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Anne H. Cross, MD

Manny and Rosalyn Rosenthal - Dr. John Trotter MS Center Chair in Neuroimmunology
Professor, Neurology
Division of Adult Neurology
Section Head, Neuroimmunology

Specialty Areas

Multiple Sclerosis
Neurology - Adult
Transverse Myelitis
Optic Neuritis
Neuromyelitis optica

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Multiple sclerosis, neuromyelitis optica, transverse myelitis, CADASIL, CNS vasculitis, experimental autoimmune encephalomyelitis, autoimmune demyelination, lymphocyte-endothelial cell adhesions.

  • Maps & Directions
  • Education
  • Publication & Research
  • In the News
  • Financial Disclosures

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Suite:
Floor:
Office Phone: 314-362-3293
Fax: 314-747-1345

Education

Education

Fellowship: Neuropathology, National Multiple Sclerosis Society, Albert Einstein College of Medicine, Bronx, New York 1990
Fellowship: Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 1987
Fellowship: Neuroimmunology Branch, National Institutes of Health, Bethesda, Maryland 1986
Residency: Neurology, George Washington University, Washington, District of Columbia 1984
Medical Degree: University Of Alabama School of Medicine, Birmingham, Alabama 1980
B.S.: Chemistry, University of South Alabama, Mobile, Alabama 1976

Publication & Research

Publication & Research

Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count.
Longbrake EE, Cantoni C, Chahin S, Cignarella F, Cross AH, Piccio L
Mult Scler. 2017 May 1; 1352458517707069. doi: 10.1177/1352458517707069.

PMID:
    28480794
    [PubMed - as supplied by publisher]
Related citations


Speaking out about gender imbalance in invited speakers improves diversity.
Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH
Nat Immunol. 2017 Apr 18; 18(5)475-478. doi: 10.1038/ni.3707.

PMID:
    28418385
    [PubMed - in process]
Related citations


Diffusion MRI quantifies early axonal loss in the presence of nerve swelling.
Lin TH, Chiang CW, Perez-Torres CJ, Sun P, Wallendorf M, Schmidt RE, Cross AH, Song SK
J Neuroinflammation. 2017 Apr 7; 14(1)78. doi: 10.1186/s12974-017-0852-3.

PMID:
    28388913
    [PubMed - in process]
Related citations


Female hormonal exposures and neuromyelitis optica symptom onset in a multicenter study.
Bove R, Elsone L, Alvarez E, Borisow N, Cortez MM, Mateen FJ, Mealy MA, Mutch K, Tobyne S, Ruprecht K, Buckle G, Levy M, Wingerchuk DM, Paul F, Cross AH, Weinshenker B, Jacob A, Klawiter EC, Chitnis T
Neurol Neuroimmunol Neuroinflamm. 2017 May; 4(3)e339. doi: 10.1212/NXI.0000000000000339.

PMID:
    28382320
    [PubMed - in process]
Related citations


Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein.
Lyons JA, Riter MM, Almatrook AM, Ramsbottom MJ, Cross AH
J Neuroimmunol. 2016 Nov 15; 30066-73. doi: 10.1016/j.jneuroim.2016.06.006.

PMID:
    27423965
    [PubMed - in process]
Related citations


"A new imaging modality to non-invasively assess multiple sclerosis pathology".
Cross AH, Song SK
J Neuroimmunol. 2017 Mar 15; 30481-85. doi: 10.1016/j.jneuroim.2016.10.002.

PMID:
    27773433
    [PubMed - in process]
Related citations


The contemporary spectrum of multiple sclerosis misdiagnosis: A multicenter study.
Solomon AJ, Bourdette DN, Cross AH, Applebee A, Skidd PM, Howard DB, Spain RI, Cameron MH, Kim E, Mass MK, Yadav V, Whitham RH, Longbrake EE, Naismith RT, Wu GF, Parks BJ, Wingerchuk DM, Rabin BL, Toledano M, Tobin WO, Kantarci OH, Carter JL, Keegan BM, Weinshenker BG
Neurology. 2016 Sep 27; 87(13)1393-9. doi: 10.1212/WNL.0000000000003152.

PMID:
    27581217
    [PubMed - indexed for MEDLINE]
Related citations


A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD
Cell Rep. 2016 Jun 7; 15(10)2136-46. doi: 10.1016/j.celrep.2016.05.009.

