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Internal Medicine / Rheumatology

Wayne M. Yokoyama, MD

Current Position
Professor, Medicine
Division of Rheumatology
Professor, Pathology and Immunology
Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis
Investigator, Howard Hughes Medical Institute
Director, Medical Scientist Training Program

Specialty Areas
Internal Medicine

Patients Seen At
Center for Advanced Medicine
Medicine Multispecialty Center
4921 Parkview Place, C, 5
St. Louis, MO  63110
Fax:   314-362-9257
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Division of Rheumatology
660 South Euclid Avenue, Campus Box 8045
St. Louis, MO  63110

Areas of Clinical Interest
Human immunology, natural killer cells


Board Certification
Internal Medicine -- Certified
Rheumatology -- Certified

Medical Education
B.A.: University of Rochester, Rochester, New York, 1974
Medical Degree: University Of Hawaii at Manoa, Honolulu, Hawaii, 1978
Residency: Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa, 1981
Fellowship: Clinical, Rheumatology, University of Iowa Hopsitals, Iowa City, Iowa, 1982
Fellowship: Research, Rheumatology, University of Iowa Hospitals, Iowa City, Iowa, 1985
Fellowship: Research, Immunology, NIAID, NIH, Bethesda, Maryland, 1989
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Listed in Best Doctors in America, 2009-2013 (Best Doctors, Inc.)
Carl and Gerty Cori Faculty Achievement Award, 2011
American Academy of Arts and Sciences, elected, 2009 
National Academy of Sciences, elected, 2007 
Association of American Physicians (AAP), elected, 2000
American Society for Clinical Investigation (ASCI), elected, 1996

Editorial Responsibilities

Transmitting Editor
International Immunology

Editorial Board
Immunology and Cell Biology

Associate Editor
Annual Review of Immunology

Selected or Recent Journal Articles
Schoggins JW, Macduff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2013 Nov 27.

Ebihara T, Jonsson AH, Yokoyama WM. Natural killer cell licensing in mice with inducible expression of MHC class I. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4232-7.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH. Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation. Mol Immunol. 2013 Sep;55(2):156-8.

Chapa TJ, Johnson LS, Affolter C, Valentine MC, Fehr AR, Yokoyama WM, Yu D. Murine cytomegalovirus protein pM79 is a key regulator for viral late transcription. J Virol. 2013 Aug;87(16):9135-47.

Fogel LA, Yokoyama WM, French AR. Natural killer cells in human autoimmune disorders. Arthritis Res Ther. 2013 Jul 11;15(4):216. [Epub ahead of print]

Pak-Wittel MA, Yang L, Sojka DK, Rivenbark JG, Yokoyama WM. Interferon-γ mediates chemokine-dependent recruitment of natural killer cells during viral infection. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E50-9.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH. Structural mechanism of ER retrieval of MHC class I by cowpox. PLoS Biol. 2012;10(11):e1001432.

Gainey MD, Rivenbark JG, Cho H, Yang L, Yokoyama WM. Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3260-7.

Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS. Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer. Cancer Res. 2012 Sep 1;72(17):4311-7. Epub 2012 Jun 29.

Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M Jr, Virgin HW, Klein RS, Sen GC, Diamond MS. 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. PLoS Pathog. 2012;8(5):e1002698.

Pinto AK, Daffis S, Brien JD, Gainey MD, Yokoyama WM, Sheehan KC, Murphy KM, Schreiber RD, Diamond MS. A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection. PLoS Pathog. 2011 Dec;7(12):e1002407.

Vargas CL, Poursine-Laurent J, Yang L, Yokoyama WM. Development of thymic NK cells from double negative 1 thymocyte precursors. Blood. 2011 Sep 29;118(13):3570-8.

Elliott JM, Yokoyama WM. Unifying concepts of MHC-dependent natural killer cell education. Trends Immunol. 2011 Aug;32(8):364-72.

Choi T, Ferris ST, Matsumoto N, Poursine-Laurent J, Yokoyama WM. Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands. J Immunol. 2011 Apr 1;186(7):3911-7.

Higuchi DA, Cahan P, Gao J, Ferris ST, Poursine-Laurent J, Graubert TA, Yokoyama WM. Structural variation of the mouse natural killer gene complex. Genes Immun. 2010 Dec;11(8):637-48.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Yokoyama.

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Copyright 2015 Washington University School of Medicine