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Akinobu Itoh, MD, PhD

Assistant Professor, Surgery
Division of Cardiothoracic Surgery

Specialty Areas

Cardiac Surgery
Heart Transplantation
Heart Failure / Transplant

Board Certifications

Japanese Board of Surgery
Japanese Board of Cardiovascular Surgery

Hospital Affiliations

Barnes-Jewish Hospital

Languages

Japanese

Areas of Clinical Interest

Heart valve repair/replacement, aortic root surgery, coronary artery bypass (bilateral IMA and off pump surgery),heart transplantation, mechanical assist device (LVAD/ECMO) for heart failure, pre/post operative patient care

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Heart & Vascular Center

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: (314) 362-8008
Fax: (314) 747-4216

Education

Education

Medical Degree: Tohoku School of Medicine, Sendai, Japan 1992
PhD : Mitral valve physiology and pathology, Tohoku School of Medicine, Sendai, Japan 2010
Residency: General Surgery, NTT Medical Center of Tokyo, Tokyo, Japan 2000
Residency: Cardiovascular Surgery, NTT Medical Center of Tokyo, Tokyo, Japan 2002
Fellowship (Research): Carl and Leah McConnell Cardiovascula Surgical Research, Stanford University School of Medicine, Stanford, CA 2008
Fellowship: Cardiovascular Surgery, St. Michael's Hospital, Toronto, Ontario 2011
Fellowship: Transplant / Heart Failure, St Michael's Hospital, Toronto, Ontario 2012

Publication & Research

Publication & Research

Photoinduced generation of acyl radicals from simple aldehydes, access to 3-acyl-4-arylcoumarin derivatives, and evaluation of their antiandrogenic activities.
Kawaai K, Yamaguchi T, Yamaguchi E, Endo S, Tada N, Ikari A, Itoh A
J Org Chem. 2018 Jan 12; doi: 10.1021/acs.joc.7b02933.

PMID:
    29327585
    [PubMed - as supplied by publisher]
Related citations


Aerobic photooxidative synthesis of β-alkoxy mono-hydroperoxides using an organo photoredox catalyst controlled by a base.
Asano Y, Nagasawa Y, Yamaguchi E, Itoh A
Chem Asian J. 2018 Jan 12; doi: 10.1002/asia.201701742.

PMID:
    29327427
    [PubMed - as supplied by publisher]
Related citations


Plant invasion: Another threat to the São Paulo Marsh Antwren (Formicivora paludicola), a species on the verge of extinction.
Del-Rio G, Rêgo MA, Silveira LF, Itoh A
PLoS One. 2017; 12(12)e0189465. doi: 10.1371/journal.pone.0189465.

PMID:
    29281668
    [PubMed - in process]
Related citations


Is Impella device really useful to unload the left ventricle during extracorporeal life support? (Reply).
Tepper S, Itoh A
Ann Thorac Surg. 2017 Dec 15; pii: S0003-4975(17)31615-6. doi: 10.1016/j.athoracsur.2017.11.039.

PMID:
    29253464
    [PubMed - as supplied by publisher]
Related citations


Atrial Septostomy: An Alternative for Left Ventricular Unloading During Extracorporeal Life Support (Reply).
Tepper S, Itoh A
Ann Thorac Surg. 2017 Dec 15; pii: S0003-4975(17)31614-4. doi: 10.1016/j.athoracsur.2017.11.038.

PMID:
    29253462
    [PubMed - as supplied by publisher]
Related citations


The profound impact of combined severe acidosis and malperfusion on operative mortality in the surgical treatment of type A aortic dissection.
Lawton JS, Moon MR, Liu J, Koerner DJ, Kulshrestha K, Damiano RJ Jr, Maniar H, Itoh A, Balsara KR, Masood FM, Melby SJ, Pasque MK
J Thorac Cardiovasc Surg. 2017 Nov 7; pii: S0022-5223(17)32428-5. doi: 10.1016/j.jtcvs.2017.11.002.

PMID:
    29249502
    [PubMed - as supplied by publisher]
Related citations


Impact of age, sex, therapeutic intent, race and severity of advanced heart failure on short-term principal outcomes in the MOMENTUM 3 trial.
Goldstein DJ, Mehra MR, Naka Y, Salerno C, Uriel N, Dean D, Itoh A, Pagani FD, Skipper ER, Bhat G, Raval N, Bruckner BA, Estep JD, Cogswell R, Milano C, Fendelander L, O'Connell JB, Cleveland J, MOMENTUM 3 Investigators.
J Heart Lung Transplant. 2018 Jan; 37(1)7-14. doi: 10.1016/j.healun.2017.11.001.

