Patient Portal

Adrian Shifren, MD

Associate Professor, Medicine
Pulmonary and Critical Care Medicine

Specialty Areas

Lung Disease
Pulmonary Disease
COPD

Board Certifications

Internal Medicine
Pulmonary Disease
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lung disease, rare lung disease, cystic lung disease, emphysema, COPD, pulmonary hypertension, interstitial lung disease.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: (314) 454-8917
Fax: (314) 454-7120

Education

Education

Medical Degree: University of Witwatersrand, Johannesburg, South Africa 1996
Fellowship (Research): Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 2008
Residency: Internal Medicine, Barnes-Jewish Hospital. St. Louis MO 2001
Fellowship: Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 2006

Publication & Research

Publication & Research

The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study.
Chen DL, Huang HJ, Byers DE, Shifren A, Belikoff B, Engle JT, Arentson E, Kemp D, Phillips S, Scherrer DE, Fujiwara H, Spayd KJ, Brooks FJ, Pierce RA, Castro M, Isakow W
PLoS One. 2018; 13(2)e0191783. doi: 10.1371/journal.pone.0191783.

PMID:
    29414995
    [PubMed - indexed for MEDLINE]
Related citations


Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study.
Walsh SLF, Maher TM, Kolb M, Poletti V, Nusser R, Richeldi L, Vancheri C, Wilsher ML, Antoniou KM, Behr J, Bendstrup E, Brown K, Calandriello L, Corte TJ, Cottin V, Crestani B, Flaherty K, Glaspole I, Grutters J, Inoue Y, Kokosi M, Kondoh Y, Kouranos V, Kreuter M, Johannson K, Judge E, Ley B, Margaritopoulos G, Martinez FJ, Molina-Molina M, Morais A, Nunes H, Raghu G, Ryerson CJ, Selman M, Spagnolo P, Taniguchi H, Tomassetti S, Valeyre D, Wijsenbeek M, Wuyts W, Hansell D, Wells A, IPF Project Consortium.
Eur Respir J. 2017 Aug; 50(2)pii: 1700936. doi: 10.1183/13993003.00936-2017.

PMID:
    28860269
    [PubMed - indexed for MEDLINE]
Related citations


Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.
Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN, Other members of the PAS2 Study Group.
Eur Respir J. 2017 Aug; 50(2)pii: 1700017. doi: 10.1183/13993003.00017-2017.

PMID:
    28860266
    [PubMed - indexed for MEDLINE]
Related citations


A Phase II Clinical Trial of an Aromatase Inhibitor for Postmenopausal Women with Lymphangioleiomyomatosis.
Lu C, Lee HS, Pappas GP, Dilling DF, Burger CD, Shifren A, Veeraraghavan S, Chapman JT, Parambil J, Ruoss SJ, Young LR, Hammes SR, Kopras EJ, Roads T, Krischer JP, McCormack FX, Trial of an Aromatase Inhibitor in Lymphangioleiomyomatosis Group.
Ann Am Thorac Soc. 2017 Jun; 14(6)919-928. doi: 10.1513/AnnalsATS.201610-824OC.

PMID:
    28570161
    [PubMed - indexed for MEDLINE]
Related citations


A safety evaluation of pirfenidone for the treatment of idiopathic pulmonary fibrosis.
Anderson A, Shifren A, Nathan SD
Expert Opin Drug Saf. 2016 Jul; 15(7)975-82. doi: 10.1080/14740338.2016.1187129.

PMID:
    27177012
    [PubMed - indexed for MEDLINE]
Related citations


Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations.
Coghlan MA, Shifren A, Huang HJ, Russell TD, Mitra RD, Zhang Q, Wegner DJ, Cole FS, Hamvas A
BMJ Open Respir Res. 2014; 1(1)e000057. doi: 10.1136/bmjresp-2014-000057.

PMID:
    25553246
    [PubMed]
Related citations


Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS Jr, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ
J Allergy Clin Immunol. 2014 Dec; 134(6)1402-1412.e7. doi: 10.1016/j.jaci.2014.07.013.

