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Faculty Physicians

C. Robert Cloninger, MD

Wallace Renard Professor, Psychiatry
Professor, Genetics
Professor, Psychology
Director, Center for Psychobiology of Personality

Specialty Areas

Psychological Testing
Adult Psychiatry

Board Certifications

Psychiatry

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

General psychology, personality testing. Research Interests: Genetic epidemiology, genetics of alcohol abuse, schizophrenia, bipolar disorder

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital (South)
Renard Hospital Building

4940 Children's Place
Room 1116
St. Louis, MO 63110

Suite: Room 3308
Office Phone: 314-362-7005
Fax: 314-362-5594

Education

Education

Fellowship: Washington University School of Medicine, St. Louis, Missouri 1969
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1970
B.A.: Philosophy, Psychology, Anthropology, University of Texas, Austin, Texas 1966

Publication & Research

Publication & Research

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
Maier R, Moser G, Chen GB, Ripke S, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH
Am J Hum Genet. 2015 Feb 5; 96(2)283-94. doi: 10.1016/j.ajhg.2014.12.006.

PMID:
    25640677
    [PubMed - indexed for MEDLINE]
Related citations


Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.
Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium
Nat Neurosci. 2015 Feb; 18(2)199-209. doi: 10.1038/nn.3922.

PMID:
    25599223
    [PubMed - indexed for MEDLINE]
Related citations


Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium
Am J Hum Genet. 2014 Nov 6; 95(5)535-52. doi: 10.1016/j.ajhg.2014.10.004.

PMID:
    25439723
    [PubMed - indexed for MEDLINE]
Related citations


"Latent" infection with Toxoplasma gondii: association with trait aggression and impulsivity in healthy adults.
Cook TB, Brenner LA, Cloninger CR, Langenberg P, Igbide A, Giegling I, Hartmann AM, Konte B, Friedl M, Brundin L, Groer MW, Can A, Rujescu D, Postolache TT
J Psychiatr Res. 2015 Jan; 6087-94. doi: 10.1016/j.jpsychires.2014.09.019.

PMID:
    25306262
    [PubMed - indexed for MEDLINE]
Related citations


Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.
Arnedo J, Svrakic DM, Del Val C, Romero-Zaliz R, Hernández-Cuervo H, Molecular Genetics of Schizophrenia Consortium, Fanous AH, Pato MT, Pato CN, de Erausquin GA, Cloninger CR, Zwir I
Am J Psychiatry. 2015 Feb 1; 172(2)139-53. doi: 10.1176/appi.ajp.2014.14040435.

PMID:
    25219520
    [PubMed - indexed for MEDLINE]
Related citations


Biopsychological traits of Sasang typology based on Sasang personality questionnaire and body mass index.
Lee SJ, Park SH, Cloninger CR, Kim YH, Hwang M, Chae H
BMC Complement Altern Med. 2014 Aug 26; 14315. doi: 10.1186/1472-6882-14-315.

PMID:
    25164072
    [PubMed - indexed for MEDLINE]
Related citations


Biological insights from 108 schizophrenia-associated genetic loci.
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Nature. 2014 Jul 24; 511(7510)421-7. doi: 10.1038/nature13595.

PMID:
    25056061
    [PubMed - indexed for MEDLINE]
Related citations


Toward a global understanding of students who participate in rural primary care longitudinal integrated clerkships: considering personality across 2 continents.
Eley DS, Brooks KD, Zink T, Cloninger CR
J Rural Health. 2014 Spring; 30(2)164-74. doi: 10.1111/jrh.12039.

PMID:
    24689541
    [PubMed - indexed for MEDLINE]
Related citations


Temperament and character in the Child and Adolescent Twin Study in Sweden (CATSS): comparison to the general population, and genetic structure analysis.
Garcia D, Lundström S, Brändström S, Råstam M, Cloninger CR, Kerekes N, Nilsson T, Anckarsäter H
PLoS One. 2013; 8(8)e70475. doi: 10.1371/journal.pone.0070475.

PMID:
    23940581
    [PubMed - indexed for MEDLINE]
Related citations


Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zöllner S, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR
Nat Genet. 2013 Sep; 45(9)984-94. doi: 10.1038/ng.2711.

PMID:
    23933821
    [PubMed - indexed for MEDLINE]
Related citations


Maturity and change in personality: developmental trends of temperament and character in adulthood.
Josefsson K, Jokela M, Cloninger CR, Hintsanen M, Salo J, Hintsa T, Pulkki-Råback L, Keltikangas-Järvinen L
Dev Psychopathol. 2013 Aug; 25(3)713-27. doi: 10.1017/S0954579413000126.

