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Benjamin Humphreys, MD, PhD

Associate Professor, Medicine
Division of Nephrology

Specialty Areas

Nephrology
Kidney Disease
Internal Medicine

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Onco-nephrology: care of cancer patients or survivors with kidney disease.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: (314) 362-7603
Fax: 314-747-5213

Education

Education

Fellowship, Nephrology (Research): Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2005
Fellowship, Nephrology: Harvard Medical School, Boston, MA 2003
Residency, Internal Medicine: Harvard Medical School, Boston, MA 2002
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, OH 2000
PhD, Physiology and Biophysics : Case Western Reserve University, Cleveland, OH 1998
AB, English and American Literature: Harvard College, Cambridge, MA 1991

Publication & Research

Publication & Research

Development and Validation of a Risk Prediction Model for Acute Kidney Injury After the First Course of Cisplatin.
Motwani SS, McMahon GM, Humphreys BD, Partridge AH, Waikar SS, Curhan GC
J Clin Oncol. 2018 Jan 10; JCO2017757161. doi: 10.1200/JCO.2017.75.7161.

PMID:
    29320311
    [PubMed - as supplied by publisher]
Related citations


Bringing Renal Biopsy Interpretation Into the Molecular Age With Single-Cell RNA Sequencing.
Malone AF, Wu H, Humphreys BD
Semin Nephrol. 2018 Jan; 38(1)31-39. doi: 10.1016/j.semnephrol.2017.09.005.

PMID:
    29291760
    [PubMed - in process]
Related citations


Mechanisms of Renal Fibrosis.
Humphreys BD
Annu Rev Physiol. 2017 Oct 25; doi: 10.1146/annurev-physiol-022516-034227.

PMID:
    29068765
    [PubMed - as supplied by publisher]
Related citations


The promise of single-cell RNA sequencing for kidney disease investigation.
Wu H, Humphreys BD
Kidney Int. 2017 Dec; 92(6)1334-1342. doi: 10.1016/j.kint.2017.06.033.

PMID:
    28893418
    [PubMed - in process]
Related citations


Targeting Phospholipase D4 Attenuates Kidney Fibrosis.
Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS
J Am Soc Nephrol. 2017 Dec; 28(12)3579-3589. doi: 10.1681/ASN.2016111222.

PMID:
    28814511
    [PubMed - indexed for MEDLINE]
Related citations


Mesenchymal Stem Cells in Fibrotic Disease.
El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S
Cell Stem Cell. 2017 Aug 3; 21(2)166-177. doi: 10.1016/j.stem.2017.07.011.

PMID:
    28777943
    [PubMed - in process]
Related citations


Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition.
Ó hAinmhire E, Humphreys BD
Nephron. 2017 Jun 9; doi: 10.1159/000474960.

PMID:
    28595180
    [PubMed - as supplied by publisher]
Related citations


Endothelial marker-expressing stromal cells are critical for kidney formation.
Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S
Am J Physiol Renal Physiol. 2017 Sep 1; 313(3)F611-F620. doi: 10.1152/ajprenal.00136.2017.

PMID:
    28539333
    [PubMed - indexed for MEDLINE]
Related citations


Gli1<sup>+</sup> Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R
Cell Stem Cell. 2017 Jun 1; 20(6)785-800.e8. doi: 10.1016/j.stem.2017.03.008.

PMID:
    28457748
    [PubMed - in process]
Related citations


The ten barriers for translation of animal data on AKI to the clinical setting.
Liu KD, Humphreys BD, Endre ZH
Intensive Care Med. 2017 Jun; 43(6)898-900. doi: 10.1007/s00134-017-4810-4.

PMID:
    28451772
    [PubMed - in process]
Related citations


(Re)Building a Kidney.
Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA
J Am Soc Nephrol. 2017 May; 28(5)1370-1378. doi: 10.1681/ASN.2016101077.

PMID:
    28096308
    [PubMed - indexed for MEDLINE]
Related citations


Cellular plasticity in kidney injury and repair.
Chang-Panesso M, Humphreys BD
Nat Rev Nephrol. 2017 Jan; 13(1)39-46. doi: 10.1038/nrneph.2016.169.

PMID:
    27890924
    [PubMed - indexed for MEDLINE]
Related citations


ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A
JCI Insight. 2016 Aug 18; 1(13)pii: e87023.

PMID:
    27642633
    [PubMed - in process]
Related citations


Gli1<sup>+</sup> Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury.
Kramann R, Wongboonsin J, Chang-Panesso M, Machado FG, Humphreys BD
J Am Soc Nephrol. 2017 Mar; 28(3)776-784. doi: 10.1681/ASN.2016030297.

PMID:
    27624490
    [PubMed - indexed for MEDLINE]
Related citations


Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Cell Stem Cell. 2016 Nov 3; 19(5)628-642. doi: 10.1016/j.stem.2016.08.001.

PMID:
    27618218
    [PubMed - indexed for MEDLINE]
Related citations


Gene Editing: Powerful New Tools for Nephrology Research and Therapy.
Miyagi A, Lu A, Humphreys BD
J Am Soc Nephrol. 2016 Oct; 27(10)2940-2947.

PMID:
    27358322
    [PubMed - indexed for MEDLINE]
Related citations


Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.
Bijkerk R, de Bruin RG, van Solingen C, van Gils JM, Duijs JM, van der Veer EP, Rabelink TJ, Humphreys BD, van Zonneveld AJ
Kidney Int. 2016 Jun; 89(6)1268-80. doi: 10.1016/j.kint.2016.01.029.

PMID:
    27165825
    [PubMed - indexed for MEDLINE]
Related citations


Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.
Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A, American Society of Nephrology Acute Kidney Injury Advisory Group.
Am J Kidney Dis. 2016 Jul; 68(1)19-28. doi: 10.1053/j.ajkd.2015.12.033.

PMID:
    26948834
    [PubMed - indexed for MEDLINE]
Related citations


A Plumbing Solution for Stem Cell-Derived Kidneys.
Ó hAinmhire E, Humphreys BD
Transplantation. 2016 Jan; 100(1)3-4. doi: 10.1097/TP.0000000000001049.

PMID:
    26674728
    [PubMed - indexed for MEDLINE]
Related citations


CD248/Endosialin: A Novel Pericyte Target in Renal Fibrosis.
Chang-Panesso M, Humphreys BD
Nephron. 2015; 131(4)262-4. doi: 10.1159/000440890.

PMID:
    26673786
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Developing new therapies for acute and chronic kidney injury.