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Neurology / Adult

John Carl Morris, MD

Current Position
Harvey A. and Dorismae Hacker Friedman Professor of Neurology
Professor, Pathology and Immunology
Director, Center for Aging
Director, Memory and Aging Project
Director, Alzheimer's Disease Research Center

Specialty Areas
Memory Disorders and Diagnosis
Alzheimer's Disease
Neurology - Adult

Additional Features and Interviews with Dr. John Morris:

Aging Workforce Means Dementia on the Job Could Rise

Patients Seen At
Memory Diagnostic Center
Center for Advanced Medicine
4921 Parkview Place, Suite C, 6th Floor
St. Louis, MO  63110
(314) 286-1967
Fax:   (314) 286-1985
View Floor Map  View Campus Map   View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

Board Certification
Internal Medicine -- Certified
Neurology -- Certified

Patients can be referred by self or referring physician.

Medical Education
B.A.: Ohio Wesleyan University, Delaware, Ohio, 1970
Medical Degree: University Of Rochester School of Medicine and Dentistry, Rochester, New York, 1974
Residency: Internal Medicine, Akron General Medical Center, Akron, Ohio, 1979
Chief Residency: Neurology, Cleveland Metropolitan General Hospital, Cleveland, Ohio, 1981
Residency: Neuropathology, Cleveland Metropolitan General Hospital, Cleveland, Ohio, 1982
Fellowship: Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri, 1985
Hospital Affiliations
Barnes-Jewish Hospital

Honors and Awards
Listed in Best Doctors in America, 2002-2013 (Best Doctors, Inc.)

Listed in America's Top Doctors, 2002-2012 (Castle Connolly Medical Ltd.)

Recognized as one of the Top 44 Providers with the Highest Patient Satisfaction, Washington University School of Medicine, 2009-2012

Lifetime Achievement Award from the Alzheimer's Association, 2004

Board of Directors, Alzheimer Association, Chicago, Illinois

Editorial Responsibilities


Alzheimer's Disease and Associated Disorders: International Journal

Editorial Board

Ad Hoc Reviewer
Alzheimer's Disease and Associated Disorders: An International Journal
American Journal of Medicine
Annals of Neurology
Archives of Internal Medicine
Archives of Neurology
Biological Psychiatry
International Psychogeriatrics
Journal of the American Geriatrics Society
Journal of the American Medical Society
Journal of Gerontology
Journal Watch Neurology
Marcel Dekker, Advisory Board for -
Neurological Disease and Therapy series
Mayo Clinic Proceedings
Neurobiology of Aging
Neurology Network Commentary

Selected or Recent Journal Articles
Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, Bellenguez C, Brown K, Medway C, Haddick PC, van der Brug MP, Bhangale T, Ortmann W, Behrens T, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Haines JL, Turton J, Braae A, Barber I, Fagan AM, Holtzman DM, Morris JC; 3C Study Group; EADI consortium; Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Disease Neuroimaging Initiative (ADNI); GERAD Consortium, Williams J, Kauwe JS, Amouyel P, Morgan K, Singleton A, Hardy J, Goate AM, Cruchaga C. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiol Aging. 2014 Jun;35(6):1510.e19-26.

Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM; Alzheimer’s Disease Neuroimaging Initiative. Phosphorylated tau-aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biol Psychiatry. 2014 May 1;75(9):723-31.

Brier MR, Thomas JB, Fagan AM, Hassenstab J, Holtzman DM, Benzinger TL, Morris JC, Ances BM. Functional connectivity and graph theory in preclinical Alzheimer's disease. Neurobiol Aging. 2014 Apr;35(4):757-68.

Dobrowolska JA, Kasten T, Huang Y, Benzinger TL, Sigurdson W, Ovod V, Morris JC, Bateman RJ. Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system. PLoS One. 2014 Mar 19;9(3):e89998.

Morris JC, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund LO, Dubois B. Harmonized diagnostic criteria for Alzheimer's disease: recommendations. J Intern Med. 2014 Mar;275(3):204-13.

Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM; Dominantly Inherited Alzheimer Network. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med. 2014 Mar 5;6(226):226ra30.

Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M; UK Brain Expression Consortium, Hardy J, Ryten M, Trabzuni D, Weale ME, Ramasamy A, Smith C, Sassi C, Bras J, Gibbs JR, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K; Alzheimer’s Research UK Consortium, Passmore P, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Kehoe PG, Hooper NM, Vardy ER, Mann DM, Pickering-Brown S, Brown K, Kalsheker N, Lowe J, Morgan K, David Smith A, Wilcock G, Warden D, Holmes C, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton AB, Hardy J, Kamboh MI, St George-Hyslop P, Cairns N, Morris JC, Kauwe JS, Goate AM. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 2014 Jan 23;505(7484):550-4.

Storandt M, Balota DA, Aschenbrenner AJ, Morris JC. Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN). Neuropsychology. 2014 Jan;28(1):19-29.

Xiong C, Luo J, Gao F, Morris JC. Optimizing parameters in clinical trials with a randomized start or withdrawal design. Comput Stat Data Anal. 2014 Jan 1;69:101-113.

Mattsson N, Insel P, Tosun D, Zhang J, Jack CR Jr, Galasko D, Weiner M; Alzheimer’s Disease Neuroimaging Initiative. Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. PLoS One. 2013 Dec 31;8(12):e85443.

Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC. CSF biomarkers of Alzheimer disease: "noncognitive" outcomes. Neurology. 2013 Dec 3;81(23):2028-31.

Su Y, D'Angelo GM, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS, Blazey TM, Christensen JJ, Vora S, Morris JC, Mintun MA, Benzinger TL. Quantitative analysis of PiB-PET with FreeSurfer ROIs. PLoS One. 2013 Nov 6;8(11):e73377.

Benzinger TL, Blazey T, Jack CR Jr, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4502-9.

Morris JC. Neurodegenerative disorders of aging: the down side of rising longevity. Mo Med. 2013 Sep-Oct;110(5):393-4. No abstract available.

Xiong C, van Belle G, Chen K, Tian L, Luo J, Gao F, Yan Y, Chen L, Morris JC, Crane P. Combining Multiple Markers to Improve the Longitudinal Rate of Progression-Application to Clinical Trials on the Early Stage of Alzheimer's Disease. Stat Biopharm Res. 2013 Jan 1;5(1).

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. John Carl Morris.

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Copyright 2015 Washington University School of Medicine