Patient Portal

Alexander C. Chen, MD

Associate Professor, Medicine
Division of Pulmonary and Critical Care Medicine
Associate Professor, Surgery
Division of Cardiothoracic Surgery
Director of Interventional Pulmonology

Specialty Areas

Lung Disease
Interventional Pulmonology
Lung Cancer
Thoracic Oncology

Board Certifications

Pulmonary Medicine
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Pulmonary complications of cancer with special interest in malignant airway obstructions and recurrent malignant pleural effusion, pleural disease, lung masses and mediastinal adenopathy, interventional pulmonary

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-747-2200

Barnes-Jewish West County Hospital
Medical Building One

1040 N. Mason Road
Creve Coeur, MO 63141

Office Phone: 314-454-8917
Fax: 314-222-6253

Education

Education

Chief Resident: Internal Medicine, Barnes-Jewish Hospital, St. Louis MO 2005
Fellowship: Interventional Pulmonary Medicine, Washington University School of Medicine, St. Louis MO 2009
Medical Degree: University of Missouri, Kansas City, Kansas City, MO 2001
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis 2004
Fellowship: Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis MO 2008

Publication & Research

Publication & Research

Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex.
Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J
Dev Cell. 2020 Jun 12; pii: S1534-5807(20)30420-2. doi: 10.1016/j.devcel.2020.05.031.

PMID:
    32574556
    [PubMed - as supplied by publisher]
Related citations


Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use.
Fang CP, Liu TH, Chung RH, Tsou HH, Kuo HW, Wang SC, Liu CC, Liu SC, Chen ACH, Liu YL
PLoS One. 2020; 15(6)e0234549. doi: 10.1371/journal.pone.0234549.

PMID:
    32555608
    [PubMed - in process]
Related citations


HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.
Chen AC, Xu R, Wang T, Wei J, Yang XY, Liu CX, Lei G, Lyerly HK, Heiland T, Hartman ZC
J Immunother Cancer. 2020 Jun; 8(1)pii: e000258. doi: 10.1136/jitc-2019-000258.

PMID:
    32532838
    [PubMed - in process]
Related citations


Current Status of Ophthalmology Residency Training in China: The Experience From Well-Structured Centers Around the Country.
Wang YE, Zhang C, Chen AC, Pineles S, Hou J
Asia Pac J Ophthalmol (Phila). 2020 Jun 4; doi: 10.1097/APO.0000000000000284.

PMID:
    32501893
    [PubMed - as supplied by publisher]
Related citations


Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report.
Mazzone PJ, Gould MK, Arenberg DA, Chen AC, Choi HK, Detterbeck FC, Farjah F, Fong KM, Iaccarino JM, Janes SM, Kanne JP, Kazerooni EA, MacMahon H, Naidich DP, Powell CA, Raoof S, Rivera MP, Tanner NT, Tanoue LK, Tremblay A, Vachani A, White CS, Wiener RS, Silvestri GA
J Am Coll Radiol. 2020 Jul; 17(7)845-854. doi: 10.1016/j.jacr.2020.04.024.

PMID:
    32485147
    [PubMed - in process]
Related citations


Spontaneous expulsion of a submucosal uterine fibroid without embolization in a pre-menopausal woman.
Rios SDS, Ribeiro JS, Mota MAS, Chen ACR, Chen JR, de Resende CN
SAGE Open Med Case Rep. 2020; 82050313X20922743. doi: 10.1177/2050313X20922743.

PMID:
    32477566
    [PubMed]
Related citations


Human embryonic stem cell-derived blastocyst-like spheroids resemble human trophectoderm during early implantation process.
Yue C, Chen ACH, Tian S, Fong SW, Lee KC, Zhang J, Ng EHY, Lee KF, Yeung WSB, Lee YL
Fertil Steril. 2020 May 19; pii: S0015-0282(20)30009-1. doi: 10.1016/j.fertnstert.2020.01.009.

PMID:
    32444068
    [PubMed - as supplied by publisher]
Related citations


A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy.
Chen AC, Cai X, Li C, Khoryati L, Gavin MA, Miao CH
Front Immunol. 2020; 11638. doi: 10.3389/fimmu.2020.00638.

PMID:
    32411127
    [PubMed - in process]
Related citations


<i>Sirt1</i> is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming.
Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL
Aging (Albany NY). 2020 Apr 26; 12(8)7431-7447. doi: 10.18632/aging.103090.

PMID:
    32335545
    [PubMed - in process]
Related citations


Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report.
Mazzone PJ, Gould MK, Arenberg DA, Chen AC, Choi HK, Detterbeck FC, Farjah F, Fong KM, Iaccarino JM, Janes SM, Kanne JP, Kazerooni EA, MacMahon H, Naidich DP, Powell CA, Raoof S, Rivera MP, Tanner NT, Tanoue LK, Tremblay A, Vachani A, White CS, Wiener RS, Silvestri GA
Chest. 2020 Apr 23; pii: S0012-3692(20)30758-3. doi: 10.1016/j.chest.2020.04.020.

