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Anne Maureen Connolly, MD

Professor, Neurology
Division of Pediatric Neurology
Professor, Pediatrics

Specialty Areas

Pediatric Neurology
Neuromuscular Disease
Nerve Disorders
Muscle Disorders
Muscular Dystrophy
ALS - Lou Gehrig's Disease
Myasthenia Gravis
Electromyography

Board Certifications

EMG
Pediatrics
Pediatric Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Childhood chronic demyelinating polyneuropathy, Duchenne muscular dystrophy, congenital muscular dystrophy syndromes, brachial plexus injury, myotonia congenita, childhood opsoclonus-myoclonus, spiral muscularatrophy, childhood myasthenia gravis, myasthenic syndrome, childhood neuropathy, childhood electromyography, neuromuscular disease, electromyography, electrodiagnostic studies,, nerve disorders.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D
Office Phone: 314-454-6120
Fax: 314-454-2523

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752
Email: connolly@kids.wustl.edu

Education

Education

Fellowship: Child Neurology, St. Louis Children's Hospital, St. Louis, Missouri 1990
Residency: Neurology, Barnes Hospital/Washington University School of Medicine, St. Louis, Missouri 1988
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1987
Medical Degree: Indiana University, Indianapolis, Indiana 1984
B.S.: Saint Mary's College, Notre Dame, Indiana 1980

Publication & Research

Publication & Research

<i>PMP22</i> exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E.
Wang DS, Wu X, Bai Y, Zaidman C, Grider T, Kamholz J, Lupski JR, Connolly AM, Shy ME
Ann Clin Transl Neurol. 2017 Apr; 4(4)236-245. doi: 10.1002/acn3.395.

PMID:
    28382305
    [PubMed]
Related citations


Comments on Letter to the Editor entitled: "Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type1 and Emery Dreifuss Muscular Dystrophy".
Sommerville RB, Vincenti MG, Winborn K, Casey A, Stitziel NO, Connolly AM, Mann DL
Trends Cardiovasc Med. 2017 Feb 7; pii: S1050-1738(17)30014-2. doi: 10.1016/j.tcm.2017.02.002.

PMID:
    28291654
    [PubMed - as supplied by publisher]
Related citations


Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F
J Clin Invest. 2017 Mar 1; 127(3)912-928. doi: 10.1172/JCI89626.

PMID:
    28165339
    [PubMed - in process]
Related citations


Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy.
Hogarth MW, Houweling PJ, Thomas KC, Gordish-Dressman H, Bello L, Cooperative International Neuromuscular Research Group (CINRG)., Pegoraro E, Hoffman EP, Head SI, North KN
Nat Commun. 2017 Jan 31; 814143. doi: 10.1038/ncomms14143.

PMID:
    28139640
    [PubMed - in process]
Related citations


Tracking diaphragm movement by using ultrasound to assess its strength.
Connolly AM, Mittendorfer B
J Physiol. 2016 Dec 15; 594(24)7147-7148. doi: 10.1113/JP273313.

PMID:
    27976400
    [PubMed - in process]
Related citations


Association Study of Exon Variants in the NF-κB and TGFβ Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy.
Bello L, Flanigan KM, Weiss RB, United Dystrophinopathy Project., Spitali P, Aartsma-Rus A, Muntoni F, Zaharieva I, Ferlini A, Mercuri E, Tuffery-Giraud S, Claustres M, Straub V, Lochmüller H, Barp A, Vianello S, Pegoraro E, Punetha J, Gordish-Dressman H, Giri M, McDonald CM, Hoffman EP, Cooperative International Neuromuscular Research Group.
Am J Hum Genet. 2016 Nov 3; 99(5)1163-1171. doi: 10.1016/j.ajhg.2016.08.023.

PMID:
    27745838
    [PubMed - in process]
Related citations


Baseline Understanding of Urinary Incontinence (UI) and Prolapse (POP) in New FPMRS Patients: Is There an Age-Related Difference?
Davidson E, Myers EM, De La Cruz JF, Connolly AM
J Minim Invasive Gynecol. 2015 Nov-Dec; 22(6S)S64-S65. doi: 10.1016/j.jmig.2015.08.172.

PMID:
    27679299
    [PubMed - as supplied by publisher]
Related citations


Evaluation of an E-learning resource on approach to the first unprovoked seizure.
Le Marne FA, McGinness H, Slade R, Cardamone M, Balbir Singh S, Connolly AM, Bye AM
J Paediatr Child Health. 2016 Sep; 52(9)896-900. doi: 10.1111/jpc.13277.

PMID:
    27650145
    [PubMed - in process]
Related citations


Diagnosis and management of adult hereditary cardio-neuromuscular disorders: A model for the multidisciplinary care of complex genetic disorders.
Sommerville RB, Vincenti MG, Winborn K, Casey A, Stitziel NO, Connolly AM, Mann DL
Trends Cardiovasc Med. 2017 Jan; 27(1)51-58. doi: 10.1016/j.tcm.2016.06.005.

