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Brian Van Tine, MD, PhD

Assistant Professor, Medicine
Division of Oncology
Section of Medical Oncology

Specialty Areas

Oncology
Sarcoma
Medical Oncology

Board Certifications

Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Medical oncology, cancer, sarcoma, soft tissue sarcoma, bone cancer, leiomyosarcoma, liposarcoma

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-747-1171

Education

Education

Medical Degree: University of Alabama at Birmingham 2005
PhD: University of Alabama at Birmingham 2003
Chief Fellow: Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri 2010
BS: University of Arizona, Tucson, Arizona 1995
Residency: Barnes-Jewish Hospital, St. Louis, Missouri 2006
Fellowship: Oncology, Washington University School of Medicine, St. Louis, Missouri 2007

Publication & Research

Publication & Research

The Immune Landscape of Cancer.
Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CE, Cancer Genome Atlas Research Network., Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich L
Immunity. 2018 Apr 17; 48(4)812-830.e14. doi: 10.1016/j.immuni.2018.03.023.

PMID:
    29628290
    [PubMed - in process]
Related citations


An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, Omberg L, Wolf DM, Shriver CD, Thorsson V, Cancer Genome Atlas Research Network., Hu H
Cell. 2018 Apr 5; 173(2)400-416.e11. doi: 10.1016/j.cell.2018.02.052.

PMID:
    29625055
    [PubMed - in process]
Related citations


A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.
Chen H, Li C, Peng X, Zhou Z, Weinstein JN, Cancer Genome Atlas Research Network., Liang H
Cell. 2018 Apr 5; 173(2)386-399.e12. doi: 10.1016/j.cell.2018.03.027.

PMID:
    29625054
    [PubMed - in process]
Related citations


Comprehensive Characterization of Cancer Driver Genes and Mutations.
Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng PK, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, MC3 Working Group., Cancer Genome Atlas Research Network., Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L
Cell. 2018 Apr 5; 173(2)371-385.e18. doi: 10.1016/j.cell.2018.02.060.

PMID:
    29625053
    [PubMed - in process]
Related citations


Pathogenic Germline Variants in 10,389 Adult Cancers.
Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A, McMichael JF, Hucthagowder V, Kim TB, Hahn A, Wang C, McLellan MD, Al-Mulla F, Johnson KJ, Cancer Genome Atlas Research Network., Lichtarge O, Boutros PC, Raphael B, Lazar AJ, Zhang W, Wendl MC, Govindan R, Jain S, Wheeler D, Kulkarni S, Dipersio JF, Reimand J, Meric-Bernstam F, Chen K, Shmulevich I, Plon SE, Chen F, Ding L
Cell. 2018 Apr 5; 173(2)355-370.e14. doi: 10.1016/j.cell.2018.03.039.

PMID:
    29625052
    [PubMed - in process]
Related citations


Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.
Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kamińska B, Huelsken J, Omberg L, Gevaert O, Colaprico A, Czerwińska P, Mazurek S, Mishra L, Heyn H, Krasnitz A, Godwin AK, Lazar AJ, Cancer Genome Atlas Research Network., Stuart JM, Hoadley KA, Laird PW, Noushmehr H, Wiznerowicz M
Cell. 2018 Apr 5; 173(2)338-354.e15. doi: 10.1016/j.cell.2018.03.034.

PMID:
    29625051
    [PubMed - in process]
Related citations


Oncogenic Signaling Pathways in The Cancer Genome Atlas.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network., Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N
Cell. 2018 Apr 5; 173(2)321-337.e10. doi: 10.1016/j.cell.2018.03.035.

PMID:
    29625050
    [PubMed - in process]
Related citations


Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Colaprico A, Bertrand D, Gibbs DL, Weerasinghe A, Huang KL, Tokheim C, Cortés-Ciriano I, Jayasinghe R, Chen F, Yu L, Sun S, Olsen C, Kim J, Taylor AM, Cherniack AD, Akbani R, Suphavilai C, Nagarajan N, Stuart JM, Mills GB, Wyczalkowski MA, Vincent BG, Hutter CM, Zenklusen JC, Hoadley KA, Wendl MC, Shmulevich L, Lazar AJ, Wheeler DA, Getz G, Cancer Genome Atlas Research Network.
Cell. 2018 Apr 5; 173(2)305-320.e10. doi: 10.1016/j.cell.2018.03.033.

