Joel S. Perlmutter, MD
Current Position
Elliot Stein Family Professor of Neurology
Section Chief, Movement Disorders
Professor, Radiology
Professor , Physical Therapy
Associate Professor, Anatomy and Neurobiology
Specialty Areas
Neurology - Adult
Dystonia
Parkinson's Disease
Huntington's Disease
Movement Disorders
Tremor
Tourette's Syndrome
Mailing Address
|
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis,
MO
63110
|
Areas of Clinical Interest
Parkinson disease, Huntington's disease, Tourette syndrome, dystonia, hyperkinetic disorders, essential tremor and other movement disorders, imaging research using PET and MR, clinical drug trials
Board Certification
Neurology
--
Certified
Medical Education
B.A.: Princeton University, Princeton, New Jersey
, 1975
Externship: Psychiatry, Menninger Foundation, Topeka, Kansas
, 1978
Medical Degree: University Of Missouri, Columbia, Missouri
, 1979
Residency: Washington University School Medicine, St. Louis, Missouri
, 1980
Fellowship: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri
, 1984
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital
Major or Recent Publications/Awards
Honors and Awards
Listed in Best Doctors in America, Best Doctors, Inc.2002 - 2009 (Best Doctors, Inc)
Listed in America's Top Doctors, Castle Connolly Medical Ltd, 2002 - 2008
Mentor Award from the Academic Women's Network of Washington University School of Medicine, 2004
Dystonia Doctor of Excellence Award, Dystonia Medical Research Foundation, Chicago, Illinois, 2000
The Eliasson Award (Neurology Professor of the Year for Resident
Teaching), Washington University School of Medicine, St. Louis,
Missouri, 1992, 1998
Outstanding Young Physician Award, Medical Alumni Organization and University of Missouri School of Medicine, 1998
Chapters and Reviews
Perlmutter JS, Mink JW. The Pathophysiology of Dystonia: Clues from Neuroimaging. Medlink Neurology
Perlmutter JS, and Mink JW. Dysfunction of dopaminergic pathways in
dsytonia. In "Dystonia4" ed. S.Fahn. Adv Neurol 2004; 94:163-70
Parsian A, Perlmutter JS. Point mutations in the á-synuclein gene. IN:
Parkinson’s Disease Methods and Protocols. ed by M. Maral Mouradian. In
Press
Perlmutter JS, Landau WM. Deep-Brain Stimulation: The Sad Story. Lancet Neurology Network 4:1-6, 2000
Hershey TA, Perlmutter JS, Moerlein SM. PET Investigations of
Parkinson's Disease. IN: Molecular Mechanisms of Neurodegenerative
Diseases, M-F Chesselet (eds.), Humana Press, New Jersey, USA
pp.177-193, 2000
Perlmutter JS, Moerlein SM. PET measurements of dopaminergic pathways
in the brain. Quarterly Journal of Nuclear Mediine 1999; 43:140-154
Peer Reviewed Articles
Earhart GM, Tabbal SD, Clark BR, Perlmutter JS. Gait and balance in essential tremor: variable effects of bilateral thalamic stimulation. Mov Disord. 24:386-91, 2009.
Kumar N, Lee JJ, Perlmutter JS, Derdeyn CP. Cervical carotid and Circle of Willis arterial anatomy of Macaque monkeys: A comparative anatomy study. Anatomic Record. (in press) 2009.
Xiao J, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello RC, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, Zhao Y, LeDoux MS. High-Throughput Mutational Analysis of TOR1A in Primary Dystonia. BMC Med Gen, 10:24 2009. {Epub ahead of print]. PMC2661056
Racette BA, Good LM, Kissel AM, Criswell SR, Perlmutter JS. A population based study of parkinsonism in an Amish community. Neuroepidemiology (in press).
Videen TO, Campbell MC, Tabbal SD, Karimi M, Hershey T, Perlmutter JS. Validation of a fiducial-based atlas localization method for deep brain stimulation contacts in the area of the subthalamic nucleus. J Neurosci Methods 168:275-281,2008. PMC2267480
Foster ER, Black KJ, Antenor J, Perlmutter JS, Hershey T. Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and Cognition 67:1-10,2008.
Antenor-Dorsey JV, Laforest R, Moerlein SM, Videen TO, Perlmutter JS. Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates. Eur J Nucl Med Mol Imaging 35:771-778,2008.
Hershey T, Wu J, Weaver PM, Perantie DC, Karimi M, Tabbal SD, Perlmutter JS. Unilateral vs. bilateral STN DBS effects on working memory and motor function in Parkinson disease. Exp Neurol 211:234-242, 2008. PMC2346537
Tobin JE, Latourelle JC, Lew MF, Klein C, Suchowersky O, Shill HA, Golbe LI, Mark MH, Growdon JH, Wooten GF, Racette BA, Perlmutter JS, Watts R, Guttman M, Baker KB, Goldwurm S, Pezzoli G, Singer C, Saint-Hilaire M-H, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Laramie JM, DeStefano AL, Litvan I, Nicholson G, Corbett AJ, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Sherman S, Al-hinti J, Drasby E, Nance M, Moller AT, Ostergaard K, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study. Neurol. 71:28-34, 2008. PMC2654275.
Earhart GM, Stevens ES, Perlmutter JS, Hong M: Perception of active and passive turning in Parkinson disease. Neurorehab Neural Repair, June 21(2):116-22, 2007 [Epub ahead of print].
Parsian AJ, Racette BA, Zhao JH, Sinha R, Patra B, Perlmutter JS, Parisan A. Association of alpha-synuclein gene haplotypes with Parkinson's disease. Parkinsonism Relat Disord Feb. 8, 2007 [Epub ahead of print].
