Patient Portal

Andreas Herrlich, MD, PhD

Associate Professor, Medicine
Division of Nephrology

Specialty Areas

Nephrology
Dialysis Management
Kidney Disease

Board Certifications

Internal Medicine
Nephrology

Hospital Affiliations

Barnes-Jewish Hospital

Languages

German
French

Areas of Clinical Interest

Acute kidney failure, chronic kidney failure

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Davita St. Louis Dialysis - Debaliviere

324 Debaliviere
St. Louis, MO 63112

Office Phone: 314-362-8232
Fax: 314-362-8237

Education

Education

Fellowship, Nephrology: Massachusetts General Hospital / Brigham and Women's Hospital, Boston, MA 2006
Chief Resident, Internal Medicine: Johns Hopkins Bayview Medical Center, Baltimore, MD 2002
Residency, Internal Medicine: Johns Hopkins Bayview Medical Center, Baltimore, MD 2002
Medical Degree: Free University Berlin, Germany 1998
PhD, Molecular Biology: Free University Berlin, Germany 1998

Publication & Research

Publication & Research

iRhoms: A Potential Path to More Specific Therapeutic Targeting of Lupus Nephritis.
Herrlich A, Kefaloyianni E
Am J Kidney Dis. 2018 Jun 7; pii: S0272-6386(18)30670-X. doi: 10.1053/j.ajkd.2018.04.010.

PMID:
    29887489
    [PubMed - as supplied by publisher]
Related citations


Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding.
Wilson JL, Kefaloyianni E, Stopfer L, Harrison C, Sabbisetti VS, Fraenkel E, Lauffenburger DA, Herrlich A
Mol Cancer Res. 2018 Jan; 16(1)147-161. doi: 10.1158/1541-7786.MCR-17-0140.

PMID:
    29018056
    [PubMed - in process]
Related citations


ADAM Metalloprotease-Released Cancer Biomarkers.
Herrlich P, Herrlich A
Trends Cancer. 2017 Jul; 3(7)482-490. doi: 10.1016/j.trecan.2017.05.001.

PMID:
    28718403
    [PubMed - indexed for MEDLINE]
Related citations


Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.
Parra LM, Hartmann M, Schubach S, Ma J, Herrlich P, Herrlich A
Sci Rep. 2016 Nov 23; 637464. doi: 10.1038/srep37464.

PMID:
    27876763
    [PubMed - indexed for MEDLINE]
Related citations


ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A
JCI Insight. 2016 Aug 18; 1(13)pii: e87023.

PMID:
    27642633
    [PubMed - in process]
Related citations


Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44.
Parra LM, Hartmann M, Schubach S, Li Y, Herrlich P, Herrlich A
Mol Cell Biol. 2015 Oct; 35(19)3381-95. doi: 10.1128/MCB.00500-15.

PMID:
    26217011
    [PubMed - indexed for MEDLINE]
Related citations


Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization.
Hartmann M, Parra LM, Ruschel A, Lindner C, Morrison H, Herrlich A, Herrlich P
J Biol Chem. 2015 Jul 10; 290(28)17041-54. doi: 10.1074/jbc.M114.610204.

PMID:
    25925953
    [PubMed - indexed for MEDLINE]
Related citations


PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization.
Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A, Abdi R
Stem Cells. 2015 Jun; 33(6)1892-901. doi: 10.1002/stem.1986.

PMID:
    25753288
    [PubMed - indexed for MEDLINE]
Related citations


Tumor Suppressor NF2 Blocks Cellular Migration by Inhibiting Ectodomain Cleavage of CD44.
Hartmann M, Parra LM, Ruschel A, Böhme S, Li Y, Morrison H, Herrlich A, Herrlich P
Mol Cancer Res. 2015 May; 13(5)879-90. doi: 10.1158/1541-7786.MCR-15-0020-T.

PMID:
    25652588
    [PubMed - indexed for MEDLINE]
Related citations


Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.
Zhang K, Jones L, Lim S, Maher CA, Adkins D, Lewis J, Kimple RJ, Fertig EJ, Chung CH, Van Tine BA, Ellis MJ, Herrlich A, Michel LS
Oncotarget. 2014 Oct 15; 5(19)9281-94.

PMID:
    25238142
    [PubMed - indexed for MEDLINE]
Related citations


Major Survey Findings of Listening to Mothers(SM) III: New Mothers Speak Out: Report of National Surveys of Women's Childbearing ExperiencesConducted October-December 2012 and January-April 2013.
Declercq ER, Sakala C, Corry MP, Applebaum S, Herrlich A
J Perinat Educ. 2014 Winter; 23(1)17-24. doi: 10.1891/1058-1243.23.1.17.

PMID:
    24453464
    [PubMed]
Related citations


Major Survey Findings of Listening to Mothers(SM) III: Pregnancy and Birth: Report of the Third National U.S. Survey of Women's Childbearing Experiences.
Declercq ER, Sakala C, Corry MP, Applebaum S, Herrlich A
J Perinat Educ. 2014 Winter; 23(1)9-16. doi: 10.1891/1058-1243.23.1.9.

PMID:
    24453463
    [PubMed]
Related citations


Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A
Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24)9776-81. doi: 10.1073/pnas.1307478110.

PMID:
    23720309
    [PubMed - indexed for MEDLINE]
Related citations


Who decides when to cleave an ectodomain?
Hartmann M, Herrlich A, Herrlich P
Trends Biochem Sci. 2013 Mar; 38(3)111-20. doi: 10.1016/j.tibs.2012.12.002.

PMID:
    23298902
    [PubMed - indexed for MEDLINE]
Related citations


Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus.
Dang M, Dubbin K, D'Aiello A, Hartmann M, Lodish H, Herrlich A
J Biol Chem. 2011 May 20; 286(20)17704-13. doi: 10.1074/jbc.M110.187823.

PMID:
    21454702
    [PubMed - indexed for MEDLINE]
Related citations


Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities.
Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA
Integr Biol (Camb). 2011 Apr; 3(4)422-38. doi: 10.1039/c0ib00083c.

PMID:
    21180771
    [PubMed - indexed for MEDLINE]
Related citations


Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes.
Herrlich A, Klinman E, Fu J, Sadegh C, Lodish H
FASEB J. 2008 Dec; 22(12)4281-95. doi: 10.1096/fj.08-113852.

PMID:
    18757500
    [PubMed - indexed for MEDLINE]
Related citations


Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction.
Herrlich A, Leitch V, King LS
Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44)15799-804.

PMID:
    15498868
    [PubMed - indexed for MEDLINE]
Related citations


Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing hormone.
Grosse R, Roelle S, Herrlich A, Höhn J, Gudermann T
J Biol Chem. 2000 Apr 21; 275(16)12251-60.

PMID:
    10766863
    [PubMed - indexed for MEDLINE]
Related citations


Gonadotropin-releasing hormone receptor initiates multiple signaling pathways by exclusively coupling to G(q/11) proteins.
Grosse R, Schmid A, Schöneberg T, Herrlich A, Muhn P, Schultz G, Gudermann T
J Biol Chem. 2000 Mar 31; 275(13)9193-200.

PMID:
    10734055
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Role of metalloprotease cleavage-release of growth factors, cytokines and their receptors (ectodomain shedding) in acute and chronic kidney failure