PMID:
    27239035
    [PubMed - in process]
Related citations


On the relationship between cellular and hemodynamic properties of the human brain cortex throughout adult lifespan.
Zhao Y, Wen J, Cross AH, Yablonskiy DA
Neuroimage. 2016 Jun; 133417-29. doi: 10.1016/j.neuroimage.2016.03.022.

PMID:
    26997360
    [PubMed - in process]
Related citations


Simultaneous multi-angular relaxometry of tissue with MRI (SMART MRI): Theoretical background and proof of concept.
Sukstanskii AL, Wen J, Cross AH, Yablonskiy DA
Magn Reson Med. 2017 Mar; 77(3)1296-1306. doi: 10.1002/mrm.26176.

PMID:
    26991525
    [PubMed - in process]
Related citations


Effect of Multiple Sclerosis Disease-Modifying Therapies on B Cells and Humoral Immunity.
Longbrake EE, Cross AH
JAMA Neurol. 2016 Feb; 73(2)219-25. doi: 10.1001/jamaneurol.2015.3977.

PMID:
    26720195
    [PubMed - indexed for MEDLINE]
Related citations


Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice.
Longbrake EE, Cross AH, Salter A
Mult Scler J Exp Transl Clin. 2016 Jan-Dec; 2doi: 10.1177/2055217316677868.

PMID:
    28280599
    [PubMed - in process]
Related citations


Predicting optimal response to B-cell depletion with rituximab in multiple sclerosis using CXCL13 index, magnetic resonance imaging and clinical measures.
Alvarez E, Piccio L, Mikesell RJ, Trinkaus K, Parks BJ, Naismith RT, Cross AH
Mult Scler J Exp Transl Clin. 2015 Jan-Dec; 12055217315623800. doi: 10.1177/2055217315623800.

PMID:
    28607711
    [PubMed]
Related citations


Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R
Lancet Neurol. 2016 Jan; 15(1)35-46. doi: 10.1016/S1474-4422(15)00322-1.

PMID:
    26621682
    [PubMed - indexed for MEDLINE]
Related citations


Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance.
Longbrake EE, Naismith RT, Parks BJ, Wu GF, Cross AH
Mult Scler J Exp Transl Clin. 2015 Jan-Dec; 1pii: 2055217315596994.

PMID:
    26550483
    [PubMed]
Related citations


Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients.
Longbrake EE, Ramsbottom MJ, Cantoni C, Ghezzi L, Cross AH, Piccio L
Mult Scler. 2016 Jul; 22(8)1061-70. doi: 10.1177/1352458515608961.

PMID:
    26459150
    [PubMed - in process]
Related citations


Detection of cortical lesions in multiple sclerosis: A new imaging approach.
Patel KR, Luo J, Alvarez E, Piccio L, Schmidt RE, Yablonskiy DA, Cross AH
Mult Scler J Exp Transl Clin. 2015 Jan-Dec; 12055217315606465. doi: 10.1177/2055217315606465.

PMID:
    28607704
    [PubMed]
Related citations


Enhancing our understanding of white matter changes in early multiple sclerosis.
Naismith RT, Cross AH
Brain. 2015 Sep; 138(Pt 9)2465-6. doi: 10.1093/brain/awv196.

PMID:
    26304148
    [PubMed - indexed for MEDLINE]
Related citations


Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis.
Wang Y, Sun P, Wang Q, Trinkaus K, Schmidt RE, Naismith RT, Cross AH, Song SK
Brain. 2015 May; 138(Pt 5)1223-38. doi: 10.1093/brain/awv046.

PMID:
    25724201
    [PubMed - indexed for MEDLINE]
Related citations


TREM2 regulates microglial cell activation in response to demyelination in vivo.
Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, Yuede CM, Galimberti D, Olivecrona G, Klein RS, Cross AH, Otero K, Piccio L
Acta Neuropathol. 2015 Mar; 129(3)429-47. doi: 10.1007/s00401-015-1388-1.

PMID:
    25631124
    [PubMed - indexed for MEDLINE]
Related citations

In the News

In the News

Anne Cross, MD

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: EMD Serona

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Genzyme/Sanofi Aventis

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017