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Catherine E. Cottrell, PhD, FACMG

Assistant Professor of Pathology and Immunology
Medical Director, Genomics and Pathology Services
Associate Director of Cytogenomics and Molecular Pathology

Specialty Areas

Pathology
Cytogenetics

Board Certifications

Clinical Molecular Genetics
Clinical Cytogenetics

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Pathology and immunology, laboratory and genomic medicine, clinical genomics

  • Education
  • Publication & Research

Education

Education

Fellowship, Clinical Cytogenomics: Ohio State University, Columbus, OH 2010
PhD, Biomedical Science: Ohio State University, Columbus, OH 2007
BS, Molecular Genetics: Ohio State University, Columbus, OH 2001
Fellowship, Clinical Molecular Genetics: Ohio State University, Columbus, OH 2009

Publication & Research

Publication & Research

Comprehensive Validation of Cytology Specimens for Next-Generation Sequencing and Clinical Practice Experience.
Balla A, Hampel KJ, Sharma MK, Cottrell CE, Sidiropoulos N
J Mol Diagn. 2018 Jul 5; pii: S1525-1578(17)30592-5. doi: 10.1016/j.jmoldx.2018.06.001.

PMID:
    29981866
    [PubMed - as supplied by publisher]
Related citations


The Effect of Presentation Level on the SCAN-3 in Children and Adults.
Stoody TM, Cottrell CE
Am J Audiol. 2018 Jun 8; 27(2)238-245. doi: 10.1044/2018_AJA-17-0098.

PMID:
    29800988
    [PubMed - in process]
Related citations


Scarring in Patients With PIK3CA-Related Overgrowth Syndromes.
Steiner JE, Cottrell CE, Streicher JL, Jensen JN, King DM, Burrows PE, Siegel DH, Tollefson MM, Drolet BA, Püttgen KB
JAMA Dermatol. 2018 Apr 1; 154(4)452-455. doi: 10.1001/jamadermatol.2017.6189.

PMID:
    29516089
    [PubMed - in process]
Related citations


Genome sequencing identifies somatic <i>BRAF</i> duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma.
Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER
Cold Spring Harb Mol Case Stud. 2018 Apr; 4(2)pii: a002618. doi: 10.1101/mcs.a002618.

PMID:
    29434027
    [PubMed - in process]
Related citations


Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer.
Rosenbaum JN, Bloom R, Forys JT, Hiken J, Armstrong JR, Branson J, McNulty S, Velu PD, Pepin K, Abel H, Cottrell CE, Pfeifer JD, Kulkarni S, Govindan R, Konnick EQ, Lockwood CM, Duncavage EJ
Mod Pathol. 2018 May; 31(5)791-808. doi: 10.1038/modpathol.2017.181.

PMID:
    29327716
    [PubMed - in process]
Related citations


Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma.
Nemeth K, Szabo S, Cottrell CE, McNulty SM, Segura A, Sokumbi O, Browning M, Siegel DH
Br J Dermatol. 2018 Mar; 178(3)804-806. doi: 10.1111/bjd.16155.

PMID:
    29193020
    [PubMed - in process]
Related citations


Analyzing the Genetic Spectrum of Vascular Anomalies with Overgrowth via Cancer Genomics.
Siegel DH, Cottrell CE, Streicher JL, Schilter KF, Basel DG, Baselga E, Burrows PE, Ciliberto HM, Vigh-Conrad KA, Eichenfield LF, Holland KE, Hogeling M, Jensen JN, Kelly ME, Kim W, King DM, McCuaig C, Mueller KA, Pope E, Powell J, Price H, Steiner JE, Frieden IJ, Tollefson MM, Drolet BA
J Invest Dermatol. 2018 Apr; 138(4)957-967. doi: 10.1016/j.jid.2017.10.033.

PMID:
    29174369
    [PubMed - in process]
Related citations


<i>FGFR2</i> amplification in colorectal adenocarcinoma.
Carter JH, Cottrell CE, McNulty SN, Vigh-Conrad KA, Lamp S, Heusel JW, Duncavage EJ
Cold Spring Harb Mol Case Stud. 2017 Nov; 3(6)pii: a001495. doi: 10.1101/mcs.a001495.

PMID:
    28835367
    [PubMed - indexed for MEDLINE]
Related citations


Routine use of clinical exome-based next-generation sequencing for evaluation of patients with thrombotic microangiopathies.
Gaut JP, Jain S, Pfeifer JD, Vigh-Conrad KA, Corliss M, Sharma MK, Heusel JW, Cottrell CE
Mod Pathol. 2017 Dec; 30(12)1739-1747. doi: 10.1038/modpathol.2017.90.

