Patient Portal

Angela C. Hirbe, MD, PhD

Assistant Professor, Medicine
Division of Oncology, Section of Medical Oncology

Specialty Areas

Oncology
Sarcoma
Medical Oncology

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Medical oncology, cancer, sarcoma

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-747-1171
Fax: 314-362-7086

Siteman Cancer Center - South County

5225 MidAmerica Plaza
St. Louis, MO 63129

Office Phone: 314-747-1171

Education

Education

Fellowship, Oncology: Washington University School of Medicine, St. Louis, MO 2016
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2011
PhD: Washington University School of Medicine, St. Louis, MO 2009
Medical Degree: Washington University School of Medicine, St. Louis, MO 2009
Bachelor of Arts: Washington University in St. Louis, St. Louis, MO 2001

Publication & Research

Publication & Research

Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST.
Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S
Oncotarget. 2018 May 1; 9(33)23018-23028. doi: 10.18632/oncotarget.25195.

PMID:
    29796169
    [PubMed]
Related citations


β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH
Neuro Oncol. 2018 May 18; 20(6)858-860. doi: 10.1093/neuonc/noy038.

PMID:
    29596596
    [PubMed - in process]
Related citations


A Phase II Study of Tumor Ablation in Patients with Metastatic Sarcoma Stable on Chemotherapy.
Hirbe AC, Jennings J, Saad N, Giardina JD, Tao Y, Luo J, Berry S, Toeniskoetter J, Van Tine BA
Oncologist. 2018 Jul; 23(7)760-e76. doi: 10.1634/theoncologist.2017-0536.

PMID:
    29487221
    [PubMed - in process]
Related citations


Gastrointestinal stromal tumors (GISTs): point mutations matter in management, a review.
Oppelt PJ, Hirbe AC, Van Tine BA
J Gastrointest Oncol. 2017 Jun; 8(3)466-473. doi: 10.21037/jgo.2016.09.15.

PMID:
    28736634
    [PubMed]
Related citations


Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors.
Hirbe AC, Cosper PF, Dahiya S, Van Tine BA
Sarcoma. 2017; 20173761292. doi: 10.1155/2017/3761292.

PMID:
    28546782
    [PubMed]
Related citations


Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
Cancer. 2017 Apr 1; 123(7)1194-1201. doi: 10.1002/cncr.30455.

PMID:
    27875628
    [PubMed - indexed for MEDLINE]
Related citations


Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH
Oncotarget. 2016 Feb 16; 7(7)7403-14. doi: 10.18632/oncotarget.7232.

PMID:
    26859681
    [PubMed - indexed for MEDLINE]
Related citations


Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
Clin Cancer Res. 2015 Sep 15; 21(18)4201-11. doi: 10.1158/1078-0432.CCR-14-3049.

PMID:
    25925892
    [PubMed - indexed for MEDLINE]
Related citations


A multidisciplinary approach in neurofibromatosis 1--authors' reply.
Epstein JA, Ingram DA Jr, Hirbe AC, Gutmann DH
Lancet Neurol. 2015 Jan; 14(1)30-1. doi: 10.1016/S1474-4422(14)70298-4.

PMID:
    25496893
    [PubMed - indexed for MEDLINE]
Related citations


Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.
Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A
Mod Pathol. 2015 Feb; 28(2)187-200. doi: 10.1038/modpathol.2014.109.

PMID:
    25189642
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1: a multidisciplinary approach to care.
Hirbe AC, Gutmann DH
Lancet Neurol. 2014 Aug; 13(8)834-43. doi: 10.1016/S1474-4422(14)70063-8.

PMID:
    25030515
    [PubMed - indexed for MEDLINE]
Related citations


BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
Neuro Oncol. 2014 Mar; 16(3)466-7. doi: 10.1093/neuonc/not248.

PMID:
    24366910
    [PubMed - indexed for MEDLINE]
Related citations


Novel pathways and molecular targets for the treatment of sarcoma.
Frith AE, Hirbe AC, Van Tine BA
Curr Oncol Rep. 2013 Aug; 15(4)378-85. doi: 10.1007/s11912-013-0319-3.

PMID:
    23661264
    [PubMed - indexed for MEDLINE]
Related citations


The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN
J Clin Invest. 2012 Oct; 122(10)3579-92. doi: 10.1172/JCI38576.

PMID:
    22996695
    [PubMed - indexed for MEDLINE]
Related citations


CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.
Zhang K, Kim S, Cremasco V, Hirbe AC, Collins L, Piwnica-Worms D, Novack DV, Weilbaecher K, Faccio R
Cancer Res. 2011 Jul 15; 71(14)4799-808. doi: 10.1158/0008-5472.CAN-10-3922.

PMID:
    21602433
    [PubMed - indexed for MEDLINE]
Related citations


The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?
Hirbe AC, Morgan EA, Weilbaecher KN
Curr Pharm Des. 2010; 16(11)1284-90.

PMID:
    20166978
    [PubMed - indexed for MEDLINE]
Related citations


The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC, Piwnica-Worms D, Rogers MJ, Weilbaecher K
Bone. 2009 May; 44(5)908-16. doi: 10.1016/j.bone.2009.01.010.

PMID:
    19442620
    [PubMed - indexed for MEDLINE]
Related citations


RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.
Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV
Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10)3897-902. doi: 10.1073/pnas.0708576105.

PMID:
    18322009
    [PubMed - indexed for MEDLINE]
Related citations


APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Uluçkan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K
J Cell Biochem. 2008 Jul 1; 104(4)1311-23. doi: 10.1002/jcb.21709.

PMID:
    18260128
    [PubMed - indexed for MEDLINE]
Related citations


A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.
Apicelli AJ, Maggi LB Jr, Hirbe AC, Miceli AP, Olanich ME, Schulte-Winkeler CL, Saporita AJ, Kuchenreuther M, Sanchez J, Weilbaecher K, Weber JD
Mol Cell Biol. 2008 Feb; 28(3)1068-80.

PMID:
    18070929
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

As a practicing medical oncologist who treats sarcoma, my research focuses on utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.