PMID:
    25216987
    [PubMed - indexed for MEDLINE]
Related citations


Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.
Sugitani H, Hirano E, Knutsen RH, Shifren A, Wagenseil JE, Ciliberto C, Kozel BA, Urban Z, Davis EC, Broekelmann TJ, Mecham RP
J Biol Chem. 2012 Jun 22; 287(26)22055-67. doi: 10.1074/jbc.M111.327940.

PMID:
    22573328
    [PubMed - indexed for MEDLINE]
Related citations


Mechanisms of remodeling in asthmatic airways.
Shifren A, Witt C, Christie C, Castro M
J Allergy (Cairo). 2012; 2012316049. doi: 10.1155/2012/316049.

PMID:
    22315625
    [PubMed]
Related citations


Point: efficacy of bronchial thermoplasty for patients with severe asthma. Is there sufficient evidence? Yes.
Shifren A, Chen A, Castro M
Chest. 2011 Sep; 140(3)573-575. doi: 10.1378/chest.11-1410.

PMID:
    21896515
    [PubMed - indexed for MEDLINE]
Related citations


Mechanisms of emphysema in autosomal dominant cutis laxa.
Hu Q, Shifren A, Sens C, Choi J, Szabo Z, Starcher BC, Knutsen RH, Shipley JM, Davis EC, Mecham RP, Urban Z
Matrix Biol. 2010 Sep; 29(7)621-8. doi: 10.1016/j.matbio.2010.06.005.

PMID:
    20600892
    [PubMed - indexed for MEDLINE]
Related citations


Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice.
Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola KM, Nolen-Walston RD, Kim CF, Tsai L, Pierce RA, Mecham RP, Ingenito EP
Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2)L158-68. doi: 10.1152/ajplung.90594.2008.

PMID:
    19915155
    [PubMed - indexed for MEDLINE]
Related citations


Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure.
Shifren A, Durmowicz AG, Knutsen RH, Faury G, Mecham RP
J Appl Physiol (1985). 2008 Nov; 105(5)1610-9. doi: 10.1152/japplphysiol.90563.2008.

PMID:
    18772328
    [PubMed - indexed for MEDLINE]
Related citations


Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin.
Broekelmann TJ, Ciliberto CH, Shifren A, Mecham RP
Matrix Biol. 2008 Sep; 27(7)631-9. doi: 10.1016/j.matbio.2008.06.001.

PMID:
    18602002
    [PubMed - indexed for MEDLINE]
Related citations


Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP
Blood. 2008 Apr 15; 111(8)4137-44. doi: 10.1182/blood-2007-07-101733.

PMID:
    18281502
    [PubMed - indexed for MEDLINE]
Related citations


Upregulation of elastin expression in constrictive bronchiolitis obliterans.
Shifren A, Woods JC, Rosenbluth DB, Officer S, Cooper JD, Pierce RA
Int J Chron Obstruct Pulmon Dis. 2007; 2(4)593-8.

PMID:
    18268933
    [PubMed - indexed for MEDLINE]
Related citations


Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema.
Shifren A, Durmowicz AG, Knutsen RH, Hirano E, Mecham RP
Am J Physiol Lung Cell Mol Physiol. 2007 Mar; 292(3)L778-87.

PMID:
    17142349
    [PubMed - indexed for MEDLINE]
Related citations


The stumbling block in lung repair of emphysema: elastic fiber assembly.
Shifren A, Mecham RP
Proc Am Thorac Soc. 2006 Jul; 3(5)428-33.

PMID:
    16799087
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Boehringer Ingelheim

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,000 - $19,999

Reporting Date: May 01, 2018


Company Name: Genetech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,000 - $19,999

Reporting Date: May 01, 2018

Areas of Research Interest

The genetic determinants of emphysema. Specifically, the role of extracellular matrix molecules in predisposing to, or protecting from, emphysema. Using knockout and transgenic mouse models to investigate the mechanisms responsible for changes in emphysema susceptibility following cigarette-smoke exposure, we translate these findings to human disease by screening populations of emphysema patients for extracellular matrix molecule gene mutations that associate with clinical markers of disease.