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Alexander C. Chen, MD

Associate Professor, Medicine
Division of Pulmonary and Critical Care Medicine
Associate Professor, Surgery
Division of Cardiothoracic Surgery
Director of Interventional Pulmonology

Specialty Areas

Lung Disease
Interventional Pulmonology
Lung Cancer
Thoracic Oncology

Board Certifications

Pulmonary Medicine
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Pulmonary complications of cancer with special interest in malignant airway obstructions and recurrent malignant pleural effusion, pleural disease, lung masses and mediastinal adenopathy, interventional pulmonary

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-747-2200

Barnes-Jewish West County Hospital
Medical Building One

1040 N. Mason Road
Creve Coeur, MO 63141

Office Phone: 314-454-8917
Fax: 314-222-6253

Education

Education

Chief Resident: Internal Medicine, Barnes-Jewish Hospital, St. Louis MO 2005
Fellowship: Interventional Pulmonary Medicine, Washington University School of Medicine, St. Louis MO 2009
Medical Degree: University of Missouri, Kansas City, Kansas City, MO 2001
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis 2004
Fellowship: Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis MO 2008

Publication & Research

Publication & Research

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks.
Leland BA, Chen AC, Zhao AY, Wharton RC, King MC
Elife. 2018 Apr 26; 7pii: e33402. doi: 10.7554/eLife.33402.

PMID:
    29697047
    [PubMed - in process]
Related citations


Biomechanics of osteochondral impact with cushioning and graft Insertion: Cartilage damage is correlated with delivered energy.
Su AW, Chen Y, Dong Y, Wailes DH, Wong VW, Chen AC, Cai S, Bugbee WD, Sah RL
J Biomech. 2018 May 17; 73127-136. doi: 10.1016/j.jbiomech.2018.03.037.

PMID:
    29628132
    [PubMed - in process]
Related citations


Estimating active layer thickness and volumetric water content from ground penetrating radar measurements in Barrow, Alaska.
Jafarov EE, Parsekian AD, Schaefer K, Liu L, Chen AC, Panda SK, Zhang T
Geosci Data J. 2017 Nov; 4(2)72-79. doi: 10.1002/gdj3.49.

PMID:
    29610660
    [PubMed]
Related citations


Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.
Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW
ERJ Open Res. 2018 Jan; 4(1)pii: 00130-2017. doi: 10.1183/23120541.00130-2017.

PMID:
    29594175
    [PubMed]
Related citations


Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles.
Chen AC, Pena OM, Nel HJ, Yerkovich ST, Chang AB, Baines KJ, Gibson PG, Petsky HL, Pizzutto SJ, Hodge S, Masters IB, Buntain HL, Upham JW
Pediatr Pulmonol. 2018 May; 53(5)575-582. doi: 10.1002/ppul.23984.

PMID:
    29575797
    [PubMed - in process]
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Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.
Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B, CheckMate 214 Investigators.
N Engl J Med. 2018 Apr 5; 378(14)1277-1290. doi: 10.1056/NEJMoa1712126.

PMID:
    29562145
    [PubMed - indexed for MEDLINE]
Related citations


Robotic Endoscopic Airway Challenge: REACH Assessment.
Chen AC, Gillespie CT
Ann Thorac Surg. 2018 Feb 24; pii: S0003-4975(18)30186-3. doi: 10.1016/j.athoracsur.2018.01.051.

PMID:
    29486178
    [PubMed - as supplied by publisher]
Related citations


Mid-term survivorship of cruciate-retaining versus posterior-stabilized total knee arthroplasty using modular mini-keel tibial implants.
Yang CP, Hsu KY, Chang YH, Chan YS, Shih HN, Chen AC
J Orthop Surg Res. 2018 Feb 13; 13(1)35. doi: 10.1186/s13018-018-0738-9.

PMID:
    29433583
    [PubMed - in process]
Related citations


APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.
Liu CC, Fang CP, Liu TH, Kuo HW, Liu SC, Wang SC, Chen ACH, Liu YL
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr 20; 8392-98. doi: 10.1016/j.pnpbp.2018.01.008.

PMID:
    29330135
    [PubMed - in process]
Related citations


CHA<sub>2</sub> DS<sub>2</sub> -VASc scores for outcome prediction in acute ischaemic stroke.
Su CH, Tsao TF, Chen AC, Chang KW, Yang YS, Ueng KC, Tsai CF
Eur J Clin Invest. 2018 Mar; 48(3)doi: 10.1111/eci.12884.

