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Brian K. Dieckgraefe, MD, PhD

Associate Professor, Medicine
Division of Gastroenterology

Chief of Gastroenterology
St. Louis VA Medical Centers

Specialty Areas

Gastroenterology

Board Certifications

Internal Medicine Certified
Gastroenterology Certified

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Crohn's disease, inflammatory bowel disease

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

VA Medical Center: John Cochran Division

915 North Grand Boulevard
St. Louis, MO 63106

Education

Education

Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1988
Ph.D.: Biological Sciences, Washington University, St. Louis, Missouri 1988
B.A.: Microbiology, University of Kansas, Lawrence, Kansas 1982

Publication & Research

Publication & Research

Reg4-induced mitogenesis involves Akt-GSK3β-β-Catenin-TCF-4 signaling in human colorectal cancer.
Bishnupuri KS, Sainathan SK, Bishnupuri K, Leahy DR, Luo Q, Anant S, Houchen CW, Dieckgraefe BK
Mol Carcinog. 2014 Feb; 53 Suppl 1E169-80. doi: 10.1002/mc.22088.

PMID:
    24151146
    [PubMed - indexed for MEDLINE]
Related citations


Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis.
Sainathan SK, Bishnupuri KS, Aden K, Luo Q, Houchen CW, Anant S, Dieckgraefe BK
Inflamm Bowel Dis. 2012 May; 18(5)955-67. doi: 10.1002/ibd.21867.

PMID:
    21953855
    [PubMed - indexed for MEDLINE]
Related citations


Dextran sodium sulfate inhibition of real-time polymerase chain reaction amplification: a poly-A purification solution.
Kerr TA, Ciorba MA, Matsumoto H, Davis VR, Luo J, Kennedy S, Xie Y, Shaker A, Dieckgraefe BK, Davidson NO
Inflamm Bowel Dis. 2012 Feb; 18(2)344-8. doi: 10.1002/ibd.21763.

PMID:
    21618356
    [PubMed - indexed for MEDLINE]
Related citations


RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.
Subramaniam D, Ramalingam S, Linehan DC, Dieckgraefe BK, Postier RG, Houchen CW, Jensen RA, Anant S
PLoS One. 2011 Feb 11; 6(2)e16958. doi: 10.1371/journal.pone.0016958.

PMID:
    21347286
    [PubMed - indexed for MEDLINE]
Related citations


Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues.
McDonald KG, McDonough JS, Dieckgraefe BK, Newberry RD
Am J Pathol. 2010 May; 176(5)2367-77. doi: 10.2353/ajpath.2010.090723.

PMID:
    20304952
    [PubMed - indexed for MEDLINE]
Related citations


NOD2 status and human ileal gene expression.
Hamm CM, Reimers MA, McCullough CK, Gorbe EB, Lu J, Gu CC, Li E, Dieckgraefe BK, Gong Q, Stappenbeck TS, Stone CD, Dietz DW, Hunt SR
Inflamm Bowel Dis. 2010 Oct; 16(10)1649-57. doi: 10.1002/ibd.21208.

PMID:
    20155851
    [PubMed - indexed for MEDLINE]
Related citations


Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.
Bishnupuri KS, Luo Q, Sainathan SK, Kikuchi K, Sureban SM, Sabarinathan M, Gross JH, Aden K, May R, Houchen CW, Anant S, Dieckgraefe BK
Gastroenterology. 2010 Feb; 138(2)616-26, 626.e1-2. doi: 10.1053/j.gastro.2009.10.050.

PMID:
    19900450
    [PubMed - indexed for MEDLINE]
Related citations


Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury.
George RJ, Sturmoski MA, May R, Sureban SM, Dieckgraefe BK, Anant S, Houchen CW
Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2)G245-54. doi: 10.1152/ajpgi.00021.2008.

