Alexander Chen, MD

Alexander C. Chen, MD

Associate Professor, Medicine
Division of Pulmonary and Critical Care Medicine
Associate Professor, Surgery
Division of Cardiothoracic Surgery
Director of Interventional Pulmonology

Specialty Areas

Lung Disease
Interventional Pulmonology
Lung Cancer
Thoracic Oncology

Board Certifications

Pulmonary Medicine
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Pulmonary complications of cancer with special interest in malignant airway obstructions and recurrent malignant pleural effusion, pleural disease, lung masses and mediastinal adenopathy, interventional pulmonary

Location(s)
Education
Publication & Research
Financial Disclosures

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-747-2200

Barnes-Jewish West County Hospital
Medical Building One

1040 N. Mason Road
Creve Coeur, MO 63141

Office Phone: 314-454-8917
Fax: 314-222-6253

Education

Chief Resident: Internal Medicine, Barnes-Jewish Hospital, St. Louis MO 2005
Fellowship: Interventional Pulmonary Medicine, Washington University School of Medicine, St. Louis MO 2009
Medical Degree: University of Missouri, Kansas City, Kansas City, MO 2001
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis 2004
Fellowship: Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis MO 2008

Publication & Research

Accuracy of a Robotic Endoscopic System in Cadaver Models with Simulated Tumor Targets: ACCESS Study.
Chen AC, Pastis NJ, Machuzak MS, Gildea TR, Simoff MJ, Gillespie CT, Mahajan AK, Oh SS, Silvestri GA
Respiration. 2019 Dec 5; 1-6. doi: 10.1159/000504181.

PMID:
31805570
[PubMed - as supplied by publisher]
Related citations

Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.
Ramsey KA, Chen ACH, Radicioni G, Lourie R, Martin M, Broomfield A, Sheng YH, Hasnain SZ, Radford-Smith G, Simms LA, Burr L, Thornton DJ, Bowler SD, Livengood S, Ceppe A, Knowles MR, Donaldson SH, Hill DB, Ehre C, Button B, Alexis NE, Kesimer M, Boucher RC, McGuckin MA
Am J Respir Crit Care Med. 2019 Nov 25; doi: 10.1164/rccm.201906-1219OC.

PMID:
31765597
[PubMed - as supplied by publisher]
Related citations

Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties.
Chen W, Chen X, Chen AC, Shi Q, Pan G, Pei M, Yang H, Liu T, He F
Free Radic Biol Med. 2019 Oct 24; pii: S0891-5849(19)31493-5. doi: 10.1016/j.freeradbiomed.2019.10.412.

PMID:
31669348
[PubMed - as supplied by publisher]
Related citations

Antigen-specific in vitro expansion of factor VIII-specific regulatory T cells induces tolerance in hemophilia A mice.
Smith BM, Lyle MJ, Chen AC, Miao CH
J Thromb Haemost. 2019 Oct 14; doi: 10.1111/jth.14659.

PMID:
31609041
[PubMed - as supplied by publisher]
Related citations

Severe Acquired Restrictive Strabismus Fixus in Patients with Trisomy 21.
Chen AC, Velez FG, Pineles SL
J Binocul Vis Ocul Motil. 2019 Oct-Dec; 69(4)153-156. doi: 10.1080/2576117X.2019.1663113.

PMID:
31584357
[PubMed - in process]
Related citations

The Effect of Hyperbaric Oxygen Treatment on Myoblasts and Muscles After Contusion Injury.
Chiu CH, Chang SS, Chang GJ, Chen AC, Cheng CY, Chen SC, Chan YS
J Orthop Res. 2019 Sep 18; doi: 10.1002/jor.24478.

PMID:
31531986
[PubMed - as supplied by publisher]
Related citations

Vascular Health of Children Conceived via In Vitro Fertilization.
Zhang WY, Selamet Tierney ES, Chen AC, Ling AY, Fleischmann RR, Baker VL
J Pediatr. 2019 Nov; 21447-53. doi: 10.1016/j.jpeds.2019.07.033.

PMID:
31443895
[PubMed - in process]
Related citations

Proteasome serves as pivotal regulator in Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis.
Chen AC, Shyu LY, Lin YC, Chen KM, Lai SC
PLoS One. 2019; 14(8)e0220503. doi: 10.1371/journal.pone.0220503.

PMID:
31415587
[PubMed - in process]
Related citations

Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines.
Hughes JME, Scarlata DA, Chen AC, Burch JD, Gleason JL
Org Lett. 2019 Aug 13; doi: 10.1021/acs.orglett.9b02426.

