Patient Portal

Alan Pestronk, MD

Professor, Neurology
Section Chief, Neuromuscular Diseases
Professor, Pathology
Director, Neuromuscular Clinical Laboratory

Specialty Areas

Nerve Disorders
Neuromuscular Disease
Neurology - Adult
Muscle Disorders
Muscular Dystrophy
ALS - Lou Gehrig's Disease
Myasthenia Gravis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Clinical neurology, neuromuscular disease, neuroimmunology, glycolipids, proteoglycans, aging and the nervous system, history of neurology, myopathy, neuropathy, weakness, myasthenia, muscle, nerve, numbness, sensory loss, pain, fatigue, muscular dystrophy, neuro muscular.



More Information on the Neuromuscular Disease Center

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752

Education

Education

Chief Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland 1974
Fellowship: Neuromuscular Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 1977
Residency: Neurology, Johns Hopkins Hospital, Baltimore, Maryland 1973
Medical Degree: Johns Hopkins School of Medicine, Baltimore, Maryland 1970
B.A.: Princeton University, Princeton, New Jersey 1966

Publication & Research

Publication & Research

Cryptogenic small-fiber neuropathies: Serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor-3.
Levine TD, Kafaie J, Zeidman LA, Saperstein DS, Massaquoi R, Bland RJ, Pestronk A
Muscle Nerve. 2019 Oct 25; doi: 10.1002/mus.26748.

PMID:
    31650561
    [PubMed - as supplied by publisher]
Related citations


Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis.
Babu S, Macklin EA, Jackson KE, Simpson E, Mahoney K, Yu H, Walker J, Simmons Z, David WS, Barkhaus PE, Simionescu L, Dimachkie MM, Pestronk A, Salameh JS, Weiss MD, Brooks BR, Schoenfeld D, Shefner J, Aggarwal S, Cudkowicz ME, Atassi N
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Oct 14; 1-9. doi: 10.1080/21678421.2019.1672750.

PMID:
    31608711
    [PubMed - as supplied by publisher]
Related citations


Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy.
Conrado DJ, Larkindale J, Berg A, Hill M, Burton J, Abrams KR, Abresch RT, Bronson A, Chapman D, Crowther M, Duong T, Gordish-Dressman H, Harnisch L, Henricson E, Kim S, McDonald CM, Schmidt S, Vong C, Wang X, Wong BL, Yong F, Romero K, Duchenne Muscular Dystrophy Regulatory Science Consortium (D-RSC).
J Pharmacokinet Pharmacodyn. 2019 Oct; 46(5)441-455. doi: 10.1007/s10928-019-09642-7.

PMID:
    31127458
    [PubMed - in process]
Related citations


A phase III trial of <i>tirasemtiv</i> as a potential treatment for amyotrophic lateral sclerosis.
Shefner JM, Cudkowicz ME, Hardiman O, Cockcroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA, VITALITY-ALS Study Group.
Amyotroph Lateral Scler Frontotemporal Degener. 2019; 0(0)1-11. doi: 10.1080/21678421.2019.1612922.

PMID:
    31081694
    [PubMed - in process]
Related citations


Immune myopathy with large histiocyte-related myofiber necrosis.
Pestronk A, Sinha N, Alhumayyd Z, Ly C, Schmidt R, Bucelli R
Neurology. 2019 Apr 9; 92(15)e1763-e1772. doi: 10.1212/WNL.0000000000007260.

PMID:
    30894448
    [PubMed - in process]
Related citations


Prevalence of Axonal Sensory Neuropathy With IgM Binding to Trisulfated Heparin Disaccharide in Patients With Fibromyalgia.
Malik A, Lopate G, Hayat G, Jones J, Atluri R, Malo B, Pestronk A
J Clin Neuromuscul Dis. 2019 Mar; 20(3)103-110. doi: 10.1097/CND.0000000000000236.

PMID:
    30801480
    [PubMed - indexed for MEDLINE]
Related citations


Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoGAA) in treatment-naïve and alglucosidase alfa-treated patients with late-onset Pompe disease: A phase 1, open-label, multicenter, multinational, ascending dose study.
Pena LDM, Barohn RJ, Byrne BJ, Desnuelle C, Goker-Alpan O, Ladha S, Laforêt P, Mengel KE, Pestronk A, Pouget J, Schoser B, Straub V, Trivedi J, Van Damme P, Vissing J, Young P, Kacena K, Shafi R, Thurberg BL, Culm-Merdek K, van der Ploeg AT, NEO1 Investigator Group.
Neuromuscul Disord. 2019 Mar; 29(3)167-186. doi: 10.1016/j.nmd.2018.12.004.

PMID:
    30770310
    [PubMed - in process]
Related citations


Assessment of disease progression in dysferlinopathy: A 1-year cohort study.
Moore U, Jacobs M, James MK, Mayhew AG, Fernandez-Torron R, Feng J, Cnaan A, Eagle M, Bettinson K, Rufibach LE, Lofra RM, Blamire AM, Carlier PG, Mittal P, Lowes LP, Alfano L, Rose K, Duong T, Berry KM, Montiel-Morillo E, Pedrosa-Hernández I, Holsten S, Sanjak M, Ashida A, Sakamoto C, Tateishi T, Yajima H, Canal A, Ollivier G, Decostre V, Mendez JB, Sánchez-Aguilera Praxedes N, Thiele S, Siener C, Shierbecker J, Florence JM, Vandevelde B, DeWolf B, Hutchence M, Gee R, Prügel J, Maron E, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Díaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V, Jain COS Consortium.
Neurology. 2019 Jan 9; pii: 10.1212/WNL.0000000000006858. doi: 10.1212/WNL.0000000000006858.

