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Neurology / Pediatric

David H. Gutmann, MD, PhD

Current Position
Donald O. Schnuck Family Professor of Neurology
Professor, Pediatrics, Neurosurgery, and Genetics

Specialty Areas
Pediatric Neurology
Neuro Oncology

Patients Seen At
St. Louis Children's Hospital
One Children's Place, Second Floor, Suite D
St. Louis, MO  63110
Fax:   314-454-2523
View Driving Directions

Mailing Address
Washington University School of Medicine
Department of Neurology
660 South Euclid Ave., Campus Box 8111
St. Louis, MO  63110

Areas of Clinical Interest
Inherited cancer syndromes of the nervous system, neurofibromatosis, NF1, NF2, familial cancer syndromes that affect the brain, spinal cord, and nerves.  Read more about neurofibromatosis at the new Washington University NF Center web site.

Board Certification
Neurology -- Certified
Pediatric Neurology

Medical Education
M.S.: Human Genetics, University of Michigan, Ann Arbor, Michigan, 1980
Ph.D.: Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, 1984
Medical Degree: University of Michigan, Ann Arbor, Michigan, 1986
Residency: Neurology, Hospital of the University of Pennsylvania, 1990
Fellowship: Human Molecular Genetics, University of Michigan Medical Center, 1993
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital

Honors and Awards
Recognized as one of the Top 44 Providers with the Highest Patient Satisfaction, Washington University School of Medicine, 2010-2012

Best Doctor in America ( Best Doctors Inc) 2007-2013

University of Arkansas MD/PhD Student Choice Speaker, 2010

Pfizer Visiting Professor, University of Virginia, 2010

Award for Excellence in Pediatric Translational Research, Society for Neuro-Oncology, 2008

Takao Hoshino Lectureship, University of California – San Francisco, 2008

Ninth Annual Arthur and Sonia Labatt Brain Tumor Research Centre Lecturer, 2007

Award for Excellence in Pediatric Basic/Translational Research, Society for Neuro-Oncology, 2007

Manuel R. Gomez Named Visiting Professor, 2006

American Society for Clinical Investigation, inducted 2003

Washington University School of Medicine Clinical Teacher of the Year Award, 2003

National Neurofibromatosis Foundation Center of Excellence Award, 2002

Donald O. Schnuck Family Chair in Neurology, 2001

Linse Block Neuro-oncology Visiting Professor, Mayo Clinic Foundation, 2001

Eliason Teaching Award, Department of Neurology, 1999

Walker Lecturer in Neurofibromatosis, 1999

National Neurofibromatosis Foundation Crystal Award, 1998

Carolyn Farb Endowed Lecture in Neurofibromatosis, 1998

American Neurological Association, elected member, 1997

Decade of the Brain Plenary Session Speaker, American Academy of Neurology, 1996

Editorial Responsibilities
Ad Hoc Reviewer
Am J Medical Genetics
Am J Pathology
Annals of Neurology
Archives of Neurology
BMC Cancer
Cancer Cell
Cancer Res
Cell Growth and Differentiation
Clinical Cancer Res
Developmental  Dynamics
Experimental Neurology
Genes & Development   
Human Molecular Genetics   
International Journal of Cancer
Journal of the Amer Med Assoc   
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Clinical Investigation
Journal of Medical Genetics
Journal of Neurobiology
Journal of Neurological Science
Journal of Neurosurgery
Journal of Neuro-oncology
Laboratory Investigation
Molecular and Cellular Biology
Nature Neuroscience
Nature Reviews Cell Biology
Nature Reviews Neuroscience
Neurobiology of Disease

Editorial Board
Familial Cancer, 1998-date
Neurobiology of Disease, 2000-date
Associate Editor, Cancer Res., 2003-date
Experimental Neurology, 2003-date
GLIA, 2004-date
Neuro-Oncology, 2005-date
Disease Models and Mechanisms, 2008-date

Selected or Recent Journal Publications
Diggs-Andrews KA, Brown JA, Gianino SM, McGowan LD, Rubin JB, Wozniak DF, Gutmann DH. Reply to Letter to the Editor. Ann Neurol. 2014 Apr 18.

Johnson KJ, Mueller NL, Williams K, Gutmann DH. Evaluation of participant recruitment methods to a rare disease online registry. Am J Med Genet A. 2014 Apr 3.

Kumar MG, Emnett RJ, Bayliss SJ, Gutmann DH. Glomus tumors in individuals with neurofibromatosis type 1. J Am Acad Dermatol. 2014 Mar 28. pii: S0190-9622(14)01051-2.

Gavilan HS, Kulikauskas RM, Gutmann DH, Fehon RG. In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. PLoS One. 2014 Mar 4;9(3):e90853.

Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK. Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res. 2014 Mar 1;74(5):1429-39.

Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH. BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. Neuro Oncol. 2014 Mar;16(3):466-7.

Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH. Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol. 2014 Feb;75(2):309-16.

Dahiya S, Emnett RJ, Haydon DH, Leonard JR, Phillips JJ, Perry A, Gutmann DH. BRAF-V600E mutation in pediatric and adult glioblastoma. Neuro Oncol. 2014 Jan;16(2):318-9.

Fisher MJ, Avery RA, Allen JC, Ardern-Holmes SL, Bilaniuk LT, Ferner RE, Gutmann DH, Listernick R, Martin S, Ullrich NJ, Liu GT; REiNS International Collaboration. Functional outcome measures for NF1-associated optic pathway glioma clinical trials. Neurology. 2013 Nov 19;81(21 Suppl 1):S15-24.

Lin AL, Gutmann DH. Advances in the treatment of neurofibromatosis-associated tumours. Nat Rev Clin Oncol. 2013 Nov;10(11):616-24.

Ostendorf AP, Gutmann DH, Weisenberg JL. Epilepsy in individuals with neurofibromatosis type 1. Epilepsia. 2013 Oct;54(10):1810-4.

Kaul A, Chen YH, Emnett RJ, Gianino SM, Gutmann DH. Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects. Genesis. 2013 Oct;51(10):708-16.

Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH. F11R is a novel monocyte prognostic biomarker for malignant glioma. PLoS One. 2013 Oct 11;8(10):e77571.

Licis AK, Vallorani A, Gao F, Chen C, Lenox J, Yamada KA, Duntley SP, Gutmann DH. Prevalence of Sleep Disturbances in Children With Neurofibromatosis Type 1. J Child Neurol. 2013 Nov;28(11):1400-1405. Epub 2013 Sep 23.

Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR. Antiangiogenic agents for nonmalignant brain tumors. J Neurol Surg B Skull Base. 2013 Jun;74(3):136-41.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David H. Gutmann

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