Patient Portal

Celeste Morley, MD, PhD

Assistant Professor,
Division of Infectious Diseases
Assistant Professor of Pathology & Immunology

Specialty Areas

Pediatric Infectious Disease

Board Certifications

Pediatrics
Pediatric Infectious Diseases

Areas of Clinical Interest

Pediatric infections

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314 454 6050
Fax: 314-454-2836

Education

Education

B.S.(Biology) : Duke University, Durham, NC 1993
PhD, Immunology: Harvard Graduate School of Arts and Sciences, Boston, MA 2002
Residency: Pediatrics, Duke University Medical School Hospitals, Nurham, NC 2005
Fellowship: Infectious Diseases, Washington University School of Medicine, St. Louis, MO 2009
Medical Degree: Harvard Medical School, Boston, MA 2002

Publication & Research

Publication & Research

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.
Lu X, Kugadas A, Smith-Page K, Lamb J, Lin T, Ru Y, Morley SC, Fichorova R, Mittal SK, Chauhan SK, Littleton S, Saban D, Gadjeva M
Front Immunol. 2020; 11547. doi: 10.3389/fimmu.2020.00547.

PMID:
    32318063
    [PubMed - in process]
Related citations


L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction.
Chellaiah MA, Moorer MC, Majumdar S, Aljohani H, Morley SC, Yingling V, Stains JP
Bone Res. 2020; 83. doi: 10.1038/s41413-019-0079-2.

PMID:
    31993243
    [PubMed]
Related citations


The Association of Medications and Vaccination with Risk of Pneumonia in Inflammatory Bowel Disease.
Gregory MH, Ciorba MA, Wiitala WL, Stidham RW, Higgins P, Morley SC, Hou JK, Feagins LA, Govani SM, Cohen-Mekelburg SA, Waljee AK
Inflamm Bowel Dis. 2020 May 12; 26(6)919-925. doi: 10.1093/ibd/izz189.

PMID:
    31504531
    [PubMed - in process]
Related citations


Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia.
Todd EM, Ramani R, Szasz TP, Morley SC
Sci Adv. 2019 Aug; 5(8)eaax3387. doi: 10.1126/sciadv.aax3387.

PMID:
    31453341
    [PubMed - indexed for MEDLINE]
Related citations


Cells under stress: The mechanical environment shapes inflammasome responses to danger signals.
Joshi H, Morley SC
J Leukoc Biol. 2019 Jul; 106(1)119-125. doi: 10.1002/JLB.3MIR1118-417R.

PMID:
    30645000
    [PubMed - indexed for MEDLINE]
Related citations


LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin.
Si M, Goodluck H, Zeng C, Pan S, Todd EM, Morley SC, Qin X, Mohan S, Xing W
J Cell Biochem. 2018 Dec; 119(12)10351-10357. doi: 10.1002/jcb.27377.

PMID:
    30136304
    [PubMed - indexed for MEDLINE]
Related citations


Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
McFarland M, Szasz TP, Zhou JY, Motley K, Sivapalan JS, Isaacson-Schmid M, Todd EM, Hogan PG, Fritz SA, Burnham CD, Hoffmann S, Morley SC
Vaccine. 2017 Aug 3; 35(34)4389-4395. doi: 10.1016/j.vaccine.2017.06.047.

PMID:
    28687405
    [PubMed - indexed for MEDLINE]
Related citations


Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate.
Stewart-Hutchinson PJ, Szasz TP, Jaeger ER, Onken MD, Cooper JA, Morley SC
J Leukoc Biol. 2017 Sep; 102(3)941-948. doi: 10.1189/jlb.1TA0117-008R.

PMID:
    28637896
    [PubMed - indexed for MEDLINE]
Related citations


Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli.
Todd EM, Zhou JY, Szasz TP, Deady LE, D'Angelo JA, Cheung MD, Kim AH, Morley SC
Blood. 2016 Dec 15; 128(24)2785-2796.

PMID:
    27758872
    [PubMed - indexed for MEDLINE]
Related citations


L-Plastin promotes podosome longevity and supports macrophage motility.
Zhou JY, Szasz TP, Stewart-Hutchinson PJ, Sivapalan J, Todd EM, Deady LE, Cooper JA, Onken MD, Morley SC
Mol Immunol. 2016 Oct; 7879-88. doi: 10.1016/j.molimm.2016.08.012.

PMID:
    27614263
    [PubMed - indexed for MEDLINE]
Related citations


Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.
Xu X, Wang X, Todd EM, Jaeger ER, Vella JL, Mooren OL, Feng Y, Hu J, Cooper JA, Morley SC, Huang YH
J Immunol. 2016 Sep 1; 197(5)1683-91. doi: 10.4049/jimmunol.1600874.

PMID:
    27465533
    [PubMed - indexed for MEDLINE]
Related citations


Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia.
Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA
J Infect Dis. 2016 Feb 15; 213(4)649-58. doi: 10.1093/infdis/jiv440.

PMID:
    26347570
    [PubMed - indexed for MEDLINE]
Related citations


Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates.
Zhou JY, Isaacson-Schmid M, Utterson EC, Todd EM, McFarland M, Sivapalan J, Niehoff JM, Burnham CD, Morley SC
Int J Infect Dis. 2015 Oct; 3950-52. doi: 10.1016/j.ijid.2015.08.010.

PMID:
    26327122
    [PubMed - indexed for MEDLINE]
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HIV-1 Nef drives macrophages into hiding.
Morley SC
Blood. 2015 Mar 5; 125(10)1512-3. doi: 10.1182/blood-2015-01-618983.

PMID:
    25745180
    [PubMed - indexed for MEDLINE]
Related citations


L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.
Deady LE, Todd EM, Davis CG, Zhou JY, Topcagic N, Edelson BT, Ferkol TW, Cooper MA, Muenzer JT, Morley SC
Infect Immun. 2014 May; 82(5)1982-93. doi: 10.1128/IAI.01199-13.

PMID:
    24595139
    [PubMed - indexed for MEDLINE]
Related citations


Successful Use of Temocillin as Salvage Therapy for Cervical Osteomyelitis Secondary to Multidrug-Resistant Burkholderia cepacia.
Rodriguez M, Nelson M, Kelly JE, Elward A, Morley SC
J Pediatric Infect Dis Soc. 2014 Mar; 3(1)77-80. doi: 10.1093/jpids/pis110.

PMID:
    26624908
    [PubMed]
Related citations


The actin-bundling protein L-plastin supports T-cell motility and activation.
Morley SC
Immunol Rev. 2013 Nov; 256(1)48-62. doi: 10.1111/imr.12102.

PMID:
    24117812
    [PubMed - indexed for MEDLINE]
Related citations


Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
Todd EM, Deady LE, Morley SC
Eur J Immunol. 2013 Jul; 43(7)1735-44. doi: 10.1002/eji.201242780.

PMID:
    23589339
    [PubMed - indexed for MEDLINE]
Related citations


The actin-bundling protein L-plastin: a critical regulator of immune cell function.
Morley SC
Int J Cell Biol. 2012; 2012935173. doi: 10.1155/2012/935173.

PMID:
    22194750
    [PubMed]
Related citations


The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Todd EM, Deady LE, Morley SC
J Immunol. 2011 Sep 15; 187(6)3015-25. doi: 10.4049/jimmunol.1101033.

PMID:
    21832165
    [PubMed - indexed for MEDLINE]
Related citations