Patient Portal

Angela C. Hirbe, MD, PhD

Assistant Professor, Medicine
Division of Oncology, Section of Medical Oncology

Specialty Areas

Oncology
Sarcoma
Medical Oncology

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Medical oncology, cancer, sarcoma

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-747-1171
Fax: 314-362-7086

Siteman Cancer Center - South County

5225 MidAmerica Plaza
St. Louis, MO 63129

Office Phone: 314-747-1171

Education

Education

Fellowship, Oncology: Washington University School of Medicine, St. Louis, MO 2016
Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO 2011
PhD: Washington University School of Medicine, St. Louis, MO 2009
Medical Degree: Washington University School of Medicine, St. Louis, MO 2009
Bachelor of Arts: Washington University in St. Louis, St. Louis, MO 2001

Publication & Research

Publication & Research

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).
Widemann BC, Lu Y, Reinke D, Okuno SH, Meyer CF, Cote GM, Chugh R, Milhem MM, Hirbe AC, Kim A, Turpin B, Pressey JG, Dombi E, Jayaprakash N, Helman LJ, Onwudiwe N, Cichowski K, Perentesis JP
Sarcoma. 2019; 20197656747. doi: 10.1155/2019/7656747.

PMID:
    31427883
    [PubMed]
Related citations


TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death.
Qin W, Godec A, Zhang X, Zhu C, Shao J, Tao Y, Bu X, Hirbe AC
Cancer Med. 2019 Jul 6; doi: 10.1002/cam4.2386.

PMID:
    31278855
    [PubMed - as supplied by publisher]
Related citations


Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.
Prudner BC, Rathore R, Robinson AM, Godec A, Chang SF, Hawkins WG, Hirbe AC, Van Tine BA
Clin Cancer Res. 2019 Aug 15; 25(16)5122-5134. doi: 10.1158/1078-0432.CCR-19-0206.

PMID:
    31113844
    [PubMed - in process]
Related citations


Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters.
Abaricia S, Hirbe AC
Curr Treat Options Oncol. 2018 Oct 25; 19(12)64. doi: 10.1007/s11864-018-0590-5.

PMID:
    30362022
    [PubMed - in process]
Related citations


Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST.
Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S
Oncotarget. 2018 May 1; 9(33)23018-23028. doi: 10.18632/oncotarget.25195.

PMID:
    29796169
    [PubMed]
Related citations


β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH
Neuro Oncol. 2018 May 18; 20(6)858-860. doi: 10.1093/neuonc/noy038.

PMID:
    29596596
    [PubMed - indexed for MEDLINE]
Related citations


A Phase II Study of Tumor Ablation in Patients with Metastatic Sarcoma Stable on Chemotherapy.
Hirbe AC, Jennings J, Saad N, Giardina JD, Tao Y, Luo J, Berry S, Toeniskoetter J, Van Tine BA
Oncologist. 2018 Jul; 23(7)760-e76. doi: 10.1634/theoncologist.2017-0536.

PMID:
    29487221
    [PubMed - in process]
Related citations


Gastrointestinal stromal tumors (GISTs): point mutations matter in management, a review.
Oppelt PJ, Hirbe AC, Van Tine BA
J Gastrointest Oncol. 2017 Jun; 8(3)466-473. doi: 10.21037/jgo.2016.09.15.

PMID:
    28736634
    [PubMed]
Related citations


Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors.
Hirbe AC, Cosper PF, Dahiya S, Van Tine BA
Sarcoma. 2017; 20173761292. doi: 10.1155/2017/3761292.

PMID:
    28546782
    [PubMed]
Related citations


Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
Cancer. 2017 Apr 1; 123(7)1194-1201. doi: 10.1002/cncr.30455.

PMID:
    27875628
    [PubMed - indexed for MEDLINE]
Related citations


Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH
Oncotarget. 2016 Feb 16; 7(7)7403-14. doi: 10.18632/oncotarget.7232.

PMID:
    26859681
    [PubMed - indexed for MEDLINE]
Related citations


Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
Clin Cancer Res. 2015 Sep 15; 21(18)4201-11. doi: 10.1158/1078-0432.CCR-14-3049.

PMID:
    25925892
    [PubMed - indexed for MEDLINE]
Related citations


A multidisciplinary approach in neurofibromatosis 1--authors' reply.
Epstein JA, Ingram DA Jr, Hirbe AC, Gutmann DH
Lancet Neurol. 2015 Jan; 14(1)30-1. doi: 10.1016/S1474-4422(14)70298-4.

PMID:
    25496893
    [PubMed - indexed for MEDLINE]
Related citations


Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.
Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A
Mod Pathol. 2015 Feb; 28(2)187-200. doi: 10.1038/modpathol.2014.109.

PMID:
    25189642
    [PubMed - indexed for MEDLINE]
Related citations


Neurofibromatosis type 1: a multidisciplinary approach to care.
Hirbe AC, Gutmann DH
Lancet Neurol. 2014 Aug; 13(8)834-43. doi: 10.1016/S1474-4422(14)70063-8.

PMID:
    25030515
    [PubMed - indexed for MEDLINE]
Related citations


BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
Neuro Oncol. 2014 Mar; 16(3)466-7. doi: 10.1093/neuonc/not248.

PMID:
    24366910
    [PubMed - indexed for MEDLINE]
Related citations


Novel pathways and molecular targets for the treatment of sarcoma.
Frith AE, Hirbe AC, Van Tine BA
Curr Oncol Rep. 2013 Aug; 15(4)378-85. doi: 10.1007/s11912-013-0319-3.

PMID:
    23661264
    [PubMed - indexed for MEDLINE]
Related citations


The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN
J Clin Invest. 2012 Oct; 122(10)3579-92. doi: 10.1172/JCI38576.

PMID:
    22996695
    [PubMed - indexed for MEDLINE]
Related citations


CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.
Zhang K, Kim S, Cremasco V, Hirbe AC, Collins L, Piwnica-Worms D, Novack DV, Weilbaecher K, Faccio R
Cancer Res. 2011 Jul 15; 71(14)4799-808. doi: 10.1158/0008-5472.CAN-10-3922.

PMID:
    21602433
    [PubMed - indexed for MEDLINE]
Related citations


The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases?
Hirbe AC, Morgan EA, Weilbaecher KN
Curr Pharm Des. 2010; 16(11)1284-90.

PMID:
    20166978
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

As a practicing medical oncologist who treats sarcoma, my research focuses on utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.