PMID:
    27452966
    [PubMed - in process]
Related citations


Clinical Follow-Up for Duchenne Muscular Dystrophy Newborn Screening: A Proposal.
Kwon JM, Abdel-Hamid HZ, Al-Zaidy SA, Mendell JR, Kennedy A, Kinnett K, Cwik VA, Street N, Bolen J, Day JW, Connolly AM
Muscle Nerve. 2016 Aug; 54(2)186-91. doi: 10.1002/mus.25185.

PMID:
    27170260
    [PubMed - in process]
Related citations


A recurrent de novo CTBP1 mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects.
Beck DB, Cho MT, Millan F, Yates C, Hannibal M, O'Connor B, Shinawi M, Connolly AM, Waggoner D, Halbach S, Angle B, Sanders V, Shen Y, Retterer K, Begtrup A, Bai R, Chung WK
Neurogenetics. 2016 Jul; 17(3)173-8. doi: 10.1007/s10048-016-0482-4.

PMID:
    27094857
    [PubMed - in process]
Related citations


Clinical trial readiness in non-ambulatory boys and men with duchenne muscular dystrophy: MDA-DMD network follow-up.
Connolly AM, Florence JM, Zaidman CM, Golumbek PT, Mendell JR, Flanigan KM, Karachunski PI, Day JW, McDonald CM, Darras BT, Kang PB, Siener CA, Gadeken RK, Anand P, Schierbecker JR, Malkus EC, Lowes LP, Alfano LN, Johnson L, Nicorici A, Kelecic JM, Quigley J, Pasternak AE, Miller JP, MDA-DMD Clinical Research Network.
Muscle Nerve. 2016 Oct; 54(4)681-9. doi: 10.1002/mus.25089.

PMID:
    26930423
    [PubMed - in process]
Related citations


Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study.
Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT, NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators.
Ann Clin Transl Neurol. 2016 Feb; 3(2)132-45. doi: 10.1002/acn3.283.

PMID:
    26900585
    [PubMed]
Related citations


Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy.
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E, Eteplirsen Study Group and Telethon Foundation DMD Italian Network.
Ann Neurol. 2016 Feb; 79(2)257-71. doi: 10.1002/ana.24555.

PMID:
    26573217
    [PubMed - indexed for MEDLINE]
Related citations


The Severity of Gliosis in Hippocampal Sclerosis Correlates with Pre-Operative Seizure Burden and Outcome After Temporal Lobectomy.
Johnson AM, Sugo E, Barreto D, Hiew CC, Lawson JA, Connolly AM, Somerville E, Hasic E, Bye AM, Cunningham AM
Mol Neurobiol. 2016 Oct; 53(8)5446-56. doi: 10.1007/s12035-015-9465-y.

PMID:
    26452360
    [PubMed - in process]
Related citations


Quantitative muscle ultrasound measures rapid declines over time in children with SMA type 1.
Ng KW, Connolly AM, Zaidman CM
J Neurol Sci. 2015 Nov 15; 358(1-2)178-82. doi: 10.1016/j.jns.2015.08.1532.

PMID:
    26432577
    [PubMed - indexed for MEDLINE]
Related citations


Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
Schweitzer GG, Collier SL, Chen Z, Eaton JM, Connolly AM, Bucelli RC, Pestronk A, Harris TE, Finck BN
JIMD Rep. 2015; 23113-22. doi: 10.1007/8904_2015_440.

PMID:
    25967228
    [PubMed]
Related citations


Feasibility and Reproducibility of Echocardiographic Measures in Children with Muscular Dystrophies.
Spurney CF, McCaffrey FM, Cnaan A, Morgenroth LP, Ghelani SJ, Gordish-Dressman H, Arrieta A, Connolly AM, Lotze TE, McDonald CM, Leshner RT, Clemens PR
J Am Soc Echocardiogr. 2015 Aug; 28(8)999-1008. doi: 10.1016/j.echo.2015.03.003.

PMID:
    25906753
    [PubMed - indexed for MEDLINE]
Related citations


Muscle ultrasound quantifies disease progression over time in infants and young boys with duchenne muscular dystrophy.
Zaidman CM, Malkus EC, Connolly AM
Muscle Nerve. 2015 Sep; 52(3)334-8. doi: 10.1002/mus.24609.

PMID:
    25704979
    [PubMed - indexed for MEDLINE]
Related citations


Electrical impedance myography in Duchenne muscular dystrophy and healthy controls: A multicenter study of reliability and validity.
Zaidman CM, Wang LL, Connolly AM, Florence J, Wong BL, Parsons JA, Apkon S, Goyal N, Williams E, Escolar D, Rutkove SB, Bohorquez JL, DART-EIM Clinical Evaluators Consortium.
Muscle Nerve. 2015 Oct; 52(4)592-7. doi: 10.1002/mus.24611.

PMID:
    25702806
    [PubMed - indexed for MEDLINE]
Related citations