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Charles F. Zorumski, MD

Samuel B. Guze Professor and Head of Psychiatry
Professor of Neurobiology

Specialty Areas

Adult Psychiatry

Board Certifications

Psychiatry

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Electroconvulsive therapy, brain stimulation methods, electrophysiology, exitotoxic neuronal damage and neuropsychiatric disorders

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Renard Hospital Building

4940 Children's Place
St. Louis, MO 63110

Suite: Room 2208
Office Phone: 314-747-2680
Fax: 314-747-2682

Education

Education

Residency: Washington University School of Medicine, St. Louis, Missouri 1982
Medical Degree: St. Louis University, St. Louis, Missouri 1978
Bachelor of Art: St. Louis University, St. Louis, Missouri 1974

Publication & Research

Publication & Research

Effect of electrical parameters on ECT convulsive threshold and duration.
Isenberg KE, Dinwiddie S, Heath AC, Osborne V, Tepper M, Jarvis M, Spitznagel EL, Zorumski CF, North CS
Ann Clin Psychiatry. 2016 May; 28(2)105-16.

PMID:
    27285391
    [PubMed - in process]
Related citations


Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats.
Stein LR, O'Dell KA, Funatsu M, Zorumski CF, Izumi Y
Neuroscience. 2016 Aug 4; 329294-305. doi: 10.1016/j.neuroscience.2016.05.020.

PMID:
    27208617
    [PubMed - in process]
Related citations


A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition.
Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S
Neuropharmacology. 2016 Sep; 108193-206. doi: 10.1016/j.neuropharm.2016.04.031.

PMID:
    27114255
    [PubMed - in process]
Related citations


GABA and Endocannabinoids Mediate Depotentiation of Schaffer Collateral Synapses Induced by Stimulation of Temperoammonic Inputs.
Izumi Y, Zorumski CF
PLoS One. 2016; 11(2)e0149034. doi: 10.1371/journal.pone.0149034.

PMID:
    26862899
    [PubMed - in process]
Related citations


Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.
Sun MY, Izumi Y, Benz A, Zorumski CF, Mennerick S
J Neurophysiol. 2016 Mar; 115(3)1263-72. doi: 10.1152/jn.00890.2015.

PMID:
    26745248
    [PubMed - in process]
Related citations


Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.
Zorumski CF, Nagele P, Mennerick S, Conway CR
Front Psychiatry. 2015; 6172. doi: 10.3389/fpsyt.2015.00172.

PMID:
    26696909
    [PubMed]
Related citations


Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors.
Stein LR, Zorumski CF, Imai S, Izumi Y
Brain Res Bull. 2015 Oct; 119(Pt A)41-51. doi: 10.1016/j.brainresbull.2015.10.005.

PMID:
    26481044
    [PubMed - in process]
Related citations


Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis.
Izumi Y, O'Dell KA, Zorumski CF
Front Cell Neurosci. 2015; 9254. doi: 10.3389/fncel.2015.00254.

PMID:
    26190975
    [PubMed]
Related citations


Experimentally Induced Mammalian Models of Glaucoma.
Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
Biomed Res Int. 2015; 2015281214. doi: 10.1155/2015/281214.

PMID:
    26064891
    [PubMed - indexed for MEDLINE]
Related citations


Quantification of bursting and synchrony in cultured hippocampal neurons.
Eisenman LN, Emnett CM, Mohan J, Zorumski CF, Mennerick S
J Neurophysiol. 2015 Aug; 114(2)1059-71. doi: 10.1152/jn.00079.2015.

PMID:
    26041823
    [PubMed - indexed for MEDLINE]
Related citations


24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.
Sun MY, Linsenbardt AJ, Emnett CM, Eisenman LN, Izumi Y, Zorumski CF, Mennerick S
Neuroscientist. 2016 Apr; 22(2)132-44. doi: 10.1177/1073858414568122.

PMID:
    25628343
    [PubMed - in process]
Related citations


Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR
Biol Psychiatry. 2015 Jul 1; 78(1)10-8. doi: 10.1016/j.biopsych.2014.11.016.

PMID:
    25577164
    [PubMed - indexed for MEDLINE]
Related citations


Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
Izumi Y, Zorumski CF
J Pharmacol Exp Ther. 2015 Feb; 352(2)267-73. doi: 10.1124/jpet.114.220582.

PMID:
    25413830
    [PubMed - indexed for MEDLINE]
Related citations


Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model.
Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
Invest Ophthalmol Vis Sci. 2014 Nov 18; 55(12)8531-41. doi: 10.1167/iovs.14-15624.

PMID:
    25406290
    [PubMed - indexed for MEDLINE]
Related citations


Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.
Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S
Br J Pharmacol. 2015 Mar; 172(5)1333-47. doi: 10.1111/bph.13007.

PMID:
    25377730
    [PubMed - indexed for MEDLINE]
Related citations


Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function.
Izumi Y, Zorumski CF
Neuropharmacology. 2014 Nov; 86273-81. doi: 10.1016/j.neuropharm.2014.08.002.

PMID:
    25128848
    [PubMed - indexed for MEDLINE]
Related citations


Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S
Neuropharmacology. 2014 Oct; 85232-42. doi: 10.1016/j.neuropharm.2014.05.027.

PMID:
    24878244
    [PubMed - indexed for MEDLINE]
Related citations


Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.
Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S
J Neurosci. 2014 Apr 23; 34(17)5800-15. doi: 10.1523/JNEUROSCI.4730-13.2014.

PMID:
    24760840
    [PubMed - indexed for MEDLINE]
Related citations


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.
Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS
Psychopharmacology (Berl). 2014 Sep; 231(17)3479-91. doi: 10.1007/s00213-014-3568-4.

PMID:
    24756762
    [PubMed - indexed for MEDLINE]
Related citations


Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus.
Purgert CA, Izumi Y, Jong YJ, Kumar V, Zorumski CF, O'Malley KL
J Neurosci. 2014 Mar 26; 34(13)4589-98. doi: 10.1523/JNEUROSCI.3451-13.2014.

PMID:
    24672004
    [PubMed - indexed for MEDLINE]
Related citations