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Barry Alan Siegel, MD

Professor, Radiology
Division of Nuclear Medicine
Professor, Medicine

Specialty Areas

Nuclear Medicine
Radiology
Diagnostic Radiology

Board Certifications

Diagnostic Radiology
Nuclear Medicine
Nuclear Radiology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Nuclear medicine, nuclear imaging, PET, positron emission tomography, radioiodine treatment, radionuclide imaging

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Mallinckrodt Institute of Radiology

510 South Kingshighway Boulevard
St. Louis, MO 63110

Suite: West Pavilion, 956
Office Phone: (314) 362-1952
Fax: (314) 362-2806

Education

Education

Fellowship: Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 1973
Residency: Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 1973
Medical School: Washington University School of Medicine, St. Louis, Missouri 1969
A.B.: Washington University, St. Louis, Missouri 1966

Publication & Research

Publication & Research

Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography in stage IB cervical cancer.
Lin AJ, Wright JD, Dehdashti F, Siegel BA, Markovina S, Schwarz J, Thaker PH, Mutch DG, Powell MA, Grigsby PW
Int J Gynecol Cancer. 2019 Nov; 29(9)1351-1354. doi: 10.1136/ijgc-2019-000528.

PMID:
    31473660
    [PubMed - in process]
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Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia.
Rabinovici GD, Gatsonis C, Apgar C, Chaudhary K, Gareen I, Hanna L, Hendrix J, Hillner BE, Olson C, Lesman-Segev OH, Romanoff J, Siegel BA, Whitmer RA, Carrillo MC
JAMA. 2019 Apr 2; 321(13)1286-1294. doi: 10.1001/jama.2019.2000.

PMID:
    30938796
    [PubMed - indexed for MEDLINE]
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Proceedings: Pathways for Successful Translation of New Imaging Agents and Modalities-Phase III Studies.
Gambhir SS, Shankar LK, Rosenthal E, Warram JM, Ghesani M, Hope TA, Jacobs PM, Jacobson GB, Wilson T, Siegel BA
J Nucl Med. 2019 Jun; 60(6)736-744. doi: 10.2967/jnumed.118.219824.

PMID:
    30850482
    [PubMed - in process]
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Intensity Modulated Radiation Therapy and Image-Guided Adapted Brachytherapy for Cervix Cancer.
Lin AJ, Kidd E, Dehdashti F, Siegel BA, Mutic S, Thaker PH, Massad LS, Powell MA, Mutch DG, Markovina S, Schwarz J, Grigsby PW
Int J Radiat Oncol Biol Phys. 2019 Apr 1; 103(5)1088-1097. doi: 10.1016/j.ijrobp.2018.11.012.

PMID:
    30445171
    [PubMed - indexed for MEDLINE]
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Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study.
Munster P, Krop IE, LoRusso P, Ma C, Siegel BA, Shields AF, Molnár I, Wickham TJ, Reynolds J, Campbell K, Hendriks BS, Adiwijaya BS, Geretti E, Moyo V, Miller KD
Br J Cancer. 2018 Oct; 119(9)1086-1093. doi: 10.1038/s41416-018-0235-2.

PMID:
    30361524
    [PubMed - indexed for MEDLINE]
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The Impact of Positron Emission Tomography with 18F-Fluciclovine on the Treatment of Biochemical Recurrence of Prostate Cancer: Results from the LOCATE Trial.
Andriole GL, Kostakoglu L, Chau A, Duan F, Mahmood U, Mankoff DA, Schuster DM, Siegel BA, LOCATE Study Group.
J Urol. 2019 Feb; 201(2)322-331. doi: 10.1016/j.juro.2018.08.050.

PMID:
    30179618
    [PubMed - indexed for MEDLINE]
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Pazopanib plus cetuximab in recurrent or metastatic head and neck squamous cell carcinoma: an open-label, phase 1b and expansion study.
Adkins D, Mehan P, Ley J, Siegel MJ, Siegel BA, Dehdashti F, Jiang X, Salama NN, Trinkaus K, Oppelt P
Lancet Oncol. 2018 Aug; 19(8)1082-1093. doi: 10.1016/S1470-2045(18)30350-4.

PMID:
    30001987
    [PubMed - indexed for MEDLINE]
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Spatial relationship of 2-deoxy-2-[<sup>18</sup>F]-fluoro-D-glucose positron emission tomography and magnetic resonance diffusion imaging metrics in cervical cancer.
Floberg JM, Fowler KJ, Fuser D, DeWees TA, Dehdashti F, Siegel BA, Wahl RL, Schwarz JK, Grigsby PW
EJNMMI Res. 2018 Jun 15; 8(1)52. doi: 10.1186/s13550-018-0403-7.

PMID:
    29904822
    [PubMed]
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Adrenal Histoplasmosis.
Sanders V, Donald J, Siegel BA
Clin Nucl Med. 2018 Jul; 43(7)502-503. doi: 10.1097/RLU.0000000000002094.

