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Barry Alan Siegel, MD

Professor, Radiology
Senior Vice-chair and Chief, Division of Nuclear Medicine
Professor, Medicine

Specialty Areas

Nuclear Medicine
Radiology
Diagnostic Radiology

Board Certifications

Diagnostic Radiology
Nuclear Medicine
Nuclear Radiology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Nuclear medicine, nuclear imaging, PET, positron emission tomography, radioiodine treatment, radionuclide imaging

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital
Mallinckrodt Institute of Radiology

510 South Kingshighway Boulevard
St. Louis, MO 63110

Suite: West Pavilion, 956
Office Phone: (314) 362-1952
Fax: (314) 362-2806

Education

Education

Fellowship: Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 1973
Residency: Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 1973
Medical School: Washington University School of Medicine, St. Louis, Missouri 1969
A.B.: Washington University, St. Louis, Missouri 1966

Publication & Research

Publication & Research

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.
Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW
Br J Cancer. 2017 Nov 7; doi: 10.1038/bjc.2017.390.

PMID:
    29112685
    [PubMed - as supplied by publisher]
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Single-Agent Ibrutinib in Relapsed or Refractory Follicular Lymphoma: A Phase 2 Consortium Trial.
Bartlett NL, Costello BA, LaPlant BR, Ansell SM, Kuruvilla JG, Reeder CB, Thye LS, Anderson DM, Krysiak K, Ramirez C, Qi J, Siegel BA, Griffith M, Griffith OL, Gomez F, Fehniger TA
Blood. 2017 Oct 26; pii: blood-2017-09-804641. doi: 10.1182/blood-2017-09-804641.

PMID:
    29074501
    [PubMed - as supplied by publisher]
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First-in-Man Evaluation of <sup>124</sup>I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment.
Laforest R, Dehdashti F, Liu Y, Frye J, Frye S, Luehmann H, Sultan D, Shan JS, Freimark BD, Siegel BA
Mol Imaging. 2017 Jan-Dec; 161536012117733349. doi: 10.1177/1536012117733349.

PMID:
    29037107
    [PubMed - in process]
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Optimal FDG PET/CT volumetric parameters for risk stratification in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial.
Salavati A, Duan F, Snyder BS, Wei B, Houshmand S, Khiewvan B, Opanowski A, Simone CB 2nd, Siegel BA, Machtay M, Alavi A
Eur J Nucl Med Mol Imaging. 2017 Nov; 44(12)1969-1983. doi: 10.1007/s00259-017-3753-x.

PMID:
    28689281
    [PubMed - in process]
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Performance Observations of Scanner Qualification of NCI-Designated Cancer Centers: Results From the Centers of Quantitative Imaging Excellence (CQIE) Program.
Rosen M, Kinahan PE, Gimpel JF, Opanowski A, Siegel BA, Hill GC, Weiss L, Shankar L
Acad Radiol. 2017 Feb; 24(2)232-245. doi: 10.1016/j.acra.2016.09.025.

PMID:
    28395794
    [PubMed - in process]
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<sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.
Lee H, Shields AF, Siegel BA, Miller KD, Krop I, Ma CX, LoRusso PM, Munster PN, Campbell K, Gaddy DF, Leonard SC, Geretti E, Blocker SJ, Kirpotin DB, Moyo V, Wickham TJ, Hendriks BS
Clin Cancer Res. 2017 Aug 1; 23(15)4190-4202. doi: 10.1158/1078-0432.CCR-16-3193.

PMID:
    28298546
    [PubMed - in process]
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Qualification of National Cancer Institute-Designated Cancer Centers for Quantitative PET/CT Imaging in Clinical Trials.
Scheuermann JS, Reddin JS, Opanowski A, Kinahan PE, Siegel BA, Shankar LK, Karp JS
J Nucl Med. 2017 Jul; 58(7)1065-1071. doi: 10.2967/jnumed.116.186759.

PMID:
    28254874
    [PubMed - indexed for MEDLINE]
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Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial.
Uppaluri R, Winkler AE, Lin T, Law JH, Haughey BH, Nussenbaum B, Paniello RC, Rich JT, Diaz JA, Michel LP, Wildes T, Dunn GP, Zolkind P, Kallogjeri D, Piccirillo JF, Dehdashti F, Siegel BA, Chernock RD, Lewis JS Jr, Adkins DR
Clin Cancer Res. 2017 May 1; 23(9)2186-2194. doi: 10.1158/1078-0432.CCR-16-1469.

PMID:
    28151720
    [PubMed - in process]
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Association of post-treatment positron emission tomography with locoregional control and survival after radiation therapy for squamous cell carcinoma of the vulva.
Rao YJ, Hassanzadeh C, Chundury A, Hui C, Siegel BA, Dehdashti F, DeWees T, Mullen D, Powell MA, Mutch DG, Schwarz JK, Grigsby PW
Radiother Oncol. 2017 Mar; 122(3)445-451. doi: 10.1016/j.radonc.2016.12.019.

PMID:
    28063696
    [PubMed - indexed for MEDLINE]
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Correlation of Ki-67 Proliferative Antigen Expression and Tumor Response to Induction Chemotherapy Containing Cell Cycle-Specific Agents in Head and Neck Squamous Cell Carcinoma.
Chatzkel J, Lewis JS Jr, Ley JC, Wildes TM, Thorstad W, Gay H, Daly M, Jackson R, Rich J, Paniello R, Nussenbaum B, Liu J, Siegel BA, Dehdashti F, Adkins D
Head Neck Pathol. 2016 Dec 26; doi: 10.1007/s12105-016-0775-9.