PMID:
    29154131
    [PubMed - in process]
Related citations


Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins.
Itoh A, Nonaka Y, Ogawa T, Nakamura T, Nishi N
Biosci Biotechnol Biochem. 2017 Nov; 81(11)2098-2104. doi: 10.1080/09168451.2017.1374828.

PMID:
    28958189
    [PubMed - indexed for MEDLINE]
Related citations


Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.
Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M
PLoS Genet. 2017 Sep; 13(9)e1007034. doi: 10.1371/journal.pgen.1007034.

PMID:
    28949961
    [PubMed - indexed for MEDLINE]
Related citations


Parosteal lipoma mimicking a breast tumor.
Suyama L, Itoh A
BMJ Case Rep. 2017 Aug 21; 2017pii: bcr-2017-220770. doi: 10.1136/bcr-2017-220770.

PMID:
    28827298
    [PubMed - in process]
Related citations


4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways.
Inoue Y, Hara H, Mitsugi Y, Yamaguchi E, Kamiya T, Itoh A, Adachi T
Neurochem Int. 2018 Jan; 112288-296. doi: 10.1016/j.neuint.2017.08.011.

PMID:
    28823537
    [PubMed - in process]
Related citations


Dioecious plants are more precocious than cosexual plants: A comparative study of relative sizes at the onset of sexual reproduction in woody species.
Ohya I, Nanami S, Itoh A
Ecol Evol. 2017 Aug; 7(15)5660-5668. doi: 10.1002/ece3.3117.

PMID:
    28808545
    [PubMed]
Related citations


Prediction of difficult laparoscopic cholecystectomy for acute cholecystitis.
Maehira H, Kawasaki M, Itoh A, Ogawa M, Mizumura N, Toyoda S, Okumura S, Kameyama M
J Surg Res. 2017 Aug; 216143-148. doi: 10.1016/j.jss.2017.05.008.

PMID:
    28807199
    [PubMed - indexed for MEDLINE]
Related citations


Effectiveness of home-based exercise in older patients with advanced chronic obstructive pulmonary disease: A 3-year cohort study.
Wakabayashi R, Kusunoki Y, Hattori K, Motegi T, Furutate R, Itoh A, Jones RC, Hyland ME, Kida K
Geriatr Gerontol Int. 2017 Aug 1; doi: 10.1111/ggi.13134.

PMID:
    28762596
    [PubMed - as supplied by publisher]
Related citations


Inflammation-free, gas-permeable, lightweight, stretchable on-skin electronics with nanomeshes.
Miyamoto A, Lee S, Cooray NF, Lee S, Mori M, Matsuhisa N, Jin H, Yoda L, Yokota T, Itoh A, Sekino M, Kawasaki H, Ebihara T, Amagai M, Someya T
Nat Nanotechnol. 2017 Sep; 12(9)907-913. doi: 10.1038/nnano.2017.125.

PMID:
    28737748
    [PubMed - in process]
Related citations


Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction.
Kajimoto K, Minami Y, Otsubo S, Sato N, investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) registry.
Am J Cardiol. 2017 Sep 1; 120(5)809-816. doi: 10.1016/j.amjcard.2017.05.051.

PMID:
    28705383
    [PubMed - indexed for MEDLINE]
Related citations


GLP-1 receptor agonist, liraglutide, ameliorates hepatosteatosis induced by anti-CD3 antibody in female mice.
Itoh A, Irie J, Tagawa H, Kusumoto Y, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Wu Y, Yamada S, Kawai T, Ridgway WM, Itoh H
J Diabetes Complications. 2017 Sep; 31(9)1370-1375. doi: 10.1016/j.jdiacomp.2017.05.013.

PMID:
    28684145
    [PubMed - in process]
Related citations


Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes.
Itoh A, Ridgway WM
Immunotargets Ther. 2017; 631-38. doi: 10.2147/ITT.S117264.

PMID:
    28580341
    [PubMed]
Related citations


Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice.
Kusumoto Y, Irie J, Iwabu K, Tagawa H, Itoh A, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Yamada S, Kawai T, Watanabe M, Oike Y, Itoh H
Metabolism. 2017 Jun; 711-6. doi: 10.1016/j.metabol.2017.02.011.

PMID:
    28521862
    [PubMed - indexed for MEDLINE]
Related citations


Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells.
Horiuchi M, Suzuki-Horiuchi Y, Akiyama T, Itoh A, Pleasure D, Carstens E, Itoh T
J Neurochem. 2017 Aug; 142(3)378-391. doi: 10.1111/jnc.14074.

PMID:
    28512742
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Clinical results in patients with LVAD, mitral valve dynamics after mitral valve repair, myocardial strain and structural alteration in heart disease