Patient Portal

Benjamin Humphreys, MD, PhD

Associate Professor, Medicine
Division of Nephrology

Specialty Areas

Nephrology
Kidney Disease
Internal Medicine

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Onco-nephrology: care of cancer patients or survivors with kidney disease.

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: (314) 362-7603
Fax: 314-747-5213

Education

Education

Fellowship, Nephrology (Research): Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2005
Fellowship, Nephrology: Harvard Medical School, Boston, MA 2003
Residency, Internal Medicine: Harvard Medical School, Boston, MA 2002
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, OH 2000
PhD, Physiology and Biophysics : Case Western Reserve University, Cleveland, OH 1998
AB, English and American Literature: Harvard College, Cambridge, MA 1991

Publication & Research

Publication & Research

Proximal Tubule Translational Profiling during Kidney Fibrosis Reveals Proinflammatory and Long Noncoding RNA Expression Patterns with Sexual Dimorphism.
Wu H, Lai CF, Chang-Panesso M, Humphreys BD
J Am Soc Nephrol. 2019 Sep 19; pii: ASN.2019040337. doi: 10.1681/ASN.2019040337.

PMID:
    31537650
    [PubMed - as supplied by publisher]
Related citations


The single-cell transcriptomic landscape of early human diabetic nephropathy.
Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD
Proc Natl Acad Sci U S A. 2019 Sep 24; 116(39)19619-19625. doi: 10.1073/pnas.1908706116.

PMID:
    31506348
    [PubMed - in process]
Related citations


Role of the Nephro-Hospitalist.
Yau TT, Humphreys BD
Clin J Am Soc Nephrol. 2019 Sep 6; 14(9)1405-1407. doi: 10.2215/CJN.03890319.

PMID:
    31399417
    [PubMed - in process]
Related citations


Recent Insights into Kidney Injury and Repair from Transcriptomic Analyses.
Kirita Y, Chang-Panesso M, Humphreys BD
Nephron. 2019 May 21; 1-4. doi: 10.1159/000500638.

PMID:
    31112966
    [PubMed - as supplied by publisher]
Related citations


Single-cell Transcriptomics and Solid Organ Transplantation.
Malone AF, Humphreys BD
Transplantation. 2019 Sep; 103(9)1776-1782. doi: 10.1097/TP.0000000000002725.

PMID:
    30946217
    [PubMed - in process]
Related citations


Authors' Reply.
Wu H, Kirita Y, Donnelly EL, Humphreys BD
J Am Soc Nephrol. 2019 Apr; 30(4)714. doi: 10.1681/ASN.2019020178.

PMID:
    30867248
    [PubMed - in process]
Related citations


Kidney and organoid single-cell transcriptomics: the end of the beginning.
Wilson PC, Humphreys BD
Pediatr Nephrol. 2019 Jan 4; doi: 10.1007/s00467-018-4177-y.

PMID:
    30607565
    [PubMed - as supplied by publisher]
Related citations


Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
Morris AP, Le TH, Wu H, Akbarov A, van der Most PJ, Hemani G, Smith GD, Mahajan A, Gaulton KJ, Nadkarni GN, Valladares-Salgado A, Wacher-Rodarte N, Mychaleckyj JC, Dueker ND, Guo X, Hai Y, Haessler J, Kamatani Y, Stilp AM, Zhu G, Cook JP, Ärnlöv J, Blanton SH, de Borst MH, Bottinger EP, Buchanan TA, Cechova S, Charchar FJ, Chu PL, Damman J, Eales J, Gharavi AG, Giedraitis V, Heath AC, Ipp E, Kiryluk K, Kramer HJ, Kubo M, Larsson A, Lindgren CM, Lu Y, Madden PAF, Montgomery GW, Papanicolaou GJ, Raffel LJ, Sacco RL, Sanchez E, Stark H, Sundstrom J, Taylor KD, Xiang AH, Zivkovic A, Lind L, Ingelsson E, Martin NG, Whitfield JB, Cai J, Laurie CC, Okada Y, Matsuda K, Kooperberg C, Chen YI, Rundek T, Rich SS, Loos RJF, Parra EJ, Cruz M, Rotter JI, Snieder H, Tomaszewski M, Humphreys BD, Franceschini N
Nat Commun. 2019 Jan 3; 10(1)29. doi: 10.1038/s41467-018-07867-7.

