FollowMyHealth Patient Portal

Carla J. Siegfried, MD

Jacquelyn E. and Allan E. Kolker, MD, Distinguished Professor of Ophthalmology and Visual Sciences

Specialty Areas

Glaucoma
Ophthalmology

Board Certifications

Ophthalmology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Diagnostic and therapeutic assessment of glaucoma, including pharmacological, surgical, and laser treatment and minimally invasive glaucoma procedures

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Eye Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 12
Office Phone: 314-362-3937
Fax: 314-362-3725

Barnes-Jewish West County Hospital
Medical Building Two

10 Barnes West Drive
Creve Coeur, MO 63141

Suite: Suite 201
Office Phone: 314-996-3300
Fax: 314-996-3490

Education

Education

Fellowship: Glaucoma, Northwestern University, Chicago, Illinois 1994
Residency: Ophthalmology, University of Illinois Eye and Ear Informary, Chicago, Illinois 1993
Medical School: University Of Missouri, Kansas City School of Medicine, Kansas City 1989
B.A. Biology: University of Missouri, Kansas City 1989

Publication & Research

Publication & Research

Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics.
Siegfried CJ, Shui YB, Tian B, Nork TM, Heatley GA, Kaufman PL
Invest Ophthalmol Vis Sci. 2017 Aug 1; 58(10)4003-4014. doi: 10.1167/iovs.17-21890.

PMID:
    28800647
    [PubMed - indexed for MEDLINE]
Related citations


GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients.
Ban N, Siegfried CJ, Lin JB, Shui YB, Sein J, Pita-Thomas W, Sene A, Santeford A, Gordon M, Lamb R, Dong Z, Kelly SC, Cavalli V, Yoshino J, Apte RS
JCI Insight. 2017 May 4; 2(9)pii: 91455. doi: 10.1172/jci.insight.91455.

PMID:
    28469085
    [PubMed - as supplied by publisher]
Related citations


Mitochondrial oxygen metabolism in primary human lens epithelial cells: Association with age, diabetes and glaucoma.
Kubota M, Shui YB, Liu M, Bai F, Huang AJ, Ma N, Beebe DC, Siegfried CJ
Free Radic Biol Med. 2016 Aug; 97513-519. doi: 10.1016/j.freeradbiomed.2016.07.016.

PMID:
    27445101
    [PubMed - in process]
Related citations


Impact of Corneal Endothelial Dysfunctions on Intraocular Oxygen Levels in Human Eyes.
Huang AJ, Shui YB, Han YP, Bai F, Siegfried CJ, Beebe DC
Invest Ophthalmol Vis Sci. 2015 Oct; 56(11)6483-8. doi: 10.1167/iovs.15-17191.

PMID:
    26447982
    [PubMed - indexed for MEDLINE]
Related citations


Reply: To PMID 25461296.
Siegfried CJ, Shui YB, Bai F, Beebe DC
Am J Ophthalmol. 2015 Mar; 159(3)610-1. doi: 10.1016/j.ajo.2014.12.027.

PMID:
    25681026
    [PubMed - indexed for MEDLINE]
Related citations


Central corneal thickness correlates with oxygen levels in the human anterior chamber angle.
Siegfried CJ, Shui YB, Bai F, Beebe DC
Am J Ophthalmol. 2015 Mar; 159(3)457-62.e1. doi: 10.1016/j.ajo.2014.11.026.

PMID:
    25461296
    [PubMed - indexed for MEDLINE]
Related citations


Longitudinal changes in peripapillary atrophy in the ocular hypertension treatment study: a case-control assessment.
Savatovsky E, Mwanza JC, Budenz DL, Feuer WJ, Vandenbroucke R, Schiffman JC, Anderson DR, Ocular Hypertension Treatment Study.
Ophthalmology. 2015 Jan; 122(1)79-86. doi: 10.1016/j.ophtha.2014.07.033.

PMID:
    25208858
    [PubMed - indexed for MEDLINE]
Related citations


Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma.
Bennett TM, Mackay DS, Siegfried CJ, Shiels A
PLoS One. 2014; 9(8)e104000. doi: 10.1371/journal.pone.0104000.

PMID:
    25090642
    [PubMed - indexed for MEDLINE]
Related citations


Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye.
Beebe DC, Shui YB, Siegfried CJ, Holekamp NM, Bai F
Jpn J Ophthalmol. 2014 May; 58(3)225-31. doi: 10.1007/s10384-014-0318-4.

