Patient Portal

Alex S. Evers, MD

Henry E. Mallinckrodt Professor, Anesthesiology
Head, Department of Anesthesiology

Specialty Areas

Anesthesiology
Critical Care Medicine

Board Certifications

Internal Medicine
Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
St. Louis Children's Hospital

Referral Information

Not Accepting New Patients

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

Fellowship: Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 1986
Fellowship: Surgical Intensive Care, Massachusetts General Hospital, Boston, Massachusetts 1983
Residency: Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 1982
Residency: Internal Medicine, Michael Resse Hospital, Chicago, Illinois 1981
Medical Degree: New York University Medical Center, New York, New York 1978

Publication & Research

Publication & Research

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.
Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G
Sci Rep. 2018 Jul 9; 8(1)10341. doi: 10.1038/s41598-018-28754-7.

PMID:
    29985445
    [PubMed - in process]
Related citations


High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABA<sub>A</sub> Receptors.
Germann AL, Shin DJ, Kuhrau CR, Johnson AD, Evers AS, Akk G
Mol Pharmacol. 2018 May; 93(5)468-476. doi: 10.1124/mol.117.111435.

PMID:
    29439087
    [PubMed - in process]
Related citations


SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain.
Orser BA, Suresh S, Evers AS
Anesth Analg. 2018 Apr; 126(4)1393-1396. doi: 10.1213/ANE.0000000000002833.

PMID:
    29401076
    [PubMed - in process]
Related citations


Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS
J Biol Chem. 2018 Feb 23; 293(8)3013-3027. doi: 10.1074/jbc.RA117.000359.

PMID:
    29301936
    [PubMed - in process]
Related citations


Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS
J Biol Chem. 2017 Jun 2; 292(22)9294-9304. doi: 10.1074/jbc.M116.773069.

PMID:
    28396346
    [PubMed - indexed for MEDLINE]
Related citations


Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS
Anal Chem. 2017 Feb 21; 89(4)2636-2644. doi: 10.1021/acs.analchem.6b05003.

PMID:
    28194953
    [PubMed - in process]
Related citations


Anesthetic Neurotoxicity: New Findings and Future Directions.
Montana MC, Evers AS
J Pediatr. 2017 Feb; 181279-285. doi: 10.1016/j.jpeds.2016.10.049.

PMID:
    27836289
    [PubMed - in process]
Related citations


Activation and modulation of recombinant glycine and GABA<sub>A</sub> receptors by 4-halogenated analogues of propofol.
Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G
Br J Pharmacol. 2016 Nov; 173(21)3110-3120. doi: 10.1111/bph.13566.

PMID:
    27459129
    [PubMed - indexed for MEDLINE]
Related citations


In Reply.
Avidan MS, Evers AS
Anesthesiology. 2016 Aug; 125(2)428-9. doi: 10.1097/ALN.0000000000001181.

PMID:
    27433761
    [PubMed]
Related citations


The GAS trial.
Orser BA, Evers AS, Suresh S, Hertz S
Lancet. 2016 Apr 16; 387(10028)1613-4. doi: 10.1016/S0140-6736(16)30199-4.

PMID:
    27116066
    [PubMed - indexed for MEDLINE]
Related citations


Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.
Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G
Curr Neuropharmacol. 2016; 14(7)772-80.

PMID:
    26830963
    [PubMed - indexed for MEDLINE]
Related citations


The Fallacy of Persistent Postoperative Cognitive Decline.
Avidan MS, Evers AS
Anesthesiology. 2016 Feb; 124(2)255-8. doi: 10.1097/ALN.0000000000000958.

PMID:
    26785428
    [PubMed - indexed for MEDLINE]
Related citations


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.
Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G
Mol Pharmacol. 2015 Oct; 88(4)736-45. doi: 10.1124/mol.115.100347.

PMID:
    26206487
    [PubMed - indexed for MEDLINE]
Related citations


Anesthetic neurotoxicity--clinical implications of animal models.
Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA
N Engl J Med. 2015 Feb 26; 372(9)796-7. doi: 10.1056/NEJMp1414786.

PMID:
    25714157
    [PubMed - indexed for MEDLINE]
Related citations


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.
Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G
Br J Pharmacol. 2014 Dec; 171(23)5446-57. doi: 10.1111/bph.12861.

PMID:
    25117207
    [PubMed - indexed for MEDLINE]
Related citations


Surgical safety checklists in ontario, Canada.
Avidan MS, Evers AS
N Engl J Med. 2014 Jun 12; 370(24)2350-1. doi: 10.1056/NEJMc1404583.

PMID:
    24918390
    [PubMed - indexed for MEDLINE]
Related citations


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.
Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS
Psychopharmacology (Berl). 2014 Sep; 231(17)3479-91. doi: 10.1007/s00213-014-3568-4.

PMID:
    24756762
    [PubMed - indexed for MEDLINE]
Related citations


Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.
Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF
J Med Chem. 2014 Jan 9; 57(1)171-90. doi: 10.1021/jm401577c.

PMID:
    24328079
    [PubMed - indexed for MEDLINE]
Related citations


Increased risk of intraoperative awareness in patients with a history of awareness.
Aranake A, Gradwohl S, Ben-Abdallah A, Lin N, Shanks A, Helsten DL, Glick DB, Jacobsohn E, Villafranca AJ, Evers AS, Avidan MS, Mashour GA
Anesthesiology. 2013 Dec; 119(6)1275-83. doi: 10.1097/ALN.0000000000000023.

PMID:
    24113645
    [PubMed - indexed for MEDLINE]
Related citations


A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP
Nat Chem Biol. 2013 Nov; 9(11)715-20. doi: 10.1038/nchembio.1340.

PMID:
    24056400
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: NeuroproteXeon

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018