PMID:
    19056768
    [PubMed - indexed for MEDLINE]
Related citations


Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.
Sureban SM, May R, George RJ, Dieckgraefe BK, McLeod HL, Ramalingam S, Bishnupuri KS, Natarajan G, Anant S, Houchen CW
Gastroenterology. 2008 May; 134(5)1448-58. doi: 10.1053/j.gastro.2008.02.057.

PMID:
    18471519
    [PubMed - indexed for MEDLINE]
Related citations


REG1A expression is a prognostic marker in colorectal cancer and associated with peritoneal carcinomatosis.
Astrosini C, Roeefzaad C, Dai YY, Dieckgraefe BK, Jöns T, Kemmner W
Int J Cancer. 2008 Jul 15; 123(2)409-413. doi: 10.1002/ijc.23466.

PMID:
    18452172
    [PubMed - indexed for MEDLINE]
Related citations


Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe.
Sureban SM, Ramalingam S, Natarajan G, May R, Subramaniam D, Bishnupuri KS, Morrison AR, Dieckgraefe BK, Brackett DJ, Postier RG, Houchen CW, Anant S
Oncogene. 2008 Jul 31; 27(33)4544-56. doi: 10.1038/onc.2008.97.

PMID:
    18427544
    [PubMed - indexed for MEDLINE]
Related citations


Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms.
Subramaniam D, Ramalingam S, May R, Dieckgraefe BK, Berg DE, Pothoulakis C, Houchen CW, Wang TC, Anant S
Gastroenterology. 2008 Apr; 134(4)1070-82. doi: 10.1053/j.gastro.2008.01.040.

PMID:
    18395088
    [PubMed - indexed for MEDLINE]
Related citations


Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity.
Subramaniam D, May R, Sureban SM, Lee KB, George R, Kuppusamy P, Ramanujam RP, Hideg K, Dieckgraefe BK, Houchen CW, Anant S
Cancer Res. 2008 Mar 15; 68(6)1962-9. doi: 10.1158/0008-5472.CAN-07-6011.

PMID:
    18339878
    [PubMed - indexed for MEDLINE]
Related citations


Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis.
Sainathan SK, Hanna EM, Gong Q, Bishnupuri KS, Luo Q, Colonna M, White FV, Croze E, Houchen C, Anant S, Dieckgraefe BK
Inflamm Bowel Dis. 2008 Jan; 14(1)88-99.

PMID:
    17932977
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel disease.
Myles MH, Dieckgraefe BK, Criley JM, Franklin CL
Inflamm Bowel Dis. 2007 Jul; 13(7)822-36.

PMID:
    17455200
    [PubMed - indexed for MEDLINE]
Related citations


Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn's disease.
Csillag C, Nielsen OH, Vainer B, Olsen J, Dieckgraefe BK, Hendel J, Vind I, Dupuy C, Nielsen FC, Borup R
Scand J Gastroenterol. 2007 Apr; 42(4)454-63.

PMID:
    17454855
    [PubMed - indexed for MEDLINE]
Related citations


Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation.
Sureban SM, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe BK, Houchen CW, Anant S
Gastroenterology. 2007 Mar; 132(3)1055-65.

PMID:
    17383427
    [PubMed - indexed for MEDLINE]
Related citations


Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes.
Bishnupuri KS, Luo Q, Korzenik JR, Henderson JO, Houchen CW, Anant S, Dieckgraefe BK
Cancer Biol Ther. 2006 Dec; 5(12)1714-20.

PMID:
    17106246
    [PubMed - indexed for MEDLINE]
Related citations


Growth factors as treatment options for intestinal inflammation.
Dieckgraefe BK, Korzenik JR, Anant S
Ann N Y Acad Sci. 2006 Aug; 1072300-6.

PMID:
    17057209
    [PubMed - indexed for MEDLINE]
Related citations


Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis.
Bluth MH, Patel SA, Dieckgraefe BK, Okamoto H, Zenilman ME
World J Gastroenterol. 2006 Jul 28; 12(28)4511-6.

PMID:
    16874863
    [PubMed - indexed for MEDLINE]
Related citations