Neurology / Adult

Specialists in the Department of Neurology see patients in the areas of adult neurology, rehabilitation, and pediatric neurology.

General adult neurology services are offered along with treatment and/or rehabilitation for stroke, spinal cord and brain injury, movement disorders, sleep problems, aging and dementia, neuromuscular and cerebrovascular disease.

Pediatric patients are seen for general neurology, stroke, movement disorders and epilepsy, in addition to neuro-rehabilitation services and epilepsy monitoring.

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David B. Clifford, MD

Specialty Areas
Neurology - Adult
Neurologic Infectious Diseases
HIV Medicine

Areas of Clinical Interest
HIV neurological disorders, peripheral neuropathy, HIV related dementia, AIDS neurology, progressive multifocal leukoencephalopathy, PML, neurologic infection, multiple sclerosis.

Major or Recent Publications/Awards

Honors and Awards
Listed in Best Doctors in America, (Best Doctors, Inc), 2005 - 2009
Jacques J. Bronfenbrenner Award 1975
Carl F. and Gerty T. Cori Prize in Biochemistry 1971

Editorial Responsibilities
Reviewer
Annals of Neurology
AIDS Research and Human Retroviruses Neuron
Experimental Neurology
Neurovirology
Neurology
Epilepsia
Pediatric Research
American Family Physician
AIDS
Editorial Board
Journal of Neurovirology
Journal of Neuro-AIDS

Journal Articles

Sacktor N, Nakasujja N, Skolasky RL, Robertson K, Musisi S, Ronald A, Katabira E, Clifford DB. Benefits and risks of stavudine therapy for HIV-associated neurologic complications in Uganda. Neurology 2009; 72:165-170.

Wenning W, Haghikia A, Laubenberger J, Clifford DB, Behrens PF, Chan A, Gold R. Treatment of severe PML associated with natalizumab monotherapy. NEJM 2009; in press.

Marra CM, Zhao Y, Clifford DB, Letendre S, Evans S, Henry K, Ellis RJ, Rodriguez B, Coombs RW, Schifitto G, McArthur JC, Robertson K. Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance. AIDS 2009; in press.

Sacktor N, Nakasujja N, Skolasky RL, Rezapour M, Robertson K, Musisi S, Katabira E, Ronald A, Clifford DB, Laevendecker O, and Quinn T. HIV subtype D is associated with dementia sompared to subtaype A in immunosuppressed individuals at risk for cognitive impairment in Kampala, Uganda. Clin Inf Dis, 2009, in press.

Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ, for the CHARTER Group. Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol 2008; 65:65-70.

Robertson K, Kopnisky K, Hakim J, Merry C, Nakasujja N, Hall C, Traore M, Sacktor N, Clifford D, Newton C, Van Rie A, Holding P, Clements J, Zink C, Mielke J, Hosseinipour M, Lalloo U, Amod F, Marra C, Evans S, Liner J, on behalf of the second Assessment of NeuroAIDS in Africa Conference Participants. Second assessment of neuroAIDS in Africa. Journal of Neurovirology 2008; 14:89-101.

Simpson DM, Brown S, Tobias J, NGX-4010 C107 Study Group. Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy. Neurology 2008; 70:2305-2313.

Clifford D. HIV-associated neurocognitive disease continues in the antiretroviral era. Topics in HIV Medicine 2008; 16:94-98.

Ellis RJ, Marquie-Beck J, Delaney P, Alexander T, Clifford DB, McArthur JC, Simpson DM, Ake C, Collier AC, Gelman BB, McCutchan JA, Morgello S, Grant I, the CHARTER Group. Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy. Annals of Neurology 2008; 64:566-572.

Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I for the CHARTER Group. Low atazanavir concentrations in cerebrospinal fluid. AIDS 2008; in press.

Clifford DB. Natalizumab and PML: a risky business? Gut 2008; 57:1347-1349.

Evans SR, Clifford DB, Kitch DW, Goodkin K, Schifitto G, McArthur JC, Simpson DM. Simplification of the research diagnosis of HIV-associated sensory neuropathy. HIV Clinical Trials 2008; 9:434-439.




