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Pediatrics

Alan L. Schwartz, PhD, MD

Current Position
The Harriet B. Spoehrer Professor and Chairman, Pediatrics
Professor, Molecular Biology and Pharmacology
Pediatrician In-Chief, St Louis Children's Hospital


Specialty Areas
Pediatric Hematology
Pediatric Oncology

Mailing Address
Washington University School of Medicine
660 South Euclid, Campus Box: 8116
St. Louis, MO  63110

Areas of Clinical Interest
Pediatric hematology, sickle cell anemia, pediatric oncology, cancer, leukemia

Areas of Research Interest
Dr. Schwartz's laboratory is focused on the cell and molecular biology of intracellular protein targeting and degradation.  He is studying the role of protein processing and degradation within the endosomal/lysosomal pathway and in the cytoplasm. A second area is the cell and molecular biology of receptor-mediated endocytosis and its regulation.

Board Certification
Pediatrics -- Certified
Pediatric Hematology & Oncology -- Board Qualified

Medical Education
B.A.: Case Western Reserve University, Cleveland, Ohio, 1970
Ph.D.: Pharmacology, Case Western Reserve University, Cleveland, Ohio, 1974
Medical Degree: Case Western Reserve University, Cleveland, Ohio, 1976
Residency: Internal Medicine, Children's Hospital Medical Center, Boston, Massachusetts, 1978
Fellowship: Pediatric, Harvard Medical School, Boston, Massachusetts, 1978
Fellowship: Hematology & Oncology, Children's Hospital Medical Center & Dana-Farber Cancer Institute, Boston, MA, 1979
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital

Honors and Awards
Listed in Best Doctors in America, 2003-2012 (Best Doctors, Inc.)
Institute of Medicine, National Academies of Science 1999
Fellows Award, Barnes-Jewish Hospital Foundation 1996
Alumni Endowed Professor of Pediatrics, Washington University School of Medicine 1987-1998

Editorial Boards
Rudolph's Pediatrics

Selected or Recent Journal Articles
Wolin KY, Schwartz AL, Matthews CE, Courneya KS, Schmitz KH. Implementing the exercise guidelines for cancer survivors. J Support Oncol. 2012 Sep-Oct;10(5):171-7.

Trausch-Azar J, Leone TC, Kelly DP, Schwartz AL. Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem. 2010 Dec 17;285(51):40192-200.

Song H, Li Y, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 2009 Feb 1;69(3):879-86.

Schwartz AL, Ciechanover A. Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol. 2009;49:73-96.

Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL. In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer. FASEB J. 2008 Jun;22(6):1694-701.

Sun L, Trausch-Azar JS, Muglia LJ, Schwartz AL. Glucocorticoids differentially regulate degradation of MyoD and Id1 by N-terminal ubiquitination to promote muscle protein catabolism. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3339-44.

Knisely JM, Li Y, Griffith JM, Geuze HJ, Schwartz AL, Bu G. Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation. Exp Cell Res. 2007 Sep 10;313(15):3298-307. Epub 2007 Jun 29.

Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL. E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation. Oncogene. 2007 Jan 18;26(3):441-8. Epub 2006 Aug 7.

Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL. E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1. Oncogene. 2005 Sep 22;24(42):6376-84.

Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL. Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. J Biol Chem. 2005 Jul 15;280(28):26448-56. Epub 2005 May 11.

McCormick LM, Urade R, Arakaki Y, Schwartz AL, Bu G. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. Biochemistry. 2005 Apr 19;44(15):5794-803.

Li Y, Lu W, He X, Schwartz AL, Bu G. LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution. Oncogene. 2004 Dec 2;23(56):9129-35.

Trausch-Azar JS, Lingbeck J, Ciechanover A, Schwartz AL. Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem. 2004 Jul 30;279(31):32614-9. Epub 2004 May 25.

Li Y, Lu W, Schwartz AL, Bu G. Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway. J Lipid Res. 2004 Jun;45(6):1084-91. Epub 2004 Mar 1.

Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, Schwartz AL. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J Biochem. 2002 Nov;132(5):743-9.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Alan L. Schwartz.


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Copyright 2014 Washington University School of Medicine