Patient Portal

Alan Pestronk, MD

Professor, Neurology
Section Chief, Neuromuscular Diseases
Professor, Pathology
Director, Neuromuscular Clinical Laboratory

Specialty Areas

Nerve Disorders
Neuromuscular Disease
Neurology - Adult
Muscle Disorders
Muscular Dystrophy
ALS - Lou Gehrig's Disease
Myasthenia Gravis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Clinical neurology, neuromuscular disease, neuroimmunology, glycolipids, proteoglycans, aging and the nervous system, history of neurology, myopathy, neuropathy, weakness, myasthenia, muscle, nerve, numbness, sensory loss, pain, fatigue, muscular dystrophy, neuro muscular.



More Information on the Neuromuscular Disease Center

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752

Education

Education

Chief Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland 1974
Fellowship: Neuromuscular Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 1977
Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland 1973
Medical Degree: Johns Hopkins School of Medicine, Baltimore, Maryland 1970
B.A.: Princeton University, Princeton, New Jersey 1966

Publication & Research

Publication & Research

Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials.
Diaz-Manera J, Fernandez-Torron R, LLauger J, James MK, Mayhew A, Smith FE, Moore UR, Blamire AM, Carlier PG, Rufibach L, Mittal P, Eagle M, Jacobs M, Hodgson T, Wallace D, Ward L, Smith M, Stramare R, Rampado A, Sato N, Tamaru T, Harwick B, Rico Gala S, Turk S, Coppenrath EM, Foster G, Bendahan D, Le Fur Y, Fricke ST, Otero H, Foster SL, Peduto A, Sawyer AM, Hilsden H, Lochmuller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V, Jain COS Consortium.
J Neurol Neurosurg Psychiatry. 2018 May 7; pii: jnnp-2017-317488. doi: 10.1136/jnnp-2017-317488.

PMID:
    29735511
    [PubMed - as supplied by publisher]
Related citations


Congenital titinopathy: Comprehensive characterisation and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi HB, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol. 2018 Apr 25; doi: 10.1002/ana.25241.

PMID:
    29691892
    [PubMed - as supplied by publisher]
Related citations


CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA).
Garcia-Santibanez R, Zaidman CM, Sommerville RB, Lopate G, Weihl CC, Pestronk A, Bucelli RC
J Neurol. 2018 Jun; 265(6)1402-1409. doi: 10.1007/s00415-018-8853-4.

PMID:
    29633012
    [PubMed - in process]
Related citations


Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study.
Moore UR, Jacobs M, Fernandez-Torron R, Jang J, James MK, Mayhew A, Rufibach L, Mittal P, Eagle M, Cnaan A, Carlier PG, Blamire A, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V
J Neurol Neurosurg Psychiatry. 2018 Jan 29; pii: jnnp-2017-317329. doi: 10.1136/jnnp-2017-317329.

PMID:
    29378789
    [PubMed - as supplied by publisher]
Related citations


Immune myopathies with perimysial pathology: Clinical and laboratory features.
Bucelli RC, Pestronk A
Neurol Neuroimmunol Neuroinflamm. 2018 Mar; 5(2)e434. doi: 10.1212/NXI.0000000000000434.

PMID:
    29359173
    [PubMed]
Related citations


224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016.
Allenbach Y, Mammen AL, Benveniste O, Stenzel W, Immune-Mediated Necrotizing Myopathies Working Group.
Neuromuscul Disord. 2018 Jan; 28(1)87-99. doi: 10.1016/j.nmd.2017.09.016.

PMID:
    29221629
    [PubMed - in process]
Related citations


Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.
McDonald CM, Henricson EK, Abresch RT, Duong T, Joyce NC, Hu F, Clemens PR, Hoffman EP, Cnaan A, Gordish-Dressman H, CINRG Investigators.
Lancet. 2018 Feb 3; 391(10119)451-461. doi: 10.1016/S0140-6736(17)32160-8.

PMID:
    29174484
    [PubMed - indexed for MEDLINE]
Related citations


Clinical and Laboratory Profiles of Idiopathic Small Fiber Neuropathy in Children: Case Series.
Kafaie J, Al Balushi A, Kim M, Pestronk A
J Clin Neuromuscul Dis. 2017 Sep; 19(1)31-37. doi: 10.1097/CND.0000000000000178.

PMID:
    28827487
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of Strength and Function in Ambulatory Adults With GNE Myopathy.
Argov Z, Bronstein F, Esposito A, Feinsod-Meiri Y, Florence JM, Fowler E, Greenberg MB, Malkus EC, Rebibo O, Siener CS, Caraco Y, Kolodny EH, Lau HA, Pestronk A, Shieh P, Skrinar AM, Mayhew JE
J Clin Neuromuscul Dis. 2017 Sep; 19(1)19-26. doi: 10.1097/CND.0000000000000181.

PMID:
    28827485
    [PubMed - indexed for MEDLINE]
Related citations


Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy.
Anderson J, Seol H, Gordish-Dressman H, Hathout Y, Spurney CF, CINRG Investigators.
Pediatr Cardiol. 2017 Dec; 38(8)1606-1612. doi: 10.1007/s00246-017-1703-9.

PMID:
    28821969
    [PubMed - in process]
Related citations


Survival among children with "Lethal" congenital contracture syndrome 11 caused by novel mutations in the gliomedin gene (GLDN).
Wambach JA, Stettner GM, Haack TB, Writzl K, Škofljanec A, Maver A, Munell F, Ossowski S, Bosio M, Wegner DJ, Shinawi M, Baldridge D, Alhaddad B, Strom TM, Grange DK, Wilichowski E, Troxell R, Collins J, Warner BB, Schmidt RE, Pestronk A, Cole FS, Steinfeld R
Hum Mutat. 2017 Nov; 38(11)1477-1484. doi: 10.1002/humu.23297.