PMID:
    29762233
    [PubMed - indexed for MEDLINE]
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Evaluation of [<sup>89</sup>Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer.
Dehdashti F, Wu N, Bose R, Naughton MJ, Ma CX, Marquez-Nostra BV, Diebolder P, Mpoy C, Rogers BE, Lapi SE, Laforest R, Siegel BA
Breast Cancer Res Treat. 2018 Jun; 169(3)523-530. doi: 10.1007/s10549-018-4696-z.

PMID:
    29442264
    [PubMed - indexed for MEDLINE]
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Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by <sup>18</sup>F-FDG PET/CT: a Case Report and Review of Literature.
Fuser D, Hedberg ML, Dehner LP, Dehdashti F, Siegel BA
J Kidney Cancer VHL. 2018; 5(1)1-6. doi: 10.15586/jkcvhl.2018.99.

PMID:
    29354391
    [PubMed]
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Hospice Admission and Survival After <sup>18</sup>F-Fluoride PET Performed for Evaluation of Osseous Metastatic Disease in the National Oncologic PET Registry.
Gareen IF, Hillner BE, Hanna L, Makineni R, Duan F, Shields AF, Subramaniam RM, Siegel BA
J Nucl Med. 2018 Mar; 59(3)427-433. doi: 10.2967/jnumed.117.205120.

PMID:
    29284672
    [PubMed - indexed for MEDLINE]
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Intended Versus Inferred Treatment After <sup>18</sup>F-Fluoride PET Performed for Evaluation of Osseous Metastatic Disease in the National Oncologic PET Registry.
Hillner BE, Hanna L, Makineni R, Duan F, Shields AF, Subramaniam RM, Gareen I, Siegel BA
J Nucl Med. 2018 Mar; 59(3)421-426. doi: 10.2967/jnumed.117.205047.

PMID:
    29191854
    [PubMed - indexed for MEDLINE]
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Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.
Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW
Br J Cancer. 2018 Jan; 118(1)72-78. doi: 10.1038/bjc.2017.390.

PMID:
    29112685
    [PubMed - indexed for MEDLINE]
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Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial.
Bartlett NL, Costello BA, LaPlant BR, Ansell SM, Kuruvilla JG, Reeder CB, Thye LS, Anderson DM, Krysiak K, Ramirez C, Qi J, Siegel BA, Griffith M, Griffith OL, Gomez F, Fehniger TA
Blood. 2018 Jan 11; 131(2)182-190. doi: 10.1182/blood-2017-09-804641.

PMID:
    29074501
    [PubMed - indexed for MEDLINE]
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First-in-Man Evaluation of <sup>124</sup>I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment.
Laforest R, Dehdashti F, Liu Y, Frye J, Frye S, Luehmann H, Sultan D, Shan JS, Freimark BD, Siegel BA
Mol Imaging. 2017 Jan-Dec; 161536012117733349. doi: 10.1177/1536012117733349.

PMID:
    29037107
    [PubMed - indexed for MEDLINE]
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Optimal FDG PET/CT volumetric parameters for risk stratification in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial.
Salavati A, Duan F, Snyder BS, Wei B, Houshmand S, Khiewvan B, Opanowski A, Simone CB 2nd, Siegel BA, Machtay M, Alavi A
Eur J Nucl Med Mol Imaging. 2017 Nov; 44(12)1969-1983. doi: 10.1007/s00259-017-3753-x.

PMID:
    28689281
    [PubMed - indexed for MEDLINE]
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Performance Observations of Scanner Qualification of NCI-Designated Cancer Centers: Results From the Centers of Quantitative Imaging Excellence (CQIE) Program.
Rosen M, Kinahan PE, Gimpel JF, Opanowski A, Siegel BA, Hill GC, Weiss L, Shankar L
Acad Radiol. 2017 Feb; 24(2)232-245. doi: 10.1016/j.acra.2016.09.025.

PMID:
    28395794
    [PubMed - indexed for MEDLINE]
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<sup>64</sup>Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.
Lee H, Shields AF, Siegel BA, Miller KD, Krop I, Ma CX, LoRusso PM, Munster PN, Campbell K, Gaddy DF, Leonard SC, Geretti E, Blocker SJ, Kirpotin DB, Moyo V, Wickham TJ, Hendriks BS
Clin Cancer Res. 2017 Aug 1; 23(15)4190-4202. doi: 10.1158/1078-0432.CCR-16-3193.

PMID:
    28298546
    [PubMed - indexed for MEDLINE]
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Qualification of National Cancer Institute-Designated Cancer Centers for Quantitative PET/CT Imaging in Clinical Trials.
Scheuermann JS, Reddin JS, Opanowski A, Kinahan PE, Siegel BA, Shankar LK, Karp JS
J Nucl Med. 2017 Jul; 58(7)1065-1071. doi: 10.2967/jnumed.116.186759.

PMID:
    28254874
    [PubMed - indexed for MEDLINE]
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