Stroke
Medical Education
B.A.: Yale University, New Haven, Connecticut
, 1985
Medical Degree: Cornell University Medical College, New York, New York
, 1993
Residency: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
, 1997
Fellowship: Cerebrovascular, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, MO
, 1999
Major or Recent Publications/Awards
Honors and Awards
Listed in Best Doctors in America, 2009 (Best Doctors, Inc)
Clinical Teacher of the Year Award, Washington University Medical School, 2000
Sven Eliasson Award for Teaching Excellence, Department of Neurology, 2000
Arthur K. Asbury Resident Award for Clinical Excellence, 1997
Winner, Zaritsky Clinical Research Award, 1996
Book Chapters/Reviews
Ford A.L., Lee J.M. Expanding the therapeutic window for intracerebral hemorrhage. Neurology, 68:883, 2007.
Lee J.-M., Markus H.S. Does the white matter in Alzheimer’s disease and cerebral amyloid angiopathy? Neurology, 66(1):6-7, 2006.
Lee, J-M., Nassief A.M., and Hsu C.Y. Pathophysiology of brain ischemia. In Transient Ischemic Attacks. Ed: Chaturvedi S, and Levine S.R. Futura Publishing Co. New York, pp31-72, 2004.
Vo K.D., Lin W., Lee J.-M. Evidence-based neuroimaging in acute ischemic stroke. Neuroimaging Clin N Am. 13(2):167-83, 2003.
Lee J-M. and Choi D.W. Neuroprotection in cerebral ischemia. In Diseases of the Nervous System. Ed: Asbury A.K., McKhann G.M., McDonald W.I., Goadsby P.J., and McArthur J.C. Cambridge University Press. Cambridge, UK, pp 62-78, 2002.
Lee J.-M., Grabb M.C., Zipfel G.J., Choi D.W. Brain tissue response to ischemia, J Clinical Investigation, 106(6):723-731, 2000.
Zipfel G.J., Babcock D.J., Lee J.-M., Choi D.W. Neuronal apoptosis after CNS injury: the roles of glutamate and calcium, J Neurotrauma,17(10):857-69, 2000.
Zipfel G.J., Lee J.-M., Choi D.W. Reducing calcium overload in the ischemic brain, New England Journal of Medicine, 341(20):1543-1544, 1999.
Lee J.-M., Zipfel G., Choi DW. The changing landscape of ischemic brain injury, Nature, 399:A7-14, 1999.
Journal Articles
Ford A.L., Connor L.T., Tan D.K., Williams J.A., Lee J.-M., Nassief A.M.,
Resident-based acute stroke protocol is expeditious and safe, Stroke,
40(40):1512-4, 2009.
Zhang R., Hu X., Khant H., Ludtke S.J., Chiu W., Schmid M.F., Frieden C., Lee
J.-M., Inter-protofilament interactions between Alzheimer's Aβ1-42 peptides in
amyloid fibrils revealed by cryo-EM, Proc Natl Acad Sci, 24:106(12):4653-8,
2009.
Schmidt R.E., Green K.G., Feng D., Dorsey D.A., Parvin C.A., Lee J.M., Xiao
Q., Brines, M. Erythropoietin and its carbamylated derivative prevent the
development of experimental diabetic autonomic neuropathy in STZ-induced
diabetic NOD-SCID mice. Exp Neurol, 209(1):161-70, 2008.
Daginakatte G.C, Gadzinski A., Emnett R.J., Stark J.L., Gonzales E.R., Yan
P., Lee J.-M., Cross A.H., Gutmann D.H., Expression profiling identifies a
molecular signature of reactive astrocytes stimulated by cyclic AMP or
proinflammatory cytokines, Exp Neurol, 210:261-7, 2008.
Lee J.M., Yan P., Xiao Q., Chen S., Lee K.Y., Hsu C.Y., Xu J.,
Methylprednisolone protects oligodendrocytes but not neurons following spinal
cord injury, J Neurosci, 28(12):3141-9, 2008.
Vetrivel, K.S., Zhang, X., Meckler X., Cheng H., Lee S., Gong P., Lopes K.O.,
Chen Y., Iwata N., Yin K.-J., Lee J.-M., Parent A.T., Saido T.C., Li Y.-M.,
Sisodia S.S., Thinakaran G. Evidence that CD147 modulation of Aβ levels is
mediated by extracellular degradation of secreted Aβ, J Biol Chem,
283(28):19489-98, 2008.