PMID:
    24687817
    [PubMed - indexed for MEDLINE]
Related citations


Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study).
Netland PA, Sarkisian SR Jr, Moster MR, Ahmed II, Condon G, Salim S, Sherwood MB, Siegfried CJ
Am J Ophthalmol. 2014 Feb; 157(2)433-440.e3. doi: 10.1016/j.ajo.2013.09.014.

PMID:
    24210765
    [PubMed - indexed for MEDLINE]
Related citations


Aqueous humor oxygen measurements.
Nguyen A, Shui YB, Zhang Q, Beebe DC, Siegfried CJ
J Glaucoma. 2013 Oct-Nov; 22(8)e23-4. doi: 10.1097/IJG.0b013e3182a4a012.

PMID:
    23965524
    [PubMed - indexed for MEDLINE]
Related citations


Series length used during trend analysis affects sensitivity to changes in progression rate in the ocular hypertension treatment study.
Gardiner SK, Demirel S, De Moraes CG, Liebmann JM, Cioffi GA, Ritch R, Gordon MO, Kass MA, Ocular Hypertension Treatment Study Group.
Invest Ophthalmol Vis Sci. 2013 Feb 15; 54(2)1252-9. doi: 10.1167/iovs.12-10218.

PMID:
    23349433
    [PubMed - indexed for MEDLINE]
Related citations


The development of a decision analytic model of changes in mean deviation in people with glaucoma: the COA model.
Kymes SM, Lambert DL, Lee PP, Musch DC, Siegfried CJ, Kotak SV, Stwalley DL, Fain J, Johnson C, Gordon MO
Ophthalmology. 2012 Jul; 119(7)1367-74. doi: 10.1016/j.ophtha.2012.01.054.

PMID:
    22537616
    [PubMed - indexed for MEDLINE]
Related citations


Racial differences in ocular oxidative metabolism: implications for ocular disease.
Siegfried CJ, Shui YB, Holekamp NM, Bai F, Beebe DC
Arch Ophthalmol. 2011 Jul; 129(7)849-54. doi: 10.1001/archophthalmol.2011.169.

PMID:
    21746975
    [PubMed - indexed for MEDLINE]
Related citations


Oxygen distribution in the human eye: relevance to the etiology of open-angle glaucoma after vitrectomy.
Siegfried CJ, Shui YB, Holekamp NM, Bai F, Beebe DC
Invest Ophthalmol Vis Sci. 2010 Nov; 51(11)5731-8. doi: 10.1167/iovs.10-5666.

PMID:
    20720218
    [PubMed - indexed for MEDLINE]
Related citations


Endocyclophotocoagulation.
Falkenberry SM, Siegfried CJ
Middle East Afr J Ophthalmol. 2009 Jul; 16(3)130-3. doi: 10.4103/0974-9233.56225.

PMID:
    20142978
    [PubMed]
Related citations


The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts.
Shui YB, Holekamp NM, Kramer BC, Crowley JR, Wilkins MA, Chu F, Malone PE, Mangers SJ, Hou JH, Siegfried CJ, Beebe DC
Arch Ophthalmol. 2009 Apr; 127(4)475-82. doi: 10.1001/archophthalmol.2008.621.

PMID:
    19365028
    [PubMed - indexed for MEDLINE]
Related citations


Trabectome (trabeculectomy-internal approach): additional experience and extended follow-up.
Minckler D, Mosaed S, Dustin L, Ms BF, Trabectome Study Group.
Trans Am Ophthalmol Soc. 2008; 106149-59; discussion 159-60.

PMID:
    19277230
    [PubMed - indexed for MEDLINE]
Related citations


The impact of anchor point on utilities for 5 common ophthalmic diseases.
Lee BS, Kymes SM, Nease RF Jr, Sumner W, Siegfried CJ, Gordon MO
Ophthalmology. 2008 May; 115(5)898-903.e4.

PMID:
    17826833
    [PubMed - indexed for MEDLINE]
Related citations


Endophthalmitis associated with a releasable suture.
Rosenberg LF, Siegfried CJ
Arch Ophthalmol. 1996 Jun; 114(6)767.

PMID:
    8639098
    [PubMed - indexed for MEDLINE]
Related citations