Patient Portal

Alex S. Evers, MD

Henry E. Mallinckrodt Professor, Anesthesiology

Specialty Areas

Anesthesiology
Critical Care Medicine

Board Certifications

Internal Medicine
Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
St. Louis Children's Hospital

Referral Information

Not Accepting New Patients

  • Education
  • Publication & Research

Education

Education

Fellowship: Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 1986
Fellowship: Surgical Intensive Care, Massachusetts General Hospital, Boston, Massachusetts 1983
Residency: Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 1982
Residency: Internal Medicine, Michael Resse Hospital, Chicago, Illinois 1981
Medical Degree: New York University Medical Center, New York, New York 1978

Publication & Research

Publication & Research

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct; 1864(10)1269-1279. doi: 10.1016/j.bbalip.2019.06.004.

PMID:
    31176038
    [PubMed - in process]
Related citations


The molecular determinants of neurosteroid binding in the GABA(A) receptor.
Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL
J Steroid Biochem Mol Biol. 2019 Sep; 192105383. doi: 10.1016/j.jsbmb.2019.105383.

PMID:
    31150831
    [PubMed - in process]
Related citations


Multiple functional neurosteroid binding sites on GABAA receptors.
Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS
PLoS Biol. 2019 Mar; 17(3)e3000157. doi: 10.1371/journal.pbio.3000157.

PMID:
    30845142
    [PubMed - in process]
Related citations


Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.
Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Krishnan K, Mydock-McGrane L, Covey DF, Evers AS
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb; 1864(2)128-136. doi: 10.1016/j.bbalip.2018.11.005.

PMID:
    30471426
    [PubMed - indexed for MEDLINE]
Related citations


Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.
Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G
Sci Rep. 2018 Jul 9; 8(1)10341. doi: 10.1038/s41598-018-28754-7.

PMID:
    29985445
    [PubMed - indexed for MEDLINE]
Related citations


High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABA<sub>A</sub> Receptors.
Germann AL, Shin DJ, Kuhrau CR, Johnson AD, Evers AS, Akk G
Mol Pharmacol. 2018 May; 93(5)468-476. doi: 10.1124/mol.117.111435.

PMID:
    29439087
    [PubMed - indexed for MEDLINE]
Related citations


SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain.
Orser BA, Suresh S, Evers AS
Anesth Analg. 2018 Apr; 126(4)1393-1396. doi: 10.1213/ANE.0000000000002833.

PMID:
    29401076
    [PubMed - indexed for MEDLINE]
Related citations


Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS
J Biol Chem. 2018 Feb 23; 293(8)3013-3027. doi: 10.1074/jbc.RA117.000359.

PMID:
    29301936
    [PubMed - indexed for MEDLINE]
Related citations


Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS
J Biol Chem. 2017 Jun 2; 292(22)9294-9304. doi: 10.1074/jbc.M116.773069.

PMID:
    28396346
    [PubMed - indexed for MEDLINE]
Related citations


Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS
Anal Chem. 2017 Feb 21; 89(4)2636-2644. doi: 10.1021/acs.analchem.6b05003.

PMID:
    28194953
    [PubMed - indexed for MEDLINE]
Related citations


Anesthetic Neurotoxicity: New Findings and Future Directions.
Montana MC, Evers AS
J Pediatr. 2017 Feb; 181279-285. doi: 10.1016/j.jpeds.2016.10.049.

PMID:
    27836289
    [PubMed - indexed for MEDLINE]
Related citations


Activation and modulation of recombinant glycine and GABA<sub>A</sub> receptors by 4-halogenated analogues of propofol.
Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G
Br J Pharmacol. 2016 Nov; 173(21)3110-3120. doi: 10.1111/bph.13566.

PMID:
    27459129
    [PubMed - indexed for MEDLINE]
Related citations


In Reply.
Avidan MS, Evers AS
Anesthesiology. 2016 Aug; 125(2)428-9. doi: 10.1097/ALN.0000000000001181.

PMID:
    27433761
    [PubMed]
Related citations


The GAS trial.
Orser BA, Evers AS, Suresh S, Hertz S
Lancet. 2016 Apr 16; 387(10028)1613-4. doi: 10.1016/S0140-6736(16)30199-4.

PMID:
    27116066
    [PubMed - indexed for MEDLINE]
Related citations


Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.
Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G
Curr Neuropharmacol. 2016; 14(7)772-80.

PMID:
    26830963
    [PubMed - indexed for MEDLINE]
Related citations


The Fallacy of Persistent Postoperative Cognitive Decline.
Avidan MS, Evers AS
Anesthesiology. 2016 Feb; 124(2)255-8. doi: 10.1097/ALN.0000000000000958.

PMID:
    26785428
    [PubMed - indexed for MEDLINE]
Related citations


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.
Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G
Mol Pharmacol. 2015 Oct; 88(4)736-45. doi: 10.1124/mol.115.100347.

PMID:
    26206487
    [PubMed - indexed for MEDLINE]
Related citations


Anesthetic neurotoxicity--clinical implications of animal models.
Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA
N Engl J Med. 2015 Feb 26; 372(9)796-7. doi: 10.1056/NEJMp1414786.

PMID:
    25714157
    [PubMed - indexed for MEDLINE]
Related citations


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.
Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G
Br J Pharmacol. 2014 Dec; 171(23)5446-57. doi: 10.1111/bph.12861.

PMID:
    25117207
    [PubMed - indexed for MEDLINE]
Related citations


Surgical safety checklists in ontario, Canada.
Avidan MS, Evers AS
N Engl J Med. 2014 Jun 12; 370(24)2350-1. doi: 10.1056/NEJMc1404583.

PMID:
    24918390
    [PubMed - indexed for MEDLINE]
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