Lee J.-M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao
F., Ohlendorf M., Ladenson J.H., The Brain Injury Biomarker, VLP-1, is increased
in the CSF of Alzheimer's Disease patients, Clin Chem, 54(10):1617-23, 2008.
Zipfel G.Z., Han H., Ford A., Lee J.-M. Cerebral amyloid angiopathy:
Progressive disruption of the neurovascular unit. Stroke, 40(3 Suppl):S16-9,
2008.
Yin K.J., Cirrito J., Yan P., Hu X., Xiao Q., Pan X., Bateman R, Song H, Hsu F.F., Turk J, Xu J, Hsu C.Y., Mills J., Holtzman DM, Lee J.M. Matrix metalloproteinases expressed by astrocytes mediate extracellular Abeta catabolism. J Neurosci, 26(43):10939-48, 2006.
Yan P., Hu X., Song H., Yin K., Bateman R.J., Cirrito J.R., Xiao Q., Hsu F.F., Turk J.W., Xu J., Hsu C.Y., Holtzman D.M., Lee J.-M. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J Biol Chem, 281(34):24566-24574, 2006.
Laterza O.F., Modur V.R., Crimmins D.L., Olander J.V., Landt Y., Lee J.M., Ladenson J.H., Identification of Novel Brain Biomarkers. Clin Chem, 52(9):1713-21, 2006.
Ouyang Y., Yang Y.F., Hu X.Y., Erbayat-Altay E., Zeng L.H., Lee J.M., Wong M. Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes. Brain Res, 1143:238-46, 2007
Yin K.J., Hsu C.Y., Hu X., Chen H., Chen S., Xu J., and Lee J.-M., PP2A regulates bim expression via the Akt/FKHRL1 signaling pathway in Aβ-induced cerebrovascular endothelial cell death. J. Neurosci, 26(8):2290-9, 2006.
Chen S., Lee J.-M., Zeng C., Chen H., Hsu C.Y., and Xu J. Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. J Neurochem, 97(3):631-40, 2006.
Hartman R.E., Lee J.-M., Zipfel G.J., Wozniak D.F., Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats. Brain Res, 1043:48-56, 2005
Lee J.-M., Yin KJ, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, and Xu J Matrix Metalloproteinase-9 in Cerebral Amyloid Angiopathy-related Hemorrhage. J. Neurol. Sci., 229-230:249-54, 2005
Xiao Q, Hsu CY, Chen H, Ma X, Xu J, and Lee JM. Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter. Biochem J., 388(3):913-20, 2005.
Yin K.J., Lee J.M., Chen H., Xu J. and Hsu C.Y., Aβ25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells. JCBFM, 25(11):1445-55, 2005.
McIver S.R., Lee C.S., Lee J.M., Green S.H., Sands M.S., Snider B.J., and Goldberg M.P. Lentiviral transduction of murine oligodendrocytes in vivo. J Neurosci Res, 82(3):397-403, 2005.
Yin K.J., Kim G.M., Lee J.-M., He Y.Y., Xu J., and Hsu C.Y., JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury. Neurobiol Dis, 20(3):881-9, 2005.
Lee J.T., Xu J., Lee J.M., Ku G., Han X., Yang D.I., Chen S., Hsu C.Y., Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J Cell Biol. 164(1):123-131, 2004.
Lin W., Lee J.-M., Lee Y.Z., Vo K.D., Pilgram T, Hsu C.Y., Temporal relationship between apparent diffusion coefficient and absolute measurements of cerebral blood flow in acute stroke patients. Stroke, 34(1):64-70. 2003.
Lee J.-M., Vo K.D., An H., Celik A., Lee Y., Hsu C.Y., Lin W., MR Cerebral metabolic rate of oxygen utilization in hyperacute stroke patients. Ann Neurol, 53:227–232, 2003.
16. Vo KD, Santiago F, Lee J-M, Hsu CY, Lee YZ, Lin W, Enhancement patterns in MRI as predictors of hemorrhagic transformation in acute ischemic stroke. Am J Neurorad. 24(4):674-9, 2003.
Lee Y.Z., Lee J.-M., Vo K.D., Hsu C.Y., Lin W., Rapid Perfusion Abnormality Estimation in Acute Stroke using Cross Correlation Analysis. Stroke. 34(7):1686-92, 2003.
Lee J.-M., Yin K.J., Hsin I., Chen S.W., Fryer J.D., Holtzman D., Hsu C. Y., Xu J, Matrix Metalloproteinase-9 and Spontaneous Hemorrhage in an Animal Model of Cerebral Amyloid Angiopathy. Ann Neurol. 54(3):379-82, 2003.
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Jin-Moo Lee