PMID:
    28025779
    [PubMed - as supplied by publisher]
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[<sup>89</sup>Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer.
Laforest R, Lapi SE, Oyama R, Bose R, Tabchy A, Marquez-Nostra BV, Burkemper J, Wright BD, Frye J, Frye S, Siegel BA, Dehdashti F
Mol Imaging Biol. 2016 Dec; 18(6)952-959.

PMID:
    27146421
    [PubMed - indexed for MEDLINE]
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Reliability of PET/CT Shape and Heterogeneity Features in Functional and Morphologic Components of Non-Small Cell Lung Cancer Tumors: A Repeatability Analysis in a Prospective Multicenter Cohort.
Desseroit MC, Tixier F, Weber WA, Siegel BA, Cheze Le Rest C, Visvikis D, Hatt M
J Nucl Med. 2017 Mar; 58(3)406-411. doi: 10.2967/jnumed.116.180919.

PMID:
    27765856
    [PubMed - indexed for MEDLINE]
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Metabolic tumor volume predicts overall survival and local control in patients with stage III non-small cell lung cancer treated in ACRIN 6668/RTOG 0235.
Bazan JG, Duan F, Snyder BS, Horng D, Graves EE, Siegel BA, Machtay M, Loo BW Jr
Eur J Nucl Med Mol Imaging. 2017 Jan; 44(1)17-24.

PMID:
    27645692
    [PubMed - indexed for MEDLINE]
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Impact on Patient Management of [18F]-Fluorodeoxyglucose-Positron Emission Tomography (PET) Used for Cancer Diagnosis: Analysis of Data From the National Oncologic PET Registry.
Subramaniam RM, Shields AF, Sachedina A, Hanna L, Duan F, Siegel BA, Hillner BE
Oncologist. 2016 Sep; 21(9)1079-84. doi: 10.1634/theoncologist.2015-0364.

PMID:
    27401896
    [PubMed - in process]
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PET/CT is a cost-effective tool against cancer: synergy supersedes singularity.
Fischer BM, Siegel BA, Weber WA, von Bremen K, Beyer T, Kalemis A
Eur J Nucl Med Mol Imaging. 2016 Sep; 43(10)1749-52. doi: 10.1007/s00259-016-3414-5.

PMID:
    27178271
    [PubMed - indexed for MEDLINE]
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[(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection.
Zhang XM, Zhang HH, McLeroth P, Berkowitz RD, Mont MA, Stabin MG, Siegel BA, Alavi A, Barnett TM, Gelb J, Petit C, Spaltro J, Cho SY, Pomper MG, Conklin JJ, Bettegowda C, Saha S
Nucl Med Biol. 2016 May; 43(5)273-9. doi: 10.1016/j.nucmedbio.2016.01.004.

PMID:
    27150029
    [PubMed - indexed for MEDLINE]
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Pretreatment 18F-FDG PET Textural Features in Locally Advanced Non-Small Cell Lung Cancer: Secondary Analysis of ACRIN 6668/RTOG 0235.
Ohri N, Duan F, Snyder BS, Wei B, Machtay M, Alavi A, Siegel BA, Johnson DW, Bradley JD, DeNittis A, Werner-Wasik M, El Naqa I
J Nucl Med. 2016 Jun; 57(6)842-8. doi: 10.2967/jnumed.115.166934.

PMID:
    26912429
    [PubMed - indexed for MEDLINE]
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Phase 1 Evaluation of [(64)Cu]DOTA-Patritumab to Assess Dosimetry, Apparent Receptor Occupancy, and Safety in Subjects with Advanced Solid Tumors.
Lockhart AC, Liu Y, Dehdashti F, Laforest R, Picus J, Frye J, Trull L, Belanger S, Desai M, Mahmood S, Mendell J, Welch MJ, Siegel BA
Mol Imaging Biol. 2016 Jun; 18(3)446-53. doi: 10.1007/s11307-015-0912-y.

PMID:
    26567113
    [PubMed - indexed for MEDLINE]
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Regional Lymph Node Uptake of [(18)F]Fluorodeoxyglucose After Definitive Chemoradiation Therapy Predicts Local-Regional Failure of Locally Advanced Non-Small Cell Lung Cancer: Results of ACRIN 6668/RTOG 0235.
Markovina S, Duan F, Snyder BS, Siegel BA, Machtay M, Bradley JD
Int J Radiat Oncol Biol Phys. 2015 Nov 1; 93(3)597-605. doi: 10.1016/j.ijrobp.2015.04.026.

PMID:
    26461002
    [PubMed - indexed for MEDLINE]
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Repeatability of 18F-FDG PET/CT in Advanced Non-Small Cell Lung Cancer: Prospective Assessment in 2 Multicenter Trials.
Weber WA, Gatsonis CA, Mozley PD, Hanna LG, Shields AF, Aberle DR, Govindan R, Torigian DA, Karp JS, Yu JQ, Subramaniam RM, Halvorsen RA, Siegel BA, ACRIN 6678 Research team., MK-0646-008 Research team.
J Nucl Med. 2015 Aug; 56(8)1137-43. doi: 10.2967/jnumed.114.147728.

PMID:
    25908829
    [PubMed - indexed for MEDLINE]
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