David H. Gutmann, MD, PhD
Current Position
Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics
Specialty Areas
Neurology - Pediatric
Pediatrics
Neurofibromatosis
Neuro Oncology
Patients Seen At
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St. Louis Children's Hospital
One Children's Place, Second Floor, Suite D
St. Louis,
MO
63110
314-454-6120
Fax:
314-454-2523
View Driving Directions
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Mailing Address
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Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis,
MO
63110
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Areas of Clinical Interest
Inherited cancer syndromes of the nervous system, neurofibromatosis 1 (NF1), familial cancer syndromes that affect the brain, spinal cord, and nerves
Board Certification
Neurology
--
Certified
Medical Education
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan
, 1980
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan
, 1984
Medical Degree: University of Michigan, Ann Arbor, Michigan
, 1986
Residency: Neurology, Hospital of the University of Pennsylvania
, 1990
Fellowship: Human Molecular Genetics, University of Michigan Medical Center
, 1993
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital
Major or Recent Publications/Awards
Awards
American Society for Clinical Investigation, inducted 2003
Washington University School of Medicine Clinical Teacher of the Year Award, 2003
National Neurofibromatosis Foundation Center of Excellence Award, 2002
Donald O. Schnuck Family Chair in Neurology, 2001
Linse Block Neuro-oncology Visiting Professor, Mayo Clinic Foundation, 2001
Eliason Teaching Award, Department of Neurology, 1999
Walker Lecturer in Neurofibromatosis, 1999
National Neurofibromatosis Foundation Crystal Award, 1998
Carolyn Farb Endowed Lecture in Neurofibromatosis, 1998
American Neurological Association, elected member, 1997
Decade of the Brain Plenary Session Speaker, American Academy of Neurology, 1996
Selected Publications
Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH: Proteomic analysis reveals hyperactivation of the mTOR pathway in NF1-associated human and mouse brain tumors. Cancer Research 65:2755-60, 2005.
Bajenaru ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH: Natural history of neurofibromatosis 1-associated optic nerve glioma formation in mice. Annals of Neurology 57:119-27, 2005.
Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, Gutmann DH: Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res. 63: 8573-8577, 2003.
Gutmann DH, Baker SJ, Giovannini M, Garbow J, Weiss W: Mouse Models of Human Cancers Consortium (MMHCC) symposium on nervous system tumors. Cancer Res. 63:3001-3004, 2003.
Kalamarides M, Niwa-Kawakita M, Leblois H, Abramowski V, Perricaudet M, Janin A, Thomas G, Gutmann DH, Giovannini M. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Genes & Development 16:1060-1065, 2002.
Ferner RE, Gutmann DH, Coffin C, Grimer R, Guha A, Judson I, Sandison A, Smith M, Viskochil D. International Consensus Statement on Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis 1. Cancer Res 62:1573-1577, 2002.
Gutmann DH, Huang Z-y, Hedrick NM, Ding H, Guha A, Watson MA: Mouse glioma gene expression profiling identifies novel human glioma-associated genes. Annals of Neurology 51:393-405, 2002.
Gutmann DH: Neurofibromatosis: When less is more. Human Molecular Genetics. 10:747-755, 2001.
Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P: The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes & Development 15:968-980, 2001.
Li J, Perry A, James CD, Gutmann DH: Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas. Neurology 56:885-890, 2001 (accompanying editorial; pages 827-829).
Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, and Viskochil D: The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. J. American Med. Assoc. 278:51-57, 1997.
Listernick R, Louis DN, Packer RJ, Gutmann DH: Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force. Annals of Neurology 41:143-149, 1997.
For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David H. Gutmann