Internal Medicine / Endocrinology, Metabolism and Lipid Research

The Washington University physicians in the Department of Internal Medicine encompass 14 specialty clinical divisions.

Over 270 physicians in the department of medicine treat patients with a wide range of diseases, disorders and conditions.

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Kenneth S. Polonsky, MD

Specialty Areas
Endocrinology
Diabetes
Metabolism

Areas of Clinical Interest
Diabetes, metabolism, endocrinology

Major or Recent Publications/Awards

Honors and Awards

Listed in America's Top Doctors, Castle Connolly Medical Ltd, 2002 - 2006, 2008

Listed in Best Doctors in America, 2002 (Best Doctors, Inc)

National Institutes of Health MERIT Award, 1997

Outstanding Scientific Achievement Award of the American Diabetes Association - Lilly Lecture, 1994

American Federation of Clinical Research Young Investigator Award, 1993

National Institutes of Health Research Career Development Award, 1984-89

Robert M. Kark Prize for Research of the Chicago Society for Internal Medicine, 1983

Schweppe Foundation Career Development Award, 1983

Solomon A. Berson Research and Development Award of the American Diabetes Association, 1981

Selected Journal Articles

Breda E, Toffolo G, Polonsky KS, Cobelli C. Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times. Diabetes 2002; Feb;51 Suppl 1:S227-33

Polonsky KS, Semenkovich CF. The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes. Cell 2001; Jun 15;105(6):705-7

Plat L, Leproult R, L’Hermite-Balériaux M, Féry F, Mockel J, Polonsky KS, Van Cauter E. Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. J Clin Endocrinol Metab Sep 1999; 84(9):3082-92

The Diabetes Prevention Program Research Group. (1999) The Diabetes Prevention Program – Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care Apr 1999; v.2 n.4

Wiesenthal SR, Sandhu H, McCall RH, Tchipashvili V, Yoshii H, Polonsky K, Shi ZQ, Lewis GF, Mari A, Giacca A. Free fatty acids impair hepatic insulin extraction in vivo. Diabetes Apr 1999; 48(4):766-74

Byrne, MM, Gliem K, Wank U, Arnold R, Katschinski M, Polonsky K, Goke B. Glucagon-like peptide-1 improves the ability of the ÿ-cell to sense and respond to glucose in subject with impaired glucose tolerance. Diabetes 1998; 47:1259-1265

Zhou Y-P, Teng T, Dralyuk F, Ostrega D, Roe MW, Philipson L, Polonsky KS. Apoptosis in insulin-secreting cells: Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. J Clin Invest 1998; 101:1623-1632

Maggs D, Burant CF, Buchanan TA, Cline G, Hsueh WA, Inzucchi S, Kelley D, Nolan JM, Olefsky J, Polonsky KS, Silver D, Valiquett TR, Shulman GI. The metabolic effects of Troglitazone monotherapy in non-insulin dependent diabetes: A randomized, double-blind, placebo controlled trial. Ann Inter Med 1998; 128:176-185

Maheux P, Chen I, Polonsky K, Reaven G. Evidence that insulin can directly inhibit hepatic glucose production. Diabetologia 1997; 40:1300-1306

Herman WH, Fajans SS, Smith MJ, Polonsky KS, Bell GI, Halter JB. Diminished insulin and glucagon secretory responses to Arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor -4ÿ/MODY1 gene. Diabetes 1997; 46:1749-1754

Regazzi R, Verchere CB, Halban PA, Polonsky KS. Insulin production: From gene to granule. Diabetologia 1997; 40:B33-B38

Van Cauter E, Polonsky KS, Scheen AJ. Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev 1997; 18(5)716-738

Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI. Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity and the onset of diabetes. Diabetes 1997; 46(9):1434-1439

Polonsky, KS, Byrne MM, Sturis. Alternative insulin delivery systems: How demanding should the patient be? Diabetologia 1997; 40:S97-101

Cavaghan M, Ehrmann DA, Byrne MM, Polonsky KS. Treatment with the oral antidiabetic agent troglitazone improves ß-cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest 1997; 100:530-537

Warren-Perry M, Manley S, Ostrega D, Polonsky K, Mussett S, Brown P, Turner R. A novel point mutation in the insulin gene giving rise to hyperproinsulinaemia. J Clin Endocrinol Metab 1997; 2(5):1629-31

Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82:2108-2116


For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Kenneth S. Polonsky

Kenneth S. Polonsky, MD