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Brian P. Hackett, PhD, MD

Current Position
Professor, Pediatrics
Division of Newborn Medicine
Director, Fellowship Program

Specialty Areas
Newborn Medicine - Neonatology
Neonatal/Perinatal Medicine

Patients Seen At
St Louis Children's Hospital
One Children's Place, Neonatal Intensive Care Unit (NICU), 5th Floor
St. Louis, MO  63110
Fax:   314-454-4633
View Driving Directions

Mailing Address
Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8116
St. Louis, MO  63110

Areas of Clinical Interest
High-risk newborn, critical care

Board Certification
Neonatal-Perinatal Medicine -- Certified
Pediatrics -- Certified

Medical Education
B.A.: Middlebury College, Middlebury, Vermont, 1975
Ph.D.: Biology, Boston College, Chesnut Hill, Massachusetts, 1984
Medical Degree: St. Louis University, St. Louis, Missouri, 1986
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri, 1989
Fellowship: Newborn Medicine, St. Louis Children's Hospital, St. Louis, Missouri, 1992
Hospital Affiliations
Barnes-Jewish Hospital
St. Louis Children's Hospital

Selected or Recent Journal Articles
Wambach JA, Yang P, Wegner DJ, An P, Hackett BP, Cole FS, Hamvas A. Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res. 2010 Sep;68(3):216-20.

Gomperts BN, Kim LJ, Flaherty SA, Hackett BP. IL-13 regulates cilia loss and foxj1 expression in human airway epithelium. Am J Respir Cell Mol Biol. 2007 Sep;37(3):339-46. Epub 2007 May 31.

Tamakoshi T, Itakura T, Chandra A, Uezato T, Yang Z, Xue XD, Wang B, Hackett BP, Yokoyama T, Miura N. Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem Biophys Res Commun. 2006 Jan 20;339(3):932-8. Epub 2005 Nov 28.

Zhang M, Bolfing MF, Knowles HJ, Karnes H, Hackett BP. Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1413-20.

Hamvas A, Nogee LM, White FV, Schuler P, Hackett BP, Huddleston CB, Mendeloff EN, Hsu FF, Wert SE, Gonzales LW, Beers MF, Ballard PL. Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene. Am J Respir Cell Mol Biol. 2004 Jun;30(6):771-6. Epub 2003 Dec 4.

Gomperts BN, Gong-Cooper X, Hackett BP. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci. 2004 Mar 15;117(Pt 8):1329-37. Epub 2004 Mar 2.

Hackett BP. Formation and malformation of the vertebrate left-right axis. Curr Mol Med. 2002 Feb;2(1):39-66. Review.

Casey B, Hackett BP. Left-right axis malformations in man and mouse. Curr Opin Genet Dev. 2000 Jun;10(3):257-61. Review.

Chen J, Knowles HJ, Hebert JL, Hackett BP. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest. 1998 Sep 15;102(6):1077-82.

Mazziotti MV, Muldowney S, Darcy M, Hackett BP, Skinner MA. Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: a case report. J Pediatr Surg. 1998 May;33(5):754-5.

Pelletier GJ, Brody SL, Liapis H, White RA, Hackett BP. A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am J Physiol. 1998 Mar;274(3 Pt 1):L351-9.

Brody SL, Hackett BP, White RA. Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member. Genomics. 1997 Nov 1;45(3):509-18.

Hackett BP, Bingle CD, Gitlin JD. Mechanisms of gene expression and cell fate determination in the developing pulmonary epithelium. Annu Rev Physiol. 1996;58:51-71. Review.

Bingle CD, Hackett BP, Moxley M, Longmore W, Gitlin JD. Role of hepatocyte nuclear factor-3 alpha and hepatocyte nuclear factor-3 beta in Clara cell secretory protein gene expression in the bronchiolar epithelium. Biochem J. 1995 May 15;308 ( Pt 1):197-202.

Hackett BP, Brody SL, Liang M, Zeitz ID, Bruns LA, Gitlin JD. Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4249-53.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Brian P. Hackett.

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Copyright 2015 Washington University School of Medicine