Patient Portal

Babak Razani, MD, PhD

Assistant Professor, Medicine
Division of Cardiology

Specialty Areas

Cardiology
Echocardiography
Cardiovascular Disease

Board Certifications

Echocardiography
Cardiovascular Diseases

Hospital Affiliations

Barnes-Jewish Hospital
VA Medical Center - St. Louis - John Cochran Division

Languages

Farsi

Areas of Clinical Interest

Clinical cardiology, preventive cardiology, echocardiography.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

VA Medical Center: John Cochran Division

915 North Grand Boulevard
St. Louis, MO 63106

Education

Education

Fellowship, Cardiology: Washington University School of Medicine, St. Louis, MO 2009
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2005
Medical Degree: Albert Einstein College of Medicine, New York, NY 2003
PhD, Molecular Pharmacology: Albert Einstein College of Medicine, New York, NY 2001

Publication & Research

Publication & Research

Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF
Diabetol Metab Syndr. 2019; 1161. doi: 10.1186/s13098-019-0456-4.

PMID:
    31384309
    [PubMed]
Related citations


Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages.
Kalugotla G, He L, Weber KJ, Daemen S, Reller A, Razani B, Schilling JD
J Leukoc Biol. 2019 Oct; 106(4)803-814. doi: 10.1002/JLB.3HI0219-045RR.

PMID:
    31166619
    [PubMed - in process]
Related citations


Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation.
Heo GS, Zhao Y, Sultan D, Zhang X, Detering L, Luehmann HP, Zhang X, Li R, Choksi A, Sharp S, Levingston S, Primeau T, Reichert DE, Sun G, Razani B, Li S, Weilbaecher KN, Dehdashti F, Wooley KL, Liu Y
ACS Appl Mater Interfaces. 2019 Jun 5; 11(22)19669-19678. doi: 10.1021/acsami.8b22752.

PMID:
    31074257
    [PubMed - in process]
Related citations


Publisher Correction: Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S
Nat Immunol. 2019 May; 20(5)664. doi: 10.1038/s41590-019-0363-8.

PMID:
    30862954
    [PubMed]
Related citations


p62/<i>SQSTM1</i> and Selective Autophagy in Cardiometabolic Diseases.
Jeong SJ, Zhang X, Rodriguez-Velez A, Evans TD, Razani B
Antioxid Redox Signal. 2019 Aug 20; 31(6)458-471. doi: 10.1089/ars.2018.7649.

PMID:
    30588824
    [PubMed - in process]
Related citations


Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.
Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S
Nat Immunol. 2019 Jan; 20(1)29-39. doi: 10.1038/s41590-018-0272-2.

PMID:
    30538339
    [PubMed - indexed for MEDLINE]
Related citations


Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.
Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ
J Clin Invest. 2019 Feb 1; 129(2)694-711. doi: 10.1172/JCI120606.

PMID:
    30511960
    [PubMed - in process]
Related citations


PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism.
Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, Schilling JD
J Immunol. 2018 Oct 1; 201(7)2054-2069. doi: 10.4049/jimmunol.1800224.

PMID:
    30143592
    [PubMed - indexed for MEDLINE]
Related citations


TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.
Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani B, Graham MJ, Hruz PW, DeBosch BJ
Autophagy. 2018; 14(11)1959-1975. doi: 10.1080/15548627.2018.1493044.

PMID:
    29996716
    [PubMed - in process]
Related citations


Classical and alternative roles for autophagy in lipid metabolism.
Zhang X, Evans TD, Jeong SJ, Razani B
Curr Opin Lipidol. 2018 Jun; 29(3)203-211. doi: 10.1097/MOL.0000000000000509.

PMID:
    29601311
    [PubMed - indexed for MEDLINE]
Related citations


TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis.
Evans TD, Jeong SJ, Zhang X, Sergin I, Razani B
Autophagy. 2018; 14(4)724-726. doi: 10.1080/15548627.2018.1434373.

PMID:
    29394113
    [PubMed - indexed for MEDLINE]
Related citations


A CD103<sup>+</sup> Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis.
Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, Lavine KJ, Husain M, Brooks DG, Robbins CS, Cybulsky M, Epelman S
Immunity. 2017 Nov 21; 47(5)974-989.e8. doi: 10.1016/j.immuni.2017.10.011.

PMID:
    29166591
    [PubMed - indexed for MEDLINE]
Related citations


CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.
Zhang H, Shi J, Hachet MA, Xue C, Bauer RC, Jiang H, Li W, Tohyama J, Millar J, Billheimer J, Phillips MC, Razani B, Rader DJ, Reilly MP
Arterioscler Thromb Vasc Biol. 2017 Nov; 37(11)2156-2160. doi: 10.1161/ATVBAHA.117.310023.

PMID:
    28882870
    [PubMed - indexed for MEDLINE]
Related citations


Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.
Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A
Autophagy. 2017; 13(11)1952-1968. doi: 10.1080/15548627.2017.1368596.

PMID:
    28853981
    [PubMed - indexed for MEDLINE]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Aug 22; 20(8)1994. doi: 10.1016/j.celrep.2017.08.019.

PMID:
    28834760
    [PubMed]
Related citations


N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damås JK, Razani B, Flo TH, Bjørkøy G
Autophagy. 2017 Oct 3; 13(10)1664-1678. doi: 10.1080/15548627.2017.1345411.

PMID:
    28820283
    [PubMed - indexed for MEDLINE]
Related citations


Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment.
Fang L, Hodge J, Saaoud F, Wang J, Iwanowycz S, Wang Y, Hui Y, Evans TD, Razani B, Fan D
Oncoimmunology. 2017; 6(5)e1312042. doi: 10.1080/2162402X.2017.1312042.

PMID:
    28638736
    [PubMed]
Related citations


Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B
Nat Commun. 2017 Jun 7; 815750. doi: 10.1038/ncomms15750.

PMID:
    28589926
    [PubMed - indexed for MEDLINE]
Related citations


Linking lysosomal acid lipase insufficiency to the development of cryptogenic cirrhosis.
Block RC, Razani B
Atherosclerosis. 2017 Jul; 262140-142. doi: 10.1016/j.atherosclerosis.2017.04.018.

PMID:
    28502381
    [PubMed - indexed for MEDLINE]
Related citations


Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.
Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC
Cell Rep. 2017 Apr 4; 19(1)188-202. doi: 10.1016/j.celrep.2017.03.030.

PMID:
    28380357
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Atherosclerosis, myocardial infarction, lipid metabolism, immunology, diabetes, obesity, fatty liver disease.