Cifelli D, Madigan R, Brensinger CM, Goldberg S, Califf RM, Ellenberg JH
Am Heart J. 2013 Sep; 166(3)435-41. doi: 10.1016/j.ahj.2013.04.009.

PMID:
    24016491
    [PubMed - indexed for MEDLINE]
Related citations


D-dimer: simple test, tough problems.
Olson JD, Cunningham MT, Higgins RA, Eby CS, Brandt JT
Arch Pathol Lab Med. 2013 Aug; 137(8)1030-8. doi: 10.5858/arpa.2012-0296-CP.

PMID:
    23899057
    [PubMed - indexed for MEDLINE]
Related citations


Warfarin replacements: good for patients, challenging for laboratories.
Eby CS
Clin Chem. 2013 May; 59(5)732-4. doi: 10.1373/clinchem.2013.203174.

PMID:
    23487173
    [PubMed - indexed for MEDLINE]
Related citations


Linear relationship between lymphocyte counts in peripheral blood and buffy coat collected during extracorporeal photopheresis.
Liu C, Shah K, Dynis M, Eby CS, Grossman BJ
Transfusion. 2013 Nov; 53(11)2635-43. doi: 10.1111/trf.12114.

PMID:
    23414109
    [PubMed - indexed for MEDLINE]
Related citations


External quality assurance of fibrinogen assays using normal plasma: results of the 2008 College of American Pathologists proficiency testing program in coagulation.
Cunningham MT, Olson JD, Chandler WL, Van Cott EM, Eby CS, Teruya J, Hollensead SC, Adcock DM, Allison PM, Kottke-Marchant KK, Smith MD
Arch Pathol Lab Med. 2012 Jul; 136(7)789-95. doi: 10.5858/arpa.2011-0322-OA.

PMID:
    22742551
    [PubMed - indexed for MEDLINE]
Related citations


Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy.
Horne BD, Lenzini PA, Wadelius M, Jorgensen AL, Kimmel SE, Ridker PM, Eriksson N, Anderson JL, Pirmohamed M, Limdi NA, Pendleton RC, McMillin GA, Burmester JK, Kurnik D, Stein CM, Caldwell MD, Eby CS, Rane A, Lindh JD, Shin JG, Kim HS, Angchaisuksiri P, Glynn RJ, Kronquist KE, Carlquist JF, Grice GR, Barrack RL, Li J, Gage BF
Thromb Haemost. 2012 Feb; 107(2)232-40. doi: 10.1160/TH11-06-0388.

PMID:
    22186998
    [PubMed - indexed for MEDLINE]
Related citations


Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study design.
Do EJ, Lenzini P, Eby CS, Bass AR, McMillin GA, Stevens SM, Woller SC, Pendleton RC, Anderson JL, Proctor P, Nunley RM, Davila-Roman V, Gage BF
Pharmacogenomics J. 2012 Oct; 12(5)417-24. doi: 10.1038/tpj.2011.18.

PMID:
    21606949
    [PubMed - indexed for MEDLINE]
Related citations


External quality assurance of antithrombin, protein C, and protein s assays: results of the College of American Pathologists proficiency testing program in thrombophilia.
Cunningham MT, Olson JD, Chandler WL, Van Cott EM, Eby CS, Teruya J, Hollensead SC, Adcock DM, Allison PM, Kottke-Marchant KK, Smith MD
Arch Pathol Lab Med. 2011 Feb; 135(2)227-32. doi: 10.1043/1543-2165-135.2.227.

PMID:
    21284443
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Bayer - Arnold Porter Law

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018


Company Name: Boehringer - Covington & Bur Law

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2018