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Alexander S. Krupnick, MD

Associate Professor, Surgery
Division of Cardiothoracic Surgery
Section of General Thoracic Surgery

Specialty Areas

Thoracic Surgery
Lung Transplantation
Lung Cancer
Thoracic Oncology
Lung Disease

Board Certifications

Surgery

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

thoracic oncology, minimally invasive thoracic surgery, lung transplantation, immunotherapy.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-362-9181
Fax: 314 -367-8459
Email: krupnicka@WUSTL.EDU

Education

Education

Fellowship: Thoracic Surgery, Washington University in St. Louis, 2004-2005 2005
Fellowship: Thoracic Transplantation, Washington University iSchool of Medicine, St. Louis, MO 2005
Residency: Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania4 2004
Research Fellowship: Surgical Research, Harrison’s Department of Surgical Research, Hospital of The University of Pennsylvania 2002
Residency: Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 1999
Medical Degree: University of Michigan Medical School, Ann Arbor, Michigan 1996

Publication & Research

Publication & Research

There and back again: An immunotherapy tale.
Guo Y, Krupnick AS
J Thorac Cardiovasc Surg. 2017 Dec 23; pii: S0022-5223(17)33030-1. doi: 10.1016/j.jtcvs.2017.11.102.

PMID:
    29409610
    [PubMed - as supplied by publisher]
Related citations


Size does really matter.
Kilbourne S, Krupnick AS
J Thorac Cardiovasc Surg. 2017 Dec 12; pii: S0022-5223(17)32831-3. doi: 10.1016/j.jtcvs.2017.12.030.

PMID:
    29342429
    [PubMed - as supplied by publisher]
Related citations


Eosinophils promote inducible NOS-mediated lung allograft acceptance.
Onyema OO, Guo Y, Wang Q, Stoler MH, Lau C, Li K, Nazaroff CD, Wang X, Li W, Kreisel D, Gelman AE, Lee JJ, Jacobsen EA, Krupnick AS
JCI Insight. 2017 Dec 21; 2(24)pii: 96455. doi: 10.1172/jci.insight.96455.

PMID:
    29263310
    [PubMed - as supplied by publisher]
Related citations


Naive CD4<sup>+</sup> T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Ibrahim M, Scozzi D, Toth KA, Ponti D, Kreisel D, Menna C, De Falco E, D'Andrilli A, Rendina EA, Calogero A, Krupnick AS, Gelman AE
J Immunol. 2018 Jan 15; 200(2)847-856. doi: 10.4049/jimmunol.1700396.

PMID:
    29212908
    [PubMed - in process]
Related citations


To bleed or not to bleed? That is the question.
Guo Y, Krupnick AS
J Thorac Cardiovasc Surg. 2018 Jan; 155(1)436-437. doi: 10.1016/j.jtcvs.2017.09.039.

PMID:
    28992966
    [PubMed - in process]
Related citations


Mechanisms of Graft Rejection and Immune Regulation after Lung Transplant.
Gauthier JM, Li W, Hsiao HM, Takahashi T, Arefanian S, Krupnick AS, Gelman AE, Kreisel D
Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3)S216-S219. doi: 10.1513/AnnalsATS.201607-576MG.

PMID:
    28945475
    [PubMed - indexed for MEDLINE]
Related citations


Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA.
Puyo CA, Peruzzi D, Earhart A, Roller E, Karanikolas M, Kollef MH, Krupnick AS, Kreisel D, Ibrahim M, Gelman AE
Mol Pain. 2017 Jan-Dec; 131744806917731696. doi: 10.1177/1744806917731696.

PMID:
    28929859
    [PubMed - in process]
Related citations


Impact of Delayed Chest Closure on Surgical Site Infection After Lung Transplantation.
Aguilar PR, Bemiss BC, Witt C, Byers DE, Kreisel D, Puri V, Meyers B, Patterson GA, Krupnick AS, Yusen RD, Trulock EP, Hachem RR
Ann Thorac Surg. 2017 Oct; 104(4)1208-1214. doi: 10.1016/j.athoracsur.2017.05.023.

PMID:
    28821338
    [PubMed - indexed for MEDLINE]
Related citations


PD-1 expression on CD8<sup>+</sup> T cells regulates their differentiation within lung allografts and is critical for tolerance induction.
Takahashi T, Hsiao HM, Tanaka S, Li W, Higashikubo R, Scozzi D, Bharat A, Ritter JH, Krupnick AS, Gelman AE, Kreisel D
Am J Transplant. 2018 Jan; 18(1)216-225. doi: 10.1111/ajt.14437.