PMID:
31407916
[PubMed - as supplied by publisher]
Related citations

Reperfusion Revision Surgery for Augmented Vertebral Nonunion with Movable Cement.
Liu H, Zhang J, Chen W, Chen AC, Ji W, Meng B, Yang H, Liu T
World Neurosurg. 2019 Dec; 132429-433.e1. doi: 10.1016/j.wneu.2019.07.212.

PMID:
31394357
[PubMed - in process]
Related citations

Real-time detection of antibiotics cytotoxicity in rabbit periosteal cells using microfluidic devices with comparison to conventional culture assays.
Chiu CH, Lei KF, Chan YS, Ueng SWN, Chen AC
BMC Musculoskelet Disord. 2019 Jul 26; 20(1)339. doi: 10.1186/s12891-019-2705-y.

PMID:
31349830
[PubMed - in process]
Related citations

The impact of molecular status on survival outcomes for invasive micropapillary carcinoma of the breast.
Lewis GD, Xing Y, Haque W, Patel T, Schwartz MR, Chen AC, Farach A, Hatch SS, Butler EB, Chang JC, Teh BS
Breast J. 2019 Nov; 25(6)1171-1176. doi: 10.1111/tbj.13432.

PMID:
31321854
[PubMed - in process]
Related citations

Clinical-Genomic Models of Node-Positive Breast Cancer: Training, Testing, and Validation.
Huang TT, Chen AC, Lu TP, Lei L, Cheng SH
Int J Radiat Oncol Biol Phys. 2019 Nov 1; 105(3)637-648. doi: 10.1016/j.ijrobp.2019.06.2546.

PMID:
31295565
[PubMed - in process]
Related citations

Using DeepLabCut for 3D markerless pose estimation across species and behaviors.
Nath T, Mathis A, Chen AC, Patel A, Bethge M, Mathis MW
Nat Protoc. 2019 Jul; 14(7)2152-2176. doi: 10.1038/s41596-019-0176-0.

PMID:
31227823
[PubMed - indexed for MEDLINE]
Related citations

The gelling effect of platelet-rich fibrin matrix when exposed to human tenocytes from the rotator cuff in small-diameter culture wells and the design of a co-culture device to overcome this phenomenon.
Chiu CH, Chen P, Yeh WL, Chen AC, Chan YS, Hsu KY, Lei KF
Bone Joint Res. 2019 May; 8(5)216-223. doi: 10.1302/2046-3758.85.BJR-2018-0258.R1.

PMID:
31214334
[PubMed]
Related citations

Status and associated factors of self-management in people living with HIV/AIDS in Liangshan area, China: a cross-sectional study.
Wang H, Chen AC, Wan S, Chen H
Patient Prefer Adherence. 2019; 13863-870. doi: 10.2147/PPA.S203799.

PMID:
31213780
[PubMed]
Related citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function.
Kubi JA, Chen ACH, Fong SW, Lai KP, Wong CKC, Yeung WSB, Lee KF, Lee YL
Environ Int. 2019 Sep; 130104885. doi: 10.1016/j.envint.2019.05.079.

PMID:
31195220
[PubMed - in process]
Related citations

Establishment of porcine and human expanded potential stem cells.
Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J, Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, Kimber SJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, Liu P
Nat Cell Biol. 2019 Jun; 21(6)687-699. doi: 10.1038/s41556-019-0333-2.

PMID:
31160711
[PubMed - indexed for MEDLINE]
Related citations

Intramedullary nailing and plating osteosynthesis in the correction of post-traumatic deformity in late-diagnosed distal radius fractures: a retrospective comparison study.
Chen AC, Cheng CY, Weng CJ, Chou YC
BMC Musculoskelet Disord. 2019 May 21; 20(1)236. doi: 10.1186/s12891-019-2605-1.

PMID:
31113405
[PubMed - in process]
Related citations

Ultrasound Findings Disclose the Mutual Impact of Vertebrobasilar Dolichoectasia and Vertebral Artery Hypoplasia.
Chi HY, Chen KW, Hsu CF, Shen CY, Chen AC, Su CH, Fu WM
J Ultrasound Med. 2019 Nov; 38(11)3037-3042. doi: 10.1002/jum.15011.

PMID:
31020689
[PubMed - in process]
Related citations

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Olympus

Royalties:

Equity: No

Consulting/Advisory Board: $20,000 - $39,999

Speaker Fees:

Reporting Date: May 01, 2019

Areas of Research Interest

Advanced techniques in diagnosis cancers of the lung

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Washington University Physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital