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Alexander C. Chen, MD

Associate Professor, Medicine
Division of Pulmonary and Critical Care Medicine
Associate Professor, Surgery
Division of Cardiothoracic Surgery
Director of Interventional Pulmonology

Specialty Areas

Lung Disease
Interventional Pulmonology
Lung Cancer
Thoracic Oncology

Board Certifications

Pulmonary Medicine
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Pulmonary complications of cancer with special interest in malignant airway obstructions and recurrent malignant pleural effusion, pleural disease, lung masses and mediastinal adenopathy, interventional pulmonary

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-747-2200

Barnes-Jewish West County Hospital
Medical Building One

1040 N. Mason Road
Creve Coeur, MO 63141

Office Phone: 314-454-8917
Fax: 314-222-6253

Education

Education

Chief Resident: Internal Medicine, Barnes-Jewish Hospital, St. Louis MO 2005
Fellowship: Interventional Pulmonary Medicine, Washington University School of Medicine, St. Louis MO 2009
Medical Degree: University of Missouri, Kansas City, Kansas City, MO 2001
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis 2004
Fellowship: Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis MO 2008

Publication & Research

Publication & Research

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function.
Kubi JA, Chen ACH, Fong SW, Lai KP, Wong CKC, Yeung WSB, Lee KF, Lee YL
Environ Int. 2019 Jun 10; 130104885. doi: 10.1016/j.envint.2019.05.079.

PMID:
    31195220
    [PubMed - as supplied by publisher]
Related citations


Establishment of porcine and human expanded potential stem cells.
Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J, Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, Kimber SJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, Liu P
Nat Cell Biol. 2019 Jun; 21(6)687-699. doi: 10.1038/s41556-019-0333-2.

PMID:
    31160711
    [PubMed - in process]
Related citations


Intramedullary nailing and plating osteosynthesis in the correction of post-traumatic deformity in late-diagnosed distal radius fractures: a retrospective comparison study.
Chen AC, Cheng CY, Weng CJ, Chou YC
BMC Musculoskelet Disord. 2019 May 21; 20(1)236. doi: 10.1186/s12891-019-2605-1.

PMID:
    31113405
    [PubMed - in process]
Related citations


Ultrasound Findings Disclose the Mutual Impact of Vertebrobasilar Dolichoectasia and Vertebral Artery Hypoplasia.
Chi HY, Chen KW, Hsu CF, Shen CY, Chen AC, Su CH, Fu WM
J Ultrasound Med. 2019 Apr 25; doi: 10.1002/jum.15011.

PMID:
    31020689
    [PubMed - as supplied by publisher]
Related citations


Neurocognitive Function and Quality of Life Outcomes in the ONTRAC Study for Skin Cancer Chemoprevention by Nicotinamide.
Martin AJ, Dhillon HM, Vardy JL, Dalziell RA, Choy B, Fernández-Peñas P, Dixon A, Renton C, St George G, Chinniah N, Halliday GM, Damian DL, Chen AC
Geriatrics (Basel). 2019 Mar 25; 4(1)pii: E31. doi: 10.3390/geriatrics4010031.

PMID:
    30934630
    [PubMed]
Related citations


Real-Time Monitoring of Ascorbic Acid-Mediated Reduction of Cytotoxic Effects of Analgesics and NSAIDs on Tenocytes Proliferation.
Chiu CH, Chen P, Chen AC, Chan YS, Hsu KY, Rei H, Lei KF
Dose Response. 2019 Jan-Mar; 17(1)1559325819832143. doi: 10.1177/1559325819832143.

PMID:
    30886547
    [PubMed]
Related citations


A new avenue for treating neuronal diseases: Ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects.
Tai CH, Bellesi M, Chen AC, Lin CL, Li HH, Lin PJ, Liao WC, Hung CS, Schwarting RK, Ho YJ
Behav Brain Res. 2019 May 17; 364149-156. doi: 10.1016/j.bbr.2019.02.020.

PMID:
    30768995
    [PubMed - in process]
Related citations


Multiple Respiratory Microbiota Profiles Are Associated With Lower Airway Inflammation in Children With Protracted Bacterial Bronchitis.
Marsh RL, Smith-Vaughan HC, Chen ACH, Marchant JM, Yerkovich ST, Gibson PG, Pizzutto SJ, Hodge S, Upham JW, Chang AB
Chest. 2019 Apr; 155(4)778-786. doi: 10.1016/j.chest.2019.01.002.

PMID:
    30660785
    [PubMed - in process]
Related citations


Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation.
Wang HJ, Lu CK, Chen WC, Chen AC, Ueng YF
J Food Drug Anal. 2019 Jan; 27(1)284-294. doi: 10.1016/j.jfda.2018.10.005.

PMID:
    30648582
    [PubMed - in process]
Related citations


Connexin 43 is involved in early differentiation of human embryonic stem cells.
Peng Q, Yue C, Chen ACH, Lee KC, Fong SW, Yeung WSB, Lee YL
Differentiation. 2019 Jan - Feb; 10533-44. doi: 10.1016/j.diff.2018.12.003.

PMID:
    30599359
    [PubMed - in process]
Related citations


Self-Renewal and Differentiation of Adipose-Derived Stem Cells (ADSCs) Stimulated by Multi-Axial Tensile Strain in a Pneumatic Microdevice.
Chiu CH, Tong YW, Yeh WL, Lei KF, Chen AC
Micromachines (Basel). 2018 Nov 19; 9(11)pii: E607. doi: 10.3390/mi9110607.

PMID:
    30463251
    [PubMed]
Related citations


Intermediate screws or kyphoplasty: Which method of posterior short-segment fixation is better for treating single-level thoracolumbar burst fractures?
Zhang J, Liu H, Liu H, Chen AC, He F, Zhou F, Yang H, Liu T
Eur Spine J. 2019 Mar; 28(3)502-510. doi: 10.1007/s00586-018-5822-7.

PMID:
    30448987
    [PubMed - in process]
Related citations


Investigation of Growth Factor and Tenocyte Proliferation Induced by Platelet Rich Plasma (PRP) in a 3-Chamber Co-Culture Device.
Chiu CH, Higashikawa R, Yeh WL, Lei KF, Chen AC
Micromachines (Basel). 2018 Sep 7; 9(9)pii: E446. doi: 10.3390/mi9090446.

PMID:
    30424379
    [PubMed]
Related citations


Biochemical and Skeletal Outcomes of Parathyroidectomy for Normocalcemic (Incipient) Primary Hyperparathyroidism.
Sho S, Kuo EJ, Chen AC, Li N, Yeh MW, Livhits MJ
Ann Surg Oncol. 2019 Feb; 26(2)539-546. doi: 10.1245/s10434-018-6998-0.

PMID:
    30406488
    [PubMed - indexed for MEDLINE]
Related citations


Healthy hearts in pediatric heart transplant patients with an exercise and diet intervention via live video conferencing-Design and rationale.
Chen AC, Rosenthal DN, Couch SC, Berry S, Stauffer KJ, Brabender J, McDonald N, Lee D, Barkoff L, Nourse SE, Kazmucha J, Wang CJ, Olson I, Selamet Tierney ES
Pediatr Transplant. 2019 Feb; 23(1)e13316. doi: 10.1111/petr.13316.

PMID:
    30393915
    [PubMed - indexed for MEDLINE]
Related citations


Influence of propofol on the electroencephalogram default mode network in patients of advanced age.
Ke JD, Xu M, Wang PP, Wang M, Tian M, Chen ACN
J Int Med Res. 2018 Nov; 46(11)4660-4668. doi: 10.1177/0300060518788241.

PMID:
    30246583
    [PubMed - indexed for MEDLINE]
Related citations


A Reduction in Inflammatory Macrophages May Contribute to Skin Cancer Chemoprevention by Nicotinamide.
Minocha R, Martin AJ, Chen AC, Scolyer RA, Lyons JG, McKenzie CA, Madore J, Halliday GM, Damian DL
J Invest Dermatol. 2019 Feb; 139(2)467-469. doi: 10.1016/j.jid.2018.08.018.

PMID:
    30244097
    [PubMed - in process]
Related citations


Application of a fluorescent marker with quantitative bioburden methods to assess cleanliness.
Hung IC, Chang HY, Cheng A, Chen AC, Ting L, Chen MW, Lai YH, Sheng WH
Infect Control Hosp Epidemiol. 2018 Nov; 39(11)1296-1300. doi: 10.1017/ice.2018.222.

PMID:
    30221609
    [PubMed - in process]
Related citations


PPARγ is reduced in the airways of non-CF bronchiectasis subjects and is inversely correlated with the presence of Pseudomonas aeruginosa.
Burr LD, Rogers GB, Chen AC, Taylor SL, Bowler SD, Keating RL, Martin ML, Hasnain SZ, McGuckin MA
PLoS One. 2018; 13(8)e0202296. doi: 10.1371/journal.pone.0202296.

PMID:
    30114278
    [PubMed - indexed for MEDLINE]
Related citations


Early and late fixation of ulnar styloid base fractures yields different outcomes.
Chen AC, Chiu CH, Weng CJ, Chang SS, Cheng CY
J Orthop Surg Res. 2018 Jul 31; 13(1)193. doi: 10.1186/s13018-018-0899-6.

PMID:
    30064441
    [PubMed - indexed for MEDLINE]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Olympus

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2019

Areas of Research Interest

Advanced techniques in diagnosis cancers of the lung