PMID:
    28752844
    [PubMed - in process]
Related citations


Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.
Lee PJ, Yoo NS, Hagemann IS, Pfeifer JD, Cottrell CE, Abel HJ, Duncavage EJ
Exp Mol Pathol. 2017 Feb; 102(1)156-161. doi: 10.1016/j.yexmp.2017.01.012.

PMID:
    28093192
    [PubMed - indexed for MEDLINE]
Related citations


Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors.
Carter JH, McNulty SN, Cimino PJ, Cottrell CE, Heusel JW, Vigh-Conrad KA, Duncavage EJ
J Mol Diagn. 2017 Mar; 19(2)328-337. doi: 10.1016/j.jmoldx.2016.10.010.

PMID:
    28042970
    [PubMed - indexed for MEDLINE]
Related citations


Utility of clinical high-depth next generation sequencing for somatic variant detection in the PIK3CA-related overgrowth spectrum.
Hucthagowder V, Shenoy A, Corliss M, Vigh-Conrad KA, Storer C, Grange DK, Cottrell CE
Clin Genet. 2017 Jan; 91(1)79-85. doi: 10.1111/cge.12819.

PMID:
    27307077
    [PubMed - indexed for MEDLINE]
Related citations


Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE
Am J Med Genet A. 2016 Mar; 170(3)583-93. doi: 10.1002/ajmg.a.37445.

PMID:
    26601658
    [PubMed - indexed for MEDLINE]
Related citations


Occult Specimen Contamination in Routine Clinical Next-Generation Sequencing Testing.
Sehn JK, Spencer DH, Pfeifer JD, Bredemeyer AJ, Cottrell CE, Abel HJ, Duncavage EJ
Am J Clin Pathol. 2015 Oct; 144(4)667-74. doi: 10.1309/AJCPR88WDJJLDMBN.

PMID:
    26386089
    [PubMed - indexed for MEDLINE]
Related citations


Identification of Medically Actionable Secondary Findings in the 1000 Genomes.
Olfson E, Cottrell CE, Davidson NO, Gurnett CA, Heusel JW, Stitziel NO, Chen LS, Hartz S, Nagarajan R, Saccone NL, Bierut LJ
PLoS One. 2015; 10(9)e0135193. doi: 10.1371/journal.pone.0135193.

PMID:
    26332594
    [PubMed - indexed for MEDLINE]
Related citations


Digynic triploidy: utility and challenges of noninvasive prenatal testing.
Fleischer J, Shenoy A, Goetzinger K, Cottrell CE, Baldridge D, White FV, Shinawi M
Clin Case Rep. 2015 Jun; 3(6)406-10. doi: 10.1002/ccr3.247.

PMID:
    26185638
    [PubMed]
Related citations


Clinical next-generation sequencing in patients with non-small cell lung cancer.
Hagemann IS, Devarakonda S, Lockwood CM, Spencer DH, Guebert K, Bredemeyer AJ, Al-Kateb H, Nguyen TT, Duncavage EJ, Cottrell CE, Kulkarni S, Nagarajan R, Seibert K, Baggstrom M, Waqar SN, Pfeifer JD, Morgensztern D, Govindan R
Cancer. 2015 Feb 15; 121(4)631-9. doi: 10.1002/cncr.29089.

PMID:
    25345567
    [PubMed - indexed for MEDLINE]
Related citations


Aggressive congenital juvenile myelomonocytic leukemia associated with somatic KRAS p.G13D mutation and concurrent germline IGF1R duplication.
Kothari A, Hulbert ML, Cottrell CE, Nguyen TT
Leuk Lymphoma. 2015 Apr; 56(4)1175-8. doi: 10.3109/10428194.2014.953152.

PMID:
    25110823
    [PubMed - indexed for MEDLINE]
Related citations


Detection of gene rearrangements in targeted clinical next-generation sequencing.
Abel HJ, Al-Kateb H, Cottrell CE, Bredemeyer AJ, Pritchard CC, Grossmann AH, Wallander ML, Pfeifer JD, Lockwood CM, Duncavage EJ
J Mol Diagn. 2014 Jul; 16(4)405-17. doi: 10.1016/j.jmoldx.2014.03.006.

PMID:
    24813172
    [PubMed - indexed for MEDLINE]
Related citations


Diagnostic utility of targeted next-generation sequencing in problematic cases.
Sehn JK, Hagemann IS, Pfeifer JD, Cottrell CE, Lockwood CM
Am J Surg Pathol. 2014 Apr; 38(4)534-41. doi: 10.1097/PAS.0000000000000161.

PMID:
    24451277
    [PubMed - indexed for MEDLINE]
Related citations