PMID:
    30604766
    [PubMed - indexed for MEDLINE]
Related citations


Single-cell genomics and gene editing: implications for nephrology.
Wilson PC, Humphreys BD
Nat Rev Nephrol. 2019 Feb; 15(2)63-64. doi: 10.1038/s41581-018-0094-3.

PMID:
    30568287
    [PubMed - in process]
Related citations


Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis.
Wu H, Kirita Y, Donnelly EL, Humphreys BD
J Am Soc Nephrol. 2019 Jan; 30(1)23-32. doi: 10.1681/ASN.2018090912.

PMID:
    30510133
    [PubMed - in process]
Related citations


Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics.
Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD
Cell Stem Cell. 2018 Dec 6; 23(6)869-881.e8. doi: 10.1016/j.stem.2018.10.010.

PMID:
    30449713
    [PubMed - indexed for MEDLINE]
Related citations


A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition.
Ó hAinmhire E, Wu H, Muto Y, Donnelly EL, Machado FG, Fan LX, Chang-Panesso M, Humphreys BD
Am J Physiol Renal Physiol. 2019 Jan 1; 316(1)F63-F75. doi: 10.1152/ajprenal.00460.2018.

PMID:
    30303712
    [PubMed - in process]
Related citations


Gli1<sup>+</sup> Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R
Cell Stem Cell. 2018 Aug 2; 23(2)308-309. doi: 10.1016/j.stem.2018.07.006.

PMID:
    30075132
    [PubMed]
Related citations


Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response.
Wu H, Malone AF, Donnelly EL, Kirita Y, Uchimura K, Ramakrishnan SM, Gaut JP, Humphreys BD
J Am Soc Nephrol. 2018 Aug; 29(8)2069-2080. doi: 10.1681/ASN.2018020125.

PMID:
    29980650
    [PubMed - indexed for MEDLINE]
Related citations


Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector.
Ikeda Y, Sun Z, Ru X, Vandenberghe LH, Humphreys BD
J Am Soc Nephrol. 2018 Sep; 29(9)2287-2297. doi: 10.1681/ASN.2018040426.

PMID:
    29976586
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.
Bijkerk R, Trimpert C, van Solingen C, de Bruin RG, Florijn BW, Kooijman S, van den Berg R, van der Veer EP, Bredewold EOW, Rensen PCN, Rabelink TJ, Humphreys BD, Deen PMT, van Zonneveld AJ
Am J Physiol Renal Physiol. 2018 Oct 1; 315(4)F1129-F1138. doi: 10.1152/ajprenal.00087.2018.

PMID:
    29846108
    [PubMed - indexed for MEDLINE]
Related citations


Mapping kidney cellular complexity.
Humphreys BD
Science. 2018 May 18; 360(6390)709-710. doi: 10.1126/science.aat7271.

PMID:
    29773732
    [PubMed - indexed for MEDLINE]
Related citations


Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.
Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD
JCI Insight. 2018 May 3; 3(9)pii: 99561. doi: 10.1172/jci.insight.99561.

PMID:
    29720573
    [PubMed - in process]
Related citations


Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response.
Chang-Panesso M, Kadyrov FF, Machado FG, Kumar A, Humphreys BD
Am J Physiol Renal Physiol. 2018 Aug 1; 315(2)F275-F290. doi: 10.1152/ajprenal.00030.2018.

PMID:
    29592525
    [PubMed - indexed for MEDLINE]
Related citations


Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.
Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA
Clin J Am Soc Nephrol. 2018 Jul 6; 13(7)1113-1123. doi: 10.2215/CJN.06820617.

PMID:
    29523680
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Chinook

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2019

Areas of Research Interest

Developing new therapies for acute and chronic kidney injury.