PMID:
    28726266
    [PubMed - indexed for MEDLINE]
Related citations


Cystinosis distal myopathy, novel clinical, pathological and genetic features.
Cabrera-Serrano M, Junckerstorff RC, Alisheri A, Pestronk A, Laing NG, Weihl CC, Lamont PJ
Neuromuscul Disord. 2017 Sep; 27(9)873-878. doi: 10.1016/j.nmd.2017.05.010.

PMID:
    28629674
    [PubMed - indexed for MEDLINE]
Related citations


Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy.
Hogarth MW, Houweling PJ, Thomas KC, Gordish-Dressman H, Bello L, Cooperative International Neuromuscular Research Group (CINRG)., Pegoraro E, Hoffman EP, Head SI, North KN
Nat Commun. 2017 Jan 31; 814143. doi: 10.1038/ncomms14143.

PMID:
    28139640
    [PubMed - in process]
Related citations


Aceneuramic Acid Extended Release Administration Maintains Upper Limb Muscle Strength in a 48-week Study of Subjects with GNE Myopathy: Results from a Phase 2, Randomized, Controlled Study.
Argov Z, Caraco Y, Lau H, Pestronk A, Shieh PB, Skrinar A, Koutsoukos T, Ahmed R, Martinisi J, Kakkis E
J Neuromuscul Dis. 2016 Mar 3; 3(1)49-66.

PMID:
    27854209
    [PubMed - indexed for MEDLINE]
Related citations


Sarcopenia, age, atrophy, and myopathy: Mitochondrial oxidative enzyme activities.
Pestronk A, Keeling R, Choksi R
Muscle Nerve. 2017 Jul; 56(1)122-128. doi: 10.1002/mus.25442.

PMID:
    27759889
    [PubMed - indexed for MEDLINE]
Related citations


Association Study of Exon Variants in the NF-κB and TGFβ Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy.
Bello L, Flanigan KM, Weiss RB, United Dystrophinopathy Project., Spitali P, Aartsma-Rus A, Muntoni F, Zaharieva I, Ferlini A, Mercuri E, Tuffery-Giraud S, Claustres M, Straub V, Lochmüller H, Barp A, Vianello S, Pegoraro E, Punetha J, Gordish-Dressman H, Giri M, McDonald CM, Hoffman EP, Cooperative International Neuromuscular Research Group.
Am J Hum Genet. 2016 Nov 3; 99(5)1163-1171. doi: 10.1016/j.ajhg.2016.08.023.

PMID:
    27745838
    [PubMed - indexed for MEDLINE]
Related citations


The Clinical Outcome Study for dysferlinopathy: An international multicenter study.
Harris E, Bladen CL, Mayhew A, James M, Bettinson K, Moore U, Smith FE, Rufibach L, Cnaan A, Bharucha-Goebel DX, Blamire AM, Bravver E, Carlier PG, Day JW, Díaz-Manera J, Eagle M, Grieben U, Harms M, Jones KJ, Lochmüller H, Mendell JR, Mori-Yoshimura M, Paradas C, Pegoraro E, Pestronk A, Salort-Campana E, Schreiber-Katz O, Semplicini C, Spuler S, Stojkovic T, Straub V, Takeda S, Rocha CT, Walter MC, Bushby K, Jain COS Consortium.
Neurol Genet. 2016 Aug; 2(4)e89. doi: 10.1212/NXG.0000000000000089.

PMID:
    27602406
    [PubMed]
Related citations


Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy.
Griggs RC, Miller JP, Greenberg CR, Fehlings DL, Pestronk A, Mendell JR, Moxley RT 3rd, King W, Kissel JT, Cwik V, Vanasse M, Florence JM, Pandya S, Dubow JS, Meyer JM
Neurology. 2016 Nov 15; 87(20)2123-2131.

PMID:
    27566742
    [PubMed - indexed for MEDLINE]
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Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study.
van der Ploeg A, Carlier PG, Carlier RY, Kissel JT, Schoser B, Wenninger S, Pestronk A, Barohn RJ, Dimachkie MM, Goker-Alpan O, Mozaffar T, Pena LD, Simmons Z, Straub V, Guglieri M, Young P, Boentert M, Baudin PY, Wens S, Shafi R, Bjartmar C, Thurberg BL
Mol Genet Metab. 2016 Sep; 119(1-2)115-23. doi: 10.1016/j.ymgme.2016.05.013.

PMID:
    27473031
    [PubMed - indexed for MEDLINE]
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Defining SOD1 ALS natural history to guide therapeutic clinical trial design.
Bali T, Self W, Liu J, Siddique T, Wang LH, Bird TD, Ratti E, Atassi N, Boylan KB, Glass JD, Maragakis NJ, Caress JB, McCluskey LF, Appel SH, Wymer JP, Gibson S, Zinman L, Mozaffar T, Callaghan B, McVey AL, Jockel-Balsarotti J, Allred P, Fisher ER, Lopate G, Pestronk A, Cudkowicz ME, Miller TM
J Neurol Neurosurg Psychiatry. 2017 Feb; 88(2)99-105. doi: 10.1136/jnnp-2016-313521.

PMID:
    27261500
    [PubMed - indexed for MEDLINE]
Related citations