PMID:
    29288496
    [PubMed - in process]
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Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke.
Wang IK, Liu CH, Yen TH, Jeng JS, Sung SF, Huang PH, Li JY, Sun Y, Wei CY, Lien LM, Tsai IJ, Sung FC, Hsu CY, Taiwan Stroke Registry Investigators.
Atherosclerosis. 2018 Feb; 269288-293. doi: 10.1016/j.atherosclerosis.2017.11.029.

PMID:
    29254692
    [PubMed - in process]
Related citations


Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy.
Kuo HW, Liu TH, Tsou HH, Hsu YT, Wang SC, Fang CP, Liu CC, Chen ACH, Liu YL
Drug Alcohol Depend. 2018 Feb 1; 18319-24. doi: 10.1016/j.drugalcdep.2017.10.014.

PMID:
    29222992
    [PubMed - in process]
Related citations


Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.
Chen AC, Xi Y, Carroll M, Petsky HL, Gardiner SJ, Pizzutto SJ, Yerkovich ST, Baines KJ, Gibson PG, Hodge S, Masters IB, Buntain HM, Chang AB, Upham JW
ERJ Open Res. 2017 Oct; 3(4)pii: 00025-2017. doi: 10.1183/23120541.00025-2017.

PMID:
    29204435
    [PubMed]
Related citations


Intestinal obstruction caused by appendiceal knot.
Lin TL, Wu SF, Chen AC, Tan TK, Wang PL
Pediatr Neonatol. 2017 Nov 15; pii: S1875-9572(17)30121-3. doi: 10.1016/j.pedneo.2017.10.008.

PMID:
    29196118
    [PubMed - as supplied by publisher]
Related citations


Extracranial and Intracranial Ultrasonographic Findings in Posterior Circulation Infarction.
Chi HY, Hsu CF, Chen AC, Su CH, Hu HH, Fu WM
J Ultrasound Med. 2017 Nov 30; doi: 10.1002/jum.14501.

PMID:
    29193196
    [PubMed - as supplied by publisher]
Related citations


Influence of age, gender, and radiographic features on the deltoid splitting approach for surgical osteosynthesis in displaced proximal humerus fractures: a comparison study.
Chen AC, Chiu CH, Hsu KY, Chan YS
BMC Musculoskelet Disord. 2017 Nov 28; 18(1)495. doi: 10.1186/s12891-017-1840-6.

PMID:
    29179714
    [PubMed - in process]
Related citations


Recent Pregnancy Is Not Associated with High-Risk Pathological Features of Well-Differentiated Thyroid Cancer.
Chen AC, Livhits MJ, Du L, Wu JX, Kuo EJ, Yeh MW, Leung AM
Thyroid. 2018 Jan; 28(1)68-71. doi: 10.1089/thy.2017.0496.

PMID:
    29160171
    [PubMed - in process]
Related citations


Comparison between xCELLigence biosensor technology and conventional cell culture system for real-time monitoring human tenocytes proliferation and drugs cytotoxicity screening.
Chiu CH, Lei KF, Yeh WL, Chen P, Chan YS, Hsu KY, Chen AC
J Orthop Surg Res. 2017 Oct 16; 12(1)149. doi: 10.1186/s13018-017-0652-6.

PMID:
    29037195
    [PubMed - in process]
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Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons.
Wapinski OL, Lee QY, Chen AC, Li R, Corces MR, Ang CE, Treutlein B, Xiang C, Baubet V, Suchy FP, Sankar V, Sim S, Quake SR, Dahmane N, Wernig M, Chang HY
Cell Rep. 2017 Sep 26; 20(13)3236-3247. doi: 10.1016/j.celrep.2017.09.011.

PMID:
    28954238
    [PubMed - in process]
Related citations


Pre-stroke physical activity is associated with fewer post-stroke complications, lower mortality and a better long-term outcome.
Wen CP, Liu CH, Jeng JS, Hsu SP, Chen CH, Lien LM, Chen AC, Lee JT, Chen PK, Hsu CS, Chern CM, Chen CC, Hsu MC, Lu K, Chen HJ, Wang HK, Muo CH, Hsu CY
Eur J Neurol. 2017 Dec; 24(12)1525-1531. doi: 10.1111/ene.13463.

PMID:
    28926165
    [PubMed - in process]
Related citations

Areas of Research Interest

Advanced techniques in diagnosis cancers of the lung