Patient Portal

Benjamin Humphreys, MD, PhD

Associate Professor, Medicine
Division of Nephrology

Specialty Areas

Nephrology
Kidney Disease
Internal Medicine

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Onco-nephrology: care of cancer patients or survivors with kidney disease.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: (314) 362-7603
Fax: 314-747-5213

Education

Education

Fellowship, Nephrology (Research): Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2005
Fellowship, Nephrology: Harvard Medical School, Boston, MA 2003
Residency, Internal Medicine: Harvard Medical School, Boston, MA 2002
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, OH 2000
PhD, Physiology and Biophysics : Case Western Reserve University, Cleveland, OH 1998
AB, English and American Literature: Harvard College, Cambridge, MA 1991

Publication & Research

Publication & Research

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response.
Wu H, Malone AF, Donnelly EL, Kirita Y, Uchimura K, Ramakrishnan SM, Gaut JP, Humphreys BD
J Am Soc Nephrol. 2018 Jul 6; pii: ASN.2018020125. doi: 10.1681/ASN.2018020125.

PMID:
    29980650
    [PubMed - as supplied by publisher]
Related citations


Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector.
Ikeda Y, Sun Z, Ru X, Vandenberghe LH, Humphreys BD
J Am Soc Nephrol. 2018 Jul 5; pii: ASN.2018040426. doi: 10.1681/ASN.2018040426.

PMID:
    29976586
    [PubMed - as supplied by publisher]
Related citations


MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.
Bijkerk R, Trimpert C, van Solingen C, de Bruin RG, Florijn BW, Kooijman S, van den Berg R, van der Veer EP, Bredewold EOW, Rensen PCN, Rabelink TJ, Humphreys BD, Deen PMT, van Zonneveld AJ
Am J Physiol Renal Physiol. 2018 May 30; doi: 10.1152/ajprenal.00087.2018.

PMID:
    29846108
    [PubMed - as supplied by publisher]
Related citations


Mapping kidney cellular complexity.
Humphreys BD
Science. 2018 May 18; 360(6390)709-710. doi: 10.1126/science.aat7271.

PMID:
    29773732
    [PubMed - indexed for MEDLINE]
Related citations


Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.
Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD
JCI Insight. 2018 May 3; 3(9)pii: 99561. doi: 10.1172/jci.insight.99561.

PMID:
    29720573
    [PubMed - as supplied by publisher]
Related citations


Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response.
Chang-Panesso M, Kadyrov FF, Machado FG, Kumar A, Humphreys BD
Am J Physiol Renal Physiol. 2018 Mar 28; doi: 10.1152/ajprenal.00030.2018.

PMID:
    29592525
    [PubMed - as supplied by publisher]
Related citations


Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.
Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA
Clin J Am Soc Nephrol. 2018 Jul 6; 13(7)1113-1123. doi: 10.2215/CJN.06820617.

PMID:
    29523680
    [PubMed - in process]
Related citations


Development and Validation of a Risk Prediction Model for Acute Kidney Injury After the First Course of Cisplatin.
Motwani SS, McMahon GM, Humphreys BD, Partridge AH, Waikar SS, Curhan GC
J Clin Oncol. 2018 Mar 1; 36(7)682-688. doi: 10.1200/JCO.2017.75.7161.

PMID:
    29320311
    [PubMed - in process]
Related citations


Bringing Renal Biopsy Interpretation Into the Molecular Age With Single-Cell RNA Sequencing.
Malone AF, Wu H, Humphreys BD
Semin Nephrol. 2018 Jan; 38(1)31-39. doi: 10.1016/j.semnephrol.2017.09.005.

PMID:
    29291760
    [PubMed - in process]
Related citations


Mechanisms of Renal Fibrosis.
Humphreys BD
Annu Rev Physiol. 2018 Feb 10; 80309-326. doi: 10.1146/annurev-physiol-022516-034227.

PMID:
    29068765
    [PubMed - in process]
Related citations


The promise of single-cell RNA sequencing for kidney disease investigation.
Wu H, Humphreys BD
Kidney Int. 2017 Dec; 92(6)1334-1342. doi: 10.1016/j.kint.2017.06.033.

PMID:
    28893418
    [PubMed - indexed for MEDLINE]
Related citations


Targeting Phospholipase D4 Attenuates Kidney Fibrosis.
Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS
J Am Soc Nephrol. 2017 Dec; 28(12)3579-3589. doi: 10.1681/ASN.2016111222.

PMID:
    28814511
    [PubMed - indexed for MEDLINE]
Related citations


Mesenchymal Stem Cells in Fibrotic Disease.
El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S
Cell Stem Cell. 2017 Aug 3; 21(2)166-177. doi: 10.1016/j.stem.2017.07.011.

PMID:
    28777943
    [PubMed - indexed for MEDLINE]
Related citations


Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition.
Ó hAinmhire E, Humphreys BD
Nephron. 2017; 137(4)264-267. doi: 10.1159/000474960.

PMID:
    28595180
    [PubMed - in process]
Related citations


Endothelial marker-expressing stromal cells are critical for kidney formation.
Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S
Am J Physiol Renal Physiol. 2017 Sep 1; 313(3)F611-F620. doi: 10.1152/ajprenal.00136.2017.

PMID:
    28539333
    [PubMed - indexed for MEDLINE]
Related citations


Gli1<sup>+</sup> Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R
Cell Stem Cell. 2017 Jun 1; 20(6)785-800.e8. doi: 10.1016/j.stem.2017.03.008.

PMID:
    28457748
    [PubMed - indexed for MEDLINE]
Related citations


The ten barriers for translation of animal data on AKI to the clinical setting.
Liu KD, Humphreys BD, Endre ZH
Intensive Care Med. 2017 Jun; 43(6)898-900. doi: 10.1007/s00134-017-4810-4.

PMID:
    28451772
    [PubMed - in process]
Related citations


(Re)Building a Kidney.
Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA
J Am Soc Nephrol. 2017 May; 28(5)1370-1378. doi: 10.1681/ASN.2016101077.

PMID:
    28096308
    [PubMed - indexed for MEDLINE]
Related citations


Cellular plasticity in kidney injury and repair.
Chang-Panesso M, Humphreys BD
Nat Rev Nephrol. 2017 Jan; 13(1)39-46. doi: 10.1038/nrneph.2016.169.

PMID:
    27890924
    [PubMed - indexed for MEDLINE]
Related citations


ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A
JCI Insight. 2016 Aug 18; 1(13)pii: e87023.

PMID:
    27642633
    [PubMed - in process]
Related citations

Areas of Research Interest

Developing new therapies for acute and chronic kidney injury.