Radiology / Nuclear Medicine

The Washington University physicians at Mallinckrodt Institute of Radiology (MIR) have been providing clinical radiology services for nearly three quarters of a century and have earned the reputation of a radiology leader.

MIR is a large and complex radiology department—a necessity for providing top quality radiology services to our patients.

Our expert radiologists, working with skilled nurses and technologists, perform and interpret more than 600,000 examinations and procedures each year. Combine this experience and expertise with productive research and training programs and you have a top-notch radiology facility for diagnosing and treating diseases.

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Home > Physicians Directory > Radiology / Nuclear Medicine

Mark A. Mintun, MD

Specialty Areas
Nuclear Medicine
PET Imaging
Radiology

Areas of Clinical Interest
Nuclear medicine, PET tumor imaging, PET brain imaging

Areas of Research Interest
PET brain imaging, Functional brain imaging, Tumor imaging, Radiology Research Development


Major or Recent Publications/Awards

Honors and Awards

Listed in Best Doctors in America, 2003 - 2009 (Best Doctors, Inc)

Tetalman Memorial Award of the Society of Nuclear Medicine, 1989

Research and Education Scholar of the Radiology Society of North America, 1988

Hugh M. Wilson Award for Research in Radiology, 1981

Editorial Responsibilities

Associate Editor:
Human Brain Mapping

Reviewer:
Journal of Nuclear Medicine
Journal of Cerebral Blood Flow and Metabolism
Radiology

Peer Reviewed Articles

Innis RB, Cunningham VJ, Delforge, J, Fujita Masahiro, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Maguire RP, Mintun MA, Morris ED, Parsey R, Slifstein M, Sossi Vesna, Suhara Tetsuya, Votaw J, Wong DF. Consensus Nomenclature for Binding Potential and Related Terms Used in Radiolgy Imaging. JCBF&M 2007; (In Press)

Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/A_42 predicts cognitive decline in nondemented older adults. Archives of Neurolgy, 2007 (in press)

Sheline YI, Vaishnavi SN, Mintun MA, Price JL, Wilkins CH, Synder AZ, Barch DM, Couture L, McKinstry RC. Regional WHM Burden in Automated Segmentation Distinguishes Late Life Depressed Subjects from Controls Matched for Vascular Risk Factors. Am Journal of Psychiatry, 2007; (submitted)

Vlassenko AG, Rundle MM, Mintun MA. Human brain glucose metabolism may evolve during activation: Findings from a modified FDG PET paradigm. NeuroImage 2006; 33: 1036-1041

Raichle ME, Mintun MA: Brain work and brain imaging. Annu Rev Neurosci 2006; 29:449-476

Mintun MA, LaRossa GN, Sheline YI, Dence CS, Yoon Lee S, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC 2006 [11C] PIB in a nondemented population: Potential antecedent marker of Alzheimer disease. Neurology 2006; 67:446-452

Fagan AM, Mintun MA, Mach RH, Lee S-Y, Dence CS, Shah AR, LaRossa G, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM (2005) Inverse relationship between in vivo amyloid imaging load and CSF A_42 in humans. Annals of Neurology 2006; 59:512-519

Chen DL, Rosenbluth DB, Mintun MA, Schuster DP. FDG-PET Imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin. J Appl. Physiol 2006 May;100(5) 1602-9

Vlassenko AG, Rundle MM, Raichle ME, Mintun MA. Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio. PNAS 2006:103 (6):1964-1969

Conway CR, Sheline YI, Chibnall JT, George MS, Fletcher JW, Mintun MA. Cerebral blood flow changes during vagus nerve stimulation for depression. Psychiatry Res 2006: 146 (2):179-184

Mathews J, Garcia KS, Mintun MA, Sheline YI. Antidepressant efficacy of olanzapine as monotherapy in major depressive disorder, without psychosis: a pilot study. Psychiatry Res. 2006 March 31;146(2):149-55

Chen DL, Ferkol TW, Mintun MA, Pittman JE, Rosenbluth DB, Schuster DP. Quantifying pulomonary inflammation in cystic fibrosis with positron emission tomography. Am J Respir Crit Care Med 2006; 173 (12); 1363-9

Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF, Sheline YI, Klunk WE, Mathis CA, Morris JC, Mintun MA. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005; 25(34):7709-17.

Mintun MA, Vlassenko AG, Shulman GL, Snyder AZ. Time-related increase of oxygen utilization in continuously activated human visual cortex. NeuroImage 2002; In press

Sheline YI, Mintun MA, Moerlein SM, Snyder AZ. Greater loss of 5-HT2A receptors in midlife than in late life. Am J Psychiatry 2002 Mar; 159(3):430-5

Gyulai FE, Mintun MA, Firestone LL. Dose-dependent enhancement of in vivo GABAA/BDZ receptor binding by isoflurane. Anesthesiology 2001 Sep; 95(3):585-93

Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ , Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study. Biol Psychiatry 2001 Nov 1; 50(9):651-8

Mintun MA, Lundstrom BN, Snyder AZ, Vlassenko AG, Shulman GL, Raichle ME. Blood flow and oxygen delivery to human brain during functional activity: Theoretical modeling and experimental data. Proc Natl Acad Sci USA 2001; 58:6859-6864

Chao KS, Bosch WR, Mutic S, Lewis JS, Dehdashti F, Mintun MA, Dempsey JF, Perez CA, Purdy JA, Welch MJ. A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 2001 Mar 15; 49(4):1171-1182

Books and Book Chapters

Mintun MA. Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's disease. CNS Spectr. 2005 Nov; 10 (11 Suppl 18); 13-6

Sheline, YI and Mintun MA. Structural and Functional Imaging Studies in Affective Disorders. In Neuropyschopharmacology: Fifth Generation of Progress, Coyle J, Charney D, Davis K, Nemeroff C, Eds, Raven Press, 2001

Mark A. Mintun, MD