PMID:
    29625049
    [PubMed - in process]
Related citations


Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, Shen R, Taylor AM, Cherniack AD, Thorsson V, Akbani R, Bowlby R, Wong CK, Wiznerowicz M, Sanchez-Vega F, Robertson AG, Schneider BG, Lawrence MS, Noushmehr H, Malta TM, Cancer Genome Atlas Network., Stuart JM, Benz CC, Laird PW
Cell. 2018 Apr 5; 173(2)291-304.e6. doi: 10.1016/j.cell.2018.03.022.

PMID:
    29625048
    [PubMed - in process]
Related citations


Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network., Thorsson V, Bass AJ, Laird PW
Cancer Cell. 2018 Apr 9; 33(4)721-735.e8. doi: 10.1016/j.ccell.2018.03.010.

PMID:
    29622466
    [PubMed - in process]
Related citations


lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network., Xie W, Yang D
Cancer Cell. 2018 Apr 9; 33(4)706-720.e9. doi: 10.1016/j.ccell.2018.03.006.

PMID:
    29622465
    [PubMed - in process]
Related citations


A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Williams C, Mestdagh P, Gunaratne PH, Yau C, Bowlby R, Robertson AG, Tiezzi DG, Wang C, Cherniack AD, Godwin AK, Kuderer NM, Rader JS, Zuna RE, Sood AK, Lazar AJ, Ojesina AI, Adebamowo C, Adebamowo SN, Baggerly KA, Chen TW, Chiu HS, Lefever S, Liu L, MacKenzie K, Orsulic S, Roszik J, Shelley CS, Song Q, Vellano CP, Wentzensen N, Cancer Genome Atlas Research Network., Weinstein JN, Mills GB, Levine DA, Akbani R
Cancer Cell. 2018 Apr 9; 33(4)690-705.e9. doi: 10.1016/j.ccell.2018.03.014.

PMID:
    29622464
    [PubMed - in process]
Related citations


Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, Lazar AJ, Cancer Genome Atlas Research Network., Cherniack AD, Beroukhim R, Meyerson M
Cancer Cell. 2018 Apr 9; 33(4)676-689.e3. doi: 10.1016/j.ccell.2018.03.007.

PMID:
    29622463
    [PubMed - in process]
Related citations


The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwaitkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WT, Robertson AG, Cancer Genome Atlas Research Network., Spellman PT, Rathmell WK, Linehan WM
Cell Rep. 2018 Apr 3; 23(1)313-326.e5. doi: 10.1016/j.celrep.2018.03.075.

PMID:
    29617669
    [PubMed - in process]
Related citations


Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.
Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS, Cancer Genome Atlas Research Network., Sood AK, Gunaratne PH, Sumazin P
Cell Rep. 2018 Apr 3; 23(1)297-312.e12. doi: 10.1016/j.celrep.2018.03.064.

PMID:
    29617668
    [PubMed - in process]
Related citations


Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.
Seiler M, Peng S, Agrawal AA, Palacino J, Teng T, Zhu P, Smith PG, Cancer Genome Atlas Research Network., Buonamici S, Yu L
Cell Rep. 2018 Apr 3; 23(1)282-296.e4. doi: 10.1016/j.celrep.2018.01.088.

PMID:
    29617667
    [PubMed - in process]
Related citations


Systematic Analysis of Splice-Site-Creating Mutations in Cancer.
Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-González H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyö D, Miner JH, Walter MJ, Cancer Genome Atlas Research Network., Vincent B, Eyras E, Chen K, Shmulevich I, Chen F, Ding L
Cell Rep. 2018 Apr 3; 23(1)270-281.e3. doi: 10.1016/j.celrep.2018.03.052.

PMID:
    29617666
    [PubMed - in process]
Related citations


Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.
Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Cancer Genome Atlas Research Network., Bathe OF, Liang H
Cell Rep. 2018 Apr 3; 23(1)255-269.e4. doi: 10.1016/j.celrep.2018.03.077.

PMID:
    29617665
    [PubMed - in process]
Related citations


Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I, Cancer Genome Atlas Research Network., Monnat RJ Jr., Xiao Y, Wang C
Cell Rep. 2018 Apr 3; 23(1)239-254.e6. doi: 10.1016/j.celrep.2018.03.076.

PMID:
    29617664
    [PubMed - in process]
Related citations


Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ, Fusion Analysis Working Group., Cancer Genome Atlas Research Network., Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep. 2018 Apr 3; 23(1)227-238.e3. doi: 10.1016/j.celrep.2018.03.050.

PMID:
    29617662
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Jansen & Jansen

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2017

Areas of Research Interest

Our focus is on understanding the genomics of osteosarcoma, leiomyosarcoma and rarer forms of sarcoma. Using mouse genetics, human tumor xenografting and cancer biology we strive to identify druggable targets that can be used in the clinic.