PMID:
    32335067
    [PubMed - as supplied by publisher]
Related citations


Exploring Chinese College Students' HPV Awareness, Knowledge, Attitudes, and Intent of HPV Vaccination: a Qualitative Study.
Chen AC, Astroth C, Reifsnider E, Yang H, Mao W, Chen H
J Cancer Educ. 2020 Apr 20; doi: 10.1007/s13187-020-01750-0.

PMID:
    32314310
    [PubMed - as supplied by publisher]
Related citations


Comparison of cervical disc arthroplasty and anterior cervical discectomy and fusion for the treatment of cervical disc degenerative diseases on the basis of more than 60 months of follow-up: a systematic review and meta-analysis.
Zhang Y, Lv N, He F, Pi B, Liu H, Chen AC, Yang H, Liu M, Zhu X
BMC Neurol. 2020 Apr 20; 20(1)143. doi: 10.1186/s12883-020-01717-0.

PMID:
    32312321
    [PubMed - in process]
Related citations


Auricular neural stimulation as a new non-invasive treatment for opioid detoxification.
Qureshi IS, Datta-Chaudhuri T, Tracey KJ, Pavlov VA, Chen ACH
Bioelectron Med. 2020; 67. doi: 10.1186/s42234-020-00044-6.

PMID:
    32266304
    [PubMed]
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Arthroscopy-Assisted Corrective Osteotomy, Reduction, Internal Fixation and Strut Allograft Augmentation for Tibial Plateau Malunion or Nonunion.
Wang JY, Cheng CY, Chen AC, Chan YS
J Clin Med. 2020 Apr 1; 9(4)pii: E973. doi: 10.3390/jcm9040973.

PMID:
    32244592
    [PubMed]
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Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.
Hodge S, Macowan M, Liu H, Hamon R, Chen AC, Marchant JM, Pizzutto SJ, Upham JW, Chang AB
Pediatr Pulmonol. 2020 Jun; 55(6)1414-1423. doi: 10.1002/ppul.24728.

PMID:
    32176839
    [PubMed - in process]
Related citations


Application of Bone Marrow-Derived Mesenchymal Stem Cells for Muscle Healing After Contusion Injury in Mice.
Chiu CH, Chang TH, Chang SS, Chang GJ, Chen AC, Cheng CY, Chen SC, Fu JF, Wen CJ, Chan YS
Am J Sports Med. 2020 Apr; 48(5)1226-1235. doi: 10.1177/0363546520905853.

PMID:
    32134689
    [PubMed - in process]
Related citations


<i>FADS</i> Genetic Variants in Taiwanese Modify Association of DHA Intake and Its Proportions in Human Milk.
Wu WC, Lin HC, Liao WL, Tsai YY, Chen AC, Chen HC, Lin HY, Liao LN, Chao PM
Nutrients. 2020 Feb 20; 12(2)pii: E543. doi: 10.3390/nu12020543.

PMID:
    32093185
    [PubMed - in process]
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An alternative approach to vaginal dilation in patients with Meyer-Rokitanski-Küster-Hauser syndrome: two case reports.
Ogliari KCM, Rios SDS, Chen ACR, Chen JR, Resende CN, Araujo Júnior E
Gynecol Endocrinol. 2020 Jan 29; 1-3. doi: 10.1080/09513590.2020.1719061.

PMID:
    31994956
    [PubMed - as supplied by publisher]
Related citations


Implementation of human factors engineering approach to improve environmental cleaning and disinfection in a medical center.
Hung IC, Chang HY, Cheng A, Chen MW, Chen AC, Ting L, Lai YH, Wang JT, Chen YC, Sheng WH
Antimicrob Resist Infect Control. 2020; 917. doi: 10.1186/s13756-020-0677-1.

PMID:
    31988745
    [PubMed - in process]
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Healthy Hearts via Live Videoconferencing: An Exercise and Diet Intervention in Pediatric Heart Transplant Recipients.
Chen AC, Ramirez FD, Rosenthal DN, Couch SC, Berry S, Stauffer KJ, Brabender J, McDonald N, Lee D, Barkoff L, Nourse SE, Kazmucha J, Wang CJ, Olson I, Selamet Tierney ES
J Am Heart Assoc. 2020 Feb 4; 9(3)e013816. doi: 10.1161/JAHA.119.013816.

PMID:
    31973598
    [PubMed - in process]
Related citations

Areas of Research Interest

Advanced techniques in diagnosis cancers of the lung