PMID:
    30626655
    [PubMed - as supplied by publisher]
Related citations


Longitudinal pulmonary function testing outcome measures in Duchenne muscular dystrophy: Long-term natural history with and without glucocorticoids.
McDonald CM, Gordish-Dressman H, Henricson EK, Duong T, Joyce NC, Jhawar S, Leinonen M, Hsu F, Connolly AM, Cnaan A, Abresch RT, CINRG investigators for PubMed.
Neuromuscul Disord. 2018 Nov; 28(11)897-909. doi: 10.1016/j.nmd.2018.07.004.

PMID:
    30336970
    [PubMed - indexed for MEDLINE]
Related citations


The relationship between deficit in digit span and genotype in nonsense mutation Duchenne muscular dystrophy.
Thangarajh M, Elfring GL, Trifillis P, McIntosh J, Peltz SW, Ataluren Phase 2b Study Group.
Neurology. 2018 Sep 25; 91(13)e1215-e1219. doi: 10.1212/WNL.0000000000006245.

PMID:
    30135256
    [PubMed - indexed for MEDLINE]
Related citations


Placebo-controlled Phase 2 Trial of Drisapersen for Duchenne Muscular Dystrophy.
McDonald CM, Wong B, Flanigan KM, Wilson R, de Kimpe S, Lourbakos A, Lin Z, Campion G, DEMAND V study group.
Ann Clin Transl Neurol. 2018 Aug; 5(8)913-926. doi: 10.1002/acn3.579.

PMID:
    30128316
    [PubMed]
Related citations


Homozygous recessive MYH2 mutation mimicking dominant MYH2 associated myopathy.
Findlay AR, Harms MB, Pestronk A, Weihl CC
Neuromuscul Disord. 2018 Aug; 28(8)675-679. doi: 10.1016/j.nmd.2018.05.006.

PMID:
    29934118
    [PubMed - indexed for MEDLINE]
Related citations


Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials.
Diaz-Manera J, Fernandez-Torron R, LLauger J, James MK, Mayhew A, Smith FE, Moore UR, Blamire AM, Carlier PG, Rufibach L, Mittal P, Eagle M, Jacobs M, Hodgson T, Wallace D, Ward L, Smith M, Stramare R, Rampado A, Sato N, Tamaru T, Harwick B, Rico Gala S, Turk S, Coppenrath EM, Foster G, Bendahan D, Le Fur Y, Fricke ST, Otero H, Foster SL, Peduto A, Sawyer AM, Hilsden H, Lochmuller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V, Jain COS Consortium.
J Neurol Neurosurg Psychiatry. 2018 Oct; 89(10)1071-1081. doi: 10.1136/jnnp-2017-317488.

PMID:
    29735511
    [PubMed - indexed for MEDLINE]
Related citations


Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol. 2018 Jun; 83(6)1105-1124. doi: 10.1002/ana.25241.

PMID:
    29691892
    [PubMed - indexed for MEDLINE]
Related citations


CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA).
Garcia-Santibanez R, Zaidman CM, Sommerville RB, Lopate G, Weihl CC, Pestronk A, Bucelli RC
J Neurol. 2018 Jun; 265(6)1402-1409. doi: 10.1007/s00415-018-8853-4.

PMID:
    29633012
    [PubMed - indexed for MEDLINE]
Related citations


Teenage exercise is associated with earlier symptom onset in dysferlinopathy: a retrospective cohort study.
Moore UR, Jacobs M, Fernandez-Torron R, Jang J, James MK, Mayhew A, Rufibach L, Mittal P, Eagle M, Cnaan A, Carlier PG, Blamire A, Hilsden H, Lochmüller H, Grieben U, Spuler S, Tesi Rocha C, Day JW, Jones KJ, Bharucha-Goebel DX, Salort-Campana E, Harms M, Pestronk A, Krause S, Schreiber-Katz O, Walter MC, Paradas C, Hogrel JY, Stojkovic T, Takeda S, Mori-Yoshimura M, Bravver E, Sparks S, Diaz-Manera J, Bello L, Semplicini C, Pegoraro E, Mendell JR, Bushby K, Straub V
J Neurol Neurosurg Psychiatry. 2018 Nov; 89(11)1224-1226. doi: 10.1136/jnnp-2017-317329.

PMID:
    29378789
    [PubMed - indexed for MEDLINE]
Related citations


Immune myopathies with perimysial pathology: Clinical and laboratory features.
Bucelli RC, Pestronk A
Neurol Neuroimmunol Neuroinflamm. 2018 Mar; 5(2)e434. doi: 10.1212/NXI.0000000000000434.

PMID:
    29359173
    [PubMed]
Related citations


224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016.
Allenbach Y, Mammen AL, Benveniste O, Stenzel W, Immune-Mediated Necrotizing Myopathies Working Group.
Neuromuscul Disord. 2018 Jan; 28(1)87-99. doi: 10.1016/j.nmd.2017.09.016.

PMID:
    29221629
    [PubMed - indexed for MEDLINE]
Related citations


Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.
McDonald CM, Henricson EK, Abresch RT, Duong T, Joyce NC, Hu F, Clemens PR, Hoffman EP, Cnaan A, Gordish-Dressman H, CINRG Investigators.
Lancet. 2018 Feb 3; 391(10119)451-461. doi: 10.1016/S0140-6736(17)32160-8.

PMID:
    29174484
    [PubMed - indexed for MEDLINE]
Related citations


Clinical and Laboratory Profiles of Idiopathic Small Fiber Neuropathy in Children: Case Series.
Kafaie J, Al Balushi A, Kim M, Pestronk A
J Clin Neuromuscul Dis. 2017 Sep; 19(1)31-37. doi: 10.1097/CND.0000000000000178.

PMID:
    28827487
    [PubMed - indexed for MEDLINE]
Related citations