PMID:
    23880387
    [PubMed - indexed for MEDLINE]
Related citations


Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia.
Mulle JG, Pulver AE, McGrath JA, Wolyniec PS, Dodd AF, Cutler DJ, Sebat J, Malhotra D, Nestadt G, Conrad DF, Hurles M, Barnes CP, Ikeda M, Iwata N, Levinson DF, Gejman PV, Sanders AR, Duan J, Mitchell AA, Peter I, Sklar P, O'Dushlaine CT, Grozeva D, O'Donovan MC, Owen MJ, Hultman CM, Kähler AK, Sullivan PF, Molecular Genetics of Schizophrenia Consortium, Kirov G, Warren ST
Biol Psychiatry. 2014 Mar 1; 75(5)371-7. doi: 10.1016/j.biopsych.2013.05.040.

PMID:
    23871472
    [PubMed - indexed for MEDLINE]
Related citations


Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders.
Minelli A, Maffioletti E, Cloninger CR, Magri C, Sartori R, Bortolomasi M, Congiu C, Bignotti S, Segala M, Giacopuzzi M, Gennarelli M
Depress Anxiety. 2013 Dec; 30(12)1170-6. doi: 10.1002/da.22158.

PMID:
    23861224
    [PubMed - indexed for MEDLINE]
Related citations


PGMRA: a web server for (phenotype x genotype) many-to-many relation analysis in GWAS.
Arnedo J, del Val C, de Erausquin GA, Romero-Zaliz R, Svrakic D, Cloninger CR, Zwir I
Nucleic Acids Res. 2013 Jul; 41(Web Server issue)W142-9. doi: 10.1093/nar/gkt496.

PMID:
    23761451
    [PubMed - indexed for MEDLINE]
Related citations


The Norwegian Junior Temperament and Character Inventory (JTCI): an assessment of its psychometric properties.
Vangberg HC, Eisemann M, Waterloo K, Richter J, Rozsa S, Cloninger CR
Compr Psychiatry. 2013 Oct; 54(7)904-10. doi: 10.1016/j.comppsych.2013.03.020.

PMID:
    23642632
    [PubMed - indexed for MEDLINE]
Related citations


Parental care-giving and home environment predicting offspring's temperament and character traits after 18 years.
Josefsson K, Jokela M, Hintsanen M, Cloninger CR, Pulkki-Råback L, Merjonen P, Hutri-Kähönen N, Keltikangas-Järvinen L
Psychiatry Res. 2013 Oct 30; 209(3)643-51. doi: 10.1016/j.psychres.2013.01.007.

PMID:
    23380545
    [PubMed - indexed for MEDLINE]
Related citations


Risk architecture of schizophrenia: the role of epigenetics.
Svrakic DM, Zorumski CF, Svrakic NM, Zwir I, Cloninger CR
Curr Opin Psychiatry. 2013 Mar; 26(2)188-95. doi: 10.1097/YCO.0b013e32835d8329.

PMID:
    23318661
    [PubMed - indexed for MEDLINE]
Related citations


Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
Fanous AH, Zhou B, Aggen SH, Bergen SE, Amdur RL, Duan J, Sanders AR, Shi J, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Freedman R, Dudbridge F, Holmans PA, Ripke S, Gejman PV, Kendler KS, Levinson DF, Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
Am J Psychiatry. 2012 Dec; 169(12)1309-17. doi: 10.1176/appi.ajp.2012.12020218.

PMID:
    23212062
    [PubMed - indexed for MEDLINE]
Related citations


Temperament and character predict body-mass index: a population-based prospective cohort study.
Hintsanen M, Jokela M, Cloninger CR, Pulkki-Råback L, Hintsa T, Elovainio M, Josefsson K, Rosenström T, Mullola S, Raitakari OT, Keltikangas-Järvinen L
J Psychosom Res. 2012 Nov; 73(5)391-7. doi: 10.1016/j.jpsychores.2012.08.012.

PMID:
    23062814
    [PubMed - indexed for MEDLINE]
Related citations


Temperament and character modify risk of drug addiction and influence choice of drugs.
Milivojevic D, Milovanovic SD, Jovanovic M, Svrakic DM, Svrakic NM, Svrakic SM, Cloninger CR
Am J Addict. 2012 Sep-Oct; 21(5)462-7. doi: 10.1111/j.1521-0391.2012.00251.x.

PMID:
    22882397
    [PubMed - indexed for MEDLINE]
Related citations