Kappos L, Bates D, Hartung HP, Havrdova E, Miller DH, Polman C, Ravnborg M, Hauser SL, Rudick RR, Weiner HL, O’Connor PW, King J, Radue EW, Yousry T, Major EO, Clifford DB. Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. The Lancet Neurology, in press, 2007.

Clifford DB, Mitke MT, Mekonnen Y, Zhang J, Zenebe G, Melaku Z, Zewede A, Gessesse N, Wolday D, Messele T, Teshome M, and Evans S. Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia. J Neuro Virol 2007; 13:67-72.

Lima MA, Marzocchetti A, Autissier P, Tompkins T, chen Y, Gordon J, Clifford DB, Gandhi RT, Venna N, Berger JR, Koralnik IJ. Fequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. Journal of Virology 2007; 81:3361-3368.

Kallianpur AR, Hulgan T, Canter JA, Ritchie MD, Haines JL, Robbins GK, Shafer RW, Clifford DB, Haas DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. AIDS 2006; 20:1503-1513.

Yousry TA, Major EO, Ryschkewitsch C, Fahle G, Fischer S, Hou J, Curfman B, Miszkiel K, Mueller-Lenke N, Sanchez E, Barkhof F, Radue EW, Jäger HR, Clifford DB. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 2006; 354:924-933.

Major EO, Yousry TA, Clifford DB. Correspondence: Natalizumab for relapsing multiple sclerosis. N. Engl J Med 2006; 354:2387-2389.

Simpson DM, Kitch D, Evans SR, McArthur JC, Asmuth DM, Cohen B, Goodkin K, Gerschenson M, So Y, Marra CM, Diaz-Arrastia R, Shriver S, Millar L, Clifford DB, ACTG A5117 Study Group. HIV neuropathy natural history cohort study. Assessment measures and risk factors. Neurology 2006; 66:1679-1687.

Lopate G, Pestronk A, Evans S, Li L, Clifford D. Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy. Neurology 2005;64:1632-1634.

Cysique LA, Brew BJ, Halman M, Catalan J, Sacktor N, Price RW, Brown S, Atkinson HJ, Clifford DB, Simpson D, Torres G, Hall C, Power C, Marder K, McArthur JC, Symonds W, and Romero C. Undetectable cerebrospinal fluid HIV RNA and b-2 microglobulin do not indicate inactive AIDS dementia complex in HAART-treated patients. JAIDS 2005;39:426-429.

Cysique LA, Brew BJ, Halman M, Catalan J, Sacktor N, Price RW, Brown S, Atkinson JH, Clifford DB, Simpson D, Torres G. Hall C, Power C, Marder K, McArthur JC, Symonds W, Romero C. Undetectable cerebrospinal fluid HIV RNA and β-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. JAIDS 2005;39:426-429.

Lopate G. Pestronk A, Evans S, Li L, Clifford D. Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy. Neurology 2005;64:1632-1634.

Snyder MD, Storch GA, Clifford DB. Atypical PML leading to a diagnosis of common variable immunodeficiency. Neurology 2005;64:1661.

Clifford DB, Evans SR, Yang Y, Gulick RM. The neuropsychological and neurologic impact of HCV co-infection on HIV-infected subjects. AIDS 2005;19(suppl 3):S64-S71.

Ellis RJ, Evans SR, Clifford DB, Moo LR, McArthur JC, Collier AC, Benson C, Bosch R, Simpson D, Yannoutsos CT, Yang Y, Robertson K, for the Neurological AIDS Research Consortium and the AIDS Clinical Trials Group Study Teams A5001 and A362. Clinical validation of the neuroscreen. J Neurovirology 2005; 11:503-511.

Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Kallianpur A, Summar M, Canter JA. Mitrochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS 2005; 19:1341-1349.

Clifford DB, Evans S, Yang Y, Acosta EP, Goodkin K, Tashima K, Simpson D, Dorfman D, Ribaudo H, Gulick RM for the A5097s Study Team. Impace of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals. Annals of Internal Medicine 2005; 143:714-721.

Clifford DB, Yang Y, Evans S. Review – Neurologic consequences of hepatitis C and human immunodeficiency virus coinfection. Journal of NeuroVirology 2005; 11(suppl):67-71.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David B. Clifford

David B. Clifford, MD