Powers WJ, Videen TO, Markham J, McGee-Minnich L, Antenor-Dorsey JAV, Hershey T, Perlmutter JS. Selective defect of in vivo glycolysis in early Huntington disease striatum. Proc Natl Acad Sci 104:2945-2949, 2007. PMC1797149
Hong M, Perlmutter JS, Earhart GM: Enhancement of rigidity in Parkinson disease with activation. Mov Disord 22:1164-1168, 2007.
Powers WJ, Haas RH, Le T, Videen TO, Hershey T, McGee-Minnich L, Perlmutter JS. Normal platelet complex I activity in Huntington's disease. Neurobiology Disease, 27(1):99-101. 2007. PMC2140002
Tabbal SD, Revilla FJ, Mink JW, Schneider-Gibson P, Wernle AR, de Erausquin GA, Perlmutter JS, Rich KM, Dowling JL. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson disease. Neurosurgery 61:119-127, 2007.
Earhart GM, Hong M, Perlmutter JS: Effects of thalamic stimulation frequency on intention and postural tremor. Exp Neurol. 208:257-263,2007. PMC2203380
Weiss EM, Hershey T, Karimi M, Racette BA, Tabbal SD, Paniello Mink JW,
Perlmutter JS. Relative risk of spread of symptoms among the focal
onset primary dystonias. Mov Disord 2006; 21:1175-1181
Perlmutter JS, Mink JW. Deep Brain Stimulation. Annu Rev Neurosci 2006; 29:229-257
Suchowersky O, Reich S, Perlmutter JS, Zesiewicz T, Gronseth G, Weiner
WJ. Practice Parameter: Diagnosis and prognosis of new onset Parkinson
disease. Neurology 2006; 66:968-975
Suchowersky O, Gronseth G, Perlmutter JS, Reich S, Zesiewicz T, Weiner
WJ. Practice Parameter: Neuroprotective strategies and alternative
therapies for PD: an evidence-based review. Neurology 2006; 66:976-982
Hershey T, Revilla F, Wernle A, Schneider-Gibson P, Dowling J,
Perlmutter JS. Stimulation of STN impairs aspects of cognitive control
in PD. Neurology 2004; 62:1110-1114
Evinger C, Perlmutter JS. Blind Men and Blinking Elephants. (invited editorial) Neurology 2003; 60:1732-1733
Hershey T, Revilla FJ, Loepker A, McGee-Minnich L, Antenor JA, Videen
TO, Rich KM, Dowling JL, Mink JW, Perlmutter JS. Cortical and
subcortical blood flow effects of subthalamic nucleus stimulation in
PD. Neurology 2003; 61:816-821
Perlmutter JS, Mink JW, Bastian AJ, Zackowski K, Hershey T. Miyawaki E,
Koller W, Videen TO. Blood flow responses to deep brain stimulation of
thalamus. Neurology 2002; 58:1388-1394
Perlmutter JS, Mink JW, Bastian AJ, Zackowski K, Hershey T, Miyawaki E,
Koller W, Videen TO. Blood flow responses to deep brain stimulation of
thalamus. Neurology 2002; 58:1388-1394
Black KJ, Hershey T, Koller JM, Videen TO, Price JL, Perlmutter JS.
Prefrontal and limbic effects of a D3-preferring dopamine agonist: a
possible substrate for dopamine-related changes in mood and behavior.
Proc Natl Acad Sci 2002; 99:172113-17118
Parsian A, Racette B, Zhang Z, Rundle M, Perlmutter JS. Parkinson's
disease and apolipoprotein E: Possible association with dementia, but
not age at onset. Genomics 2002; 79(3):458-461
Racette BA, Rundle M, Wang JC, Goate A, Saccone NL, Farrer M, Lin J,
Suarez B, Parisan A, Perlmutter JS. A multi-incident, old-order Amish
family with Parkinson disease. Neurology 2002; 58:568-574
Zackowski K, Bastian A, Hakimian S, Mink JW, Perlmutter JS, Koller WC,
Thach WE. Thalamic stimulation reduces essential tremor but not delayed
antagonist muscle timing. Neurology 2002; 58:402-410
Racette B, Perlmutter JS. Late-onset neurodegeneration with brain iron
accumulation type 1: Expanding the clinical spectrum. Mov Disord 2001;
16:1148-1152
Racette BA, McGee-Minnich L, Moerlein SM, Mink JW, Videen TO,
Perlmutter JS. Welding-related parkinsonism: Clinical features,
treatment, and athophysiology. Neurology 2002; 56:8-13
Revilla FJ, Racette BA, Perlmutter JS. Chorea and jaw-opening dystonia
as a manifestation of NeuroBehcet's syndrome. Mov Disord 2000;
15:741-744
Miyawaki E, Perlmutter JS. Troster AI, Videen TO, Koller WC. The
behavioral complications of pallidal stimulation: A case report. Brain
Cogn 2000; 42:417-434
Invited Presentations
“Neuroimaging Highlights” American Academy of Neurology Annual Meeting, Denver, Co 4/18/02
Chair of Session: “Parkinson disease: Neuroimaging” at the American Academy of Neurology Meeting, Denver, CO,4/18/02
Visiting Professor and Grand Rounds: “Parkinson disease: New Research
in Pathophysiology and Treatment”, University of Arkansas, Little Rock,
Arkansas, 7/19/2001
“New Research in Parkinson disease” Parkinson Education Program, St. Louis, MO, 10/28/01
Chair of Session: “Parkinsonism: Neuroimaging” at the American Academy of Neurology Meeting, Philadelphia, PA, 5/8/01
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Joel S. Perlmutter