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Neurology / Pediatric

David H. Gutmann, MD, PhD

Current Position
Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics


Specialty Areas
Pediatric Neurology
Neurofibromatosis
Neuro Oncology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Second Floor, Suite D
St. Louis, MO  63110
314-454-6120
Fax:   314-454-2523
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

Board Certification
Neurology -- Certified
Pediatric Neurology

Medical Education
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan, 1980
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, 1984
Medical Degree: University of Michigan, Ann Arbor, Michigan, 1986
Residency: Neurology, Hospital of the University of Pennsylvania, 1990
Fellowship: Human Molecular Genetics, University of Michigan Medical Center, 1993
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital


Honors and Awards
Recognized as one of the Top 44 Providers with the Highest Patient Satisfaction, Washington University School of Medicine, 2010-2012
Best Doctor in America ( Best Doctors Inc) 2007-2013
University of Arkansas MD/PhD Student Choice Speaker, 2010
Pfizer Visiting Professor, University of Virginia, 2010
Award for Excellence in Pediatric Translational Research, Society for Neuro-Oncology, 2008
Takao Hoshino Lectureship, University of California – San Francisco, 2008
Ninth Annual Arthur and Sonia Labatt Brain Tumor Research Centre Lecturer, 2007
Award for Excellence in Pediatric Basic/Translational Research, Society for Neuro-Oncology, 2007
Manuel R. Gomez Named Visiting Professor, 2006
American Society for Clinical Investigation, inducted 2003
Washington University School of Medicine Clinical Teacher of the Year Award, 2003
National Neurofibromatosis Foundation Center of Excellence Award, 2002
Donald O. Schnuck Family Chair in Neurology, 2001
Linse Block Neuro-oncology Visiting Professor, Mayo Clinic Foundation, 2001
Eliason Teaching Award, Department of Neurology, 1999
Walker Lecturer in Neurofibromatosis, 1999
National Neurofibromatosis Foundation Crystal Award, 1998
Carolyn Farb Endowed Lecture in Neurofibromatosis, 1998
American Neurological Association, elected member, 1997
Decade of the Brain Plenary Session Speaker, American Academy of Neurology, 1996

Editorial Responsibilities
Ad Hoc Reviewer
Am J Medical Genetics
Am J Pathology
Annals of Neurology
Archives of Neurology
Blood
BMC Cancer
Brain
Cancer
Cancer Cell
Cancer Res
Cell Growth and Differentiation
Clinical Cancer Res
Developmental  Dynamics
Experimental Neurology
Genes & Development   
GLIA
Human Molecular Genetics   
International Journal of Cancer
Journal of the Amer Med Assoc   
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Clinical Investigation
Journal of Medical Genetics
Journal of Neurobiology
Journal of Neurological Science
Journal of Neurosurgery
Journal of Neuro-oncology
Laboratory Investigation
Molecular and Cellular Biology
Nature Neuroscience
Nature Reviews Cell Biology
Nature Reviews Neuroscience
Neurobiology of Disease
Neurology
Oncogene
Pediatrics           
Science

Editorial Board
Familial Cancer, 1998-date
Neurobiology of Disease, 2000-date
Associate Editor, Cancer Res., 2003-date
Experimental Neurology, 2003-date
GLIA, 2004-date
Neuro-Oncology, 2005-date
Disease Models and Mechanisms, 2008-date

Selected or Recent Journal Publications

Chen YH, Gutmann DH. The molecular and cell biology of pediatric low-grade gliomas.
Oncogene. 2013 Apr 29. doi: 10.1038/onc.2013.148

Diggs-Andrews KA, Gutmann DH.Modeling cognitive dysfunction in neurofibromatosis-1. Trends Neurosci. 2013 Apr;36(4):237-47. doi: 10.1016/j.tins.2012.12.002. Epub 2013 Jan 8.

Gutmann DH, Avery R, Ferner RE, Listernick R.Visual function and optic pathway glioma: a critical response. JAMA Ophthalmol. 2013 Jan;131(1):120-1.

Johnson KJ, Hussain I, Williams K, Santens R, Mueller NL, Gutmann DH.Development of an international internet-based neurofibromatosis Type 1 patient registry. Contemp Clin Trials. 2013 Mar;34(2):305-11.

Ho CY, Bar E, Giannini C, Marchionni L, Karajannis MA, Zagzag D, Gutmann DH, Eberhart CG, Rodriguez FJ. MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.

Kaul A, Chen YH, Emnett RJ, Dahiya S, Gutmann DH.Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes Dev. 2012 Dec 1;26(23):2561-6.

Wessel LE, Gao F, Gutmann DH, Dunn CM.Longitudinal Analysis of Developmental Delays in Children With Neurofibromatosis Type 1. J Child Neurol. 2012 Oct 30.

Wessel LE, Albers AC, Gutmann DH, Dunn CM.The Association Between Hypotonia and Brain Tumors in Children With Neurofibromatosis Type 1.J Child Neurol. 2012 Oct 17.

Gutmann DH, Parada LF, Silva AJ, Ratner N.Neurofibromatosis type 1: modeling CNS dysfunction. J Neurosci. 2012 Oct 10;32(41):14087-93.

Avery RA, Ferner RE, Listernick R, Fisher MJ, Gutmann DH, Liu GT.Visual acuity in children with low grade gliomas of the visual pathway: implications for patient care and clinical research. J Neurooncol. 2012 Oct;110(1):1-7.

Brown JA, Gianino SM, Gutmann DH: Defective cyclic AMP generation underlies the sensitivity of central nervous system neurons to neurofibromatosis-1 heterozygosity.  J Neurosci 30:5579-89, 2010.

Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH: Neurofibromin controls cell growth by regulating STAT3 activity in vitro and in vivo.  Cancer Res 70:1356-66, 2010.

Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck D, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumbolt Z, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ: Defining Future Directions in Spinal Cord Tumor Research: National Institutes of Health Workshop Report. J Neurosurg Spine 12:117-121, 2010.

Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Robert AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra MC, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake DR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T: Proceedings from Genetic Syndromes of the Ras/MAPK Pathway:  From Bedside to Bench and Back 2009. Am J Med Genet A 152A:4-24, 2010.

Schiffman JD, Hodgson JG, Vandenberg SR, Flaherty P, Polley M-YC, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD: Combined oncogenic BRAF mutation and CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res 70:512-519, 2010.

Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A: Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath tumor explant xenografts.  Int J Cancer 126:563-71, 2010.

Darken R, Bogitch R, Leonard J, Perry A, McKinstry RC, Gutmann DH, Rubin JB: Brainstem glioma presenting as pruritus in children with neurofibromatosis-1.  J Ped Hem-Onc. 31:972-976, 2009.

Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA, Nagarajan R, Gutmann DH: Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology 73:1526-31, 2009. [chosen for editorial]

Mawrin C, Wolke C, Haase D, Kruger S, Firsching R, Keilhoff G, Paulus W, Gutmann DH, Lal A, Lendeckel U: Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC.  Brain Pathol. Epub Feb 18, 2009.

Dickinson PJ, Surace EI, Cambell M, Higgins RJ, Leutenegger CM, Bollen AW, LeCouteur RA, Gutmann DH: Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas.  Vet Pathol. 46:884-892, 2009.

Nunley KS, Gao F, Albers AC, Bayliss SJ, Gutmann DH: Predictive value of café-au-lait macules at initial consultation in the diagnosis of neurofibromatosis type 1.  Arch Dermat. 145:883-887, 2009.

Yeh T-H, Lee DY, Gianino SM, Gutmann DH: Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation.  GLIA 57:1239-49, 2009.

Hegedus B, Hughes WF, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA, Gutmann DH: Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. J Neuropathol Exp Neurol. 68:542-551, 2009. [cover feature]

Houshmandi SS, Emnett RJ, Giovannini M, Gutmann DH: The neurofibromatosis-2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner.  Mol Cell Biol. 29:1472-86, 2009.

Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard J: Histopathologic predictors of pilocytic astrocytoma event-free survival.  Acta Neuropathologica 117:657-665, 2009.

Filion C, Motoi T, Olshen A, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M. Labelle Y: The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor: use of tumor expression profiles to guide the search for candidate transcriptional target genes. J Pathol 217:83-93, 2009.

Jost SC, Ackerman JW, Garbow JR, Manwaring LP, Gutmann DH, McKinstry RC: Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma.  Pediatric Radiology 38:1293-1299, 2008.

Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH: Increased JNK signaling in Neurofibromatosis-1 (Nf1) heterozygous microglia drives microglia activation and promotes optic glioma proliferation.  Cancer Res. 68:10358-10366, 2008.

Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart EG, Sarkaria JN, Gutmann DH: Gene expression profiling of NF1-associated and sporadic pilocytic astrocytomas identifies ALDH1L1 as an underexpressed candidate biomarker in aggressive astrocytoma subtypes. J Neuropath Exp Neurol. 67:1194-1204, 2008. [cover feature]

Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ: Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell 135:549-560, 2008.

Striedinger K, McDermott MW, VandenBerg SR, Gutmann DH, Lal A: The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth through YAP.  Neoplasia 10:1204-1214, 2008.

Books and Book Chapters

Listernick R, Gutmann DH: Pediatric low-grade glioma: The role of neurofibromatosis-1 in guiding therapy. In Pediatric Tumors (Hayat M.A., editor), Springer: Secaucus NJ (in press).

Crouse NR, Dahiya S, Gutmann DH: Rethinking Pediatric Gliomas as Developmental Brain Abnormalities. In: Cancer & Development. (Dyer MA, editor). Current Topics in Developmental Biology. Elsevier Press: Cambridge (in press).

Darken RS, Gutmann DH: Neurofibromatosis Type 1.  In: Molecular Oncology: Causes of Cancer and Targets for Treatment. (Gelmann E, Sawyers C, Rauscher F III, editors). Cambridge University Press: New York (in press).

Gutmann RJ, Gutmann DH: Predisposition Syndromes: Neurofibromatosis 1, Neurofibromatosis 2, Tuberous Sclerosis Complex. In: Principles and Practice of Neuro-Oncology. (M Mehta et al., editors). Demos Publishing: New York (in press).

Listernick R, Gutmann DH: Neurofibromatosis.  In: Ocular Disease: Mechanisms and Management. (LA Levin and DM Albert, Editors).

Zeng L-H, Gutmann DH, Wong M: Glial-mediated mechanisms of epileptogenesis in tuberous sclerosis.  In: Encyclopedia of Basic Epilepsy Research. (PA Schwartzkroin, Editor). Elsevier: Oxford. 2009. Elsevier: Oxford 2010.

Jost S, Gutmann DH: Neurofibromatosis and Other Genetic Syndromes.  In: Handbook of Clinical Neurology, Neuro-Oncology Volume 95. (Aminoff, Biller and Swaab, Editors). Elsevier: New York. 2009.

Gutmann DH: Using neurofibromatosis type 1 mouse models to understand human pediatric low-grade gliomas.  In: CNS Cancer: Models, Prognostic Factors, Targets and Therapeutic Approaches. (E. Van Meir, editors). Springer Press: New York.  Pages 45-60, 2009.


For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David H. Gutmann


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