PMID:
    28730633
    [PubMed - in process]
Related citations


Gastric conduit revision postesophagectomy: Management for a rare complication.
Rove JY, Krupnick AS, Baciewicz FA, Meyers BF
J Thorac Cardiovasc Surg. 2017 Oct; 154(4)1450-1458. doi: 10.1016/j.jtcvs.2017.04.012.

PMID:
    28526499
    [PubMed - in process]
Related citations


Adjuvant Chemotherapy Is Associated With Improved Survival in Locally Invasive Node Negative Non-Small Cell Lung Cancer.
Ahmad U, Crabtree TD, Patel AP, Morgensztern D, Robinson CG, Krupnick AS, Kreisel D, Jones DR, Patterson GA, Meyers BF, Puri V
Ann Thorac Surg. 2017 Jul; 104(1)303-307. doi: 10.1016/j.athoracsur.2017.01.069.

PMID:
    28433225
    [PubMed - indexed for MEDLINE]
Related citations


Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.
Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS
Oncoimmunology. 2017; 6(2)e1265721. doi: 10.1080/2162402X.2016.1265721.

PMID:
    28344875
    [PubMed]
Related citations


Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance.
Arefanian S, Schäll D, Chang S, Ghasemi R, Higashikubo R, Zheleznyak A, Guo Y, Yu J, Asgharian H, Li W, Gelman AE, Kreisel D, French AR, Zaher H, Plougastel-Douglas B, Maggi L, Yokoyama W, Beer-Hammer S, Krupnick AS
Oncoimmunology. 2016; 5(12)e1238543. doi: 10.1080/2162402X.2016.1238543.

PMID:
    28123874
    [PubMed]
Related citations


Defining the Ideal Time Interval Between Planned Induction Therapy and Surgery for Stage IIIA Non-Small Cell Lung Cancer.
Samson P, Crabtree TD, Robinson CG, Morgensztern D, Broderick S, Krupnick AS, Kreisel D, Patterson GA, Meyers B, Puri V
Ann Thorac Surg. 2017 Apr; 103(4)1070-1075. doi: 10.1016/j.athoracsur.2016.09.053.

PMID:
    28110809
    [PubMed - indexed for MEDLINE]
Related citations


Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
Aw Yeang HX, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C, Krupnick AS, Chapman WC, Yokoyama WM
J Immunol. 2017 Feb 15; 198(4)1417-1422. doi: 10.4049/jimmunol.1601818.

PMID:
    28093522
    [PubMed - indexed for MEDLINE]
Related citations


Necessity is the mother of invention: Alternative techniques in living-related lobar transplantation come to the mainstream.
Walters DM, Krupnick AS
J Thorac Cardiovasc Surg. 2017 Feb; 153(2)487. doi: 10.1016/j.jtcvs.2016.11.014.

PMID:
    27939496
    [PubMed - in process]
Related citations


Quality Measures in Clinical Stage I Non-Small Cell Lung Cancer: Improved Performance Is Associated With Improved Survival.
Samson P, Crabtree T, Broderick S, Kreisel D, Krupnick AS, Patterson GA, Meyers B, Puri V
Ann Thorac Surg. 2017 Jan; 103(1)303-311. doi: 10.1016/j.athoracsur.2016.07.003.

PMID:
    27665480
    [PubMed - indexed for MEDLINE]
Related citations


Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.
Ghasemi R, Lazear E, Wang X, Arefanian S, Zheleznyak A, Carreno BM, Higashikubo R, Gelman AE, Kreisel D, Fremont DH, Krupnick AS
Nat Commun. 2016 Sep 21; 712878. doi: 10.1038/ncomms12878.

PMID:
    27650575
    [PubMed - in process]
Related citations


Neoadjuvant Chemotherapy versus Chemoradiation Prior to Esophagectomy: Impact on Rate of Complete Pathologic Response and Survival in Esophageal Cancer Patients.
Samson P, Robinson C, Bradley J, Lockhart AC, Puri V, Broderick S, Kreisel D, Krupnick AS, Patterson GA, Meyers B, Crabtree T
J Thorac Oncol. 2016 Dec; 11(12)2227-2237. doi: 10.1016/j.jtho.2016.07.031.

PMID:
    27544058
    [PubMed - indexed for MEDLINE]
Related citations


Heart-resident CCR2<sup>+</sup> macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling.
Li W, Hsiao HM, Higashikubo R, Saunders BT, Bharat A, Goldstein DR, Krupnick AS, Gelman AE, Lavine KJ, Kreisel D
JCI Insight. 2016 Aug 4; 1(12)pii: e87315.

PMID:
    27536731
    [PubMed]
Related citations